state mandates for health education, 235-7, 23:13, 23:15-l& 23-18 state smoking laws, 2127-28 LEUKEMIA (See also NEOPLASMS) benzene and, 14:51 LEUKOCYTES cell count in cigar and pipe smokers, 1281 cell count in ex-smokers, 1281 cell count in smokers vs. nonsmokers, 12:xX32 chemotaxis in smokers vs. nonsmok- ers, 12:82 effect of inhalation and smoking lev- els on cell count, 79-82 granular, levels in smokers, 10:20 LEUKOPLAKIA (See also MOUTB NEOPLASMS) betel chewing and, 5:41 bidi smoking and, 5:41 snuff in etiology of, 13:40 tobacco chewing and, 5:41 tobacco chewing in etiology of, 13:til LIFE EXPECTANCY (See also MORTALITY) definition, 2:ll effect of smoking levels in the Unit- ed states, 2:12 LIFE SKILLS TRAINING antismoking education component, 2O:ll LIP NEOPLASMS (See also MOUTH NEOPLASMS) alcohol consumption and smoking and, 5:41 pipe smoking and, 127 pipe smoking in etiology of, 13:21 relative risk in cigarette vs. cigar vs. pipe smokers, 1322 LIPIDS effect of smoking on metabolism, 1265 LIVER function, effect of aromatic hydro- carbons, 12:78 organ weight in smokers vs. non- smokers, 12:9 LOBELINE nicotine substitute, 19:16-l? LOCUS OF CONTROL academic achievement and, 2022 cessation of smoking and, 18:18 maintenance of smoking and, 18:9 Low-tar cigarettm See CIGARETTES, LOW-TAR Lung diseases See BRONCHOPULMONARY DIS- EASES; BYSSINOSIS; CHRONIC OBSTRUCTIYE LUNG DISEASES; RESPIRATORY TRACT DIS- EASES LUNG FUNCTION (See also RESPIRATORY FUNC- TION TESTS) effect of carbon monoxide exposure, 1127-28 effect of cessation of smoking, 62% 23 effect of cigar smoking, 1334-35, 13s effect of nicotine, 1499 effect of passive smoking in asth- matic patients, 1022 effect of pipe smoking, 13:34-35, 1338 effect of smoking, 622, 1499 effect of smoking, summary of find- ings, 1:18 effect of smoking levels, 622 sex ratio, 6:21X2 in smokers vs. nonsmokers, 6:21 in smokers vs. nonsmokers vs. ex- smokers, 623 smoking in chlorine workers and, 7:lO smoking in coal miners and, 7:9 smoking in cotton workers and, 7:9 in white, black and oriental smoking and nonsmoking men and wom- en, 6:21 LUNG NEOPLASMS (See also BRONCBIAL NEO- PLASMs RESPIRATORY TRACT NEOPLASM@ air pollution in etiology of, 525-27 animal models, 52931 aryl hydrocarbon hydroxylase induci- bility and, 5:57 asbestos and smoking in etiology of, 529 carcinoembryonic antigen test in di- agnosis of, 1261 chloromethyl ethers and smoking in etiology of, 529 in chloromethyl ether workers, 7:16 cigar and pipe smoking and, summa- ry of findings, 1% cigar smoking in etiology of, 1328 effect of age began smoking on mortality ratio, 13:14 effect of cessation of smoking on risk and mortality ratios, 524-26 effect of filtered vs. unfiltered ciga- rettes on risk, 5:16, 5:18-19 effect of inhalation on mortality ra- tio, 5:lP15 effect of low tar and nicotine ciga- rettes on mortality ratio, 5:X-17 effect of smoking levels on mortality ratio, 5:13 effect of smoking levels on risk, 5:l2-13, 5:16, 5:18-19 effect of smoking on histologic type, 523-24 effect of smoking on mortality rates, 59-11 heredity and, 523 histologic types, 5:2X&4 induced by benzc(a)pyrene in ham- sters, 539 induced by nitrosamines in animals, 5:30 mortality in asbestos workers, 7:11- 12 mortality rates in cigar vs. pipe smokers, 523 mortality rates in women, 5:X-18, 5:20- mortality ratio in cigar vs. cigarette vs. pipe smokers, 13% mortality rate trends in Great Brit- ain and the United States, 5:19 11 mortality ratio in smokers vs. non- smokers, 5:11-12 nickel and smoking in etiology of, 528 occupational exposures and smoking in etiology of, 527-29, 7:17 relative risk in cigar vs. cigarette vs. pipe smokers, 1329-30 role of pulmonary alveolar macro- phages, 5:31 smoking and, summary of findings, 1:16 smoking and occupational risk in whites and nonwhites, 7:17 smoking in asbestos workers and, 7:11-13 smoking in etiology of, historical per- spective, 5:9 smoking in uranium miners and, 7:14 in smoking vs. nonsmoking twins, 5% uranium and smoking in etiology of, 528 in urban vs. rural areas, 52527 LUNGS (See also RESPIRATORY SYSTEM) air pollution and pathology in smok- ers vs. nonsmokers, 6:36 effect of cigar smoking, 13:35 effect of pipe smoking, 1335 effect of smoke inhalation in dogs, 14:76 effect of smoke inhalation in mon- keys, 14:76 effect of smoking, 6:18 effect of smoking, summary of find- ings, l:lb19 effect of smoking levels on patholo gy, 624-27 effect of smoking on pathogenesis, 625-26 enzyme induction of emphysema, 628 nicotine absorption, 1485 organ weight in smokers vs. non- smokers, 12:9 LYMPHOCYTES B and T, in smokers vs. nonsmokers, 6:31 effect of smoking, lo:19 effect of tobacco smoke in mice, 10:19 effect of tobacco smoke on immune function, lo:17 MACROPHAGES, ALVEOLAR (See also PHAGOCYTOSIS) in bronchial fluid of smokers, 628 count in smokers vs. nonsmokers, 629 effect of cigarette smoke, 629-30 effect of cigarette smoke on phago cytic activity, lo:17 effect of tobacco smoke, 10:1516 effect of tobacco smoke on count and ultrastructure, lo:16 effect of smoke inhalation in dogs, 14:76 effect of smoke inhalation in mon- keys, 1476 elastasc release in smokers vs. non- smokers, 636 in lung neoplasm etiology, 5:31 protease activity in smokers vs. non- smokers, 629 in smokers vs. nonsmokers, 6:31 Mainatre8m smoke see SMOBE, c1cARBITE MAIN- STREAM; SMOKE STREAMS MALBIC IIYDRAZIDE hydrasine levels and, 14:41 structural formula, 14:62 tobacco curing and, 14:47 (See also SEX RATIO) smoking prevalence, A:ll, A:1213, A:1718 MARIJUANA (See aleo CANNABIS; DRUG ABUSE) correlation with tobacco smoking, 18:14 effect on enzyme activity, 124243 effect on pharmacokinetics, 1242-43 effect on pregnant animals, 853 MATERNAL-FETAL EXCHANGE aromatic hydrocarbons in animals, 856 benao(a)pyrene in animals, 866 carbon monoxide in sheep, 8:59 carbon monoxide in sheep and dogs, 858 nicotine in animals, 854 Maternal smoking See SMOKING, MATERNAL Maximum mid+xpiratory flow rate measurements See RESPIRATORY FUNCTION TESTS MECAMYLAMINE nicotine antagonist, 16:89 MEDICAL STUDENTS antismoking education, 22:17-18 perceptions of physicians' smoking habits, 22:7 smoking habits, 18:8, 22:18 MEDITATION in modification of smoking behavior, 19:z Men See MALES MEPERIDINB total clearance in smokers vs. non- smokers, 12:39 MEPROBAMATE cessation aid, 19:17 MERCURY (See ul.so METALS) levels in smokers vs. nonsmokers, 12:73 smoking and occupational exposure, 7:7 MESOTHELIOMA (See also CARCINOGENESIS; NBOPLASMS) smoking and asbestos exposure and, 7:l2 MBI'ABOLISM (See also NICOTINE MEXABO- LISM) carbon monoxide in maintenance of smoking habit, 15:17 effect of smoking on carbohydrates, lipids and proteins, 12% effect of tobacco smoke on food con- stituents and additives, 12:75-76 nicotine in maintenance of smoking habit, 15:16 nicotine, in smokers vs. nonsmokers, 15:9 tar, in maintenance of smoking hab it, 15:17 METALS (see also CADMIUM; CALCIUM; LEAD; MERCURY; NICKEL) cardiovascular diseases and, 4:62 in cigarette smoke as carcinogens, 14:59-60 levels in particulate phase cigarette smoke, 14:59 levels in smokers vs. nonsmokers, 12:73-74 in tobacco smoke, 14zX-59 MERIYL PARATHION smoking and occupational exposure, 7:7 METHYLCHOLANTHRENE (See ah AROMATIC IIYDROCAR BONS) effect on aryl hydrocarbon hydroxyl- ase activity in rats, l2:28-29 effect on enzyme activity, 12:21-B effect on phenacetin pharmacokinet- its in rats, 12:2%29 effect on RNA metabolism, 12:21-22 effect on theophylline metabolism in rata, 12:32 in oral neoplasm induction in ham- sters, 5:42 METBYLENE CHLORIDE occupational hazards, 7:%9 MORBIDITY (See also MORTAIJIY) bed disability in smokers vs. non- smokers, 3: 12 bronchitis and emphysema