NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 FINAL#2, 2 YEAR CHRONIC Facility: Battelle Northwest Chemical CAS #: 22398-80-7 Lock Date: 10/02/98 Cage Range: All Reasons For Removal: 25022 Accidently Killed 25019 Moribund Sacrifice 25020 Natural Death 25021 Terminal Sacrifice Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9| | 7| 7| 6| 7| 6| 7| 7| 4| 6| 7| 6| 6| 6| 5| 4| 5| 6| 5| 7| 7| 6| 5| 7| 6| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | M + + + + + + + + + + + + + + A + + + + + + + + A| Inflammation, Suppurative | 1 1 | __________________________________________________________________________| Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | A + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Small, Jejunum | A + + + + + + + + + + + + + + A + + + + + + + + A| Peyer's Patch, Hyperplasia | 2 | __________________________________________________________________________| Intestine Small, Ileum | A + + + + + + + + + + + + + + A + + + + + + + + A| Epithelium, Hyperplasia | | Peyer's Patch, Hyperplasia | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X | Clear Cell Focus | X X | Eosinophilic Focus | | Hematopoietic Cell Proliferation | 1 | Hyperplasia, Lymphoid | | Karyomegaly | | Necrosis | 1 1 | Tension Lipidosis | X | Vacuolization Cytoplasmic | 1 | Bile Duct, Cyst | 2 | __________________________________________________________________________| Mesentery | + + + + + + + +| Angiectasis | 3| Fat, Necrosis | 2 2 2 4 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + M + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Hyperplasia | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 | __________________________________________________________________________| Tooth | + | Malformation | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 | Artery, Inflammation | 1| Atrium, Thrombosis | 2| Epicardium, Inflammation | | Valve, Thrombosis | 4| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9| | 7| 7| 6| 7| 6| 7| 7| 4| 6| 7| 6| 6| 6| 5| 4| 5| 6| 5| 7| 7| 6| 5| 7| 6| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | | Degeneration, Cystic | 2 | Hematopoietic Cell Proliferation | | Hypertrophy | 1 1 1 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + M + + + + + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Parathyroid Gland | + M + + + + + + + + M + M + + + M + + + + + + M +| Hyperplasia | 2 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 4 1 1 1 1 2 | Pars Intermedia, Hyperplasia | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicle, Cyst | 3 | Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + M + + + + + + + + + + + M M + + + + + + + M + +| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 4 | Cyst | 1 3 2 3 2 1 | Interstitial Cell, Hyperplasia | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Hydrometra | 2 2 4 2 3 2 | Hyperplasia, Cystic | 2 2 2 2 4 1 2 3 1 4 3 2 2 2 2 2 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | | Hyperplasia | 2 | __________________________________________________________________________| Lymph Node | | __________________________________________________________________________| Lymph Node, Bronchial | + + M M + + M M M + + + M + + + M + + + + M + + +| Hyperplasia | 1 1 | __________________________________________________________________________| Lymph Node, Mandibular | + M + M + + + + + + + M M + + + M + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | | Hyperplasia | 2 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9| | 7| 7| 6| 7| 6| 7| 7| 4| 6| 7| 6| 6| 6| 5| 4| 5| 6| 5| 7| 7| 6| 5| 7| 6| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Inflammation, Chronic Active | | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + M M M + M + + M + + + + + + + + + + + +| Hyperplasia | 2 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 1 1 2 1 1 2| Hyperplasia, Lymphoid | 2 2 2 2 3 2 2 | __________________________________________________________________________| Thymus | + + + + + + + I + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Inflammation, | | Chronic Active | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 2 1 1 3 2 1 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Meninges, Infiltration