BLASTX+BEAUTY Search Results

WU-BLAST 2.0 search of the National Center for Biotechnology Information's NR Protein Database.

BEAUTY post-processing provided by the Human Genome Sequencing Center, Baylor College of Medicine.

BEAUTY Reference:
Worley KC, Culpepper P, Wiese BA, Smith RF. BEAUTY-X: enhanced BLAST searches for DNA queries. Bioinformatics 1998;14(10):890-1. Abstract

Worley KC, Wiese BA, Smith RF. BEAUTY: an enhanced BLAST-based search tool that integrates multiple biological information resources into sequence similarity search results. Genome Res 1995 Sep;5(2):173-84 Abstract

RepeatMasker repeats found in sequence:

No Repeats Found.

Reference:  Gish, Warren (1994-1997).  unpublished.
Gish, Warren and David J. States (1993).  Identification of protein coding
regions by database similarity search.  Nat. Genet. 3:266-72.

Notice:  statistical significance is estimated under the assumption that the
equivalent of one entire reading frame in the query sequence codes for protein
and that significant alignments will involve only coding reading frames.

Query=  B12E11.seq(1>399)
        (371 letters)
  Translating both strands of query sequence in all 6 reading frames

Database:  nr
           625,274 sequences; 197,782,623 total letters.


     Observed Numbers of Database Sequences Satisfying
    Various EXPECTation Thresholds (E parameter values)

        Histogram units:      = 14 Sequences     : less than 14 sequences

 EXPECTation Threshold
 (E parameter)
    |
    V   Observed Counts-->
  10000 9435 853 |============================================================
   6310 8582 731 |====================================================
   3980 7851 706 |==================================================
   2510 7145 721 |===================================================
   1580 6424 638 |=============================================
   1000 5786 548 |=======================================
    631 5238 367 |==========================
    398 4871 348 |========================
    251 4523 292 |====================
    158 4231 257 |==================
    100 3974 209 |==============
   63.1 3765 198 |==============
   39.8 3567 197 |==============
   25.1 3370 166 |===========
   15.8 3204 167 |===========
 >>>>>>>>>>>>>>>>>>>>>  Expect = 10.0, Observed = 3037  <<<<<<<<<<<<<<<<<
   10.0 3037 140 |==========
   6.31 2897 163 |===========
   3.98 2734  99 |=======
   2.51 2635 143 |==========
   1.58 2492  85 |======
   1.00 2407  94 |======
   0.63 2313  85 |======
   0.40 2228 118 |========
   0.25 2110  49 |===
   0.16 2061  66 |====
   0.10 1995  54 |===
  0.063 1941  50 |===
  0.040 1891  89 |======
  0.025 1802 114 |========
  0.016 1688 130 |=========
  0.010 1558  76 |=====
 0.0063 1482 112 |========
 0.0040 1370  78 |=====
 0.0025 1292  89 |======
 0.0016 1203  86 |======


                                                                     Smallest
                                                                       Sum
                                                     Reading  High  Probability
Sequences producing High-scoring Segment Pairs:        Frame Score  P(N)      N
gi|1523800|emb|CAA68958.1|(Y07694) MAP kinase kinase ... +3   444  3.7e-43   2
gi|11259770|pir||T51340mitogen-activated protein kina... +3   444  3.7e-43   2
gi|11358510|pir||T51339mitogen-activated protein kina... +3   449  2.0e-41   1
gi|12484128|gb|AAG53979.1|AF325168_1(AF325168) mitoge... +3   434  7.6e-40   1
gi|11120804|gb|AAG30984.1|AC012396_20(AC012396) MAP k... +3   271  1.4e-22   1
gi|6714299|gb|AAF25995.1|AC013354_14(AC013354) F15H18... +3   264  7.9e-22   1
gi|6862927|gb|AAF30316.1|AC018907_16(AC018907) putati... +3   232  1.9e-18   1
gi|11869988|gb|AAG40578.1|AF216314_1(AF216314) MAP ki... +3   213  4.0e-16   1
gi|7434320|pir||T02056protein kinase MEK1 (EC 2.7.1.-... +3   209  1.1e-15   1
gi|547915|sp|P36507|MPK2_HUMANDUAL SPECIFICITY MITOGE... +3   204  6.7e-15   1
gi|9843771|emb|CAA04261.2|(AJ000728) MAP kinase kinas... +3   201  9.4e-15   1
gi|2499630|sp|Q90891|MPK2_CHICKDUAL SPECIFICITY MITOG... +3   201  1.4e-14   1
gi|7434316|pir||T06583protein kinase MEK1 - tomato       +3   198  2.1e-14   1
gi|547916|sp|P36506|MPK2_RATDUAL SPECIFICITY MITOGEN-... +3   198  3.1e-14   1
gi|1083711|pir||S32412MEK2 protein - rat                 +3   198  3.1e-14   1
gi|1096928|prf||2113192AMEK2 protein [Rattus norvegicus] +3   198  3.1e-14   1
gi|2499629|sp|Q63932|MPK2_MOUSEDUAL SPECIFICITY MITOG... +3   197  4.0e-14   1
gi|7682432|gb|AAF67262.1|AF165186_1(AF165186) MAP kin... +3   195  4.5e-14   1
gi|7434309|pir||T04262mitogen-activated protein kinas... +3   193  7.3e-14   1
gi|12331300|emb|CAC24705.1|(AJ302651) MAP kinase [Nic... +3   193  7.3e-14   1
gi|12718822|dbj|BAB32405.1|(AB055514) NQK1 MAPKK [Nic... +3   193  7.3e-14   1
gi|2499627|sp|Q63980|MPK1_CRIGRDUAL SPECIFICITY MITOG... +3   193  1.0e-13   1
gi|7434321|pir||T08542mitogen-activated protein kinas... +3   191  1.3e-13   1
gi|11259772|pir||T51735mitogen-activated protein kina... +3   191  1.3e-13   1
gi|266566|sp|Q01986|MPK1_RATDUAL SPECIFICITY MITOGEN-... +3   191  1.7e-13   1
gi|5579478ref|NP_002746.1| mitogen-activated protein ... +3   191  1.7e-13   1
gi|6678794ref|NP_032953.1| mitogen activated protein ... +3   191  1.7e-13   1
gi|266565|sp|P29678|MPK1_RABITDUAL SPECIFICITY MITOGE... +3   191  1.7e-13   1
gi|4929202|gb|AAD33901.1|AF143201_1(AF143201) mitogen... +3   191  1.7e-13   1
gi|7670399|dbj|BAA95051.1|(AB041567) unnamed protein ... +3   191  1.7e-13   1
gi|422819|pir||B46723extracellular signal-regulated k... +3   191  1.7e-13   1
gi|2499628|sp|Q91447|MPK1_SERCADUAL SPECIFICITY MITOG... +3   190  2.1e-13   1
gi|10176761|dbj|BAB09875.1|(AB013392) protein kinase ... +3   181  1.6e-12   1
gi|12731723ref|XP_004045.2| serine-threonine protein ... +3   172  4.4e-12   1
gi|6324805ref|NP_014874.1| protein kinase involved in... +3   166  4.8e-12   2
gi|4033698|sp|Q05116|MPK1_XENLADUAL SPECIFICITY MITOG... +3   177  6.1e-12   1
gi|2499631|sp|Q90321|MPK2_CYPCADUAL SPECIFICITY MITOG... +3   176  7.9e-12   1
gi|8920605|gb|AAF81327.1|AC007767_7(AC007767) Contain... +3   171  1.2e-11   1
gi|7001372|gb|AAF34870.1|AF112183_1(AF112183) serine/... +3   173  2.3e-11   1
gi|2149570|gb|AAB58577.1|(U87912) MAP kinase kinase p... +3   163  2.3e-11   2
gi|2499636|sp|Q24324|DSOR_DROMEDUAL SPECIFICITY MITOG... +3   171  2.7e-11   1
gi|7291037|gb|AAF46475.1|(AE003446) Dsor1 gene produc... +3   171  2.8e-11   1
gi|7001374|gb|AAF34871.1|AF112184_1(AF112184) serine/... +3   173  2.8e-11   1
gi|7706059ref|NP_057592.1| serine-threonine protein k... +3   172  2.9e-11   1
gi|7671654|emb|CAB89421.1|(AL109839) dJ1069P2.1 (seri... +3   171  3.4e-11   1
gi|1117791|gb|AAA83254.1|(U18297) MST1 [Homo sapiens]    +3   171  4.3e-11   1
gi|5454096ref|NP_006273.1| serine/threonine kinase 4;... +3   171  4.3e-11   1
gi|12328814ref|NP_067395.1| serine/threonine kinase 4... +3   171  4.3e-11   1
gi|6016066|sp|Q99078|FUZ7_USTMADUAL SPECIFICITY PROTE... +3   170  4.4e-11   1
gi|12742313ref|XP_009522.2| serine/threonine kinase 4... +3   171  4.5e-11   1

Use the  and  icons to retrieve links to Entrez:
E = Retrieve Entrez links (e.g., Medline abstracts, FASTA-formatted sequence reports).
R = Retrieve links to Related sequences (neighbors).

Use the  icon (if present) to retrieve links to the Sequence Retrieval System (SRS).

Use the  icon (if present) to retrieve links to the Ligand Enzyme and Chemical Compound Database .

Use the  icon (if present) to retrieve links to the Protein Data Bank database.

WARNING:  Descriptions of 2987 database sequences were not reported due to the
          limiting value of parameter V = 50.



 >gi|1523800|emb|CAA68958.1|  (Y07694) MAP kinase kinase alpha protein kinase
            [Arabidopsis thaliana]
            Length = 348

Frame  3 hits (HSPs):            _________________                        
Frame  1 hits (HSPs):                           __                        
                        __________________________________________________
Database sequence:     |                     |                    |       | 348
                       0                   150                  300

  Plus Strand HSPs:

 Score = 444 (156.3 bits), Expect = 3.7e-43, Sum P(2) = 3.7e-43
 Identities = 86/114 (75%), Positives = 99/114 (86%), Frame = +3

Query:     3 AELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDAN 182
             +ELER+NRIGSG+GGTVYKV+H  + R +ALKVIYG+HE++VRRQI REI+ILR VD  N
Sbjct:    68 SELERVNRIGSGAGGTVYKVIHTPTSRPFALKVIYGNHEDTVRRQICREIEILRSVDHPN 127

Query:   183 VVKCHEMYDQNSEIQVLLEFMDGGSLEGKHITQEQQLAXLSRQILRGLAYLHRR 344
             VVKCH+M+D N EIQVLLEFMD GSLEG HI QEQ+LA LSRQIL GLAYLHRR
Sbjct:   128 VVKCHDMFDHNGEIQVLLEFMDQGSLEGAHIWQEQELADLSRQILSGLAYLHRR 181

 Score = 38 (13.4 bits), Expect = 3.7e-43, Sum P(2) = 3.7e-43
 Identities = 7/7 (100%), Positives = 7/7 (100%), Frame = +1

Query:   349 GLAYLHR 369
             GLAYLHR
Sbjct:   174 GLAYLHR 180


 >gi|11259770|pir||T51340  mitogen-activated protein kinase kinase (EC 2.7.1.-) 5
            [imported] - Arabidopsis thaliana >gi|3219273|dbj|BAA28831.1|
            (AB015316) MAP kinase kinase 5 [Arabidopsis thaliana]
            >gi|9280224|dbj|BAB01714.1| (AB023045) MAP kinase kinase 5
            [Arabidopsis thaliana]
            Length = 348

Frame  3 hits (HSPs):            _________________                        
Frame  1 hits (HSPs):                           __                        
                        __________________________________________________
Database sequence:     |                     |                    |       | 348
                       0                   150                  300

  Plus Strand HSPs:

