DAVID Gene Report
3027358
hepatocyte growth factor (hepapoietin a; scatter factor) Related Genes Homo sapiens
SP_COMMENT
function:HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. It has no detectable protease activity.,
similarity:Belongs to the peptidase S1 family. Plasminogen subfamily.,
similarity:Contains 1 PAN domain.,
similarity:Contains 1 peptidase S1 domain.,
similarity:Contains 4 kringle domains.,
subunit:Dimer of an alpha chain and a beta chain linked by a disulfide bond.,
ENTREZ_GENE_SUMMARY
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.,
GENPEPT_ACCESSION
AAA35980 ,
AAA52648 ,
AAA52649 ,
AAA52650 ,
AAA64239 ,
AAA64297 ,
AAC50539 ,
AAC71655 ,
AAG53459 ,
AAG53460 ,
AAH22308 ,
AAH63485 ,
AAI05798 ,
AAI30285 ,
AAI30287 ,
AAO61091 ,
BAA14348 ,
BAD92137 ,
BAF84363 ,
CAA34387 ,
CAA40802 ,
EAL24189 ,
EAW76992 ,
EAW76993 ,
Genomic_DNA ,
JOINED ,
NOT_ANNOTATED_CDS ,
mRNA ,
GENE_SYMBOL
Hgf ,
GENE_NAME
Hepapoietin A; scatter factor,
Hepatocyte growth factor isoform 1 preproprotein variant,
Hepatocyte growth factor precursor,
Hepatopoeitin-A,
SF,
Scatter factor,
hepatocyte growth factor,
hepatocyte growth factor (hepapoietin A; scatter factor),
GENERIF_SUMMARY
hepatocyte growth factor Downregulates E-cadherin and Desmoglein 1 during melanoma development ,
Hepatocyte growth factor ,
Hepatocyte growth factor/scatter factor inhibits UVB-induced apoptosis of human keratinocytes but not of keratinocyte-derived cell lines via the phosphatidylinositol 3-kinase/AKT pathway. ,
Hepatocyte growth factor is essential for migration of myogenic cells and promotes their proliferation during the early periods of tongue morphogenesis in mouse embryos. ,
Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer ,
Polymorphonuclear neutrophils are a source of hepatocyte growth factor in patients with severe alcoholic hepatitis. ,
Scatter factor/hepatocyte growth factor stimulation of glioblastoma cell cycle progression through G(1) is c-Myc dependent and independent of p27 suppression, Cdk2 activation, or E2F1-dependent transcription. ,
Unlike other growth factors, HGF did not show any activity on the fibrinolytic system in both normal and dystrophic myoblasts. ,
regulation of production, subcellular localization and molecular form in neutrophils ,
play important roles in lung development, lung inflammation, and repair. ,
role in inhibiting anoikis in head and neck squamous cell carcinoma cells by activation of ERK and Akt signaling independent of NFkappa B ,
a diagnostic marker of thrombus formation in patients with cerebral infarction. ,
A new crystal form of the NK1 splice variant of HGF/SF demonstrates extensive hinge movement and suggests that the NK1 dimer originates by domain swapping. ,
HGF/SF decreased transendothelial resistance (TER) and increased paracellular permeability in human vascular endothelial cells ,
HGF in combination with vitamin D3 may have an autocrine and/or paracrine effect on the osteogenic maturation of bone marrow stromal cells, as well as on bone repair and remodeling. ,
These results suggest that hepatocyte growth factor and interleukin-6 upregulate each other's receptors, and thus cooperatively enhance tissue invasion. ,
Data show that thymosin beta4 was differentially expressed in HGF-treated HUVECs compared with control. ,
HGF and HGFR have an alternative role activating the via STAT3 transdution and operating on placental tissues, overall in organogenesis alteration conditions ,
The serum level of HGF represents the degree of the carcinogenic state in the liver of patients with C-viral chronic hepatitis and cirrhosis. ,
Overexpression of HGF/c-met appears to be a biological feedback response to the fibrotic process of systemic sclerosis. ,
HGF induces a strong and transient tyrosine phosphorylation of c-Cbl, resulting in an increased association with Fyn, Lyn, PI-3K, and CrkL. ,
aberrant signaling involvement in rhabdomyosarcomagenesis ,
plasma kallikrein and FXIa activate pro-HGF in vitro ,
NK4-transfected clone showed significant inhibition of pancreatic tumor progression in both the orthotopic implantation and liver metastasis models ,
Hepatocyte growth factor triggers signaling cascades mediating vascular smooth muscle cell migration. ,
HGF may stimulate the progression and growth of tumor cells in vivo by induction of Cox-2 ,
Increased expression of HGF and KGF by buccal mucosal fibroblasts may partly be responsible for the faster wound healing with less scar formation in the oral cavity compared with normal skin. ,