Cellular, | | Mononuclear Cell | | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Epithelium, Hyperplasia | 1 1 1 1 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 1 1 1 1 | Inflammation, Chronic Active | 2 | Mediastinum, Inflammation, Chronic | | Active | | Perivascular, Infiltration Cellular, | | Mononuclear Cell | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Inflammation, Suppurative | 1 1 1| Olfactory Epithelium, Atrophy | 1 1 2 | Olfactory Epithelium, Degeneration, | | Hyaline | 1 | Respiratory Epithelium, Degeneration,| | Hyaline | 1 1 1 1 1 2 1 1 2 1 2 2| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9| | 7| 7| 6| 7| 6| 7| 7| 4| 6| 7| 6| 6| 6| 5| 4| 5| 6| 5| 7| 7| 6| 5| 7| 6| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Inflammation, Suppurative | 1 | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1| Metaplasia, Osseous | 1 1 | Nephropathy | 1 2 1 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | __________________________________________________________________________| Urinary Bladder | A + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| | | 7| 7| 6| 6| 5| 6| 7| 6| 6| 6| 5| 9| 6| 6| 6| 7| 5| 5| 6| 7| 8| 6| 5| 7| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + M + + + + + + + + + + + + + + + + + + + + + +| 46 | Inflammation, Suppurative | | 2 1.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +| 46 | Peyer's Patch, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + + + + +| 46 | Epithelium, Hyperplasia | 2 | 1 2.0| Peyer's Patch, Hyperplasia | 2 2 | 2 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X | 2 | Clear Cell Focus | | 2 | Eosinophilic Focus | X X X X X X | 6 | Hematopoietic Cell Proliferation | 3 1 | 3 1.7| Hyperplasia, Lymphoid | 2 | 1 2.0| Karyomegaly | 1 | 1 1.0| Necrosis | 1 1 | 4 1.0| Tension Lipidosis | X | 2 | Vacuolization Cytoplasmic | | 1 1.0| Bile Duct, Cyst | | 1 2.0| __________________________________________________________________________|____________| Mesentery | + + + + + | 13 | Angiectasis | | 1 3.0| Fat, Necrosis | 2 3 3 2 2 | 10 2.6| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2 | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epithelium, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Suppurative | 2 | 2 1.5| __________________________________________________________________________|____________| Tooth | | 1 | Malformation | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 45 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| | | 7| 7| 6| 6| 5| 6| 7| 6| 6| 6| 5| 9| 6| 6| 6| 7| 5| 5| 6| 7| 8| 6| 5| 7| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Artery, Inflammation | | 1 1.0| Atrium, Thrombosis | | 1 2.0| Epicardium, Inflammation | 2 | 1 2.0| Valve, Thrombosis | | 1 4.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Amyloid Deposition | 2 2 | 2 2.0| Degeneration, Cystic | | 1 2.0| Hematopoietic Cell Proliferation | 1 | 1 1.0| Hypertrophy | 1 1 1 1 1 | 9 1.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 1 1 | 4 1.3| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 | 2 2.5| __________________________________________________________________________|____________| Parathyroid Gland | M M + M + + + + M + + M M + M M M + + + M + + + M| 34 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Hyperplasia | 2 2 3 2 3 4 1 2 1 2 | 16 2.0| Pars Intermedia, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicle, Cyst | | 1 3.0| Follicular Cell, Hyperplasia | 2| 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Ovary | + + + + + + + + M + + + + + + + + + M + + + M + +| 47 | Angiectasis | 2 | 2 3.0| Cyst | 2 1 2 2 4 2| 12 2.1| Interstitial Cell, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 | 1 1.0| Hydrometra | 2 3 | 8 2.5| Hyperplasia, Cystic | 4 3 2 3 2 1 2 2 2 2 2 2 2 2 2 2 3 3 4 1 3| 38 2.