 Score = 444 (156.3 bits), Expect = 3.7e-43, Sum P(2) = 3.7e-43
 Identities = 86/114 (75%), Positives = 99/114 (86%), Frame = +3

Query:     3 AELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDAN 182
             +ELER+NRIGSG+GGTVYKV+H  + R +ALKVIYG+HE++VRRQI REI+ILR VD  N
Sbjct:    68 SELERVNRIGSGAGGTVYKVIHTPTSRPFALKVIYGNHEDTVRRQICREIEILRSVDHPN 127

Query:   183 VVKCHEMYDQNSEIQVLLEFMDGGSLEGKHITQEQQLAXLSRQILRGLAYLHRR 344
             VVKCH+M+D N EIQVLLEFMD GSLEG HI QEQ+LA LSRQIL GLAYLHRR
Sbjct:   128 VVKCHDMFDHNGEIQVLLEFMDQGSLEGAHIWQEQELADLSRQILSGLAYLHRR 181

 Score = 38 (13.4 bits), Expect = 3.7e-43, Sum P(2) = 3.7e-43
 Identities = 7/7 (100%), Positives = 7/7 (100%), Frame = +1

Query:   349 GLAYLHR 369
             GLAYLHR
Sbjct:   174 GLAYLHR 180


 >gi|11358510|pir||T51339  mitogen-activated protein kinase kinase (EC 2.7.1.-) 4
            [validated] - Arabidopsis thaliana >gi|3219271|dbj|BAA28830.1|
            (AB015315) MAP kinase kinase 4 [Arabidopsis thaliana]
            >gi|11692830|gb|AAG40018.1|AF324667_1 (AF324667) F19C24.26
            [Arabidopsis thaliana] >gi|11908062|gb|AAG41460.1|AF326878_1
            (AF326878) putative MAP kinase kinase 4 (ATMKK4) protein
            [Arabidopsis thaliana] >gi|12321661|gb|AAG50863.1|AC025294_1
            (AC025294) MAP kinase kinase 4 (ATMKK4) [Arabidopsis thaliana]
            Length = 366

Frame  3 hits (HSPs):             ________________                        
                        __________________________________________________
Database sequence:     |                    |                   |         | 366
                       0                  150                 300

  Plus Strand HSPs:

 Score = 449 (158.1 bits), Expect = 2.0e-41, P = 2.0e-41
 Identities = 88/114 (77%), Positives = 100/114 (87%), Frame = +3

Query:     3 AELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDAN 182
             ++L R NRIGSG+GGTVYKV+HR S R+YALKVIYG+HEE+VRRQI REI+ILRDV+  N
Sbjct:    77 SDLVRGNRIGSGAGGTVYKVIHRPSSRLYALKVIYGNHEETVRRQICREIEILRDVNHPN 136

Query:   183 VVKCHEMYDQNSEIQVLLEFMDGGSLEGKHITQEQQLAXLSRQILRGLAYLHRR 344
             VVKCHEM+DQN EIQVLLEFMD GSLEG H+ +EQQLA LSRQIL GLAYLH R
Sbjct:   137 VVKCHEMFDQNGEIQVLLEFMDKGSLEGAHVWKEQQLADLSRQILSGLAYLHSR 190


 >gi|12484128|gb|AAG53979.1|AF325168_1  (AF325168) mitogen-activated protein
            kinase 2 [Nicotiana tabacum]
            Length = 372

Frame  3 hits (HSPs):             ________________                        
                        __________________________________________________
Database sequence:     |                    |                   |         | 372
                       0                  150                 300

  Plus Strand HSPs:

 Score = 434 (152.8 bits), Expect = 7.6e-40, P = 7.6e-40
 Identities = 82/114 (71%), Positives = 100/114 (87%), Frame = +3

Query:     3 AELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDAN 182
             +ELER+NRIGSG+GGTVYKV+HR +GR+YALKVIYG+HE+SVR Q+ REI+ILRDVD+ N
Sbjct:    80 SELERINRIGSGAGGTVYKVLHRPTGRLYALKVIYGNHEDSVRLQMCREIEILRDVDNPN 139

Query:   183 VVKCHEMYDQNSEIQVLLEFMDGGSLEGKHITQEQQLAXLSRQILRGLAYLHRR 344
             VV+CH+M+D N EIQVLLEFMD GSLEG HI +E  L+ L+RQ+L GL YLHRR
Sbjct:   140 VVRCHDMFDHNGEIQVLLEFMDKGSLEGIHIPKESALSDLTRQVLSGLYYLHRR 193


 >gi|11120804|gb|AAG30984.1|AC012396_20  (AC012396) MAP kinase, putative
            [Arabidopsis thaliana]
            Length = 310

Frame  3 hits (HSPs):          ___________________                        
                        __________________________________________________
Database sequence:     |       |       |        |       |       |       | | 310
                       0      50     100      150     200     250     300

  Plus Strand HSPs:

 Score = 271 (95.4 bits), Expect = 1.4e-22, P = 1.4e-22
 Identities = 54/114 (47%), Positives = 81/114 (71%), Frame = +3

Query:     6 ELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANV 185
             +LE+LN +G G+GG VYKV H+T+  +YALK + G  +    RQ+ RE++ILR  D   V
Sbjct:    46 DLEKLNVLGCGNGGIVYKVRHKTTSEIYALKTVNGDMDPIFTRQLMREMEILRRTDSPYV 105

Query:   186 VKCHEMYDQN--SEIQVLLEFMDGGSLEGKH--ITQEQQLAXLSRQILRGLAYLH 338
             VKCH ++++    E+ +L+E+MDGG+LE     +T EQ+LA  ++QIL+GL+YLH
Sbjct:   106 VKCHGIFEKPVVGEVSILMEYMDGGTLESLRGGVT-EQKLAGFAKQILKGLSYLH 159


 >gi|6714299|gb|AAF25995.1|AC013354_14  (AC013354) F15H18.14 [Arabidopsis
            thaliana]
            Length = 307

Frame  3 hits (HSPs):         ____________________                        
                        __________________________________________________
Database sequence:     |       |        |       |       |       |       | | 307
                       0      50      100     150     200     250     300

  Plus Strand HSPs:

 Score = 264 (92.9 bits), Expect = 7.9e-22, P = 7.9e-22
 Identities = 52/115 (45%), Positives = 80/115 (69%), Frame = +3

Query:     3 AELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDAN 182
             +++E+L+ +G GS G VYKV H+T+G +YALK + G    +  RQ+ RE++ILR  D   
Sbjct:    43 SDVEKLHVLGRGSSGIVYKVHHKTTGEIYALKSVNGDMSPAFTRQLAREMEILRRTDSPY 102

Query:   183 VVKCHEMYDQN--SEIQVLLEFMDGGSLEG-KHITQEQQLAXLSRQILRGLAYLH 338
             VV+C  ++++    E+ +L+E+MDGG+LE  +    E+QLA  SRQIL+GL+YLH
Sbjct:   103 VVRCQGIFEKPIVGEVSILMEYMDGGNLESLRGAVTEKQLAGFSRQILKGLSYLH 157


 >gi|6862927|gb|AAF30316.1|AC018907_16  (AC018907) putative MAP kinase
            [Arabidopsis thaliana]
            Length = 293

Frame  3 hits (HSPs):           ___________________                       
                        __________________________________________________
Database sequence:     |        |       |        |       |        |       | 293
                       0       50     100      150     200      250

  Plus Strand HSPs:

 Score = 232 (81.7 bits), Expect = 1.9e-18, P = 1.9e-18
 Identities = 50/112 (44%), Positives = 75/112 (66%), Frame = +3

Query:     3 AELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDAN 182
             A L+R++ +GSG+GGTV+KV  +T+  +YALK +    +E+      REI+ILR V+   
Sbjct:    51 ANLDRISVLGSGNGGTVFKVKDKTTSEIYALKKV----KENWDSTSLREIEILRMVNSPY 106

Query:   183 VVKCHEMYDQNS-EIQVLLEFMDGGSLEGKHITQEQQLAXLSRQILRGLAYLH 338
             V KCH+++   S E+ +L+++MD GSLE      E+QLA +SRQ+L G  YLH
Sbjct:   107 VAKCHDIFQNPSGEVSILMDYMDLGSLESLRGVTEKQLALMSRQVLEGKNYLH 159


 >gi|11869988|gb|AAG40578.1|AF216314_1  (AF216314) MAP kinase kinase 1 [Oryza
            sativa]
            Length = 355

Frame  3 hits (HSPs):            _________________                        
                        __________________________________________________
Database sequence:     |                    |                     |       | 355
                       0                  150                   300

  Plus Strand HSPs:

 Score = 213 (75.0 bits), Expect = 4.0e-16, P = 4.0e-16
 Identities = 49/115 (42%), Positives = 72/115 (62%), Frame = +3

Query:     6 ELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANV 185
             +LE +  IG GSGG V  V H+  G +YALK I  + +E+VR+QI +E++I +   +A++
Sbjct:    70 DLEMIQVIGKGSGGIVQLVRHKWVGTLYALKGIQMNIQEAVRKQIVQELKINQATQNAHI 129

Query:   186 VKCHEMYDQNSEIQVLLEFMDGGSLEG--KHITQ--EQQLAXLSRQILRGLAYLH 338
             V CH+ +  N  I ++LE+MD GSL    K +    E  LA L +Q+L GL YLH
Sbjct:   130 VLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLH 184


 >gi|7434320|pir||T02056  protein kinase MEK1 (EC 2.7.1.-) - maize
            >gi|2737973|gb|AAC83393.1| (U83625) protein kinase ZmMEK1 [Zea
            mays]
            Length = 355

Frame  3 hits (HSPs):            __________________                       
                        __________________________________________________
Database sequence:     |                    |                     |       | 355
                       0                  150                   300

  Plus Strand HSPs:

 Score = 209 (73.6 bits), Expect = 1.1e-15, P = 1.1e-15
 Identities = 48/117 (41%), Positives = 71/117 (60%), Frame = +3

Query:     6 ELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANV 185
             +LE +  IG GSGG V  V H+  G ++ALK I  + +ESVR+QI +E++I +     ++
Sbjct:    70 DLEMIQVIGKGSGGVVQLVRHKWVGTLFALKGIQMNIQESVRKQIVQELKINQATQSPHI 129

Query:   186 VKCHEMYDQNSEIQVLLEFMDGGSLEG--KHITQ--EQQLAXLSRQILRGLAYLHRR 344
             V CH+ +  N  I ++LE+MD GSL    K +    E  LA L +Q+L GL YLH +
Sbjct:   130 VMCHQSFYHNGVIYLVLEYMDRGSLADIVKQVKTILEPYLAVLCKQVLEGLLYLHHQ 186


 >gi|547915|sp|P36507|MPK2_HUMAN  DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN
            KINASE KINASE 2 (MAP KINASE KINASE 2) (MAPKK 2) (ERK ACTIVATOR
            KINASE 2) (MAPK/ERK KINASE 2) (MEK2) >gi|476903|pir||A46723 MAP
            kinase kinase 2 (EC 2.7.1.-) - human
            >gi|12653403|gb|AAH00471.1|AAH00471 (BC000471) Unknown (protein for
            MGC:8600) [Homo sapiens]
            Length = 400

Frame  3 hits (HSPs):           ________________                          
Annotated Domains:      _________________________________________________ 
                        __________________________________________________
Database sequence:     |                  |                  |            | 400
                       0                150                300
__________________