HGF, but not VEGF, serum levels in the coronary circulation correlated with left ventricular remodeling, suggesting HGF interaction in the wound-healing process associated with inflammation after AMI ,
in human tumor cells, HGF and M-CSF stimulate osteopontin production (which is subsequently used as a substrate for cell adhesion) ,
The production of this factor in kidney increases after unilateral nephrectomy. ,
immunoexpression of hepatocyte growth factor and c-Met in the eutopic endometrium of patients with pelvic endometrioisis is possibly useful to predict greater activity of the ectopic endometrium ,
These results argue for growth factor-dependent hepatocellular carcinoma development and provide novel and combined prognosis markers after HCC surgery. ,
In the presence of keratinocytes, fibroblasts from buccal mucosa, periodontal ligament, & skin increased increased HGF and KGF production 2-3 times. This may influence the proliferation & migration of junctional epithelium and affect periodontal disease. ,
The hepatocyte growth factor/Met pathway controls proliferation and apoptosis in multiple myeloma. ,
Tetranectin binds to this protein and TTPA. ,
Post-myocardial infarction human HGF gene therapy improved LV remodeling and dysfunction through hypertrophy of cardiomyocytes, infarct wall thickening, preservation of vessels, and antifibrosis in a mouse model ,
Autocrine and paracrine support of HGF-c-Met system attenuates degeneration of anterior horn cells in amyotrophic lateral sclerosis. Disruption of neuronal HGF-c-Met system at advanced stage accelerates cellular degeneration and cell death. ,
HGF and VEGF modulate the expression of cell adhesion and migration molecules and induce proliferation in endothelial cells, which may contribute to chronic hepatitis C-associated liver angiogenesis. ,
stimulates eNOS activity by a PI3K/Akt-dependent phosphorylation in a Ca(2+)-sensitive manner in vascular endothelial cells ,
HGF increased the invasive potential of prostate cancer cells probably through enhancement of cell motility and the production of MMPs and u-PA ,
Hepatocyte growth factor may be a mediator of heparin-induced osteoporosis. ,
HGF found in articular cartilage is produced by osteoblasts, diffuses into the cartilage, and may be implicated in the osteoarthritic process. ,
Hepatocyte growth factor induces apoptosis through the extrinsic pathway in hepatoma cells ,
Amyloid beta-protein expression and secretion are regulated via activation of ERK1/2 by HGF in cells transfected with APP751. ,
N-terminal domain of HGF inhibits angiogenesis not by disrupting the HGF/c-met interaction but rather by interfering with the endothelial glycosaminoglycans. ,
HGF, SDF-1, and MMP-9 have roles in stress-induced human CD34+ stem cell recruitment to the liver ,
results show that HGF suppresses TGF-beta1-mediated renal interstitial myofibroblastic activation; and this action of HGF is likely related to a mitogen-activated protein kinase-dependent blockade of Smad nuclear translocation ,
After acceleration of regenerative response by HGF, subsequent elevation of TGF-beta1 synergistically controls graft size, regulating uncontrolled proliferation of hepatocytes. ,
hepatocyte growth factor and c-Met/HGF receptor have roles in prostate neoplasm progression ,
HGF/SF-met signaling may up-regulate oncogenes, signal transduction genes, apoptosis-related genes, metastasis related genes, and down-regulate a number of genes. ,
hepatocyte growth factor values were significantly elevated in pregnancies of small-for-gestational age (SGA) fetuses compared to uncomplicated pregnancies ,
HGF is modulated by stanninocalcin 1 and has roles in wound healing, tissue regeneration, and angiogenesis ,
Retroviral ribozyme transgenes targeting HGF/SF in fibroblasts or its receptor cMET in mammary cancer cells can reduce the growth of mammary cancer and associated angiogenesis by inhibiting paracrine stromal-tumor cell interactions. ,
c-Met and HGF-SF have roles in the growth and progression of human and canine osteosarcoma ,
Mediates angiogenesis in cultured cancer cells by regulating the expression of hepatocyte growth factor and thrombospondin 1. ,
regulation of expression is affected by stat3 activation ,
the role of HGF in basement membrane formation during wound healing by immortalized alveolar type II epithelial cells ,
Serum HGF levels did not change significantly after adult-to-adult living donor liver transplantation with right lobe graft. ,