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| | | 7| 7| 6| 6| 5| 6| 7| 6| 6| 6| 5| 9| 6| 6| 6| 7| 5| 5| 6| 7| 8| 6| 5| 7| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 1 1 | 2 1.0| Hyperplasia | 2 2 3 2 3 | 6 2.3| __________________________________________________________________________|____________| Lymph Node | + | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + M + + + M + + + M + + + M M + + + + + + M + + +| 36 | Hyperplasia | 2 2 3| 5 1.8| __________________________________________________________________________|____________| Lymph Node, Mandibular | M + + + + + + + M + M M + + M M M + + + M M + + +| 36 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + M + + + + + + + M + + + + + + + + + + + + + +| 48 | Hematopoietic Cell Proliferation | 2 | 1 2.0| Hyperplasia | 2 2 2 2 2 1 2 | 8 1.9| Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + M + + + + + + + + + + + + M + + + + M + + + +| 42 | Hyperplasia | | 2 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 1 1 1 3 1 1 2 3 3 | 16 1.6| Hyperplasia, Lymphoid | 2 2 4 2 2 2 2 2| 15 2.2| __________________________________________________________________________|____________| Thymus | + + + + + + + + M + + + + + + + + + + + + M + + +| 47 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 | 2 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Inflammation, | | | Chronic Active | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 2 1 1 1 1 | 11 1.5| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Meninges, Infiltration Cellular, | | | Mononuclear Cell | 1 2 | 2 1.5| __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Epithelium, Hyperplasia | 2 1 1 1 1| 9 1.1| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| | | 7| 7| 6| 6| 5| 6| 7| 6| 6| 6| 5| 9| 6| 6| 6| 7| 5| 5| 6| 7| 8| 6| 5| 7| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Hemorrhage | | 4 1.0| Inflammation, Chronic Active | 3 | 2 2.5| Mediastinum, Inflammation, Chronic | | | Active | 3 | 1 3.0| Perivascular, Infiltration Cellular, | | | Mononuclear Cell | 2 | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 | 1 1.0| Inflammation, Suppurative | 1 2 1 1 | 7 1.1| Olfactory Epithelium, Atrophy | 1 1 1 | 6 1.2| Olfactory Epithelium, Degeneration, | | | Hyaline | 2 1 | 3 1.3| Respiratory Epithelium, Degeneration,| | | Hyaline | 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 | 28 1.2| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | | 1 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 1.0| Metaplasia, Osseous | | 2 1.0| Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 37 1.1| __________________________________________________________________________|____________| Urinary Bladder | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 | Angiectasis | 1 | 2 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4| 6| 6| 6| 6| 7| 7| 7| 7| 6| 5| DAY ON TEST | 3| 2| 5| 3| 8| 1| 3| 1| 5| 8| 0| 3| 3| 8| 2| 8| 7| 4| 7| 3| 3| 3| 3| 8| 8| | 7| 7| 9| 7| 9| 5| 2| 7| 3| 9| 0| 5| 5| 7| 6| 8| 4| 5| 4| 7| 6| 6| 5| 8| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + A + + + A + + + + + + + + + + + + + + + +| Degeneration, Hyaline | 1 | Inflammation, Suppurative | | __________________________________________________________________________| Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + A + + + A + + + + + + + + + + M + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + A + + + A + + + + + + + + + + + + + + + +| Epithelium, Hyperplasia | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | | Eosinophilic Focus | X X X | Eosinophilic Focus, Multiple | X X X | Hematopoietic Cell Proliferation | 1 | Inflammation | | Necrosis | 1 | Tension Lipidosis | X| __________________________________________________________________________| Mesentery | + + + + | Artery, Inflammation | 3 | Fat, Necrosis | 2 2 | __________________________________________________________________________| Pancreas | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +| Ulcer | 2 2| Epithelium, Hyperplasia | 3 2| __________________________________________________________________________| Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 | Artery, Inflammation | 1 2 2 2 1 2 | Atrium, Thrombosis | | Epicardium, Inflammation | 3 | Pericardium, Inflammation | 1 2 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | 1 | Hypertrophy | 1 1 2 1 1 | Capsule, Hyperplasia | | __________________________________________________________________________| Adrenal Medulla | + + + + A + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4| 6| 6| 6| 6| 7| 7| 7| 7| 6| 5| DAY ON TEST | 3| 2| 5| 3| 8| 