Annotated Domains:
   BLOCKS               BL00107A: Protein kinases ATP-binding re 184..214
   BLOCKS               BL00107B: Protein kinases ATP-binding re 247..262
   Entrez               Domain: PROTEIN KINASE.                  72..369
   Entrez               np-binding site: ATP (BY SIMILARITY).    78..86
   Entrez               binding site: ATP (BY SIMILARITY).       101
   Entrez               active site: BY SIMILARITY.              194
   Entrez               phosphorylation site: (BY RAF) (BY SIMIL 222
   Entrez               phosphorylation site: (BY RAF) (BY SIMIL 226
   Entrez               Domain: PRO-RICH.                        266..315
   PFAM                 pkinase: Eukaryotic protein kinase domai 72..369
   PRODOM               PD008976: MPK1(6) MPK2(5)                5..70
   PRODOM               PD000001: KKIT(14) CC2(14) KPC1(13)      72..278
   PRODOM               PD012430: MPK2(5)                        280..310
   PRODOM               PD004800: MPK1(6) MPK2(5) FUZ7(1)        312..390
   PROSITE              PROTEIN_KINASE_ST: Serine/Threonine prot 190..202
__________________


  Plus Strand HSPs:

 Score = 204 (71.8 bits), Expect = 6.7e-15, P = 6.7e-15
 Identities = 46/117 (39%), Positives = 72/117 (61%), Frame = +3

Query:     6 ELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANV 185
             + ER++ +G+G+GG V KV HR SG + A K+I+   + ++R QI RE+Q+L + +   +
Sbjct:    71 DFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 130

Query:   186 VKCHEMYDQNSEIQVLLEFMDGGSL-----EGKHITQEQQLAXLSRQILRGLAYLHRR 344
             V  +  +  + EI + +E MDGGSL     E K I +E  L  +S  +LRGLAYL  +
Sbjct:   131 VGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEI-LGKVSIAVLRGLAYLREK 187


 >gi|9843771|emb|CAA04261.2|  (AJ000728) MAP kinase kinase [Lycopersicon
            esculentum]
            Length = 357

Frame  3 hits (HSPs):            _________________                        
                        __________________________________________________
Database sequence:     |                    |                    |        | 357
                       0                  150                  300

  Plus Strand HSPs:

 Score = 201 (70.8 bits), Expect = 9.4e-15, P = 9.4e-15
 Identities = 46/116 (39%), Positives = 73/116 (62%), Frame = +3

Query:     3 AELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDAN 182
             A+ E +  IG G+GG V  V H+ +G+ +ALKVI  + +ES+R+ I +E++I +      
Sbjct:    68 ADFEAVKVIGKGNGGIVRLVQHKWTGQFFALKVIQMNIDESMRKHIAQELRINQSSQCPY 127

Query:   183 VVKCHEMYDQNSEIQVLLEFMDGGSLEG--KHITQ--EQQLAXLSRQILRGLAYLH 338
             VV C++ +  N  I ++LE+MDGGSL    K +    E+ LA + +Q+L+GL YLH
Sbjct:   128 VVICYQSFFDNGAISLILEYMDGGSLADFLKKVKTIPERFLAVICKQVLKGLWYLH 183


 >gi|2499630|sp|Q90891|MPK2_CHICK  DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN
            KINASE KINASE 2 (MAP KINASE KINASE 2) (MAPKK 2) (ERK ACTIVATOR
            KINASE 2) (MAPK/ERK KINASE 2) (MEK2) >gi|994710|gb|AAA75576.1|
            (L28703) mitogen-activated protein kinase kinase type 2 [Gallus
            gallus]
            Length = 398

Frame  3 hits (HSPs):           ________________                          
Annotated Domains:      _________________________________________________ 
                        __________________________________________________
Database sequence:     |                  |                  |            | 398
                       0                150                300
__________________

Annotated Domains:
   BLOCKS               BL00107A: Protein kinases ATP-binding re 182..212
   BLOCKS               BL00107B: Protein kinases ATP-binding re 245..260
   Entrez               Domain: PROTEIN KINASE.                  70..367
   Entrez               np-binding site: ATP (BY SIMILARITY).    76..84
   Entrez               binding site: ATP (BY SIMILARITY).       99
   Entrez               active site: BY SIMILARITY.              192
   Entrez               phosphorylation site: (BY RAF) (BY SIMIL 220
   Entrez               phosphorylation site: (BY RAF) (BY SIMIL 224
   Entrez               Domain: PRO-RICH.                        264..313
   PFAM                 pkinase: Eukaryotic protein kinase domai 70..279
   PFAM                 pkinase: Eukaryotic protein kinase domai 339..367
   PRODOM               PD008976: MPK1(6) MPK2(5)                1..68
   PRODOM               PD000001: KKIT(14) CC2(14) KPC1(13)      70..276
   PRODOM               PD012430: MPK2(5)                        278..308
   PRODOM               PD004800: MPK1(6) MPK2(5) FUZ7(1)        310..388
   PROSITE              PROTEIN_KINASE_ST: Serine/Threonine prot 188..200
__________________


  Plus Strand HSPs:

 Score = 201 (70.8 bits), Expect = 1.4e-14, P = 1.4e-14
 Identities = 45/117 (38%), Positives = 72/117 (61%), Frame = +3

Query:     6 ELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANV 185
             + ER++ +G+G+GG V KV H+ SG + A K+I+   + ++R QI RE+Q+L + +   +
Sbjct:    69 DFERISELGAGNGGVVTKVQHKPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 128

Query:   186 VKCHEMYDQNSEIQVLLEFMDGGSL-----EGKHITQEQQLAXLSRQILRGLAYLHRR 344
             V  +  +  + EI + +E MDGGSL     E K I +E  L  +S  +LRGLAYL  +
Sbjct:   129 VGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEI-LGKVSIAVLRGLAYLREK 185


 >gi|7434316|pir||T06583  protein kinase MEK1 - tomato
            Length = 357

Frame  3 hits (HSPs):            _________________                        
                        __________________________________________________
Database sequence:     |                    |                    |        | 357
                       0                  150                  300

  Plus Strand HSPs:

 Score = 198 (69.7 bits), Expect = 2.1e-14, P = 2.1e-14
 Identities = 46/116 (39%), Positives = 72/116 (62%), Frame = +3

Query:     3 AELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDAN 182
             A+ E    IG G+GG V  V H+ +G+ +ALKVI  + +ES+R+ I +E++I +      
Sbjct:    68 ADFESSKVIGKGNGGIVRLVQHKWTGQFFALKVIQMNIDESMRKHIAQELRINQSSQCPY 127

Query:   183 VVKCHEMYDQNSEIQVLLEFMDGGSLEG--KHITQ--EQQLAXLSRQILRGLAYLH 338
             VV C++ +  N  I ++LE+MDGGSL    K +    E+ LA + +Q+L+GL YLH
Sbjct:   128 VVICYQSFFDNGAISLILEYMDGGSLADFLKKVKTIPERFLAVICKQVLKGLWYLH 183


 >gi|547916|sp|P36506|MPK2_RAT  DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE
            KINASE 2 (MAP KINASE KINASE 2) (MAPKK 2) (ERK ACTIVATOR KINASE 2)
            (MAPK/ERK KINASE 2) (MEK2) >gi|539973|pir||A48081 mitogen-activated
            protein kinase kinase (EC 2.7.1.-) 2 - rat
            >gi|303804|dbj|BAA03442.1| (D14592) MAP kinase kinase-related
            protein [Rattus norvegicus] >gi|349545|gb|AAA41620.1| (L14936) MAP
            kinase kinase 2 [Rattus norvegicus]
            Length = 400

Frame  3 hits (HSPs):           ________________                          
Annotated Domains:      _________________________________________________ 
                        __________________________________________________
Database sequence:     |                  |                  |            | 400
                       0                150                300
__________________

Annotated Domains:
   Entrez               Domain: PROTEIN KINASE.                  72..369
   Entrez               np-binding site: ATP (BY SIMILARITY).    78..86
   Entrez               binding site: ATP (BY SIMILARITY).       101
   Entrez               active site: BY SIMILARITY.              194
   Entrez               phosphorylation site: (BY RAF) (BY SIMIL 222
   Entrez               phosphorylation site: (BY RAF) (BY SIMIL 226
   Entrez               Domain: PRO-RICH.                        266..315
   PFAM                 pkinase: Eukaryotic protein kinase domai 72..369
   PRODOM               PD008976: MPK1(6) MPK2(5)                5..70
   PRODOM               PD000001: KKIT(14) CC2(14) KPC1(13)      72..275
   PRODOM               PD012430: MPK2(5)                        280..310
   PRODOM               PD004800: MPK1(6) MPK2(5) FUZ7(1)        312..390
   PROSITE              PROTEIN_KINASE_ST: Serine/Threonine prot 190..202
__________________


  Plus Strand HSPs:

 Score = 198 (69.7 bits), Expect = 3.1e-14, P = 3.1e-14
 Identities = 46/117 (39%), Positives = 70/117 (59%), Frame = +3

Query:     6 ELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANV 185
             + ER++ +G+G+GG V K  HR SG + A K+I+   + +VR QI RE+Q+L + +   +
Sbjct:    71 DFERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQVLHECNSPYI 130

Query:   186 VKCHEMYDQNSEIQVLLEFMDGGSL-----EGKHITQEQQLAXLSRQILRGLAYLHRR 344
             V  +  +  + EI + +E MDGGSL     E K I  E  L  +S  +LRGLAYL  +
Sbjct:   131 VGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIP-EDILGKVSIAVLRGLAYLREK 187


 >gi|1083711|pir||S32412  MEK2 protein - rat
            Length = 400

Frame  3 hits (HSPs):           ________________                          
Annotated Domains:              __________________________________________
                        __________________________________________________
Database sequence:     |                  |                  |            | 400
                       0                150                300
__________________

Annotated Domains:
   DOMO                 DM00004: PROTEINKINASEDOMAIN             74..400
   Entrez               domain: protein kinase homology #label K 70..369
   PROSITE              PROTEIN_KINASE_ST: Serine/Threonine prot 190..202
__________________


  Plus Strand HSPs:

 Score = 198 (69.7 bits), Expect = 3.1e-14, P = 3.1e-14
 Identities = 46/117 (39%), Positives = 70/117 (59%), Frame = +3

Query:     6 ELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANV 185
             + ER++ +G+G+GG V K  HR SG + A K+I+   + +VR QI RE+Q+L + +   +
Sbjct:    71 DFERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQVLHECNSPYI 130

Query:   186 VKCHEMYDQNSEIQVLLEFMDGGSL-----EGKHITQEQQLAXLSRQILRGLAYLHRR 344
             V  +  +  + EI + +E MDGGSL     E K I  E  L  +S  +LRGLAYL  +
Sbjct:   131 VGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIP-EDILGKVSIAVLRGLAYLREK 187


 >gi|1096928|prf||2113192A  MEK2 protein [Rattus norvegicus]
            Length = 400

Frame  3 hits (HSPs):           ________________                          
                        __________________________________________________
Database sequence:     |                  |                  |            | 400
                       0                150                300

  Plus Strand HSPs:

 Score = 198 (69.7 bits), Expect = 3.1e-14, P = 3.1e-14
 Identities = 46/117 (39%), Positives = 70/117 (59%), Frame = +3

Query:     6 ELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANV 185
             + ER++ +G+G+GG V K  HR SG + A K+I+   + +VR QI RE+Q+L + +   +
Sbjct:    71 DFERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQVLHECNSPYI 130

Query:   186 VKCHEMYDQNSEIQVLLEFMDGGSL-----EGKHITQEQQLAXLSRQILRGLAYLHRR 344
             V  +  +  + EI + +E MDGGSL     E K I  E  L  +S  +LRGLAYL  +
Sbjct:   131 VGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIP-EDILGKVSIAVLRGLAYLREK 187