in the United States, 6% coronary heart disease in ex-smokers, 438 effect of cessation of smoking, sum- mary of findings, 1:12-13 effect of smoking, 3:5 effect of smoking, summary of find- ings, 1:12-13 effect of smoking on acute condi- tions, 3:6 effect of smoking on chronic condi- tions, 36-7 findings of NCHS National Health Interview Survey, l:lZ-13 incidence of acute conditions in smokers vs. nonsmokers vs. ex- smokers, 3:9 peptic ulcer in the United States, 9:17 prevalence rate of chronic conditons, 36-7 smoking and lung neoplasms and oc- cupational risk, 737 workdays lost, 3%9 WORBIDITY RATIO angina pectoris, effect of smoking levels, 448 coronary heart disease in ex-smokers, 42a-31, 43435 coronary heart disease in smokers vs. nonsmokers, 4:2733, 4:3637 HORTALUY (See also EXCESS DEATHS; FE- TAL MORTALITY; INFANT MOR- TALITY; LIFE EXPECTANCY; MORBIDITY; PERINATAL MOR TALITY) annual probability of dying in smok- ers vs. nonsmokers vs. ex-smok- ers, 2:3934 bronchitis in cigar vs. cigarette vs. pipe smokers, 1334 chronic obstructive lung disease in smokers, 2:41, 6:9 chronic obstructive lung disease in smokers vs. nonsmokers vs. ex- smokers, 6:lO cigar and pipe smokers vs. ex-smok- ers, 13:8 cigar vs. cigarette vs. pipe smokers, 13:13-14 effect of age began smoking, 2:19 effect of cigar smoking, 2:30, 23.537 effect of environmental factors, 2:42 effect of heredity in smoking related disease, 2:41M2 effect of inhalation, 220 effect of inhalation in cigar and pipe smokers, 13: 18 effect of nicotine and tar content, 222 effect of pipe smoking, 230. 233537 effect of smoking in the United states, 2:9 effect of smoking in women, 225 effect of smoking levels in cigar and pipe smokers, 13:1&16 effect of social factors, 242 effect of years since quitting in ex- smokers, 22734, 235 emphysema in cigar vs. cigarette vs. pipe smokers, 1334 epidemiological studies, 2:X%15 esophageal neoplasms in cigar vs. cigarette vs. pipe smokers, 13:24 ex-smokers. 22630 methods of measuring, 2:1&11 peptic ulcer in cigar vs. cigarette vs. pipe smokers, 13% peptic ulcer in smokers, 2:41, 9:lO peptic ulcer in smokers vs. nonsmok- ers, 9:17 respiratory tract infections in smok- ers. 2:41 risk from pregnancy and childbirth vs. oral contraceptive use, 12:X? smoking and lung neoplasms and as- bestos exposure, 7:ll MORTALITY RATES age groups in the United States, 2:ll cerebrovascular disease in male vs. female smokers, 451 circulatory diseases, effect of oral contracdptives and smoking, 12:51 coronary heart disease in ex-smokers, 438 definition, 2:16-11 effect of cigar and pipe smoking, summary of findings, 1:27 effect of less hazardous cigarettes, 2% lung neoplasms and smoking, summa- ry of findings, 1:16 lung neoplasms, effect of smoking, 59-11 lung neoplasms in cigar and pipe smokers, 5% lung neoplasms in women, 5:16-18, 526 lung neoplasms, trends in Great Brit- ain and the United States, 5:lC myocardial infarct in smokers vs. nonsmokers, 435-36 smokers vs. nonsmokers, 2:15 thrombosis in smokers vs. nonsmok- ers, 4:59 MORTALITY RATIO age groups in the United States, 2:11, 2:1'7-18 age groups worldwide, 2:17-18 aortic aneurysm, effect of smoking levels, 455 bladder neoplasms in smokers, 5:4.5- 46 cardiovascular diseases in cigar vs. cigarette vs. pipe smokers, 13:33- 34 cardiovascular diseases in smokers, 2:39 cardiovascular diseases in smokers vs. nonsmokers in Japan, 4:21, 434 35 cause-specific, effect of smoking, 2:3741 cerebrovascular disease in cigar vs. cigarette vs. pipe smokers, 13:33 cerebrovascular disease in male vs. female smokers, 4~51 chronic obstructive lung disease, 6:lO chronic obstructive lung disease in cigar vs. cigarette vs. pipe smok- ers, 13% cigar vs. cigarette vs. pipe smokers, 230, 236-36 cigarette vs. cigar vs. pipe vs. mixed smokers, 13:14 coronary heart disease in cigar vs. cigarette vs. pipe smokers, 13:33- 34 coronary heart disease in smokers, 239 coronary heart disease in ex-smokers, 434-35 coronary heart disease in smokers vs. nonsmokers, 422-26, 4:36-37 definition, 2:lO effect of age began smoking, 2:1%22 effect of cigar and pipe smoking, 1:11-E. effect of combined tobacco product use, 239 effect of inhalation, 222-24 effect of inhalation, smoking dura- tion and smoking levels in wom- en, 22627 effect of less hazardous cigarettes, l:ll, 223-25 effect of reasons for quitting in ex- smokers, 22"29 effect of smoking, summary of find- ings, 1:16-C? effect of smoking duration, 2:17-19 effect of smoking duration in cigar smokers, 2:37 effect of smoking duration in ex- smokers, 228-29 effect of smoking duration in pipe smokers, 238 effect of smoking levels, 2:16-18, 222 effect of smoking levels in cigar smokers, 13:15-17, 2:36-37 effect of smoking levels in ex-smok- ers, 228-29 effect of smoking levels in pipe smokers, 2:3638, 13:15-17 esophageal neoplasms in cigar and pipe smokers, 5:43 esophageal neoplaams in cigar vs. cigarette vs. pipe smokers, 1325 esophageal neoplasms in smokers, 542-43 ex-smokers, 23.5 kidney neoplasms in smokers, 54349 laryngeal neoplasms in cigar vs. cig- arette vs. pipe smokers, 1324 laryngeal neoplasms in smokers, 5:3%33 lung neoplasms, effect of age began smoking, 5:13-14 iunk. neoplasms, effect of cessation of smoking, 524-26 lung neoplaams, effect of inhalation, 5:lP15 lung neoplaams, effect of low tar and nicotine cigarettes, 5:X--17 lung neoplasms, effect of smoking levels, 5:13 lung neoplasms in cigar vs. cigarette vs. pipe smokers, 1326-23 lung neoplasms in smokers vs. non- smokers, 5:11-E? lung neoplasms in smoking women, 5:Bl-22 neoplasms, effect of cigar and pipe smoking, 13% neoplasms in smokers, 2:38 oral neoplasms in cigar vs. cigarette vs. pipe smokers, 1321-23 oral neoplasms in smokers, 5:39-M pancreatic neoplasms in smokers, 550-52 pharyngeal neoplasms in cigar vs. cigarette vs. pipe smokers, 1323 in smoking twins, 2:42 sudden cardiac death, effect of smoking levels, 443 MORTALITY RISK infant, and gestational age in smok- ing vs. nonsmoking mothers, 8:43, 8:45 infant, effect of maternal smoking, age, parity, and education, 833 infant, effect of maternal smoking, age, parity, and social class, 8:31 infant, synergism of maternal smok- ing and other risk factors, 835 infants of smokers vs. nonsmokers, MOTIVATION (See also BEHAVIOR) cessation of smoking and, 18:1%20 emotional influences in smoking be- havior, 16:6 maintenance of smoking and, 18:1& 13, 18:15-17 smoking habit in developing wun- tries and, 1824 smoking habit in the Solomon Islands and, 182.4 MOUTH nicotine absorption, 14% MOLl% MUCOSA (See also LEUKOPLAKLQ effect of snuff in women, 13:3940 MOUTH NEOPLASMS (See also LEUKOPLAKL4; LIP NEOPLASMS; TONGUE NEO- PLASMS) alcohol consumption and smoking and, 5:4&U cigar and pipe smoking and, summa- ry of findings, 127 MUCOCILL4RY SYSTEM (See also CILL4RY ACTMTY; CILL4ToxICITy) effect of cigarette smoke, 6:3%X?, 10:15 MULTICOMPONENT TREATMENT (See also CESSATION OF SMOK- ING) in cessation of smoking, 16:16-17, 16:19 evaluation, 19:36 modification of smoking behavior, 19:2w2a self-administered, 1929 MULTIPLE RISK FACTOR INTER- VENTION TRIAL effect on cessation of smoking, 19:X MUTAGENS in atherosclerosis etiology, 4: 10 MYOCARDIAL INFARCT 6ee also CORONARY HEART DISEASE) animal models, 420 atherosclerosis in etiology of, 4:19-26 cessation of smoking after, 19:14 effect of oral contraceptives and smoking on risk, 466 effect of smoke inhalation in dogs, 8234 14177 effect of smoking on risk of reeur- rence or death, 4:3738 estrogens and smoking and, 12:52 ex-smokers, 4:21 ischemia and, 4:19-20, 4:394O morbidity ratios in ex-smokers, 434 morbidity ratios in smokers vs. non- smokers, 427-33 oral contraceptives and smoking and, 