1| 3| 1| 5| 8| 0| 3| 3| 8| 2| 8| 7| 4| 7| 3| 3| 3| 3| 8| 8| | 7| 7| 9| 7| 9| 5| 2| 7| 3| 9| 0| 5| 5| 7| 6| 8| 4| 5| 4| 7| 6| 6| 5| 8| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + I + M + M + + M M + + + + + M + + M + M M + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 3 3 1 2 1 1 2 2 2 | __________________________________________________________________________| Thyroid Gland | + + + + A + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + M + + + + + + + + + + + M M + + + + + + + + +| __________________________________________________________________________| Ovary | + + + + A + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 1 | Cyst | 1 2 3 2 | Thrombosis | | Interstitial Cell, Hyperplasia | 2 | __________________________________________________________________________| Uterus | + + + + A + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 2 2 | Hydrometra | 3 3 4 4 4 | Hyperplasia, Cystic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| Inflammation, Suppurative | 2 | Mineralization | 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 1 1 1 2 3 2 | __________________________________________________________________________| Lymph Node | + + + + | Iliac, Angiectasis | 2 | Iliac, Hyperplasia | 2 | Lumbar, Hyperplasia | 2 | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Hyperplasia | 3 3 2 3 4 4 2 2 3 3 4 3 3 2 2 2 2 4 2 4 3 2| Artery, Inflammation | 2 | __________________________________________________________________________| Lymph Node, Mandibular | M M + M M + + + + + + + + + M + + M + + + M + M +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + A + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 | __________________________________________________________________________| Lymph Node, Mediastinal | M + + + + + + + + + + + + + + M + + + + + + + + +| Foreign Body | 1 1 1 1 1 1 1 1 1 | Hyperplasia | 4 2 3 4 4 2 2 3 2 4 3 4 3 2 2 2 2 4 3 3 2| __________________________________________________________________________| Spleen | + + + + A + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 2 2 2 3 1 3 3 2 2 2 2 2 2 2 3 2 2 1 3 | Hyperplasia, Lymphoid | 2 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4| 6| 6| 6| 6| 7| 7| 7| 7| 6| 5| DAY ON TEST | 3| 2| 5| 3| 8| 1| 3| 1| 5| 8| 0| 3| 3| 8| 2| 8| 7| 4| 7| 3| 3| 3| 3| 8| 8| | 7| 7| 9| 7| 9| 5| 2| 7| 3| 9| 0| 5| 5| 7| 6| 8| 4| 5| 4| 7| 6| 6| 5| 8| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Thymus | + M + + + + + + + + + + + + + + + + M + + + + + +| Hyperplasia, Lymphoid | 2 2 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | Metaplasia, Squamous | 1 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | Subcutaneous Tissue, Angiectasis | 2 | Subcutaneous Tissue, Inflammation, | | Chronic | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 | Fibrous Osteodystrophy | 1 1 1 2 1 2 1 1 3 | Inflammation, Chronic | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Meninges, Infiltration Cellular, | | Mononuclear Cell | 3 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 | Squamous Epithelium, Hyperplasia | 1 1 1 2 1 1 1 1 2| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | X X X X X X X X X X X X X X X X X X X X X X X X| Hemorrhage | 1 1 | Inflammation, Chronic Active | 3 4 3 3 2 3 2 3 3 3 3 3 3 2 4 3 3 3 3 2 2 3 3 3 2| Alveolar Epithelium, Hyperplasia | | Alveolus, Infiltration Cellular, | | Histiocyte | | Alveolus, Proteinosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Artery, Inflammation | | Interstitium, Fibrosis | 1 | Serosa, Fibrosis | 4 4 3 4 3 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 3 4 3 4 3| Serosa, Metaplasia, Osseous | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 1 2 1 | Olfactory Epithelium, Atrophy | | Olfactory Epithelium, Degeneration, | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4| 6| 6| 6| 6| 7| 7| 7| 7| 6| 5| DAY ON TEST | 3| 2| 5| 3| 8| 1| 3| 1| 5| 8| 0| 3| 3| 8| 2| 8| 7| 4| 7| 3| 3| 3| 3| 8| 8| | 7| 7| 9| 7| 9| 5| 2| 7| 3| 9| 0| 5| 5| 7| 6| 8| 4| 5| 4| 7| 6| 6| 5| 8| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Hyaline | 1 | Respiratory Epithelium, Degeneration,| | Hyaline | 1 1 1 2 1 1 1 1 1 | __________________________________________________________________________| Pleura | + + + + + + | Mesothelium, Hyperplasia | 1 2 1 1 4 1 | __________________________________________________________________________| Trachea | + + + + A + + + I + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + A + + + + + + + + + + + + + + + + + + + +| Metaplasia, Osseous | 2 | Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 | __________________________________________________________________________| Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 5| 7| 6| 5| 6| 7| 6| 6| 5| 5| 6| 6| 6| 6| 5| 5| 6| 7| 7| 7| 5| 7| 5| 6| 6| | DAY ON TEST | 1| 3| 8| 3| 5| 3| 8| 4| 8| 3| 1| 8| 8| 4| 3| 3| 7| 3| 3| 0| 1| 3| 4| 4| 3| | | 4| 7| 7| 3| 7| 5| 8| 5| 9| 3| 7| 6| 6| 5| 3| 3| 1| 6| 6| 6| 4| 7| 8| 5| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + M + M + + + + + + + + + + + + + + + + A| 45 | Degeneration, Hyaline | | 1 1.0| Inflammation, Suppurative | 1 1 | 2 1.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Epithelium, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X | 2 | Eosinophilic Focus | X X| 5 | Eosinophilic Focus, Multiple | X | 4 | Hematopoietic Cell Proliferation | 4 1 | 3 2.0| Inflammation | 2 | 1 2.0| Necrosis | 1 1 | 3 1.0| Tension Lipidosis | | 1 | __________________________________________________________________________|____________| Mesentery | + + + + | 8 | Artery, Inflammation | 4 3 1 | 4 2.8| Fat, Necrosis | 3 | 3 2.3| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Ulcer | | 2 2.0| Epithelium, Hyperplasia | 1 2 | 4 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1| 39 1.1| Artery, Inflammation | 2 1 2 4 1 3 1 2 1 2 | 16 1.8| Atrium, Thrombosis | 3 | 1 3.0| Epicardium, Inflammation | 1 2 2 2 | 5 2.0| Pericardium, Inflammation | 1 3 3 2 2 2 | 9 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 5| 7| 6| 5| 6| 7| 6| 6| 5| 5| 6| 6| 6| 6| 5| 5| 6| 7| 7| 7| 5| 7| 5| 6| 6| | DAY ON TEST | 1| 3| 8| 3| 5| 3| 8| 4| 8| 3| 1| 8| 8| 4| 3| 3| 7| 3| 3| 0| 1| 3| 4| 4| 3| | | 4| 7| 7| 3| 7| 5| 8| 5| 9| 3| 7| 6| 6| 5| 3| 3| 1| 6| 6| 6| 4| 7| 8| 5| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Amyloid Deposition | | 1 1.0| Hypertrophy | 2 1 | 7 1.3| Capsule, Hyperplasia | 4 | 1 4.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 2 2 | 5 1.6| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + M M + + + + M + M + M + M M M + + M + + +| 31 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Hyperplasia | 2 2 1 1 2 3 | 15 1.9| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Suppurative | 1 | 2 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + M + + + + M + M + + M M + + + + + + M M + + +| 40 | __________________________________________________________________________|____________| Ovary | M + M + I + + + + + + + + + + + + + + + + + + + +| 46 | Angiectasis | | 2 1.5| Cyst | 2 1 2 3 2| 9 2.0| Thrombosis | 3 | 1 3.0| Interstitial Cell, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | | 3 1.7| Hydrometra | 1 3 2 | 8 3.0| Hyperplasia, Cystic | 1 1 1 3 2 2 4 1 2 2 1 1 2 2 | 31 1.9| Inflammation, Suppurative | | 1 2.0| Mineralization | | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 3 | 13 1.9| __________________________________________________________________________|____________| Lymph Node | + | 5 | Iliac, Angiectasis | | 1 2.0| Iliac, Hyperplasia | | 1 2.0| Lumbar, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 44 1.0| Hyperplasia | 4 2 4 2 3 2 3 4 2 4 3 3 3 2 4 3 3 2 2 2| 42 2.8| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 5| 7| 6| 5| 6| 7| 6| 6| 5| 5| 6| 6| 6| 6| 5| 5| 6| 7| 7| 7| 5| 7| 5| 6| 6| | DAY ON TEST | 1| 3| 8| 3| 5| 3| 8| 4| 8| 3| 1| 8| 8| 4| 3| 3| 7| 3| 3| 0| 1| 3| 4| 4| 3| | | 4| 7| 7| 3| 7| 5| 8| 5| 9| 3| 7| 6| 6| 5| 3| 3| 1| 6| 6| 6| 4| 7| 8| 5| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Artery, Inflammation | 3 | 2 2.5| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + M M M + + + + + + M M M + + + + + + + + +| 36 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 4 4 | 6 2.7| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 | 20 1.0| Hyperplasia | 4 4 3 4 2 2 4 2 4 3 3 3 4 3 3 3 3 2 3| 40 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hematopoietic Cell Proliferation | 2 4 2 2 2 3 2 2 3 2 2 2 2 1 2 2 | 36 2.1| Hyperplasia, Lymphoid | 2 2 | 3 2.