 >gi|2499629|sp|Q63932|MPK2_MOUSE  DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN
            KINASE KINASE 2 (MAP KINASE KINASE 2) (MAPKK 2) (ERK ACTIVATOR
            KINASE 2) (MAPK/ERK KINASE 2) (MEK2) >gi|2143494|pir||I52829
            mitogen-activated protein kinase kinase (EC 2.7.1.-) 2 - mouse
            >gi|545203|gb|AAC60678.1| (S68267) MEK2=MAP kinase/Erk kinase
            [mice, BALB/c, neonatal brain, Peptide, 401 aa] [Mus sp.]
            Length = 401

Frame  3 hits (HSPs):           ________________                          
                        __________________________________________________
Database sequence:     |                  |                  |            | 401
                       0                150                300

  Plus Strand HSPs:

 Score = 197 (69.3 bits), Expect = 4.0e-14, P = 4.0e-14
 Identities = 46/117 (39%), Positives = 70/117 (59%), Frame = +3

Query:     6 ELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANV 185
             + ER++ +G+G+GG V K  HR SG + A K+I+   + +VR QI RE+Q+L + +   +
Sbjct:    71 DFERISELGAGNGGVVTKARHRPSGFIMARKLIHLEIKPAVRNQIIRELQVLHECNSPYI 130

Query:   186 VKCHEMYDQNSEIQVLLEFMDGGSL-----EGKHITQEQQLAXLSRQILRGLAYLHRR 344
             V  +  +  + EI + +E MDGGSL     E K I  E  L  +S  +LRGLAYL  +
Sbjct:   131 VGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIP-EDILGKVSIAVLRGLAYLREK 187


 >gi|7682432|gb|AAF67262.1|AF165186_1  (AF165186) MAP kinase kinase [Nicotiana
            tabacum]
            Length = 357

Frame  3 hits (HSPs):            _________________                        
                        __________________________________________________
Database sequence:     |                    |                    |        | 357
                       0                  150                  300

  Plus Strand HSPs:

 Score = 195 (68.6 bits), Expect = 4.5e-14, P = 4.5e-14
 Identities = 45/116 (38%), Positives = 71/116 (61%), Frame = +3

Query:     3 AELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDAN 182
             A+ E +  IG G+GG V  V H+ +G+ +ALK I  + EES+R+ I +E++I +      
Sbjct:    68 ADFEAVKVIGKGNGGIVRLVQHKWTGQFFALKAIQMNIEESMRKHIAQELRINQSSQVPY 127

Query:   183 VVKCHEMYDQNSEIQVLLEFMDGGSLEG--KHITQ--EQQLAXLSRQILRGLAYLH 338
             VV  ++ +  N  I ++LE+MDGGSL    K +    E+ LA + +Q+L+GL YLH
Sbjct:   128 VVISYQSFFDNGAISIILEYMDGGSLADFLKKVKTIPERYLAAICKQVLKGLWYLH 183


 >gi|7434309|pir||T04262  mitogen-activated protein kinase kinase (EC 2.7.1.-) 1
            [similarity] - Arabidopsis thaliana >gi|2196704|gb|AAB97145.1|
            (AF000977) MEK1 [Arabidopsis thaliana] >gi|2723388|dbj|BAA24079.1|
            (AB004796) mitogen activated protein kinase kinase [Arabidopsis
            thaliana] >gi|4538936|emb|CAB39672.1| (AL049483) mitogen activated
            protein kinase kinase (nMAPKK) [Arabidopsis thaliana]
            >gi|7269458|emb|CAB79462.1| (AL161564) mitogen activated protein
            kinase kinase (nMAPKK) [Arabidopsis thaliana]
            Length = 354

Frame  3 hits (HSPs):            _________________                        
                        __________________________________________________
Database sequence:     |                     |                    |       | 354
                       0                   150                  300

  Plus Strand HSPs:

 Score = 193 (67.9 bits), Expect = 7.3e-14, P = 7.3e-14
 Identities = 44/116 (37%), Positives = 69/116 (59%), Frame = +3

Query:     3 AELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDAN 182
             A+LE +  IG GS G V  V H+ + + +ALKVI  + EES  R I +E++I        
Sbjct:    66 ADLEVIKVIGKGSSGNVQLVKHKLTQQFFALKVIQLNTEESTCRAISQELRINLSSQCPY 125

Query:   183 VVKCHEMYDQNSEIQVLLEFMDGGSLEG--KHITQ--EQQLAXLSRQILRGLAYLH 338
             +V C++ +  N  + ++LEFMDGGSL    K + +  E  L+ + +++LRGL Y+H
Sbjct:   126 LVSCYQSFYHNGLVSIILEFMDGGSLADLLKKVGKVPENMLSAICKRVLRGLCYIH 181


 >gi|12331300|emb|CAC24705.1|  (AJ302651) MAP kinase [Nicotiana tabacum]
            Length = 354

Frame  3 hits (HSPs):            _________________                        
                        __________________________________________________
Database sequence:     |                     |                    |       | 354
                       0                   150                  300

  Plus Strand HSPs:

 Score = 193 (67.9 bits), Expect = 7.3e-14, P = 7.3e-14
 Identities = 47/115 (40%), Positives = 70/115 (60%), Frame = +3

Query:     6 ELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANV 185
             +LE +  IG GSGG V  V H+  G ++ALKVI    +E +R+QI +E++I +    ++V
Sbjct:    68 DLETIKVIGKGSGGVVQLVRHKWVGTLFALKVIQMTIQEDIRKQIVQELKINQASQCSHV 127

Query:   186 VKCHEMYDQNSEIQVLLEFMDGGSLEGKHITQ-----EQQLAXLSRQILRGLAYLH 338
             V C+  +  N  I ++LE+MD GSL    I Q     E  LA + +Q+L+GL YLH
Sbjct:   128 VVCYHSFYHNGAISLVLEYMDRGSLADV-IRQLKTILEPYLAVVCKQVLQGLVYLH 182


 >gi|12718822|dbj|BAB32405.1|  (AB055514) NQK1 MAPKK [Nicotiana tabacum]
            Length = 354

Frame  3 hits (HSPs):            _________________                        
                        __________________________________________________
Database sequence:     |                     |                    |       | 354
                       0                   150                  300

  Plus Strand HSPs:

 Score = 193 (67.9 bits), Expect = 7.3e-14, P = 7.3e-14
 Identities = 47/115 (40%), Positives = 70/115 (60%), Frame = +3

Query:     6 ELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANV 185
             +LE +  IG GSGG V  V H+  G ++ALKVI    +E +R+QI +E++I +    ++V
Sbjct:    68 DLETIKVIGKGSGGVVQLVRHKWVGTLFALKVIQMTIQEDIRKQIVQELKINQASQCSHV 127

Query:   186 VKCHEMYDQNSEIQVLLEFMDGGSLEGKHITQ-----EQQLAXLSRQILRGLAYLH 338
             V C+  +  N  I ++LE+MD GSL    I Q     E  LA + +Q+L+GL YLH
Sbjct:   128 VVCYHSFYHNGAISLVLEYMDRGSLADV-IRQLKTILEPYLAVVCKQVLQGLVYLH 182


 >gi|2499627|sp|Q63980|MPK1_CRIGR  DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN
            KINASE KINASE 1 (MAP KINASE KINASE 1) (MAPKK 1) (ERK ACTIVATOR
            KINASE 1) (MAPK/ERK KINASE 1) (MEK1) >gi|1085487|pir||S46361
            mitogen-activated protein kinase kinase (EC 2.7.1.-) 1, splice form
            A - Chinese hamster >gi|547337|gb|AAB31379.1| (S70933) mitogen
            activated protein kinase kinase, MAP kinase kinase, MAPKK [Chinese
            hamsters, lung fibroblast cells, Peptide, 393 aa] [Cricetulus
            griseus]
            Length = 393

Frame  3 hits (HSPs):           ________________                          
Annotated Domains:      _________________________________________________ 
                        __________________________________________________
Database sequence:     |                  |                   |           | 393
                       0                150                 300
__________________

Annotated Domains:
   BLOCKS               BL00107A: Protein kinases ATP-binding re 180..210
   BLOCKS               BL00107B: Protein kinases ATP-binding re 243..258
   Entrez               Domain: PROTEIN KINASE.                  68..361
   Entrez               np-binding site: ATP (BY SIMILARITY).    74..82
   Entrez               binding site: ATP (BY SIMILARITY).       97
   Entrez               active site: BY SIMILARITY.              190
   Entrez               phosphorylation site: (BY RAF) (BY SIMIL 218
   Entrez               phosphorylation site: (BY RAF) (PROBABLE 222
   Entrez               Domain: PRO-RICH.                        262..307
   Entrez               mutagenized site: D->N: NO LOSS OF ACTIV 208
   Entrez               mutagenized site: S->A: INACTIVATION AND 222
   Entrez               mutagenized site: S->D: NO LOSS OF ACTIV 222
   Entrez               mutagenized site: S->A: NO LOSS OF ACTIV 228
   PFAM                 pkinase: Eukaryotic protein kinase domai 68..361
   PRODOM               PD008976: MPK1(6) MPK2(5)                2..66
   PRODOM               PD000001: KKIT(14) CC2(14) KPC1(13)      68..274
   PRODOM               PD012429: MPK1(4)                        276..302
   PRODOM               PD004800: MPK1(6) MPK2(5) FUZ7(1)        304..382
   PROSITE              PROTEIN_KINASE_ST: Serine/Threonine prot 186..198
__________________


  Plus Strand HSPs:

 Score = 193 (67.9 bits), Expect = 1.0e-13, P = 1.0e-13
 Identities = 41/117 (35%), Positives = 73/117 (62%), Frame = +3

Query:     6 ELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANV 185
             + E+++ +G+G+GG V+KV H+ SG V A K+I+   + ++R QI RE+Q+L + +   +
Sbjct:    67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126

Query:   186 VKCHEMYDQNSEIQVLLEFMDGGSLEG--KHITQ--EQQLAXLSRQILRGLAYLHRR 344
             V  + ++  + EI + +E MDGGSL+   K   +  EQ L  +S  +++GL YL  +
Sbjct:   127 VGFYGVFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183


 >gi|7434321|pir||T08542  mitogen-activated protein kinase kinase (EC 2.7.1.-) 2
            [similarity] - Arabidopsis thaliana >gi|3219267|dbj|BAA28828.1|
            (AB015313) MAP kinase kinase 2 [Arabidopsis thaliana]
            >gi|4914405|emb|CAB43656.1| (AL050352) MAP kinase kinase 2
            [Arabidopsis thaliana] >gi|7269880|emb|CAB79739.1| (AL161575) MAP
            kinase kinase 2 [Arabidopsis thaliana]
            Length = 363

Frame  3 hits (HSPs):            _________________                        
                        __________________________________________________
Database sequence:     |                    |                    |        | 363
                       0                  150                  300

  Plus Strand HSPs:

 Score = 191 (67.2 bits), Expect = 1.3e-13, P = 1.3e-13
 Identities = 42/116 (36%), Positives = 72/116 (62%), Frame = +3

Query:     3 AELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDAN 182
             ++L+ +  IG GS G V  V H+ +G+ +ALKVI  + +E++R+ I +E++I +     N
Sbjct:    68 SDLDMVKVIGKGSSGVVQLVQHKWTGQFFALKVIQLNIDEAIRKAIAQELKINQSSQCPN 127

Query:   183 VVKCHEMYDQNSEIQVLLEFMDGGSLEG--KHITQ--EQQLAXLSRQILRGLAYLH 338
             +V  ++ +  N  I ++LE+MDGGSL    K +    +  L+ + RQ+L+GL YLH
Sbjct:   128 LVTSYQSFYDNGAISLILEYMDGGSLADFLKSVKAIPDSYLSAIFRQVLQGLIYLH 183


