KINZIG-SCHIPPERS M, HINDER M, GOHLER K, KIVISAARI E, PELLINEN P, ILLAUER M, MIGNOT A, SORGEL F; Interscience Conference on Antimicrobial Agents and Chemotherapy.
Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2000 Sep 17-20; 40: 21.
IBMP, Inst. for Biomedical and Pharmaceutical Res., Nurnberg-Heroldsberg, Germany
BACKGROUND: The measurement of site concentrations (conc.s) of antibacterials is important to both assess and support their clinical use in that sites infectious processes.METHODS: Eighteen patients (age: 52.2+/-12.7 yrs, 14 males/4 females, weight: 80.6+/-16.7 kg; mean+/-SD) with radiologically confirmed acute sinusitis, acute exacerbation of chronic sinusitis or chronic sinusitis were treated with 400 mg GTX once daily for at least 5 and up to 10 days. On day 4+/-1, a blood and maxillary sinus tissue sample and sinus fluid was taken. The 18 patients were randomly assigned to three groups with different sampling time frames after daily morning administration of GTX. Tissue and fluids were taken approximately at the same time. GTX was measured in all specimens by validated LC-fluorescence assays.RESULTS: [table: see text]. The penetration ratios of GTX > 1 demonstrate that GTX penetrates well into the sinus mucosa tissue. Comparing the time course of the sinus mucosa/ plasma ratios reveals that high tissue conc.s of GTX are maintained for a longer period of time in the tissue than in plasma. Conclusion: Thus, the data demonstrate that once-daily oral doses of GTX lead to therapeutically relevant tissue conc.s for long periods of time, confirming the results of clinical trials where GTX proved to be effective in the treatment of sinusitis when given at once-daily doses.KEYWORDS: Gatifloxacin; Penetration; Sinus mucosa
Publication Types:
Keywords:
- Acute Disease
- Anti-Bacterial Agents
- Body Fluids
- Female
- Fluoroquinolones
- Humans
- Male
- Maxillary Sinus
- Maxillary Sinusitis
- Mucous Membrane
- Paranasal Sinuses
- Sinusitis
- gatifloxacin
- therapy
Other ID:
UI: 102247046
From Meeting Abstracts