435, 12:51-52 pathogenesis, 4:1820 research needs, 449-41 risk factors, 426-21 smokers vs. nonsmokers, 435-36 smoking in etiology of, 4:21, 43846 smoking vs. nonsmoking women, 12:52 sudden cardiac death and, 4:43 MY~CARDIUM effect of hypoxia and ischemia, 4:19- 20 NAPHTHALJXNE in cigarette smoke, 1451 tobacw pyrolysis and, I4:49 NAPHTHYLAMINES (See also AROMATIC AMINES) pancreatic neoplasms and, 5:51 NATIONAL ASSOCIATION OF SEC- ONDARY SCHOOL PRINCIPALS statement on school smoking policies, 23:8, 23:11, 23:13 NATIONAL CANCER INSTITUTE funding of "Know Your Body" Pro- gram, 21% NATIONAL CENTER FOR HEALTH STATISTICS, 3:5 findings of National Health Inter- view Survey, I:1213 Health and Nutrition Examination Survey, 3:11-12 Health Interview Survey, 38-18 NATIONAL CLEARINGHOUSE FOR SMOKING AND HEALTH definition of smokers and nonsmok- ers, 2324 establishment of San Diego Commu- nity Laboratory, 2614 Health Consequences of Smoking re- ports, 19-10 smoking prevalence in adults by edu- cational level, A:1416 smoking prevalence in adults by family income, A:&&16 survey of adolescent smoking, 17:7-8 survey of adult tobacco use, 18:19, 22:6 survey of cigar and pipe smoking in the United States, 138-9 survey of smoking attitudes of health professionals, 22:7 survey of smoking habits of health professionals, 22:X&-13 survey of tar and nicotine levels of cigarette brands, 3:ll survey of teenage smoking, A:14 training of health educators, 23~32 NATIONAL INSTITIJTJB OF HEALTH respiratory disease study, 17:15 NATIONAL INTERAGENCY COUN- CIL ON SMOKING AND REALTR funding of youth antismoking projects, 2624 research guidelines, 19:5-8, 21:16-17 NATIONAL PARENT-TEACHER AS- SOCIATION health education programs, 21:21, 21% NEONATAL MORTALITY (See also INFANT MORTALITY; MORTALITY RISK; PERINATAL MORTALITY) effect of maternal smoking and ges- tational age, 843 effect of maternal smoking and oth- er factors, 8:41 etiology of perinatal death in smok- ers vs. nonsmokers, 8:37 maternal smoking and, research needs, 8:76 maternal smoking levels and, 8:39-46 NEOPLASMS (See atso CARCINOGENESIS; LEUKEMIA; MESOTHELIOMA) aryl hydrocarbon hydroxylase induci- bility and smoking and, 5:57 cigar and pipe smoking and, summa- ry of findings, 1:2'-28 effect of smoking on mortality ratio, 2:38 induced by polonium-210 in Syrian hamsters, 14:61 induced by tobacco smoke in animals, 1:17 mortality ratio in cigar and pipe smokers, 1326 nitrosamines in etiology of, 12:74 in progeny after maternal exposure to benzo(a)pyrene in mice, 8:67 smoking and, summary of findings, 1:1617 smoking and asbestos exposure and, 7:11-13 smoking in etiology of, historical per- spective, 5:9 Neoplaans, bronchial See BRONCHIAL NEOPLASMS Nwplaeme. =phagerrl See ESOPHAGEAL NEOPLASMS N-P- krynseal See LARYNGEAL NEOPLASMS Neoplasnu, lip See I.lF' NEOPLASMS Neophans, lung See LUNG NROPLASMS Nwplasms, mouth See MOUTH NBOPLASMS Neophmu, pan-tic See PANCREATIC NEOPLASMS Neopluaae, phuyngecll See PHARYNGBAL NEOPLASMS Neoplamns, oral See ORAL NEOPLASMS Ned-m tonsw See TONGUE NEOPLASMS NEUROTICISM 6% also ANXIETY; STRESS) cessation of smoking and, 18:17-18 maintenance of smoking and, 18:7-g smoking characteristics and, 18:13 NICKEL (See abo MFXALS) levels in tobacco smoke, 1459 and smoking in lung neoplasm etiolo gy, 528 NICOTINE (See &IO ALKALOIDS, TOBACCO) absorption by involuntary smoking, 11% addiction, 16:7-g, 18:l2 in allergy induction, 10% in amniotic fluid after maternal in- jection in animals, 8:54 in atherosclerosis induction in ani- mals, 4:16 cardiovascular diseases and, 14:79 carotid blood levels after oral admin- istration, 14:86 central nervous system receptor sites, 16:1%19 dependence and, 1497 effect of cigar smoke inhalation on absorption, 13:16-17 effect of fetal injection in utero in animals, 855 effect of maternal injection on fetus in animals, 854-57 effect of maternal injection on num- ing kittens, 8:49 effect of maternal injection on off- spring in rats, 8:10-11 effect of maternal injection on psy- chomotor function in newborn animals, 8:57 effect of self-administration on smoking habit, 15:l2 effect of smoking characteristics on absorption, 14:87 effect on angina pectoris, 4:39 effect on antidiuretic hormone secre- tion, 12:37, 1254 effect on arousal, 15:ll effect on arteries in rabbits, 4:56 effect on behavior in monkeys, 15:12 effect on behavior in rata, 15:11, 15:18 effect on birth weight in animals, 853 effect on blood lipid levels in ani- mals, 4:61 effect on blood pressure and heart rate, 458, 14:87, 14:91 effect on cardiovascular system, 12:52-&l, 14339 effect on cardiovascular system in animals, 855-56 effect on cardiovascular system in animals with myocardial infarct, 445 effect on catecholamines in rats, 14% effect on central nervous system, 14:89 effect on cerebrovascular circulation, 456 effect on corticosteroid secretion, 1246 effect on drug assays, 1234 effect on enzyme activity, 1227-28, 14:87 effect on enzyme activity in rat in- testines, 1276 effect on exercise induced angina pectoris, 4 :47 effect on fetal and newborn central nervous system, 857 effect on fetal and newborn central nervous system in animals, 856 effect on fetus, research needs, 8:79 effect on fetus and breastfed infants of smoking mothers, 8:51 effect on free fatty acids, 1240, 1490 effect on gastric secretion in cats, 9:12-13 effect on gastric secretion in man, 9:1114 effect on heart function in animals with coronary heart disease, 449 effect on hormones in monkeys, 1520 effect on immunoglobulins, 6:31 effect on ischemia, 4:3S effect on lactation in cats, 8:49 effect on lactation in cows, 8:49 effect on lactation in rats, 8:49 effect on lung function, 1490 effect on lymphocytes in mice, lo:19 effect on nitrosamine biosynthesis, 12:75 effect on pancreatic secretion in dogs, 553, 9:14-15 effect on patellar reflex, 14:92 effect on pharmacokinetics, 12:27-23 effect on psychomotor performance, 16:8 effect on pregnant rats, 8:19-11 effect on serum secretin levels, 9:14- 15 effect on smoking habit, 15:7-8 effect on smoking habit, summary of findings, 1:3932 effect on tolerance in rats, 15:16 effect on vitamin C levels in ani- mals, 1266 in establishing smoking habit, 15:5 excretion under stress, 16:8 induction of hyperglycemia in cats, 14:SS induction of peptic ulcer in cats, 9:12-13 induction of peptic ulcer in rata, 9:E interactive effect with oxprenolol on blood pressure, 1254 interactive effect with propranolol on cardiovascular system, l2:53 internal regulation in smokers, 16:13- 14 in maintenance of smoking habit, 15:14 maternal-fetal exchange in animals, 854 metabolism in maternal and fetal liv- er in animals, 855 metabolism in smokers vs. nonsmok- ers, 15:s methods of absorption, 14% myocardial infarct and, 420 pancreatic neoplasms and, 553 pharmacology in cessation of smok- ing, 1494, 14:97 protonation and, 14: 198 as reinforcer, 16:l2, 16:lB relative molar potency in cigarette smoke, 14% role as hapten, 1O:ll role in alteration of drug metabo- lism, 1240 sales weighted average delivery in American cigarettes, 14-111 smoke dosimetry and, 14:75 structural formula, 1446 summary of physiological effects, 1:3&31 NICOTINE CONTENT (See also ALKALOID CONTENT) in blood, effect of smoking cigarettes vs. little cigars, 14:87 in blood after oral administration, 1436 in cigar vs. cigarette smoke, 13:ll in cigarette smoke, 14% in cigarettes, health characteristics and, 3:ll in cigarettes vs. little cigars, 14:44- 45 in cow's milk after intramuscular in- jection, 8:49 decrease in modem cigarettes, A:lS 20 effect on mortality, 2:22 filters and, 14:104 in milk of lactating smoking vs. non- smoking mothers, 850-51 as smoke inhalation indicator, 14:75 in