 >gi|11259772|pir||T51735  mitogen-activated protein kinase kinase (EC 2.7.1.-)
            2k-beta [imported] - Arabidopsis thaliana
            >gi|3228219|emb|CAA07281.1| (AJ006871) MAP2k beta [Arabidopsis
            thaliana] >gi|3859486|gb|AAC72754.1| (AF067792) MAP kinase kinase 1
            [Arabidopsis thaliana]
            Length = 363

Frame  3 hits (HSPs):            _________________                        
                        __________________________________________________
Database sequence:     |                    |                    |        | 363
                       0                  150                  300

  Plus Strand HSPs:

 Score = 191 (67.2 bits), Expect = 1.3e-13, P = 1.3e-13
 Identities = 42/116 (36%), Positives = 72/116 (62%), Frame = +3

Query:     3 AELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDAN 182
             ++L+ +  IG GS G V  V H+ +G+ +ALKVI  + +E++R+ I +E++I +     N
Sbjct:    68 SDLDMVKVIGKGSSGVVQLVQHKWTGQFFALKVIQLNIDEAIRKAIAQELKINQSSQCPN 127

Query:   183 VVKCHEMYDQNSEIQVLLEFMDGGSLEG--KHITQ--EQQLAXLSRQILRGLAYLH 338
             +V  ++ +  N  I ++LE+MDGGSL    K +    +  L+ + RQ+L+GL YLH
Sbjct:   128 LVTSYQSFYDNGAISLILEYMDGGSLADFLKSVKAIPDSYLSAIFRQVLQGLIYLH 183


 >gi|266566|sp|Q01986|MPK1_RAT  DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE
            KINASE 1 (MAP KINASE KINASE 1) (MAPKK 1) (ERK ACTIVATOR KINASE 1)
            (MAPK/ERK KINASE 1) (MEK1) >gi|484493|pir||JN0840 mitogen-activated
            protein kinase kinase (EC 2.7.1.-) 1, splice form A - rat
            >gi|56629|emb|CAA78905.1| (Z16415) protein  kinase [Rattus
            norvegicus] >gi|205310|gb|AAA41571.1| (L04485) protein kinase
            [Rattus norvegicus] >gi|220812|dbj|BAA02603.1| (D13341) MAP kinase
            kinase [Rattus norvegicus] >gi|303803|dbj|BAA03441.1| (D14591) MAP
            kinase kinase [Rattus norvegicus] >gi|407861|emb|CAA44192.1|
            (X62313) mitogen activated protein kinase-kinase [Rattus
            norvegicus]
            Length = 393

Frame  3 hits (HSPs):           ________________                          
Annotated Domains:      _________________________________________________ 
                        __________________________________________________
Database sequence:     |                  |                   |           | 393
                       0                150                 300
__________________

Annotated Domains:
   Entrez               Domain: PROTEIN KINASE.                  68..361
   Entrez               np-binding site: ATP (BY SIMILARITY).    74..82
   Entrez               binding site: ATP (BY SIMILARITY).       97
   Entrez               active site: BY SIMILARITY.              190
   Entrez               phosphorylation site: (BY RAF) (BY SIMIL 218
   Entrez               phosphorylation site: (BY RAF) (BY SIMIL 222
   Entrez               Domain: PRO-RICH.                        262..307
   PFAM                 pkinase: Eukaryotic protein kinase domai 67..360
   PRODOM               PD008976: MPK1(6) MPK2(5)                1..65
   PRODOM               PD000001: KKIT(14) CC2(14) KPC1(13)      67..273
   PRODOM               PD012429: MPK1(4)                        275..301
   PRODOM               PD004800: MPK1(6) MPK2(5) FUZ7(1)        303..381
   PROSITE              PROTEIN_KINASE_ST: Serine/Threonine prot 186..198
__________________


  Plus Strand HSPs:

 Score = 191 (67.2 bits), Expect = 1.7e-13, P = 1.7e-13
 Identities = 41/117 (35%), Positives = 72/117 (61%), Frame = +3

Query:     6 ELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANV 185
             + E+++ +G+G+GG V+KV H+ SG V A K+I+   + ++R QI RE+Q+L + +   +
Sbjct:    67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126

Query:   186 VKCHEMYDQNSEIQVLLEFMDGGSLEG--KHITQ--EQQLAXLSRQILRGLAYLHRR 344
             V  +  +  + EI + +E MDGGSL+   K   +  EQ L  +S  +++GL YL  +
Sbjct:   127 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183


 >gi|5579478  ref|NP_002746.1| mitogen-activated protein kinase kinase 1; protein
            kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1) [Homo
            sapiens] >gi|400274|sp|Q02750|MPK1_HUMAN DUAL SPECIFICITY
            MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (MAP KINASE KINASE 1)
            (MAPKK 1) (ERK ACTIVATOR KINASE 1) (MAPK/ERK KINASE 1) (MEK1)
            >gi|346266|pir||A45100 mitogen-activated protein kinase kinase (EC
            2.7.1.-) 1, splice form A - human >gi|188569|gb|AAA36318.1|
            (L05624) MAP kinase kinase [Homo sapiens]
            Length = 393

Frame  3 hits (HSPs):           ________________                          
                        __________________________________________________
Database sequence:     |                  |                   |           | 393
                       0                150                 300

  Plus Strand HSPs:

 Score = 191 (67.2 bits), Expect = 1.7e-13, P = 1.7e-13
 Identities = 41/117 (35%), Positives = 72/117 (61%), Frame = +3

Query:     6 ELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANV 185
             + E+++ +G+G+GG V+KV H+ SG V A K+I+   + ++R QI RE+Q+L + +   +
Sbjct:    67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126

Query:   186 VKCHEMYDQNSEIQVLLEFMDGGSLEG--KHITQ--EQQLAXLSRQILRGLAYLHRR 344
             V  +  +  + EI + +E MDGGSL+   K   +  EQ L  +S  +++GL YL  +
Sbjct:   127 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183


 >gi|6678794  ref|NP_032953.1| mitogen activated protein kinase kinase 1; protein
            kinase, mitogen activated, kinase 1, p45; MAP kinase kinase 1 [Mus
            musculus] >gi|400275|sp|P31938|MPK1_MOUSE DUAL SPECIFICITY
            MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (MAP KINASE KINASE 1)
            (MAPKK 1) (ERK ACTIVATOR KINASE 1) (MAPK/ERK KINASE 1) (MEK1)
            >gi|2137691|pir||I59571 mitogen-activated protein kinase kinase (EC
            2.7.1.-) 1, splice form A - mouse >gi|199124|gb|AAA39523.1|
            (L02526) protein kinase [Mus musculus]
            Length = 393

Frame  3 hits (HSPs):           ________________                          
                        __________________________________________________
Database sequence:     |                  |                   |           | 393
                       0                150                 300

  Plus Strand HSPs:

 Score = 191 (67.2 bits), Expect = 1.7e-13, P = 1.7e-13
 Identities = 41/117 (35%), Positives = 72/117 (61%), Frame = +3

Query:     6 ELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANV 185
             + E+++ +G+G+GG V+KV H+ SG V A K+I+   + ++R QI RE+Q+L + +   +
Sbjct:    67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126

Query:   186 VKCHEMYDQNSEIQVLLEFMDGGSLEG--KHITQ--EQQLAXLSRQILRGLAYLHRR 344
             V  +  +  + EI + +E MDGGSL+   K   +  EQ L  +S  +++GL YL  +
Sbjct:   127 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183


 >gi|266565|sp|P29678|MPK1_RABIT  DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN
            KINASE KINASE 1 (MAP KINASE KINASE 1) (MAPKK 1) (ERK ACTIVATOR
            KINASE 1) (MAPK/ERK KINASE 1) (MEK1) >gi|543165|pir||S42068
            mitogen-activated protein kinase kinase (EC 2.7.1.-) 1, splice form
            A - rabbit >gi|261332|gb|AAB24424.1| mitogen-activated protein
            kinase kinase, MAPKK [rabbits, Peptide, 393 aa]
            >gi|456202|emb|CAA82912.1| (Z30163) MAP kinase kinase 1
            [Oryctolagus cuniculus]
            Length = 393

Frame  3 hits (HSPs):           ________________                          
Annotated Domains:      _________________________________________________ 
                        __________________________________________________
Database sequence:     |                  |                   |           | 393
                       0                150                 300
__________________

Annotated Domains:
   BLOCKS               BL00107A: Protein kinases ATP-binding re 179..209
   BLOCKS               BL00107B: Protein kinases ATP-binding re 242..257
   Entrez               Domain: PROTEIN KINASE.                  68..361
   Entrez               np-binding site: ATP (BY SIMILARITY).    74..82
   Entrez               binding site: ATP (BY SIMILARITY).       97
   Entrez               active site: BY SIMILARITY.              190
   Entrez               phosphorylation site: (BY RAF).          218
   Entrez               phosphorylation site: (BY RAF).          222
   Entrez               Domain: PRO-RICH.                        262..307
   PFAM                 pkinase: Eukaryotic protein kinase domai 67..360
   PRODOM               PD008976: MPK1(6) MPK2(5)                1..65
   PRODOM               PD000001: KKIT(14) CC2(14) KPC1(13)      67..273
   PRODOM               PD012429: MPK1(4)                        275..301
   PRODOM               PD004800: MPK1(6) MPK2(5) FUZ7(1)        303..381
   PROSITE              PROTEIN_KINASE_ST: Serine/Threonine prot 186..198
__________________


  Plus Strand HSPs:

 Score = 191 (67.2 bits), Expect = 1.7e-13, P = 1.7e-13
 Identities = 41/117 (35%), Positives = 72/117 (61%), Frame = +3

Query:     6 ELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANV 185
             + E+++ +G+G+GG V+KV H+ SG V A K+I+   + ++R QI RE+Q+L + +   +
Sbjct:    67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126

Query:   186 VKCHEMYDQNSEIQVLLEFMDGGSLEG--KHITQ--EQQLAXLSRQILRGLAYLHRR 344
             V  +  +  + EI + +E MDGGSL+   K   +  EQ L  +S  +++GL YL  +
Sbjct:   127 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183


 >gi|4929202|gb|AAD33901.1|AF143201_1  (AF143201) mitogen-activated protein
            kinase kinase MEK [Pan troglodytes]
            Length = 393

Frame  3 hits (HSPs):           ________________                          
                        __________________________________________________
Database sequence:     |                  |                   |           | 393
                       0                150                 300

  Plus Strand HSPs:

 Score = 191 (67.2 bits), Expect = 1.7e-13, P = 1.7e-13
 Identities = 41/117 (35%), Positives = 72/117 (61%), Frame = +3

Query:     6 ELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANV 185
             + E+++ +G+G+GG V+KV H+ SG V A K+I+   + ++R QI RE+Q+L + +   +
Sbjct:    67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126

Query:   186 VKCHEMYDQNSEIQVLLEFMDGGSLEG--KHITQ--EQQLAXLSRQILRGLAYLHRR 344
             V  +  +  + EI + +E MDGGSL+   K   +  EQ L  +S  +++GL YL  +
Sbjct:   127 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183


 >gi|7670399|dbj|BAA95051.1|  (AB041567) unnamed protein product [Mus musculus]
            Length = 393

Frame  3 hits (HSPs):           ________________                          
                        __________________________________________________
Database sequence:     |                  |                   |           | 393
                       0                150                 300

  Plus Strand HSPs:

 Score = 191 (67.2 bits), Expect = 1.7e-13, P = 1.7e-13
 Identities = 41/117 (35%), Positives = 72/117 (61%), Frame = +3

Query:     6 ELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANV 185
             + E+++ +G+G+GG V+KV H+ SG V A K+I+   + ++R QI RE+Q+L + +   +
Sbjct:    67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126