higher levels in vitreous body of people with proliferative retinopathy in vitrectomy ,
Densisty of HGF in hepatic allograft biopsy specimens compared with those from a control group of healthy patients. ,
Down-regulation of hSulf1 contributes to hepatocarcinogenesis by enhancing heparin-binding growth factor signaling and resistance to apoptosis. ,
Relationship of intercellular adhesion molecule-3 and hepatocyte growth factor with amyloidosis A in chronic renal-failure patients.There was no significant difference regarding the level of positivity for hepatocyte growth factor. ,
HGF/Met system is involved in the pathogenesis of endometriosis by promoting stromal cell proliferation and invasion of shed endometria and endometrial lesions via autocrine and paracrine pathways. ,
Shc is a critical angiogenic switch for VEGF production downstream from the HGF and ErbB2 RTKs. ,
Decreased HGF may be related to vascular endothelial cell damage in the development of pregnancy induced hypertension. ,
Quantitative-histogram scores of HGF in cuboidal or columnar cells surrounding red lesions showed statistically significant correlation with accumulation of macrophage in cells; no similar correlation was demonstrated for black lesions. ,
two convergent proinvasive agents secreted by myofibroblasts, namely hepatocyte growth factor and the TGF-beta-upregulated extracellular matrix glycoprotein tenascin-C, are each necessary though not sufficient for neoplasm invasion ,
HGF polymorphism may be a candidate susceptibility loci that affects the progression of carotid atherosclerosis in japanese population. ,
a decrease of insulin-like growth factor 1 along with an increase of hepatocyte growth factor may reflect an underlying biological process that influences cognitive decline as well as carotid atherosclerosis in the elderly ,
Theca cell-derived HGF may be capable of stimulating the proliferation of granulosa cells and suppressing progesterone synthesis via an activating MAPK pathway. ,
Increased levels of HGF in circulating blood is associated with non-Hodgkin's lymphoma or Hodgkin's lymphoma ,
C/A polymorphism in intron 13 of the HGF gene is associated with susceptibility to essential hypertension in lean or female subjects. ,
The HGF/c-met signaling system may have an important role in hMSC recruitment sites of tissue regeneration. ,
autocrine/paracrine role of HGF in glial cell responses during proliferative vitreoretinal disorders as well as in retinal neovascularization, by stimulating of VEGF release ,
elevated plasma levels in systemic inflammatory response syndrome and bacterial infections ,
hepatocyte growth factor (HGF) activation is catalyzed by multiple myeloma cells secreting the serine protease HGF-activator ,
early spreading responses to HGF may partly relate to increased paxillin availability for incorporation into, and turnover within, dynamic cytoskeletal/membrane complexes whose rapid and transient adhesion to the matrix drives migration. ,
both Met and HGF are overexpressed in papillary thyroid carcinomas ,
catalase and hepatocyte growth factor have roles in ceramide-induced apoptosis ,
Increased serum HGF concentrations correlate with the presence of thrombi in patients with acute coronary syndrome, acute aortic dissection, and pulmonary thromboembolism. ,
Results indicate that hepatocyte growth factor plays a role in regulating dendritic morphology in the developing cerebral cortex. ,
A positive correlation between platelet count in liver cirrhosis and serum level of thrombopoietin and hepatocyte growth factor was observed. ,
By regulating HIF-1 activity and specific gene expression downstream, NF-kappaB may influence the survival threshold, with an impact on the fate of carcinoma cells after prolonged hepatocyte growth factor treatment. ,
HGF and IL-1ra adhesion-dependent release from human blood granulocytes and monocytes involves plasma IgG, complement C3 and beta2 integrin ,
may have an important role in cyclosporin-induced gingival overgrowth ,
Mitogenic effects of HGF on hepatocytes may be accompanied by undesired cholangiogenesis and angiogenesis ,
Hepatocyte growth factor/scatter factor-mediates activation of Met and consequent downstream signaling in the glycosaminoglycan metabolism. ,
Transfected HGF is expressed in hepatic cells and has the activity of promoting cell division and protecting hepatic cells against poisoning. ,
HGF plays an important role in hepatocyte proliferation but contrary to in vitro results, HGF does not play a major role for the progression of hepatocarcinoma cells in vivo. ,