urine and plasma of smokers vs. nonsmokers, 11% in urine as measure of tobacco us- age, 1523 in urine of smokers vs. nonsmokers, 15:2S NICOTINE CHEWING GUM in cessation of smoking, 19:X-17 in reduction of smoking, 16:8 NICOTINE-IN-SAIdVA TEST correlation with self-reported smok- ing, 1724 NICOTINE METAROtiSM (See dao MEI'AROLISM) degree of proton&ion in relation to pH, 14386 distribution and clearance in rats, 14%) effect of urinary pH on excretion, 14:92-S3 enzymes and, 14:87 pathway, 14:93 rate of absorption, 14:92 NICOTINE METAROLFTES (See also COTININE; NORNICO- TINE) in cigarette smoke, 14:~S4 effect of urinary pH on excretion, 1492 NICOTINR REDUCTION in cigarettes in the United States, 1444 effect on lung neoplasm mortality patio, 595-16 methods, 143114 in particulate phase of cigarette smoke, 14:108 NICOTINE mxIcrN atherosclerosis and, 1439 effect on heart, 14:78 effect on smoke inhalation dosimetry, 14:75 hypertension and, 14:79 NITRIC OXIDE in blood of smokers vs. nonsmokers, 1436 effect on enzyme activity in rata, 14:Bl levels in cigarette smoke, 1446 NITROGEN COMPOUNDS in cigarette smoke, 14:41 in soil, effect on tobacco leaf quality, 14:15-16 NITROGEN DIOXIDE effect on antibody response to back rial vaccines in mice, 1259 effect on respiratory tract in rata, 14:Bl NITROGEN OXIDES absorption, 1493 cardiovascular diseases and, 4:62 content in mainstream cigarette smoke, 14:39 NITROSAMINE CONTENT in cigarette smoke, 1433, 14% effect of curing and fermentation, 1445 effect of homogenized leaf curing, effect of smoking in enclosed spaces, 1125 reduction in gas phase cigarette smoke, 14:lM reduction in particulate phase ciga- rette smoke, 14:ll.Z in tobacco and tobacco smoke, 12:74 NITROSAMINES (See also DVOSA- =E) agricultural practices and, 14:lM biosynthesis in' smokers, l2:74-75 bladder neoplasms and, 5:47 in chewing tobacco, 1445 effect of maternal injection on tra- cheal neoplasms in hamster off- spring, 856 effect of nicotine on biosynthesis, l2:75 in esophageal neoplasm induction in animals, 5:44 in lung neoplasm induction in ham- sters, 530 in neoplasm etiology, 12:74 in pancreatic neoplasm induction in hamstem, 5:51-53 precursors, 14:41 quantification by thermal energy an- alyzer, 14:ll in respiratory tract neoplasm induc- tion in animals, 530 structural formulae, 14:46 NONSMOKERS (See also SMOKFXS VS. NON- SMOREBS) absorption of tobacco smoke constitu- ents, 11:6 annoyance caused by tobacco smoke, 1125 annual probability of dying, 23634 effect of involuntary smoking, 11:5, 11:15, 1128 effect of involuntary smoking on carboxyhemoglobin levels, 11:21, 11:23 effect of tobacco smoke, 112.5 median carboxyhemoglobin levels by location, 1123 nicotine absorption by involuntary smoking, 11% perception of health status, 3:lP15 rights, 16:19-m, 21:14, 21:lB typology, 18:13 NORNICOTINE (See de0 NICOTINE METABO- LIT)=) relative molar potency in cigarette smoke, 1496 structural formula, 14:46 NORTRFIYLINE plasma concentrations in smokers vs. nonsmokers, 12:39 NOSE IRRITATION effect of smoking in enclosed spaces, 1126 NURSES role in cessation decision, 21:l2, 21:14, 22:17 smoking habita, 22:l2-14 NURSING HOMES smoking policies, 2220 OBESITY (See also BODY WEIGHT) cessation of smoking and, 12:67 OBSTRUCTIVB AIRWAY DISEASES (See also BRONCHITIS; BRON- CHOPULMONARY DISEASES; CHRONIC OBSTRUCTIVB LUNG DISEASE; EMPHYSEMA) smoking in cotton workers and, 7% 10 smoking in fire fighters and, 7:19-11 smoking in miners and, 7:s OCCUPATIONAL DISEASES (See ah ASBBSTOSIS; BYSSINO SIS; NBOPLASMS; POLYMBR PUME PRVRR) asbestosis, 7:11-13 byssinosis, 7:s "Monday morning fever", 7:s polymer fume fever, 75-6 OCCUPATIONAL EXPOSURE bionchopulmonary diseases and, 1:19, 636, 7:13 interactive effect with smoking, sum- mary of findings, 1:19-20 smoking and bladder neoplasms and, 5:47 smoking and pancreatic neoplasms and, 5~47 and smoking in lung neoplasm etiolw gy, 5:27-29 smoking levels and health risk, 7:17 OCCUPATIONAL HAZARDS alpha irradiation from radon, 7:14 aromatic amines, 7:16 asbestos, 7:11-13 beta radiation, 7:lO carbon monoxide, 7:8 chlorine, 7:lO chloromethyl ether, 7:X-16 dust, coal, 7:9 dust, cotton, 7:s dust, gold, 7:15 effect of smoking and recommends- tions for research, 7:lS hydrogen cyanide, 7~7-8 rubber, 7:13 OCCUPATIONS asbestos workers, 528, 7:11-13 battery factory workers, 7:15 benzene workers, 14:51 blast furnace workers, 7:8 blue- and white-collar workers, 7:17 bronchitis in smokers vs. nonsmokers and, 639 chemists, 5:51 chlorine workers, 7:lO chloromethyl ether workers, 529, 7:15-16 coal gas workers, 7:16 coal miners, 1335 cotton workers, 7:9 electroplaters, 7:7 fire fighters, 7:19-11 gold miners, 7:15 industrial workers, 22:16-17, 22:lS insulation workers, 7:ll methylene chloride workers, 7:89 miners, 7:s nickel workers, 528 rubber workers, 7:13 smoking prevalence rates and, 18:16, A:16 steelworkers, 7:8 telephone workers, 6:37 tobacco workers, female, 8:s uranium miners, 528, 7:14, 12% OFFICE ON SMOKING AND HEALTH information dissemination function, 2327-28 OldiiS See ALKRNES ONTARIO PERINATAL MORTALITY STUDY, 833-35, 8:37, 839-42, 84.5 ORAL NEOPLASMS, 5:39--Q (See ah LEIJROPLAIUA; LIP NEOPLASM& MOUTH NEO- PLASMS; TONGUE NEOPLASMS) alcohol consumption and smoking and, 5:4@-41 animal models, 5:41-42 betel chewing in etiology of, 1349 41 cigar and pipe smoking and, 539 induced by benzo(a)pyrene in ham- sters, 542 induced by dimethyl benzanthracene in hamsters, 542 induced by methylcholanthrene in hamsters, 542 mortality ratio in cigarette vs. cigar vs. pipe smokers, 13:21-23 mortality ratio in smokers, 539-46 smoking and, summary of findings, 1:17 smoking in etiology of, 5:3942 snuff in etiology of, 13:3940 tobacco chewing and, 539-46 tobacco chewing in etiology of, 1340-41 ORALITY smoking habit and, 18:s ORGAIUOTIN smoking and occupational exposure, 7:7 OSTEOPOROSIS smokers vs. nonsmokers, 12:67 OXPRENOLOL interactive effect with nicotine on blood pressure, 1254 OXYGEN TENSION effect of maternal and fetal carbox- yhemoglobin levels, 864 OXYGEN TRANSPORT effect of carbon monoxide in mother and fetus, 8:61 OXYBEMOGLOBIN SATURATION CURVES maternal and fetal, effect of carbon monoxide levels in blood, 8:62-G& 8:72 PANCREATIC NROPLASMS animal models, 5:5153 correlation with bladder neoplasms, 5:47 diet and, 5:51 effect of smoking levels on mortality and risk ratios, 550, 5:52 effect of smoking and occupational exposure, 7:17 induced by nitrosamines in hamsters, 5:51L53 mortality and risk ratios in male vs. female smokers, 550-52 naphthylamines and, 5:51 nicotine and, 553 occupational exposure and, 5:51 smoking and, summary of findings, 1:17 PANCREATIC SECRETION effect of nicotine in animals and man, 9:lP15 effect of nicotine in dogs, 553 effect of smoking, 9:14-15 Paper, cigarette See CIG- PAPER Parental smoking See SMOKING, PARENTAL PARKINSONISM smoking and, 2:41 PARTICULATE PHASE, CIGARETTE SMOKE (See also TARS, TOBACCO; TO- TAL PARTICULATR MATTBR) aromatic hydrocarbons reduction, 14:109 component levels, 15:6 definition, 1435, 1438 determination of tar levels, 14:43 levels of toxic compounds, 1464-65 levels of metals, 1459 nicotine reduction, 14:103 nitrosamines reduction, 14:112 ratio of constituents in main- vs. sidestream smoke, 11:6 polonium-210 reduction, 14:113 tar reduction methods, 14:llO toxicity reduction, 14:103 toxicity reduction methods, 14:114 Pan&e smoking See INVOLUNTARY SMOKING Peak explratory flow measurements See RESPIRATORY FUNCTION TESTS PEER GROUPS influence on cessation of smoking, l&21 influence on drug abuse in adoles- cents, 1314 influence on initiation of smoking, 16:5 influence on smoking habit in adoles- cents, 17:10, 17:14, 21:X%14 