Query:   186 VKCHEMYDQNSEIQVLLEFMDGGSLEG--KHITQ--EQQLAXLSRQILRGLAYLHRR 344
             V  +  +  + EI + +E MDGGSL+   K   +  EQ L  +S  +++GL YL  +
Sbjct:   127 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183


 >gi|422819|pir||B46723  extracellular signal-regulated kinase activator kinase
            1, ERK kinase 1, MAP kinase 1, MEK1 - human
            Length = 394

Frame  3 hits (HSPs):           ________________                          
Annotated Domains:              ______________________________________    
                        __________________________________________________
Database sequence:     |                  |                  |            | 394
                       0                150                300
__________________

Annotated Domains:
   Entrez               domain: protein kinase homology #label K 66..362
   PROSITE              PROTEIN_KINASE_ST: Serine/Threonine prot 186..198
__________________


  Plus Strand HSPs:

 Score = 191 (67.2 bits), Expect = 1.7e-13, P = 1.7e-13
 Identities = 41/117 (35%), Positives = 72/117 (61%), Frame = +3

Query:     6 ELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANV 185
             + E+++ +G+G+GG V+KV H+ SG V A K+I+   + ++R QI RE+Q+L + +   +
Sbjct:    67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126

Query:   186 VKCHEMYDQNSEIQVLLEFMDGGSLEG--KHITQ--EQQLAXLSRQILRGLAYLHRR 344
             V  +  +  + EI + +E MDGGSL+   K   +  EQ L  +S  +++GL YL  +
Sbjct:   127 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183


 >gi|2499628|sp|Q91447|MPK1_SERCA  DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN
            KINASE KINASE 1 (MAP KINASE KINASE 1) (MAPKK 1) (ERK ACTIVATOR
            KINASE 1) (MAPK/ERK KINASE 1) (MEK1) >gi|530192|gb|AAA49539.1|
            (L35244) MAP kinase kinase [Serinus canaria]
            Length = 388

Frame  3 hits (HSPs):          ________________                           
Annotated Domains:             _______________________________________    
                        __________________________________________________
Database sequence:     |                   |                  |           | 388
                       0                 150                300
__________________

Annotated Domains:
   Entrez               Domain: PROTEIN KINASE.                  61..356
   Entrez               np-binding site: ATP (BY SIMILARITY).    67..75
   Entrez               binding site: ATP (BY SIMILARITY).       90
   Entrez               active site: BY SIMILARITY.              183
   Entrez               phosphorylation site: (BY RAF) (BY SIMIL 211
   Entrez               phosphorylation site: (BY RAF) (BY SIMIL 215
   Entrez               Domain: PRO-RICH.                        255..302
   PFAM                 pkinase: Eukaryotic protein kinase domai 61..356
   PROSITE              PROTEIN_KINASE_ST: Serine/Threonine prot 179..191
__________________


  Plus Strand HSPs:

 Score = 190 (66.9 bits), Expect = 2.1e-13, P = 2.1e-13
 Identities = 40/117 (34%), Positives = 72/117 (61%), Frame = +3

Query:     6 ELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANV 185
             + E+++ +G+G+GG V+KV H+ SG + A K+I+   + ++R QI RE+Q+L + +   +
Sbjct:    60 DFEKISELGAGNGGVVFKVSHKPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 119

Query:   186 VKCHEMYDQNSEIQVLLEFMDGGSLEG--KHITQ--EQQLAXLSRQILRGLAYLHRR 344
             V  +  +  + EI + +E MDGGSL+   K   +  EQ L  +S  +++GL YL  +
Sbjct:   120 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 176


 >gi|10176761|dbj|BAB09875.1|  (AB013392) protein kinase MEK1 homolog
            [Arabidopsis thaliana]
            Length = 356

Frame  3 hits (HSPs):            _________________                        
                        __________________________________________________
Database sequence:     |                    |                    |        | 356
                       0                  150                  300

  Plus Strand HSPs:

 Score = 181 (63.7 bits), Expect = 1.6e-12, P = 1.6e-12
 Identities = 43/116 (37%), Positives = 68/116 (58%), Frame = +3

Query:     6 ELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDA-N 182
             +LE +  IG GSGG V  V H+  G+ +A+KVI  + +E +R+QI +E++I +      +
Sbjct:    69 DLETVKVIGKGSGGVVQLVRHKWVGKFFAMKVIQMNIQEEIRKQIVQELKINQASSQCPH 128

Query:   183 VVKCHEMYDQNSEIQVLLEFMDGGSLEG--KHITQ--EQQLAXLSRQILRGLAYLH 338
             VV C+  +  N    ++LE+MD GSL    + +    E  LA + +Q+L GL YLH
Sbjct:   129 VVVCYHSFYHNGAFSLVLEYMDRGSLADVIRQVKTILEPYLAVVCKQVLLGLVYLH 184


 >gi|12731723  ref|XP_004045.2| serine-threonine protein kinase NKIAMRE [Homo
            sapiens]
            Length = 192

Frame  3 hits (HSPs):    ______________________________                   
                        __________________________________________________
Database sequence:     |            |            |            |           | 192
                       0           50          100          150

  Plus Strand HSPs:

 Score = 172 (60.5 bits), Expect = 4.4e-12, P = 4.4e-12
 Identities = 39/113 (34%), Positives = 63/113 (55%), Frame = +3

Query:    12 ERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANVVK 191
             E L ++G GS GTV K  H+ +G++ A+K+ Y   E+SV +   REI+ L+     N+V 
Sbjct:     5 ETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHENLVN 64

Query:   192 CHEMYDQNSEIQVLLEFMDGGSLEGK----HITQEQQLAXLSRQILRGLAYLH 338
               E++ Q  +I ++ EF+D   L+      H  + ++L     QILR + YLH
Sbjct:    65 LIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLH 117


 >gi|6324805  ref|NP_014874.1| protein kinase involved in protein kinase C
            pathway; Mkk1p [Saccharomyces cerevisiae]
            >gi|417302|sp|P32490|MKK1_YEAST PROTEIN KINASE MKK1/SSP32
            >gi|477083|pir||A48069 protein kinase MKK1 (EC 2.7.1.-) - yeast
            (Saccharomyces cerevisiae) >gi|218492|dbj|BAA02364.1| (D13001)
            Ssp32 protein kinase [Saccharomyces cerevisiae]
            >gi|1420531|emb|CAA99451.1| (Z75139) ORF YOR231w [Saccharomyces
            cerevisiae]
            Length = 508

Frame  3 hits (HSPs):                        _____________                
Frame  1 hits (HSPs):                                   __                
                        __________________________________________________
Database sequence:     |              |              |              |     | 508
                       0            150            300            450

  Plus Strand HSPs:

 Score = 166 (58.4 bits), Expect = 4.8e-12, Sum P(2) = 4.8e-12
 Identities = 40/123 (32%), Positives = 71/123 (57%), Frame = +3

Query:     9 LERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYG-HHEESVRRQIHREIQILRDVDDANV 185
             +E L  +G G+GG+V K   +   +++ALKVI   + +   ++QI RE+Q  R      +
Sbjct:   221 IETLGILGEGAGGSVSKCKLKNGSKIFALKVINTLNTDPEYQKQIFRELQFNRSFQSEYI 280

Query:   186 VKCHEMY--DQNSEIQVLLEFMDGGSLEG--KHITQ------EQQLAXLSRQILRGLAYL 335
             V+ + M+  D+NS I + +E+M G SL+   K++ +      E+ L  ++  +LRGL+YL
Sbjct:   281 VRYYGMFTDDENSSIYIAMEYMGGRSLDAIYKNLLERGGRISEKVLGKIAEAVLRGLSYL 340

Query:   336 HRR 344
             H +
Sbjct:   341 HEK 343

 Score = 36 (12.7 bits), Expect = 4.8e-12, Sum P(2) = 4.8e-12
 Identities = 6/8 (75%), Positives = 8/8 (100%), Frame = +1

Query:   343 VRGLAYLH 366
             +RGL+YLH
Sbjct:   334 LRGLSYLH 341


 >gi|4033698|sp|Q05116|MPK1_XENLA  DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN
            KINASE KINASE 1 (MAP KINASE KINASE 1) (MAPKK 1) (ERK ACTIVATOR
            KINASE 1) (MAPK/ERK KINASE 1) (MEK1) >gi|486829|pir||S36186
            mitogen-activated protein kinase kinase (EC 2.7.1.-) 1 - African
            clawed frog >gi|222965|dbj|BAA02860.1| (D13700) MAP kinase kinase
            [Xenopus laevis]
            Length = 395

Frame  3 hits (HSPs):           ________________                          
Annotated Domains:      _________________________________________________ 
                        __________________________________________________
Database sequence:     |                  |                  |            | 395
                       0                150                300
__________________

Annotated Domains:
   BLOCKS               BL00107A: Protein kinases ATP-binding re 179..209
   BLOCKS               BL00107B: Protein kinases ATP-binding re 242..257
   Entrez               Domain: PROTEIN KINASE.                  68..363
   Entrez               np-binding site: ATP (BY SIMILARITY).    74..82
   Entrez               binding site: ATP (BY SIMILARITY).       97
   Entrez               active site: BY SIMILARITY.              190
   Entrez               phosphorylation site: (BY RAF) (BY SIMIL 218
   Entrez               phosphorylation site: (BY RAF) (BY SIMIL 222
   Entrez               Domain: PRO-RICH.                        262..309
   PFAM                 pkinase: Eukaryotic protein kinase domai 67..362
   PRODOM               PD008976: MPK1(6) MPK2(5)                1..65
   PRODOM               PD000001: KKIT(14) CC2(14) KPC1(13)      67..273
   PRODOM               PD062051: MPK1_XENLA                     275..303
   PRODOM               PD004800: MPK1(6) MPK2(5) FUZ7(1)        305..383
   PROSITE              PROTEIN_KINASE_ST: Serine/Threonine prot 186..198
__________________


  Plus Strand HSPs:

 Score = 177 (62.3 bits), Expect = 6.1e-12, P = 6.1e-12
 Identities = 38/117 (32%), Positives = 71/117 (60%), Frame = +3

Query:     6 ELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANV 185
             + E+++ +G+G+GG V+KV H+ +  + A K+I+   + ++R QI RE+Q+L + +   +
Sbjct:    67 DFEKVSELGAGNGGVVFKVSHKPTSLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126

Query:   186 VKCHEMYDQNSEIQVLLEFMDGGSLE------GKHITQEQQLAXLSRQILRGLAYLHRR 344
             V  +  +  + EI + +E MDGGSL+      GK    E+ L  +S  +++GL YL  +
Sbjct:   127 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGK--IPEKILGKVSIAVIKGLTYLREK 183


 >gi|2499631|sp|Q90321|MPK2_CYPCA  DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN
            KINASE KINASE 2 (MAP KINASE KINASE 2) (MAPKK 2) (ERK ACTIVATOR
            KINASE 2) (MAPK/ERK KINASE 2) (MEK2) >gi|542618|pir||S41054
            mitogen-activated protein kinase kinase (EC 2.7.1.-) 2 - common
            carp >gi|397678|gb|AAA19788.1| (L23935) MAP kinase kinase [Cyprinus
            carpio]
            Length = 397

Frame  3 hits (HSPs):           ________________                          
Annotated Domains:      _________________________________________________ 
                        __________________________________________________
Database sequence:     |                  |                  |            | 397
                       0                150                300
__________________