Semiquantitative analysis of HGF mRNA expression between decidua basalis and decidua parietalis showed no statistically significant difference. ,
The autocrine mechanism between over-expressed c-Met and HGF/SF in malignant tumors is part of the process of pleural metastatic spread. ,
Administration of rh-HGF before storage improved cardiac function after prolonged myocardial preservation by preventing apoptosis through c-Met/HGF receptor. May be promising strategy for prolonged heart graft preservation. ,
HGF maintains the hematopoietic microenvironment through stimulating proliferation and adhesion to the extracellular matrix and promoting hematopoiesis through inducing constitutive production of IL-11, SDF-1 alpha, and SCF by stromal cells themselves ,
The beneficial effect of HGF in chronic renal disease is attributable, at least in part, to a direct anti-inflammatory action, likely via NF-kappaB, on tubular epithelial cells. ,
Exogenous hHGF reduced rat lung expression levels of endothelin-1 & transforming growth factor-beta, pulmonary artery medial wall thickening, and the total collagen deposition in the lung. ,
Correlation between the vitreal levels of scatter factor and VCAM-1 was observed in diabetic patients. ,
This study revealed that HGF is densely found in the carotid fork, and its CSF level is markedly elevated in moyamoya disease, suggesting that HGF may be a key protein for pathogenesis of moyamoya disease. ,
HGF specifically induced the expression of Smad transcriptional co-repressor SnoN but not Ski and TG-interacting factor at both mRNA and protein levels in kidney cells ,
Suppressed intestinal mRNA expression of T-helper 1 cytokines. Total and CD4-positive T cells, neutrophils, and myloperoxidase activity in intestinal epithelium were diminished by HGF gene transfer, which also prevented weight loss and improved survival. ,
The HGF has a role of signal in colon tumorigenesis that is associated to progression of adenoma into carcinoma. ,
is produced by peritoneal macrophages and is possibly involved in the growth of endometriosis ,
HGF induces fibronectin expression and its extracellular assembly on the surface of melanoma cells through activation of mitogen-activated protein (MAP) kinase pathway, and induction and transcriptional activation of Early growth response-1 (Egr-1). ,
Epidermal and hepatocyte growth factors, but not keratinocyte growth factor, modulate protein kinase Calpha translocation to the plasma membrane ,
in chronic skin ulcers, decreased biological activity of endogenous HGF and overexpression of c-met may have roles in fibrosis and delayed recovery ,
Hepatocyte growth factor(HGF/SF)facilitates intercellular communication between the epithelial carcinoma and surrounding stromal tissue during metastatic invasion through interaction with its proto-oncogenic receptor, Met, found on carcinoma cells. ,
HGF/MET signalling protects Plasmodium sporozoite-infected host cells from apoptosis. ,
HGF electrogene therapy would prevent liver from radiation-induced liver damage by preventing apoptosis and down-regulation of TGF-beta1. ,
all-trans-retinoic acid augments the induction of HGF production caused by increased intracellular cAMP ,
inhibition of RANTES expression is mediated by activation of PI3K-Akt-GSK3beta pathway ,
a novel activity of HGF-the stimulation of NO production-which occurs via eNOS phosphorylation that may in turn be mediated by cross-talk between the PI3K/Akt and MAPK pathways ,
HGF/SF released FGF-2 in the matrix but did not induce FGF-2 expression in external auditory canal cholesteatoma. ,
Suppression of metastasis of human pancreatic cancer to the liver by transportal injection of recombinant adenoviral NK4 in nude mice ,
TGF-beta1 inhibits hepatocyte growth factor (HGF/SF) levels in external auditory canal cholesteatoma (EACC) epithelial cells ,
HGF is involved in the development and/or progression of gastric carcinoma through an autocrine mechanism ,
IL-6 and TNFalpha are involved in the production of HGF by endometrial stromal cells and may be involved in the growth of endometriosis by an autocrine mechanism ,
results reveal a signaling pathway for G1 arrest induced by HGF ,
It is concluded that level and duration of MAPK activation by Met receptor are crucial for the induction of a full HGF-dependent mitogenic and invasive program in KS cells. ,
Hepatocyte growth factor promotes lymphatic vessel formation and function. ,
Circulating HGF may counteract thrombogenesis by negatively modulating platelet functions. ,