youth-to-youth antismoking programs 20:9 PENTAZGCINE dosage requirements in smokers vs. nonsmokers, 12:36 Peptic ulcer See ULCER, PEPTIC PERINATAL MORTALITY (See also INFANT MORTALITY; MORTALITY RISK; NEONATAL MORTALITY) effect of maternal smoking, summa- ry of findings, 122 gestational age and risk in smoking vs. nonsmoking mothers, 843 maternal smoking in etiology of, 12:67 maternal smoking levels and, 83940 PERIPHERAL VASCULAR DISEASE animal models, 453 clinical and pathological features, 4:52 research needs, 454 risk factors, 4:52 smoking and, summary of findings, 1:1&15 smoking and, 453-54 smoking vs. nonsmoking diabetics, 453 PERSONALITY (See also BEHAVIOR) cessation of smoking and, 18:17-l& 18:21-22 effect on pharmacokinetica, 12:4041 effect on success rates for cessation of smoking, 1524 maintenance of smoking and, 18:NO maternal smoking and, 826 and recidivism, 19:31 and smoking habits in adolescents, 17:16 PESTICIDE RESIDUES hydrazine formation, 14:41 reduction in tobacco, 14:61 structural formulae, 14:62 in tobacco leaf, 14:lB in tobacco smoke, 12:75 toxic effects in smokers, 12:75 PB cigar vs. cigarette vs. pipe smoke, 13:15-16 PIL4GOCYTOSIs (See also MACROPBAGBS, AL VEoLAN effect of tobacco smoke, 639-31 role in lung neoplasm etiology, 5:31 PHARMACISTS antismoking advice to customers, 22:17 as role models, 22:3-Q smoking habits, 22% PRARMACODYNAMICS (See aleo DRUG METABOLISM; PBARMAcoLOGY) absence of smoking effect, D&37-39 clinical importance of smoking hi&c+ ry in drug monitoring, l2:4142 dexamethasone, effect of smoking, 12:37 diazepam, effect of smoking, 12:33 effect of smoking, l2:2744 effect of smoking, summary of find- ings, 1325-26 furosemide, effect of smoking, 1237 propranolol, effect of smoking, 1237 research needs, 1244 smokers vs. nonsmokers, l236-37 PIL4RMAcoRINErw3 (SW ako DRUG MEXARGLISM; PRARMAcoL4xY) absence of smoking effect, 12:37-39 antipyrine, in smokers vs. nonsmok- ers, 1229-31 caffeine, effect of aromatic hydrocar- bons in rats, 12:32-33 clinical importance of smoking his& ry in drug monitoring, 12:41-42 effect of behavior and personality, 1246-41 effect of marijuana, 1242-43 effect of smoking, 1227-44 effect of smoking, summary of find- ings, 125-26 ethanol, in smokers vs. nonsmokers, 1239 glutethimide, in smokers vs. non- smokers, 1233 imipramine, effect of smoking, 1233 meperidine, in smokers vs. nonsmok- ers, 1239 nortriptyline, in smokers vs. non- smokers, 1239 pentazocine, in smokers vs. nonsmok- ers, 1236 phenacetin, effect of cigarette smoke in rats, l2:29-29 phenacetin, in smokers vs. nonsmok- ers, 1228-29 phenytoin, in smokers vs. nonsmok- ers, 1238 research needs, 1244 theophylline, effect of methylcholan- threne in rats, 12:32 theophylline, in smokers vs. nonsmok- ers, l2:3132 warfarin, effect of benzo(a)pyrene in rata, 1239 warfarin, in smokers vs. nonsmokers, 12% PIIARMACOLOGY (See aleo PHARMACODYNAMICS; PHARMAcoKINEmcs) carbon monoxide in establishing smoking habit, 15:7 cigarette smoke, 14385, 1494, 14:97- 99 dependence and tolerance in mainte- nance of smoking habit, 15:14 nicotine in establishing smoking hab it, 15:5, 15:7-9 tar in establishing smoking habit, 16:7 PIIARYNGEAL NEOPLASMS (See also RESPIRATORY TRACT NEOPLASMS) alcohol consumption and smoking and, 5:4&H mortality in cigar vs. cigarette vs. pipe smokers, 1322-23 PIIENACRTIN effect of cigarette smoke on pharma- cokinetica in rats, 12:~29 effect of methylcholanthrene on pharmacokinetics in rats, 12:28- 29 pharmacokinetics in smokers vs. non- smokers, 1223-29 PHENOLS in cigarette smoke condensate, 14:52 effect of filters, 1454 effect on ciliary activity, 14:Bl levels in cigar vs. cigarette smoke, 13:11-12 levels in smoke of filtered vs. nonfil- tered cigarettes, 14:57 reduction of levels in gas phase ciga- rette smoke, 14:166 structural formulae, 14% PIIRNYLRuTAz0NR effect of smoking on pharmacokinetr its, 1233 PIIRNYTQIN pharmacokinetics in smokers vs. non- smokers, 1238 PHYSICAL ACTIVITY (See also EXERCISE) effect on coronary heart disease inci- dence in smokers, 438 PHYSICALDEVELOPMENT effect of maternal smoking on chil- dren, 1:21 PIIYsMAN VISITS smokers vs. nonsmokers vs. ex-smok- era, 3:15, 3:17 PHYSICIANS as health educators, 22:X-16 role in cessation decision, 19:l2-14, 21:11-12, 21:14, 22:19, 22-22 as role models, 226-8 in school antismoking programs, 299-10 tobacco alkaloids, 1494 smoking habits, 21:12, 229-14 See SMOKE, PIPE; SMOKERS, PIPE; SMOKING, PIPE; TOBAC- CO, PIPE PLACENTA aryl hydrocarbon hydroxylase activity after maternal exposure to ben- zo(a)pyrene in rats, 8-66 effect of maternal smoking, 8:69 effect of maternal smoking, research needs, 8:78 PLACENTA PREVIA gestational age and risk in smoking vs. nonsmoking mothers, 8:44, 8:46 maternal smoking levels and, 839 maternal smoking levels and perina- tal mortality, 8:40 PLACENTAL RATIO effect of maternal smoking, 8:1&18 effect of oxygen availability, 8:17 in smokers vs. nonsmokers, 8:15-16, 8:lB POLONIUM-210 cardiovascular diseases and, 4:62 levels in cigarette smoke, 14:60 levels in smokers vs. nonsmokers, 12374-75 neoplasm induction in Syrian ham- sters, 14:61 reduction in particulate phase ciga- rette smoke, 14:113 in tissues of smokers vs. nonsmokers, 14:6@-61 as tobacco contaminant, 14:2&21 POLYCYTBEMIA smoking in etiology of, 12:83 POLYMER FUME FEVER (See also OCCUPATIONAL DIS- EASES) smoking and, 7:s PREECLAMPSLA maternal smoking and, research needs, 8~77 maternal smoking levels and, 8:42 PREGNANCY (See also PRETERM DELIVERY) accidental hemorrhage in smokers vs. nonsmokers, 8% cessation of smoking during, 22:16, 22:18, 2223 complications, research needs, 8:76-77 smoking and abruptio placentae and placenta previa, 8:39 smoking and bleeding, 8% smoking and premature membrane rupture, 8:39 gestational age and premature mem- brane rupture in smokers vs. nonsmokers, 8:44, 846 smoking levels and abruptio placen- tae, bleeding, placenta previa and premature membrane rupture, 3- 39-41 smoking levels and perinatal mortali- ty, 8:40 PRETERM DELIVERY effect of maternal smoking levels, 8:43 and infant mortality risk in smoking vs. nonsmoking mothers, 8:42 maternal smoking and, 192 in smoking vs. nonsmoking mothers, 8:42 PREVENTION OF SMOKING (See also ANTISMOKING CAM- PAIGNS; CESSATION OF SMOK- IN'3 communication models, 17:11-E? recommendations for the future, 17:2225 summary of methodologies and pro- g-rams, 133-34 Swedish Wyear program, 17:21-22 youth programs, 17:6, 17:17-Z PROI'OXYPBRNR clinical effect in smokers vs. non- smokers, l2:3f%37 PROPRANOML interactive effect with cigarette smoke on airways, 1254 interactive effect with nicotine on cardiovascular system, 1253 interactive effect with smoking on cardiovascular system, l2:37 PROSTAGLANDINS effect of cigarette smoke on met&c+ lism in lungs in rabbits, 1239 PROTEINS effect of smoking on metabolism, 12s-66 synthesis, role in enzyme induction, 12:21-22 PROTONATION nicotine in relation to pH, 14:86 nicotine reduction and, 14:198 PSYCIIOMoToR PERFORMANCE effect of carbon monoxide, 11:2X$ 11:34 nicotine deficit and, 16:8 PUBLIC HEALTH CIGARETITE SMOKING ACT, A:7 pulmonuy isholu --P&r- See MACROPHAGES, ALVEOLAR Pulmonary ckucm& See CILIARY ACTIVITY; LUNG FUNCTION Pulmonary fun&on See LUNG PUNCTION PYLORIC PRESSURE effect of smoking, 9:16 RADIATION alpha exposure from radon as occu- pational hazard, 7:14 beta exposure as occupational hazard, 7:lO bladder neoplasms and smoking and, 12% and cigarette tars in neoplasm induc- tion in mice, 7:lO laryngeal neoplasms and smoking and, l2:99 and smoking in lung neoplasm etiolo- gy, 5:23 synergistic effect with smoking on respiratory tract, 1299 RADIOELEMENTS levels in tobacco and tobacco smoke, 14:60 