Annotated Domains:
   BLOCKS               BL00107A: Protein kinases ATP-binding re 181..211
   BLOCKS               BL00107B: Protein kinases ATP-binding re 244..259
   Entrez               Domain: PROTEIN KINASE.                  69..366
   Entrez               np-binding site: ATP (BY SIMILARITY).    75..83
   Entrez               binding site: ATP (BY SIMILARITY).       98
   Entrez               active site: BY SIMILARITY.              191
   Entrez               phosphorylation site: (BY RAF) (BY SIMIL 219
   Entrez               phosphorylation site: (BY RAF) (BY SIMIL 223
   Entrez               Domain: PRO-RICH.                        263..312
   PFAM                 pkinase: Eukaryotic protein kinase domai 69..278
   PFAM                 pkinase: Eukaryotic protein kinase domai 338..366
   PRODOM               PD008976: MPK1(6) MPK2(5)                3..67
   PRODOM               PD000001: KKIT(14) CC2(14) KPC1(13)      69..275
   PRODOM               PD012430: MPK2(5)                        277..307
   PRODOM               PD004800: MPK1(6) MPK2(5) FUZ7(1)        309..387
   PROSITE              PROTEIN_KINASE_ST: Serine/Threonine prot 187..199
__________________


  Plus Strand HSPs:

 Score = 176 (62.0 bits), Expect = 7.9e-12, P = 7.9e-12
 Identities = 41/117 (35%), Positives = 69/117 (58%), Frame = +3

Query:     6 ELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANV 185
             + + +  +G+G+GG V+KV H+ S  V A K+I+   + ++R QI RE+Q+L + +   +
Sbjct:    68 DFDPICELGAGNGGVVHKVRHKPSRLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 127

Query:   186 VKCHEMYDQNSEIQVLLEFMDGGSL-----EGKHITQEQQLAXLSRQILRGLAYLHRR 344
             V  +  +  + EI + +E MDGGSL     E + I +E  L  +S  +LRGL YL  +
Sbjct:   128 VGFYGAFYSDGEISICMEHMDGGSLDQVLKEARRIPEEI-LGKVSIAVLRGLVYLREK 184


 >gi|8920605|gb|AAF81327.1|AC007767_7  (AC007767) Contains similarity to MAP
            kinase kinase 4 from Arabidopsis thaliana gb|AB015315.  It contains
            a eukaryotic protein kinase domain PF|00069.
            >gi|12597861|gb|AAG60170.1|AC084110_3 (AC084110) MAP kinase,
            putative [Arabidopsis thaliana]
            Length = 305

Frame  3 hits (HSPs):          ___________________                        
                        __________________________________________________
Database sequence:     |        |       |       |       |       |        || 305
                       0       50     100     150     200     250      300

  Plus Strand HSPs:

 Score = 171 (60.2 bits), Expect = 1.2e-11, P = 1.2e-11
 Identities = 38/112 (33%), Positives = 69/112 (61%), Frame = +3

Query:     6 ELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANV 185
             +LE+L+ +G GSGGTVYK  HR +  +YALKV+      ++   +  E  IL+ ++ + +
Sbjct:    47 DLEKLSVLGQGSGGTVYKTRHRRTKTLYALKVL----RPNLNTTVTVEADILKRIESSFI 102

Query:   186 VKCHEMYDQNSEIQVLLEFMDGGSLEGKHITQ----EQQLAXLSRQILRGLAYLHR 341
             +KC+ ++    ++  ++E M+ GSL    + Q    E  ++ L+ +IL+GL YL +
Sbjct:   103 IKCYAVFVSLYDLCFVMELMEKGSLHDALLAQQVFSEPMVSSLANRILQGLRYLQK 158


 >gi|7001372|gb|AAF34870.1|AF112183_1  (AF112183) serine/threonine kinase NKIATRE
            beta [Rattus norvegicus]
            Length = 457

Frame  3 hits (HSPs):   _____________                                     
                        __________________________________________________
Database sequence:     |                |               |                || 457
                       0              150             300              450

  Plus Strand HSPs:

 Score = 173 (60.9 bits), Expect = 2.3e-11, P = 2.3e-11
 Identities = 40/113 (35%), Positives = 63/113 (55%), Frame = +3

Query:    12 ERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANVVK 191
             E L ++G GS GTV K  H+ +GR+ A+K+ Y   E+SV +   REI+ L+     N+V 
Sbjct:     5 ETLGKVGEGSYGTVMKCKHKDTGRIVAIKIFYEKPEKSVNKIATREIKFLKQFRHENLVN 64

Query:   192 CHEMYDQNSEIQVLLEFMDGGSLEGK----HITQEQQLAXLSRQILRGLAYLH 338
               E++ Q  +I ++ EF+D   L+      H  + ++L     QILR + YLH
Sbjct:    65 LIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIEYLH 117


 >gi|2149570|gb|AAB58577.1|  (U87912) MAP kinase kinase protein DdMEK1
            [Dictyostelium discoideum]
            Length = 660

Frame  3 hits (HSPs):                        __________                   
Frame  1 hits (HSPs):                                 _                   
                        __________________________________________________
Database sequence:     |           |          |           |          |    | 660
                       0         150        300         450        600

  Plus Strand HSPs:

 Score = 163 (57.4 bits), Expect = 2.3e-11, Sum P(2) = 2.3e-11
 Identities = 42/117 (35%), Positives = 64/117 (54%), Frame = +3

Query:     6 ELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANV 185
             +L+ +  +G G+GG V    H TSG   ALKVI    +E++R+QI  E++ L       +
Sbjct:   291 DLKIIRVLGRGAGGVVKLAYHETSGTYIALKVITLDIQENIRKQIILELKTLHKTSYPYI 350

Query:   186 VKCHEMYDQNSEIQVLLEFMDGGSLEG---KHIT-QEQQLAXLSRQILRGLAYLHRR 344
             V  ++ +     I + LEFM+ GSL     K  T  E  L  ++ Q+L+GL YLHR+
Sbjct:   351 VSFYDAFYTEGSIFIALEFMELGSLSDIMKKTSTIPEPVLGKIAFQVLQGLVYLHRK 407

 Score = 36 (12.7 bits), Expect = 2.3e-11, Sum P(2) = 2.3e-11
 Identities = 6/9 (66%), Positives = 8/9 (88%), Frame = +1

Query:   343 VRGLAYLHR 369
             ++GL YLHR
Sbjct:   398 LQGLVYLHR 406


 >gi|2499636|sp|Q24324|DSOR_DROME  DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN
            KINASE KINASE DSOR1 (DOWNSTREAM OF RAF) (MAPKK)
            >gi|348381|pir||A45176 protein kinase Dsor1 - fruit fly (Drosophila
            melanogaster) >gi|217334|dbj|BAA02925.1| (D13782) Dsor1 [Drosophila
            melanogaster] >gi|265496|gb|AAB25349.1| Dsor1=protein kinase
            [Drosophila, Peptide, 393 aa]
            Length = 393

Frame  3 hits (HSPs):             _______________                         
Annotated Domains:      __________________________________________________
                        __________________________________________________
Database sequence:     |                  |                   |           | 393
                       0                150                 300
__________________

Annotated Domains:
   BLOCKS               BL00107A: Protein kinases ATP-binding re 196..226
   BLOCKS               BL00107B: Protein kinases ATP-binding re 259..274
   Entrez               Domain: PROTEIN KINASE.                  84..361
   Entrez               np-binding site: ATP (BY SIMILARITY).    90..98
   Entrez               binding site: ATP (BY SIMILARITY).       113
   Entrez               active site: BY SIMILARITY.              206
   Entrez               phosphorylation site: (BY RAF) (BY SIMIL 234
   Entrez               phosphorylation site: (BY RAF) (BY SIMIL 238
   PFAM                 pkinase: Eukaryotic protein kinase domai 84..361
   PRODOM               PD060621: DSOR_DROME                     1..83
   PRODOM               PD000001: KKIT(14) CC2(14) KPC1(13)      85..359
   PRODOM               PD046930: DSOR_DROME                     361..392
   PROSITE              PROTEIN_KINASE_ST: Serine/Threonine prot 202..214
__________________


  Plus Strand HSPs:

 Score = 171 (60.2 bits), Expect = 2.7e-11, P = 2.7e-11
 Identities = 38/114 (33%), Positives = 71/114 (62%), Frame = +3

Query:     6 ELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANV 185
             +LE+L  +GSG+GG V KV H  +  + A K+I+   + ++++QI RE+++L + +  ++
Sbjct:    83 DLEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQILRELKVLHECNFPHI 142

Query:   186 VKCHEMYDQNSEIQVLLEFMDGGSLEG--KHITQ--EQQLAXLSRQILRGLAYL 335
             V  +  +  + EI + +E+MDGGSL+   K   +  E  L  ++  +L+GL+YL
Sbjct:   143 VGFYGAFYSDGEISICMEYMDGGSLDLILKRAGRIPESILGRITLAVLKGLSYL 196


 >gi|7291037|gb|AAF46475.1|  (AE003446) Dsor1 gene product [Drosophila
            melanogaster]
            Length = 396

Frame  3 hits (HSPs):             _______________                         
                        __________________________________________________
Database sequence:     |                  |                  |            | 396
                       0                150                300

  Plus Strand HSPs:

 Score = 171 (60.2 bits), Expect = 2.8e-11, P = 2.8e-11
 Identities = 38/114 (33%), Positives = 71/114 (62%), Frame = +3

Query:     6 ELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANV 185
             +LE+L  +GSG+GG V KV H  +  + A K+I+   + ++++QI RE+++L + +  ++
Sbjct:    86 DLEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQILRELKVLHECNFPHI 145

Query:   186 VKCHEMYDQNSEIQVLLEFMDGGSLEG--KHITQ--EQQLAXLSRQILRGLAYL 335
             V  +  +  + EI + +E+MDGGSL+   K   +  E  L  ++  +L+GL+YL
Sbjct:   146 VGFYGAFYSDGEISICMEYMDGGSLDLILKRAGRIPESILGRITLAVLKGLSYL 199


 >gi|7001374|gb|AAF34871.1|AF112184_1  (AF112184) serine/threonine kinase NKIATRE
            alpha [Rattus norvegicus]
            Length = 505

Frame  3 hits (HSPs):   ____________                                      
                        __________________________________________________
Database sequence:     |              |              |              |     | 505
                       0            150            300            450

  Plus Strand HSPs:

 Score = 173 (60.9 bits), Expect = 2.8e-11, P = 2.8e-11
 Identities = 40/113 (35%), Positives = 63/113 (55%), Frame = +3

Query:    12 ERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANVVK 191
             E L ++G GS GTV K  H+ +GR+ A+K+ Y   E+SV +   REI+ L+     N+V 
Sbjct:     5 ETLGKVGEGSYGTVMKCKHKDTGRIVAIKIFYEKPEKSVNKIATREIKFLKQFRHENLVN 64

Query:   192 CHEMYDQNSEIQVLLEFMDGGSLEGK----HITQEQQLAXLSRQILRGLAYLH 338
               E++ Q  +I ++ EF+D   L+      H  + ++L     QILR + YLH
Sbjct:    65 LIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIEYLH 117


 >gi|7706059  ref|NP_057592.1| serine-threonine protein kinase NKIAMRE [Homo
            sapiens] >gi|7108631|gb|AAF36509.1|AF130372_1 (AF130372)
            serine-threonine protein kinase NKIAMRE [Homo sapiens]
            Length = 455

Frame  3 hits (HSPs):   _____________                                     
                        __________________________________________________
Database sequence:     |                |               |                || 455
                       0              150             300              450

  Plus Strand HSPs:

 Score = 172 (60.5 bits), Expect = 2.9e-11, P = 2.9e-11
 Identities = 39/113 (34%), Positives = 63/113 (55%), Frame = +3

Query:    12 ERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANVVK 191
             E L ++G GS GTV K  H+ +G++ A+K+ Y   E+SV +   REI+ L+     N+V 
Sbjct:     5 ETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHENLVN 64

