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Title Interaction of free fatty acids with the erythrocyte membrane as affected by hyperthermia and ionizing radiation
Creator/Author Rybczynska, M. ; Csordas, A. (K. Marcinkowski Academy of Medicine, Poznan (Poland))
Publication Date1990 Apr 01
OSTI IdentifierOSTI ID: 6645095
Other Number(s)ISSN0144-8463; CODEN: BRPTD
Resource TypeJournal Article
Resource RelationBioscience Reports ; Vol/Issue: 10:2
Subject560120 -- Radiation Effects on Biochemicals, Cells, & Tissue Culture; CARBOXYLIC ACIDS-- BIOLOGICAL FUNCTIONS;ERYTHROCYTES-- BIOLOGICAL RADIATION EFFECTS;HYPERTHERMIA-- BIOLOGICAL EFFECTS; CELL MEMBRANES;GAMMA RADIATION;HEMOLYSIS;MAN
Related SubjectANIMALS;BIOLOGICAL EFFECTS;BIOLOGICAL MATERIALS;BLOOD;BLOOD CELLS;BODY FLUIDS;BODY TEMPERATURE;CELL CONSTITUENTS;ELECTROMAGNETIC RADIATION;FUNCTIONS;IONIZING RADIATIONS;LYSIS;MAMMALS;MATERIALS;MEMBRANES;ORGANIC ACIDS;ORGANIC COMPOUNDS;PATHOLOGICAL CHANGES;PRIMATES;RADIATION EFFECTS;RADIATIONS;VERTEBRATES
Description/Abstract The interference of hyperthermia and ionizing radiation, respectively, with the effects of capric (10:0), lauric (12:0), myristic (14:0), oleic (cis-18:1) and elaidic (trans-18:1) acids on the osmotic resistance of human erythrocytes was investigated.^The results are summarized as follows: (A) not only at 37 degrees, but also at 42 and 47{degrees}C lauric acid (12:0) represents the minimum chain length for the biphasic behaviour of protecting against hypotonic hemolysis at a certain lower concentration range and hemolysis promotion at subsequent higher concentrations; (B) with increasing temperatures the protecting as well as the hemolytic effects occur at lower concentrations of the fatty acids; (C) the increase of temperature promotes the extent of hemolysis and reduces the extent of protection against hypotonic hemolysis; (D) Gamma-irradiation of erythrocytes selectively affects the concentration of oleic acid at which maximum protection against hypotonic hemolysis occurs, without altering the minimum concentration for 100% hemolysis.
Country of PublicationUnited States
LanguageEnglish
FormatPages: 155-163
System Entry Date2001 May 13

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