reduction in particulate phase ciga- rette smoke, 14:113 as tobacco contaminants, 14:20-21 RADIUM-226 levels in cigarette smoke, 1469 as tobacco contaminant, 14:2&21 Rapid t?moking see AVERSIVE THERAPY RECIDIVISM carboxyhemoglobin levels as measure of, 15:29-30 cognitive and physiological factors, 16:lB post-treatment followup, 193 prevention, 1939-31, 19:35 ratee in cessation programs, 21:15-17 withdrawal state and, 16:18 Remnetituted tthum sheet see TOBACCO SHEET REFLEXES effect of nicotine, 14:92 Relative molar potency See MOLAR POTENCY RELIGION church attendance and motivation for smoking, 18:ll effects of beliefs on tobacco con- sumption, 1824 RESPIRATORY FUNCTION TESTS (See aLso LUNG FUNCTION) in smokers vs. nonsmokers vs. ex- smokers, 6:14-16 RESPIRATORY SYMF'TOMS in cigar and pipe smokers vs. non- smokers, 1334 in childhood and adult respiratory tract disease, 638-39 in cigar vs. cigarette vs. pipe smok- ers, 13:3C37 effect of air pollution in smokers vs. nonsmokers, 6:37 effect of smoking, 6:7 effect of smoking in children, 6:11- 12 rate of decline of FEV in smokers vs. nonsmokers and, 622 in smokers vs. nonsmokers, 6% smoking and, summary of findings, 1:13-19 smoking and sex ratio, 6% smoking levels and, 620 in smoking vs. nonsmoking twins, 6% RESPIRATORY SYSTEM (See also LUNGS; TRACHEA) effect of cessation of smoking, 1521 effect of inhalation in cigar and pipe smokers, 13:15-16 effect of nitrogen dioxide in rats, 14:Bl effect of rapid smoking, 19:26 synergistic effect of uranium and smoking, 12% RESPIRATORY TRACT DISEASES (See also LUNG DISEASES) cessation of smoking in patients, 12:18-19 effect of involuntary smoking in children, 11:32 effect of parental smoking on inci- dence in children, 11:3%34 effect of smoking and history of childhood respiratory symptoms, 638-39 mass media preventive campaign, 21:lO smoking and, 6:7 smoking history of young adults and, 6:12 smoking in children and, 6:11-12 RESPIRATORY TRACT INFECTIONS allergic predisposition and smoking, 1022 effect of parental smoking on inci- dence in children, lO:lZ, 11:32 effect of passive smoking in infants, 845 effect of smoking on mortality, 2:41 in smokers vs. nonsmokers, 629 smoking levels and, 630 RESPIRATORY TRACT MUCOSA effect of smoking, lo:14 RESPIRATORY TRACT NEOPLASMS (See duo LARYNGEAL NEO- PLASM& LUNG NEOPLASM& PHARYNGEU NEOPIhSMS; TRACHEAL NEOPLASMS) smoking in uranium miners and, 7:14 RNA effect of methylcholanthrene on me- tabolism, 12:21-Z role in enzyme induction, 12:21-22 ROBERT WOOD JOHNSON FOUN- DATION Health Activities Project, 21% ROLE MODEIS (See also PARENTAL SMOKING; PEER GROUPS; SIBLING SMOK- ING; TEACHERS; HEALTH PRO- FESSIONALS) in cessation of smoking, 18:21, 226-9 influence on smoking in adolescents, 17:11, 20:6, 21:11-14, 2335 RUBBER occupational hazards, 7:13 SALIVA nicotine and thiocyanates in smokers vs. nonsmokers, 1539 SAN DIEGO COMMUNITY LABORA- TORY program description, 2O:lP15, 212.5 SASKATOON SMOKING STUDY description 29-11-12, 2325 SATURATED FATS in atherosclerosis induction in ani- mals, 4:9 SCHICK SMOKING CONTROL CEN- TERS cessation program, 21:16 SCHOOL HEALTH CURRICULUM PROJECT community agency involvement, 23:15 curriculum development approach, 23:19 description, 20:X4-22 evaluation, 17:1W20, 20% parental involvement, 21:19 teacher training, 2321-23, 23:32 SCHOOL HEALTH EDUCATION STUDY antismoking education component, 23:18 SCHOOL PROGR.AMS (See aLso names of individual pro- grams) antismoking education, 205-22 colleges, 21:!&11 curriculum theory, 23:X-22 effect on students' smoking habits, 17:15 evaluation, 17:18-21, 2024-25, 23:23- 25 influence on parents, 21:19-21 recommendations for the future, 2326-39 smoking policies, 23%15 state health education laws, 23:5-7 teaching methods, 23:2.%?7 SECREl'IN RELEASE effect of nicotine, 9:lP15 effect of smoking, 9:15-16 SELF-REPORTS (See also VERBAL REPORT ) carboxyhemoglobin levels as indicator of accuracy, 3:l2 validity, 1724, 19:C7, 19:33, 21:~~ SENSORY DEPRIVATION cessation of smoking and, 19:13-19 SERUM IMMUNOGLOBULIN LEV- EIS effect of smoking, lo:18 SERUM PRECIPITINS in smokers vs. nonsmokers, 1O:ll SEVENTH DAY ADVENTISTS 5Day Plan (cessation program), 19:10, 21:X-16 SEX RATIO absenteeism and, 3:8, 3:13 adolescent smoking, 177, 17:13, 18:16, 21% bed disability in smokers vs. non- smokers, 3:12 bladder neoplasms in smokers, 5:45 47 cessation of smoking and, 3:18, 18:21 cessation of smoking and alcohol con- sumption, 1820 cessation of smoking and personality, 18:17-18 chronic obstructive lung disease and, 6~7 consumption of cigarettes, cigars, snuff, pipe and chewing tobacco in the United States, 14-13 coronary heart disease morbidity ra- tios in smokers vs. nonsmokers vs. ex-smokers, 429-30 coronary heart disease mortality ra- tios in smokers vs. nonsmokers, 424 effect of less hazardous cigarettes on mortality, 224-25 heart conditions and, 3:19 high density lipoprotein levels in smokers vs. nonsmokers, 4:61X2 laryngeal neoplasm risk in smokers and ex-smokers, 533, 535.38 lung function, 6:21-22 lung function in ex-smokers, 623 lung neoplasm mortality ratio in low tar and nicotine cigarette smok- ers, 5:16-17 lung neoplasm mortality ratio in smokers, 5:11-l.2 lung neoplasm risk in filtered vs. un- filtered cigarette smokers, 5:16, 5:X-19 pancreatic neoplasm mortality and risk ratios in smokers, 550-52 prevalence of acute conditions in smokers vs. nonsmokers, 3:9 prevalence of chronic conditions in smokers vs. nonsmokers, 37 prevalence of chronic obstructive pul- monary disease, 620 recidivism and, 19:31 smoking and respiratory symptoms, 620 smoking and respiratory symptoms in children, 6:11-12 smoking characteristics, 5:21, 523 smoking habit and neuroticism, 18:B smoking habit and socioeconomic sta- tus, 18:16 smoking habit in the United States, 5:19-21 smoking in blue- and white-collar workers, 7:17 smoking levels and lung pathology, 627 snuff users in the United States, 13:lO Teenage Self Test scores, 20% tobacco chewers in the United states, 13:lO SIBLING SMOKING adolescents, 17:14 maintenance of smoking and, 18:15 Side&ream smoke See SMOKE, CIGARJTITE SIDE- STREAM; SMOKE STREAMS SLEEP deprived vs. nondeprived smokers, 15:ll SMALL AIRWAYS FUNCTION (See also RESPIRATORY FUNC- TION TESTS) chronic obstructrve lung disease and, 6:ll effect of smoking levels, 6:1%19 pathological lesions of small airways and, 6:X+-19 screening methods for individuals at high risk for chronic obstructive lung disease, 6:l2 in smokers vs. nonsmokers, 6:13 in smokers vs. nonsmokers vs. ex- smokers, 6:lP16 SMOKE, CIGAR (See also SMOKERS, CIGAR; SMOKING, CIGAR; TOBACCO, CI- G-W ammonia content, 1439 aromatic hydrocarbon content, 13:11- 12 carbon monoxide content, 13:l2, 1438, 14:104 chemical analysis, 13:11-13 ciliatoxicity, 13:36-37 effect of inhalation on respiratory tract, 13:15-16 pH, 13:15-16 phenol content, 13:E! SMOKE, CIGARETl'E (See also SMOKERS; SMOKING; TOBACCO, CIGAIWITE) alcohol content, 1442 alkene content, 1443 aldehyde content, 1442 amine content, 14:41 aromatic hydrocarbon content, 14:41- 42 benzene compound content, 14:49 carcinogenic PAH activity, 1454 chemical composition percent distri- bution, 14% constituents, and biological response, 14% constituents, research recommenda- tions, 14:l29 effect of cigarette manufacturing on constituents, 1423-30 effect of constituents on enzyme ac- tivity, 12:7 effect of static burning temperature, 14336 effect on antibody response in mice, 12:59 effect on central nervous system, 15:ll effect on immunoglobulins, 6:31-32 effect on lung function, 1499 effect on macrophages, 629-39 effect on mucociliary system, 6:3233 effect on phagocytic activity of al- veolar