Query:   192 CHEMYDQNSEIQVLLEFMDGGSLEGK----HITQEQQLAXLSRQILRGLAYLH 338
               E++ Q  +I ++ EF+D   L+      H  + ++L     QILR + YLH
Sbjct:    65 LIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLH 117


 >gi|7671654|emb|CAB89421.1|  (AL109839) dJ1069P2.1 (serine/threonine kinase 4)
            [Homo sapiens]
            Length = 435

Frame  3 hits (HSPs):      ______________                                 
                        __________________________________________________
Database sequence:     |                 |                |               | 435
                       0               150              300

  Plus Strand HSPs:

 Score = 171 (60.2 bits), Expect = 3.4e-11, P = 3.4e-11
 Identities = 38/109 (34%), Positives = 69/109 (63%), Frame = +3

Query:    18 LNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANVVKCH 197
             L ++G GS G+VYK +H+ +G++ A+K +     ES  ++I +EI I++  D  +VVK +
Sbjct:    33 LEKLGEGSYGSVYKAIHKETGQIVAIKQV---PVESDLQEIIKEISIMQQCDSPHVVKYY 89

Query:   198 EMYDQNSEIQVLLEFMDGGS------LEGKHITQEQQLAXLSRQILRGLAYLH 338
               Y +N+++ +++E+   GS      L  K +T E ++A + +  L+GL YLH
Sbjct:    90 GSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLT-EDEIATILQSTLKGLEYLH 141


 >gi|1117791|gb|AAA83254.1|  (U18297) MST1 [Homo sapiens]
            Length = 487

Frame  3 hits (HSPs):      ____________                                   
                        __________________________________________________
Database sequence:     |               |              |               |   | 487
                       0             150            300             450

  Plus Strand HSPs:

 Score = 171 (60.2 bits), Expect = 4.3e-11, P = 4.3e-11
 Identities = 38/109 (34%), Positives = 69/109 (63%), Frame = +3

Query:    18 LNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANVVKCH 197
             L ++G GS G+VYK +H+ +G++ A+K +     ES  ++I +EI I++  D  +VVK +
Sbjct:    33 LEKLGEGSYGSVYKAIHKETGQIVAIKQV---PVESDLQEIIKEISIMQQCDSPHVVKYY 89

Query:   198 EMYDQNSEIQVLLEFMDGGS------LEGKHITQEQQLAXLSRQILRGLAYLH 338
               Y +N+++ +++E+   GS      L  K +T E ++A + +  L+GL YLH
Sbjct:    90 GSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLT-EDEIATILQSTLKGLEYLH 141


 >gi|5454096  ref|NP_006273.1| serine/threonine kinase 4; serine/threonine kinase
            4 (Ste20, yeast homolog) [Homo sapiens] >gi|1477791|gb|AAB17262.1|
            (U60207) serine/threonine protein kinase Krs-2 [Homo sapiens]
            Length = 487

Frame  3 hits (HSPs):      ____________                                   
                        __________________________________________________
Database sequence:     |               |              |               |   | 487
                       0             150            300             450

  Plus Strand HSPs:

 Score = 171 (60.2 bits), Expect = 4.3e-11, P = 4.3e-11
 Identities = 38/109 (34%), Positives = 69/109 (63%), Frame = +3

Query:    18 LNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANVVKCH 197
             L ++G GS G+VYK +H+ +G++ A+K +     ES  ++I +EI I++  D  +VVK +
Sbjct:    33 LEKLGEGSYGSVYKAIHKETGQIVAIKQV---PVESDLQEIIKEISIMQQCDSPHVVKYY 89

Query:   198 EMYDQNSEIQVLLEFMDGGS------LEGKHITQEQQLAXLSRQILRGLAYLH 338
               Y +N+++ +++E+   GS      L  K +T E ++A + +  L+GL YLH
Sbjct:    90 GSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLT-EDEIATILQSTLKGLEYLH 141


 >gi|12328814  ref|NP_067395.1| serine/threonine kinase 4; STE20-like kinase MST1
            [Mus musculus] >gi|8489867|gb|AAF75789.1|AF271360_1 (AF271360)
            STE20-like kinase MST1 [Mus musculus]
            Length = 487

Frame  3 hits (HSPs):      ____________                                   
                        __________________________________________________
Database sequence:     |               |              |               |   | 487
                       0             150            300             450

  Plus Strand HSPs:

 Score = 171 (60.2 bits), Expect = 4.3e-11, P = 4.3e-11
 Identities = 38/109 (34%), Positives = 69/109 (63%), Frame = +3

Query:    18 LNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANVVKCH 197
             L ++G GS G+VYK +H+ +G++ A+K +     ES  ++I +EI I++  D  +VVK +
Sbjct:    33 LEKLGEGSYGSVYKAIHKETGQIVAIKQV---PVESDLQEIIKEISIMQQCDSPHVVKYY 89

Query:   198 EMYDQNSEIQVLLEFMDGGS------LEGKHITQEQQLAXLSRQILRGLAYLH 338
               Y +N+++ +++E+   GS      L  K +T E ++A + +  L+GL YLH
Sbjct:    90 GSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLT-EDEIATILQSTLKGLEYLH 141


 >gi|6016066|sp|Q99078|FUZ7_USTMA  DUAL SPECIFICITY PROTEIN KINASE FUZ7
            >gi|476334|gb|AAA62242.1| (U07801) serine/threonine/tyrosine kinase
            [Ustilago maydis]
            Length = 435

Frame  3 hits (HSPs):               ______________                        
Annotated Domains:      __________________________________________________
                        __________________________________________________
Database sequence:     |                 |                |               | 435
                       0               150              300
__________________

Annotated Domains:
   Entrez               Domain: PROTEIN KINASE.                  109..417
   Entrez               np-binding site: ATP (BY SIMILARITY).    115..123
   Entrez               binding site: ATP (BY SIMILARITY).       138
   Entrez               active site: BY SIMILARITY.              231
   PFAM                 pkinase: Eukaryotic protein kinase domai 109..304
   PFAM                 pkinase: Eukaryotic protein kinase domai 376..417
   PRODOM               PD072646: FUZ7_USTMA                     1..110
   PRODOM               PD000001: KKIT(14) CC2(14) KPC1(13)      112..310
   PRODOM               PD062052: FUZ7_USTMA                     312..362
   PRODOM               PD004800: MPK1(6) MPK2(5) FUZ7(1)        364..429
   PROSITE              PROTEIN_KINASE_ST: Serine/Threonine prot 227..239
__________________


  Plus Strand HSPs:

 Score = 170 (59.8 bits), Expect = 4.4e-11, P = 4.4e-11
 Identities = 41/115 (35%), Positives = 67/115 (58%), Frame = +3

Query:     6 ELERLNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANV 185
             +L+ L+ +G+G+GGTV KV+H  SG V A KV++   + SVR+QI RE+QIL + +   +
Sbjct:   108 DLKTLSELGAGNGGTVTKVLHEKSGTVMAKKVVFIDAKPSVRKQILRELQILHECNSPYI 167

Query:   186 VKCHEMYDQNSEIQVLLEFMDGGSLEG---KHITQEQQLAX-LSRQILRGLAYLH 338
             V  +  Y     I + +EFM   SL+G   K+     ++   ++  +  GL YL+
Sbjct:   168 VSFYGAYLNEPHICMCMEFMQKDSLDGIYKKYGPISPEICGKIAVAVSHGLTYLY 222


 >gi|12742313  ref|XP_009522.2| serine/threonine kinase 4 [Homo sapiens]
            Length = 499

Frame  3 hits (HSPs):       ____________                                  
                        __________________________________________________
Database sequence:     |              |              |              |     | 499
                       0            150            300            450

  Plus Strand HSPs:

 Score = 171 (60.2 bits), Expect = 4.5e-11, P = 4.5e-11
 Identities = 38/109 (34%), Positives = 69/109 (63%), Frame = +3

Query:    18 LNRIGSGSGGTVYKVVHRTSGRVYALKVIYGHHEESVRRQIHREIQILRDVDDANVVKCH 197
             L ++G GS G+VYK +H+ +G++ A+K +     ES  ++I +EI I++  D  +VVK +
Sbjct:    45 LEKLGEGSYGSVYKAIHKETGQIVAIKQV---PVESDLQEIIKEISIMQQCDSPHVVKYY 101

Query:   198 EMYDQNSEIQVLLEFMDGGS------LEGKHITQEQQLAXLSRQILRGLAYLH 338
               Y +N+++ +++E+   GS      L  K +T E ++A + +  L+GL YLH
Sbjct:   102 GSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLT-EDEIATILQSTLKGLEYLH 153


WARNING:  HSPs involving 2987 database sequences were not reported due to the
          limiting value of parameter B = 50.


Parameters:
  filter=none
  matrix=BLOSUM62
  V=50
  B=50
  E=10
  gi
  H=1
  sort_by_pvalue
  echofilter

  ctxfactor=5.98

  Query                        -----  As Used  -----    -----  Computed  ----
  Frame  MatID Matrix name     Lambda    K       H      Lambda    K       H
   Std.    0   BLOSUM62                                 0.318   0.135   0.401  
   +3      0   BLOSUM62        0.318   0.135   0.401    0.325   0.141   0.406  
               Q=9,R=2         0.244   0.0300  0.180     n/a     n/a     n/a
   +2      0   BLOSUM62        0.318   0.135   0.401    0.320   0.141   0.457  
               Q=9,R=2         0.244   0.0300  0.180     n/a     n/a     n/a
   +1      0   BLOSUM62        0.318   0.135   0.401    0.340   0.139   0.550  
               Q=9,R=2         0.244   0.0300  0.180     n/a     n/a     n/a
   -1      0   BLOSUM62        0.318   0.135   0.401    0.329   0.142   0.440  
               Q=9,R=2         0.244   0.0300  0.180     n/a     n/a     n/a
   -2      0   BLOSUM62        0.318   0.135   0.401    0.342   0.143   0.539  
               Q=9,R=2         0.244   0.0300  0.180     n/a     n/a     n/a
   -3      0   BLOSUM62        0.318   0.135   0.401    0.325   0.139   0.468  
               Q=9,R=2         0.244   0.0300  0.180     n/a     n/a     n/a

  Query
  Frame  MatID  Length  Eff.Length     E    S W   T  X   E2     S2
   +3      0      123       122       10.  71 3  12 22  0.099   33
                                                    29  0.11    35
   +2      0      123       121       10.  71 3  12 22  0.098   33
                                                    29  0.11    35
   +1      0      123       121       10.  71 3  12 22  0.098   33
                                                    29  0.11    35
   -1      0      123       122       10.  71 3  12 22  0.099   33
                                                    29  0.11    35
   -2      0      123       122       10.  71 3  12 22  0.099   33
                                                    29  0.11    35
   -3      0      123       121       10.  71 3  12 22  0.098   33
                                                    29  0.11    35


Statistics:

  Database:  /usr/local/dot5/sl_home/beauty/seqdb/blast/nr
    Title:  nr
    Release date:  unknown
    Posted date:  4:06 PM CST Feb 28, 2001
    Format:  BLAST
  # of letters in database:  197,782,623
  # of sequences in database:  625,274
  # of database sequences satisfying E:  3037
  No. of states in DFA:  570 (56 KB)
  Total size of DFA:  166 KB (192 KB)
  Time to generate neighborhood:  0.00u 0.01s 0.01t  Elapsed: 00:00:00
  No. of threads or processors used:  6
  Search cpu time:  171.20u 1.25s 172.45t  Elapsed: 00:00:32
  Total cpu time:  171.23u 1.30s 172.53t  Elapsed: 00:00:32
  Start:  Wed Feb  6 14:31:37 2002   End:  Wed Feb  6 14:32:09 2002

WARNINGS ISSUED:  2


Annotated Domains Database:   March 14, 2000 

Release Date:  March 14, 2000