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + M + + + M + + + + + + + + +| 46 | Hyperplasia, Lymphoid | | 3 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 | 2 2.0| Metaplasia, Squamous | | 1 1.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 3 4 | 2 3.5| Subcutaneous Tissue, Angiectasis | | 1 2.0| Subcutaneous Tissue, Inflammation, | | | Chronic | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 3.0| Fibrous Osteodystrophy | 1 2 2 1 1 | 14 1.4| Inflammation, Chronic | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Meninges, Infiltration Cellular, | | | Mononuclear Cell | 1| 2 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | | 1 1.0| Squamous Epithelium, Hyperplasia | 1 1 1 1 1 1 1 2 | 17 1.2| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 5| 7| 6| 5| 6| 7| 6| 6| 5| 5| 6| 6| 6| 6| 5| 5| 6| 7| 7| 7| 5| 7| 5| 6| 6| | DAY ON TEST | 1| 3| 8| 3| 5| 3| 8| 4| 8| 3| 1| 8| 8| 4| 3| 3| 7| 3| 3| 0| 1| 3| 4| 4| 3| | | 4| 7| 7| 3| 7| 5| 8| 5| 9| 3| 7| 6| 6| 5| 3| 3| 1| 6| 6| 6| 4| 7| 8| 5| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Foreign Body | X X X X X X X X X X 1 X X X X X X X X X X X X X X| 49 1.0| Hemorrhage | 1 | 3 1.0| Inflammation, Chronic Active | 2 2 4 2 3 3 3 4 3 2 3 3 3 4 4 3 3 2 2 4 2 4 2 3| 49 2.9| Alveolar Epithelium, Hyperplasia | 2 | 1 2.0| Alveolus, Infiltration Cellular, | | | Histiocyte | 2 2 | 2 2.0| Alveolus, Proteinosis | 1 1 2 1 1 1 1 1 2 1 1 1 1 1 1 | 31 1.1| Artery, Inflammation | 4 | 1 4.0| Interstitium, Fibrosis | | 1 1.0| Serosa, Fibrosis | 4 3 3 3 4 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4 3 4 4 4| 50 3.8| Serosa, Metaplasia, Osseous | | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 1 1 1 | 7 1.1| Olfactory Epithelium, Atrophy | 1 | 1 1.0| Olfactory Epithelium, Degeneration, | | | Hyaline | 1 1 | 3 1.0| Respiratory Epithelium, Degeneration,| | | Hyaline | 1 1 1 1 1 1 1 1 | 17 1.1| __________________________________________________________________________|____________| Pleura | + + + + + + + + + +| 16 | Mesothelium, Hyperplasia | 4 1 1 1 1 3 1 2 2 2| 16 1.8| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Metaplasia, Osseous | 1 1 | 3 1.3| Nephropathy | 1 1 1 1 2 1 1 3 1 1 1 1 1 1 1 | 30 1.1| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 6| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| DAY ON TEST | 8| 2| 4| 6| 3| 3| 3| 3| 3| 8| 3| 9| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3| | 7| 9| 7| 4| 6| 6| 6| 7| 5| 1| 6| 1| 6| 7| 7| 7| 7| 7| 7| 6| 6| 5| 9| 6| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.1MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 1 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Hyperplasia | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Eosinophilic Focus | X X | Hematopoietic Cell Proliferation | 2 3 2 | Inflammation | 2 | Necrosis | 3 1 3 1 2 1 | Tension Lipidosis | X X | Vacuolization Cytoplasmic | | __________________________________________________________________________| Mesentery | + + + + + + | Artery, Inflammation | 2 | Fat, Necrosis | 2 2 3 4 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | | Epithelium, Hyperplasia | 2 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Tooth | + | Inflammation | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 2 3 1 1 1 1 1 1 1 2 2 1 1 2| Mineralization | 1 | Artery, Inflammation | 3 2 2 2 1 2| Atrium, Thrombosis | 2 | Valve, Inflammation | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 6| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| DAY ON TEST | 8| 2| 4| 6| 3| 3| 3| 3| 3| 8| 3| 9| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3| | 7| 9| 7| 4| 6| 6| 6| 7| 5| 1| 6| 1| 6| 7| 7| 7| 7| 7| 7| 6| 6| 5| 9| 6| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.1MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | 3 | Hematopoietic Cell Proliferation | 1 | Hypertrophy | 1| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Parathyroid Gland | M + + + + + + M M M + + + + + M M M M + + + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 2 2 2 2 1 1 2 2 1 2 1 1 1| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 2| Follicular