macrophages, lo:17 effect on phenacetin pharmacokinet- its in rats, 1228-29 effect on prostaglandin F-2a metabo- lism in lungs in rabbits, 1239 effect on systemic humoral immunity in mice, lo:18 free fatty acid levels, 1455 heterocyclic compounds, 14:52, 14,57 hydraaine levels, 14:41 ketone levels, 14~42 naphthalene levels, 14:51 nickel levels, 14:59 nicotine levels, effect on blood pres- sure, 14:87 nicotine metabolites, 14:93-M nitrile levels, 1449 nitrogen compound levels, 14:41 nitrosamine precursors, 14:41 nonvolatile nitrosamine levels, 14345 pharmacology, 14:85, 15:5 phenol levels, 14:57 physical and chemical nature, 14% polynuclear aromatic hydrocarbon in- dicators, 14:lll polynuclear aromatic hydrocarbons, 14:51 radioelements, 1469 reaction mechanisms, 14:9 reduction of toxicity, 14:194, 14:198 relative molar potency of alkaloids, 14% retention in buccal cavity and respi- w.ory tract, l2:7 standard smoking conditions for analysis, 14% structural formulae of pesticide resi- dues, 14:62 sulfur compounds levels, 14:49 summary of gas and particulate phase constitutents, 129-30 summary of toxic and carcinogenic constituents, 130 toxicity reduction methods, 14:114 weakly acidic heterocyclic compounds structural formulae, 14:56 SMOKE, GIG- MAINSTREAM (Se aleo SMOKE STREAMS) alkane content, 1443 amine content, 14347 ammonia content, 1439 arsenic content, 14:59 cadmium content, 1460 c&echo1 content, 1453 chemical composition, 1435 ciliatoxicity and, 14:195 cyanide content, 1439-49 humectant content, 1463 nicotine content, 144.5 nitrogen oxide content, 1439 phenol content, effect of filters, 14:106 tar content determination, 1443 temperature profile, 14% SMOKE, CIGARETTE SIDESTREAM (See ah SMOlLE STREAMS) alkane content, 1448 amine content, 1439, 14:41, 14:47 catechol content, 14~54 chemical composition, 1438 nicotine content, 1445 tar content, 14:44 temperature profile, 14:36 Smoke exposure See SMOKE INIIAIATION SMOKE CONBENSATBS (See also SMOKE, TOBACCO; TABS, TOBACCO) benzo(a)pyrene content, 14:1l2 carcinogenicity, 1330-32 carcinogenicity of experimental ciga- rettes in mice, 1436 cigar, alkaloid content, 13:ll cigar, aromatic hydrocarbon content, 13:11-I2 cigar, nicotine content, 13:l2 cigar, phenol content, 13:11-12 effect of cigarette manufacturing on composition, 1428-36 effect on antiprotease activity in vi- tro, 628 effect on elastase release from lungs in rats, 629 effect on enzyme release from poly- morphonuclear leukocytes, 628 phenol content, 14:52 role of cigarette manufacturers in control of constituents, 14:9 SMOKE INHALATION (See alao SMOKING) effect of cigar and pipe smoke pH, 13:15-16 effect of switching tobacco products on patterns, 13:1%19 effect on arterioles in dogs, 4:18 effect on blood pressure in cats, 14:77 effect on carboxyhemoglobin levels in cigar and pipe smokers, 13:18 effect on cigarette smoke retention in buccal cavity, 12:7 effect on coronary heart disease mortality ratios, 4:37 effect on enzymes in dogs, 14:78 effect on exercise tolerance in rats, 14:77 effect on hemodynamics in dogs, 14:76 effect on leukocyte count, 8:82 effect on lung neoplasm mortality ratio, 5:14-15 effect on lung neoplasm mortality ratio in women, 5:21-Z? effect on lungs in dogs, 14:76 effect on lungs in monkeys, 14:76 effect on mortality, 229-21 effect on mortality in cigar and pipe smokers, 13:18 effect on mortality ratio, 222-24 effect on mortality ratio in women, 226-27 effect on myocardial infarct morbidi- ty and mortality, 435 effect on nicotine absorption in cigar smokers, 13:X-17 effect on pregnant rats, 8:19-11 effect on respiratory system in cigar and pipe smokers, 13:X-16 effect on tolerance in dogs, 15:16 exercise in dogs and, 14:78 exposure methodology, 14:73-74 in laryngeal neoplasm induction in hamsters, 5% males vs. females, 5:21, 523 maternal, effect on mother and fetus in sheep, 853 maternal, effect on offspring in rats, 8:1911 in myocardial infarct induction in dogs, 14:77 patterns in cigar vs. cigarette vs. pipe smokers in Great Britain, 13:18-19 patterns in the United States, 233 SMOKE, PIPE (See aleo SMOKERS. PIPE; SMOKING, PIPE; TOBACCO, PIPE) aromatic hydrocarbon content, 13:11- 12 pH, 13:15-16 SMOKB STBEAMS (See also SMOKE, CIGARETTE MAINSTREAM; SMOKE, CIGA- RElTE SIDESTREAM) carbon monoxide content, 11:15 involuntary smoking and, 11:5 ratio of constituents in main- vs. sidestream smoke, 11:6 SMOKE WATCHERS cessation program, 21:16 SMOKBNBEBS cessation program, 21:16 followup evaluation, 19:ll SMOKE, TOBACCO ( See ala SMOKE, CIGAR; SMOKE, CIGARElTE; SMOKE, PIPE; SMOKING) absorption of constituents by non- smokers, 11:6, 11:15 in allergy etiology, 10:2%?4 amine and nitrosamine content, 12:74 amine content, 14:47 antigens, identification of, 1O:ll carcinogens, ciliatoxic agents and tu- mor promoters in gas phase, 554-55 carcinogens, cocarcinogens and tumor promoters in particulate phase, 5354-57 constituents, correlation with tobacco leaf characteristics, 1424 effect of exposure in allergic chil- dren and adults, 10:14, lo:21 effect of leaf components, 14:ll effect on alveolar macrophages, 6:36- 31, 10:X-16 effect on blood lipid levels in ani- mals, 4:61 effect on cardiovascular system in animals with myocardial infarct, 445 effect on cellular and humoral im- munity, 639-31 effect on ciliary function, 1O:lP15 effect on enzyme activity, 1227-28, 12:75-76 effect on enzyme systems, lo:16 effect on fetal weight and biih weight in animals, 8:52 effect on fetal weight and maternal food intake in rats, 8:5253 effect on fetus, research needs, 8:79 effect on immune system, 10:5, lo:17 effect on lymphocytes in mice, lo:19 effect on metabolism of food constit- uents and additives, 12:75-76 effect on nonsmokers, 11% effect on preexisting allergies, lo:13 effect on pregnant animals, 8:52 effect on rat fetus, 853 effect on tracheobronchial clearance in dogs, lo:15 eye irritation and, lo:21 heterocyclic compound carcinogens structural formulae, 14:55 measurement of constituents in enc- losed spaces, 11:7-14 measurement of constituents under natural conditions, 11:16-20 metal levels, 1458-59 in neoplasm induction in animals, 1:17 nickel levels, 14:59 pesticide residues, l2:75 radioelement levels, 14:69 skin test reactions, lo:13 SMOKERS (See also SMOKEBS, CIGAB; SMOKERS, PIPE) B and T cell count and ratio, lo:19 granular leukocyte levels, 1O:Xl SMOKERS, CIGAR (See aho SMOKE, CIGAR; SMOK- ING, CIGAR; TOBACCO. CIGAR) blood cholesterol levels, 4:61 bronchitis and emphysema mortality, 1324 cardiovascular disease mortality ratio, 1333 chronic obstructive pulmonary disease mortality ratio, 1335 coronary heart disease mortality ra- tio, 42223 effect of inhalation on mortality, 13:lB esophageal neoplasm mortality, 13:~25 esophageal neoplasm mortality ratio, 543 inhalation patterns in Great Britain, 13:lB leukocyte count, 12:Bl lung neoplasm mortality rates, 523 lung neoplasm mortality ratio, 13:26- 28 mortality, 13:13-14 myocardial infarct morbidity and mortality, 4% oral neoplasm mortality ratio, 13:21 relative risk ratio for lip neoplasms, 13% relative risk ratio for lung neo- plaslns, 1329-30 respiratory symptoms, 1334 thrombosis mortality rates, 4:59 in the United States, 13:9 SMOKERS, PIPE (See alm SMOKB, PIPE; SMOK- ING, PIPE; TOBACCO, PIPE) blood cholesterol levels, 4:61 bronchitis and emphysema mortality, 1334 cardiovascular disease mortality ratio, 13% chronic obstructive pulmonary disease mortality ratio, 1385 coronary heart disease mortality ra- tio, 422-23 effect of inhalation on mortality, 13:18 effect of inhalation on respiratory tract, 13:16-16 esophageal neoplasm mortality, 1324-25 esophageal neoplasm mortality ratio, 543 inhalation patterns in Great