HGF modulates endothelial K+ channels causing an activation of the eNOS; the increase of nitric oxide is necessary for the phosphorylation of the MAPK inducing the proliferation of HUCVEC. ,
This article reviews the published evidence of the roles hepatocyte growth factor/scatter factor plays in prostate cancer progression. ,
Significantly higher serum HGF level is associated with esophageal squamous cell carcinomas ,
expression of hepatocyte and keratinocyte growth factors and their receptors is preserved in patients with lung emphysema as compared to patients without emphysema; hepatocyte growth factor mRNA correlates with severity of airflow obstruction in smokers ,
Recombinant human HGF accelerates the regeneration of severely damaged livers, a situation in which the proliferation of mature hepatocytes is impaired. ,
XIAP expression in colorectal cancer is regulated by hepatocyte growth factor/C-met pathway via Akt signaling ,
The crystal structure of the beta-chain of HGF was studied. ,
A potential physiological pathway for inactivation of HGF and generation of NK4-like antagonists. ,
The presence of HGF receptors in the processus vaginalis is consistent with a role for HGF in triggering epithelial-mesenchymal transformation during inguinal hernia closure ,
Overexpression of the hepatocyte growth factor gene results in liver defects in Agille syndrome ,
p70S6K activation induces expression of MMP-9 associated with hepatocyte growth factor-mediated invasion in human ovarian cancer cells ,
The consistent expression of HGF and c-met during the perinatal period supports a physiological role for HGF in human lung development. ,
HGF has pivotal role for functional recovery after cerebral infarction through neuritogenesis, improved microcirculation, and prevention of gliosis. Evidence for feasibility of gene therapy in chronic stage of cerebral infarction. ,
Upon injury, skin keratinocytes might produce biologically active HGF in an autocrine fashion. This HGF might have different structural and/or biological properties from HGF produced by mesenchymal cells. ,
Liver cancer patients had a significantly higher level of serum hepatocyte growth factor than normal controls ,
Since we demonstrated that not only SDF-1, but also HGF and LIF are upregulated in damaged tissues, we postulate that CXCR4+ c-Met+ LIF-R+ TCSC could be mobilized from the BM into the PB, where they play a role in tissue repair/regeneration. ,
HGF abolished the phenotypic conversion of biliary epithelial cells induced by TGF-beta1. These results suggest that HGF ameliorates hepatic biliary fibrosis in part by blocking bile duct epithelial to mesenchymal transition. ,
HGF orchestrates several biochemical pathways, which allow cell survival under cell stress conditions encountered during tumor progression, overccoming the death signal of sustained p38 MAPK activation. ,
A specific upregulation of HGF synthesis by Oncostatin M supports the suggestion that oncostatin M may participate in lung repair through HGF production. ,
As discussed in this review, receptor tyrosine kinase Met and its ligand HGF/SF (hepatocyte growth factor/scatter factor) are essential in the signalling pathways required for embryogenesis and tissue regeneration. ,
Granulocytes transport HGF in peripheral blood to injured sites caused by blood coagulation, where HGF may promote tissue repair. ,
This is the first study reporting the association of an HGF gene polymorphism with high myopia. ,
progenitor cells are potent sources of VEGF, HGF, and IGF-I ,
Promotes survival of RPE(rertinal pigment epithelium) cells and retinal neurons, the inhibition of production of HGF by visible light, especially by blue light, may enhance the phototoxic effects of visible light on the RPE and retinal neurons. ,
HGF/SF has a role in increasing tumor blood volume ,
Serum HGF levels were higher in non-alcoholic steatohepatitis patients than in the controls ,
These results suggest that the sustained phosphorylation of Gab1 through Crk in response to HGF contributes to the prominent activation of Rac1. ,
HGF gene transfection inhibited T helper 2 immune responses and reduced lupus nephritis, autoimmune sialoadenitis, and cholangitis in chronic GVHD mice. HGF may be novel strategy for treatment of SLE, Sjogren's syndrome, and primary biliary cirrhosis. ,
neurons treated with hepatocyte HGF increased expression of the N-methyl-D-aspartate receptor NR2B subunit, calcium/calmodulin-dependent protein kinase II, and GluR1 subunit of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor ,
