Bibliographic Citation
| Document | For copies of Journal Articles, please contact the Publisher or your local public or university library and refer to the information in the Resource Relation field. For copies of other documents, please see the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or Document Availability. |
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| DOI | http://dx.doi.org/10.1016/S0360-3016(02)03036-5 |
| Title | Using the magnitude of PSA bounce after MRI-guided prostate brachytherapy to distinguish recurrence, benign precipitating factors, and idiopathic bounce |
| Creator/Author | Das, Prajnan E-mail: pdas@partners.org ; Chen, M.-H. ; Valentine, Kristin ; Lopes, Lynn ; Cormack, Robert A. ; Renshaw, Andrew A. ; Tempany, Clare M. ; Kumar, Sanjaya ; D'Amico, Anthony V |
| Publication Date | 2002 Nov 01 |
| OSTI Identifier | OSTI ID: 20390522 |
| Other Number(s) | ISSN 0360-3016; IOBPD3 ; TRN: US03S0818012569 |
| Resource Type | Journal Article |
| Resource Relation | International Journal of Radiation Oncology, Biology and Physics ; VOL. 54 ; ISSUE: 3 ; PII: S0360301602030365; Copyright (c) 2002 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); PBD: 1 Nov 2002 |
| Subject | 62 RADIOLOGY AND NUCLEAR MEDICINE ; ACCURACY; ANTIGENS; NEOPLASMS; PROCTITIS; PROSTATE; SPATIAL DOSE DISTRIBUTIONS |
| Description/Abstract | Purpose: To identify events that precipitated a prostate-specific antigen (PSA) bounce and characterize the magnitude, duration, and time to PSA bounce after MRI-guided prostate brachytherapy. Methods and Materials: Between 1997 and 2001, 186 patients with low-risk prostate cancer underwent MRI-guided permanent{sup 125}I source implantation, with or without external beam radiotherapy. A PSA bounce was defined as a{>=}15% elevation in PSA compared with the most recent value, followed by a decline to a level at or less than the prebounce value. At the time of PSA measurement, data were prospectively collected on whether the patient had recent ejaculation, ongoing radiation proctitis, or recent instrumentation. Results: A total of 115 patients (61.8%) had a total of 156 PSA bounces. Of these, 36 patients had PSA bounces associated with ejaculation, proctitis, or instrumentation, and 79 experienced idiopathic PSA bounces (not associated with a precipitating event). The magnitude of the PSA bounce was significantly lower for the idiopathic PSA bounce (0.6 ng/mL) compared with that associated with ejaculation (p=0.003), proctitis (p<0.0001), or instrumentation (p=0.007). Patients with biopsy-proven local recurrence had a median PSA elevation of 1.2 ng/mL, significantly higher (p=0.006) than the magnitude of the idiopathic PSA bounce, but not significantly different from the magnitude of the PSA bounce due to ejaculation, proctitis, or instrumentation. Conclusion: In patients treated with MRI-guided prostate brachytherapy, recent ejaculation, instrumentation, or ongoing radiation proctitis can cause a transient increase in PSA, the magnitude of which is significantly higher than that for idiopathic PSA bounce, but is similar to that in patients with recurrent disease. |
| Country of Publication | United States |
| Language | English |
| Format | page(s) 698-702 |
| System Entry Date | 2003 Nov 24 |
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Last Updated: 02/10/2009