Britain, 13:18 leukocyte count, 12:81 lung neoplasm mortality rates, 523 lung neoplasm mortality ratio, 1326 28 mortality, 13:13-14 myocardial infarct morbidity and mortality, 435 oral neoplasm mortality ratio, 13:21 relative risk ratio for lip neoplasma, 1322 relative risk ratio for lung neo- phunns, 13Cz9-30 respiratory symptoms, 13% thrombosis mortality rates, 4:59 in the United States, 13:9 SMOKERS VS. NONSMOKERS (See a.h NONSMOKERS) abruptio placentae, placenta previa, and bleeding during pregnancy, 839 absenteeism, 3:8, 3:10, 3:13 accidental hemorrhage in pregnancy, 839 activity limitation, 3:13-14 acute conditions, 3~6 air pollution and chronic obstructive lung disease, 6:36 air pollution and lung pathology, 636 alcohol consumption and drug use, 12:41 alpha-l-antitrypsin deficiency and emphysema, 634 alveolar macrophage migration, 6:31 angina pectoris morbidity ratios, 448 annual probability of dying, 230-34 antibody response to viral vaccines, 12s3-59 antipyrine pharmacokinetics, 1229-31 anxiety levels, 16A-8 Arthus skin test characteristics, 1O:lO asphyxia in infants of, 869 atherosclerosis, 4:19-12, 4:lP16 B and T lymphocytes, 6:31 bed disability, 3:12 bicarbonate levels in infants of, 869 bilirubin levels, 1234 birth weight of infants of, 8:11, 8: 14-17, 820-21 bladder neoplasm mortality ratio, 5A5-46 blood calcium levels, 1284 blood cholesterol levels, 4:61-62 blood circulation, 15:l2-13 blood coagulation, 1284-85 blood glucose levels, 1284 blood lipid levels, 128884 blood pressure, 4:57 blood protein levels, 1284 breast feeding, 8:48 bronchitis in gold miners, 7:15 bronchitis prevalence by occupations, 639 c&oxyhemoglobin levels and carbon monoxide occupational exposure, `7~8 carboxyhemoglobin levels in infants of, 869 carcinoembryonic antigen levels, 12:6142, 12546 cardiovascular disease mortality ra- tios in Japan, 4:21, 434-35 cerebrovascular disease mortality rates and ratios in males vs. fe- males, 4:51 chronic obstructive lung disease and mortality, 69-10 ciliary function, lo:15 clinical effects of propoxyphene, 12:36-37 clinical effects of selected drugs, 12:3637 coronary heart disease morbidity ra- tios, 427-83, 436-37 coronary heart disease mortality ra- tios, 422-26, 4~3637 definition, 2324 drug use patterns, 18:1115 duration of gestation, 8:18 effect of behavior and personality on pharmacokinetics, 1240-41 elastase release from macrophages, 630 emphysema, 625-26 emphysema and lung pathology, 623-24 erythrocyte parameters, 12:8%33 esophageal neoplasm mortality ratio, 542-43 ethanol phannacokinetics, 12% etiology of fetal and neonatal death, 838 etiology of perinatal death, 8% etiology of stillbiih, 8:3'7 fibrosis in asbestos workers, 7:12 gastric secretion in, 9:13 gestational age and infant mortality, 843, 845 gestational age and risk for abruptio placentae, placenta previa and premature membrane rupture, 3 44, 846 gestational age and risk for preterm delivery, 844 gestations1 age at birth of infants of, 8~43 glutethimide pharmacokinetiq 1233 growth and development of children of, 8:21-23 heart conditions, 3:1&l?, 3:19 head circumference in infants of, 8:2%21 hematocrit in infants of, 8:69 high density lipoprotein levels in males vs. females, 4:61-62 histologic changes in esophagus, 5:44 hospitalization, 3:14-16 hyaline thickening in small arteries and arterioles in myocardium, 4:16 hypertension, 457 immunoglobulin containing cell counts in lobar bronchi, lo:17 immunoglobulin levels, 6:31-32 infant mortality, 827, 834 infant mortality risk, 8:31 infarct mortality risk in black vs. white mothers, 830 job accident rates, 7:15 kidney, liver, and lung weights, 129 , kidney neoplasm mortality and risk ratios, 543-49 lactation, 8:48 laryngeal neoplasm mortality ratio, 5:32--B learning, 15:19 leukocyte count, 259-82 level of well-being, 3:18 long-term study of children of, 8:22 23 lung diseases in rubber workers, 7:13 lung function, 6:21 lung function after cadmium expo sure, 7:15 lung function in black vs. white vs. oriental men and women, 6:21 lung function in chlorine workers, 7:lO lung function in cotton workers, 7:9 lung function in miners, 7:9 lung neoplasm mortality and asbestoe exposure, 7:ll lung neoplasm mortality in twins, 523 lung neoplasm mortality ratio in males vs. females, 5:11-12 lung neoplasm mortality ratio in women, 520-22 lung neoplasm risk in asbestos facto- ry workers, 7:11-12 lung neoplasm risk in insulation workers, 7:ll lung neoplasms in chloromethyl ether workers, 7:16 lung neoplasms in uranium miners, 7:14 lung pathology, 624-2'7 lung pathology in sudden death vic- tims, 6:18 macrophage count and ultrastructure, lo:16 macrophages in bronchopulmonary la- vage fluid, 629 maternal weight gain and fetal growth, 824-25 meperidine clearance, 1239 mortality in twins, 2:42 mortality rates, 2:15 myocardial infarct in women, 12:52 myocardial infarct morbidity and mortality, 435-36 neonatal mortality, 849 nicotine and cotinine content in urine, 1124 nicotine content in plasma, 1124 nicotine content of breast milk in lactating mothers, 8:51 nicotine content of saliva, 1530 nicotine levels in urine, 1529 nicotine metabolism, 15:16, 15:9 nitric oxide levels, 1480 nortriptyline pharmacokinetics, 1239 obstructive airway dii in miners, 7:9 oral neoplasm mortality ratio, 5:39- 40 osteoporosis, l2:67 pancreatic neoplasm mortality and risk ratios, 550-52 pentaxocine dosage requirements, 12% peptic ulcer healing, 99-10 peptic ulcer indicence, 95-6 peptic ulcer mortality rates, 9:ll peptic ulcer prevalence, 6:7-8 peptic ulcer prevalence ratios in six countries, 9:8 peptic ulcer size and recurrence, 9:9 perception of health status, 814-15 perinatal mortality, 835, 840 perinatal mortality and maternal age, parity, and education, 833 perinatal mortality risk for infants of, 8~32 peripheral vascular disease in diabet ica, 453 pemonality, 185-10 phagocytic activity of alveolar mac- rophages, lo:17 phenacetin pharmacokinetice, 122829 phenytoin pharmacokinetica, 12% physician visits, 3:14, 3:17 placental changes, 869 placental ratioa, 8:18 polonium-210 levels in tissues, 10:60- 61 preeclampsia and toxemia in preg- nancy, 842 pregnancy weight gain and fetal growth, 824 premature membrane rupture during pregnancy, 889 preterm delivery and infant mortali- ty risk, 8:42 prevalence of acute conditions, 3:9 prevalence of chronic conditions, 3:7 prognosis following vascular grafting, 453 protease activity of macrophages, 6% proteinuria after cadmium exposure, 7:15 rate of decline of FEV and respira- tory symptoms, 622 respiratory symptoms in twins, 635 respiratory tract diseases in young adults, 6:l2 respiratory tract infections, 6% respiratory tract neoplasms in urani- um miners, 7:14 respiratory tract symptoms, 620 response to diagnostic tests, l2:79 risk of low birth weight in infants of, 8:13 serum albumin, uric acid, and creati- nine concentration, l2:49, 12% serum precipitins in, 10~11 skin test reactions to tobacco leaf extracts, lo:13 small airways function, 6:13-16 socioeconomic status and chronic ob stmctive lung diseases, 638 spontaneous abortion, 830-32 stillbirth incidence, 8:36 sudden cardiac death, 44344 sudden infant death syndrome in in- fants, 8:45 T cell counts, lo:19 theophylline pharmacokinetics, 12:31- 32 thiocyanate levels in saliva, 15:30 thiocyanates in plasma, 7:7 thiocyanates in urine, 7~7 thrombosis mortality rates, 4:59 tolerance to cigarette smoke, 15:16- 17 trace metal levels, 12:73-74 tryptophan metabolism, 12:67 umbilical artery changes, 869 vitamin BIZ levels in pregnancy, 8:73 vitamin C levels in breast milk of lactating mothers, 852 vitamin C levels in pregnancy, 8:74 vitamin C levels in serum, 1234 warfarin metabolism, 1255