These findings suggest that HGF has potent and direct anti-inflammatory effects on the basis of suppression of NF-kappaB activation and downstream endothelial inflammation. ,
HGF-mediated PAI-1 production may provide a novel link between atherothrombosis and metabolic derangements. Targeting HGF signaling pathway may modulate the thrombotic risk in high-risk patients. ,
Mimp expression reduces hepatocyte growth factor/scatter factor-induced proliferation and scattering by attenuating and altering the downstream signaling of met proto-oncogene. ,
HGF stimulation led to increased agar colony formation of esophageal adenocarcinoma. ,
Novel c-Akt-regulated genes contributing to Scatter factor-mediated antineoplastic drug resistance. ,
Serum levels of HGF/SF are associated with the clinical course of metastatic breast cancer patients with liver metastases. ,
HGF induces genes favoring growth and is mitogenic when HepG2 cells are plated under low density; however, the opposite occurs under high density ,
In angiographically silent cardiac allograft vasculopathy, circulating HGF may have a protective effect on vascular endothelium and thus attenuate the severity of intimal hyperplasia. ,
HGF up-regulates the expression of the bone morphogenetic protein receptors, BMPR-IB and BMPR-II, in prostate cancer cells ,
glycosphingolipids, particularly GM2, form a complex with CD82, and this complex interacts with Met and thereby inhibits HGF-induced Met tyrosine kinase activity, as well as integrin to Met cross-talk ,
Expression of nephrin mRNA as well as nephrin promoter activity was suppressed by a putative dedifferentiation factor of podocytes, hepatocyte growth factor. ,
HGF may facilitate osteophyte development by promoting MCP-1-mediated entry of monocytes/macrophages into the osteoarthritis-affected joint and/or by stimulating macrophage-derived growth factors ,
HGF secreted by subepithelial fibroblasts contributes to human bronchial epithelial cell differentiation. ,
HGF stimulation of c-Met-overexpressing H69 small cell lung cancer cells (40 ng/ml, 15 min) resulted in an increase of reactive oxygen species ,
although serine proteases and HGF have quite distinct functions in proteolysis and Met signal transduction, respectively, they share a similar activation mechanism ,
These results indicate that cytokines and PGE(2) may indirectly mediate epithelial cell proliferation via the regulation of HGF in bronchial stromal cells and that HGF plays a crucial role in proinflammatory cytokine-induced proliferation. ,
Salivary HGF measured at baseline may predict future alveolar bone loss. ,
HGF measured during the early posttransplant period might be a useful parameter for early detection of acute renal allograft rejection ,
HGF has a role in the IL-1-induced chemokine response of epithelial cells in inflamed mucosal tissues. ,
HGF appears best suited for stimulating production of hyaluronic acid and elastin, which may be essential for normal superficial lamina propria restoration. ,
Imbalance in c-Met expression between tumour and surrounding normal tissue is associated with aggressive ductal carcinoma in situ phenotype. c-Met and HGF/SF may contribute to tumour development by different means than those controlled by Her2/neu. ,
Upregulation of hepatocyte growth factor plays a role in skin homeostasis after UV irradiation. ,
Reduced levels of HGF are present in African Americans with systemic sclerosis. ,
CREB activation, in concert with Sp1, constitutes a molecular switch that confers the cell type-specific induction of SnoN in response to HGF stimulation ,
No significant SNP or haplotypic associations were observed for TGFbeta1 or hepatocyte growth factor in autism ,
Recombinant human hepatocyte growth factor suppresses collagen type II-induced T cell priming in mouse spleen and diminishes the severity and incidence of experimental arthritis with up-regulation of IL-10 and suppression of IL-17. ,
These data indicate that HGF may play a role in cell proliferation processes occurring in thyroid glands affected by HT, probably under the regulation of the lymphoid infiltrate. ,
CHROMOSOME
7,
ENTREZ_GENE_ID
3082 ,
UNIGENE
Hs.396530 ,
PIR_NREF_ID
NF00080791,
NF00097383,
NF00104728,
NF00104867,
NF00120563,
NF00124350,
NF00127781,
NF00136165,
NF00887741,
NF02397967,
UNIPROT_ID
HGF_HUMAN ,
Q3KRB2_HUMAN ,
Q59H59_HUMAN ,
CYTOBAND
7q21.1,
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