Cell, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + M + M + + + + + + + M + + + + M + + + + + + + +| __________________________________________________________________________| Ovary | + + + + + + + + M + + + I + + + + + + + + + + + M| Cyst | 2 2 2 4 1 2 | Thrombosis | 4 | Interstitial Cell, Hyperplasia | | __________________________________________________________________________| Oviduct | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Hydrometra | 2 2 4 2 | Hyperplasia, Cystic | 2 2 1 2 2 2 3 1 2 2 3 3 2 1 1 1 1 1| Inflammation, Suppurative | 4 | Thrombosis | 4 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | | Hyperplasia | 3 3 2 2| __________________________________________________________________________| Lymph Node | + + + + | Lumbar, Angiectasis | | Lumbar, Hemorrhage | | Lumbar, Inflammation, Chronic | | Renal, Angiectasis | 3 | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + M +| Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Hyperplasia | 3 2 2 2 2 2 2 2 2 2 2 2 3 2 3 2| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 6| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| DAY ON TEST | 8| 2| 4| 6| 3| 3| 3| 3| 3| 8| 3| 9| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3| | 7| 9| 7| 4| 6| 6| 6| 7| 5| 1| 6| 1| 6| 7| 7| 7| 7| 7| 7| 6| 6| 5| 9| 6| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.1MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Artery, Inflammation | | __________________________________________________________________________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + M + + + M + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 2 2 | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | 1 1 1 | Hyperplasia | 2 1 2 2 2 2 2 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 1 2 3 2 2 1 3 2 2 1 2 2 | Hyperplasia, Lymphoid | 2 3| Metaplasia, Osseous | | __________________________________________________________________________| Thymus | + + + M + + + + + + + + + + + M M + + + + + + + +| Hyperplasia, Lymphoid | 2 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Inflammation, | | Chronic | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 1 1 2 3 2 1 1 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Meninges, Infiltration Cellular, | | Mononuclear Cell | 1 | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 | Squamous Epithelium, Hyperplasia | 1 1 1 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | X X X X X X X X X X X X X X X X X X X X| Hemorrhage | 1 1 | Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 1 2 2 2 3 1 2 2 3 1 1 2| Thrombosis | 1 | Alveolar Epithelium, Hyperplasia | | Alveolus, Infiltration Cellular, | | Histiocyte | 3 2 | Artery, Inflammation | 1 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 6| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| DAY ON TEST | 8| 2| 4| 6| 3| 3| 3| 3| 3| 8| 3| 9| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3| | 7| 9| 7| 4| 6| 6| 6| 7| 5| 1| 6| 1| 6| 7| 7| 7| 7| 7| 7| 6| 6| 5| 9| 6| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.1MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Artery, Mediastinum, Inflammation | 2 | Serosa, Fibrosis | 2 1 2 2 2 2 2 2 2 2 2 1 2 2 2 2 1 1 2 3 1 2 2| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 1 1 | Olfactory Epithelium, Atrophy | | Olfactory Epithelium, Degeneration, | | Hyaline | 1 1 1 | Respiratory Epithelium, Degeneration,| | Hyaline | 1 1 2 1 1 1 1 1 2 2 1 1 1 1| Respiratory Epithelium, Hyperplasia | | __________________________________________________________________________| Pleura | + + + | Mesothelium, Hyperplasia | 2 1 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Degeneration | 4 | __________________________________________________________________________| Harderian Gland | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 | Metaplasia, Osseous | 1 1 1 | Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 | Artery, Inflammation | 1 | Renal Tubule, Karyomegaly | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + + + + +| Angiectasis | 1 1 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| | DAY ON TEST | 3| 3| 1| 9| 3| 3| 7| 3| 3| 3| 3| 2| 8| 3| 5| 3| 3| 3| 3| 3| 9| 8| 7| 3| 3| | | 5| 5| 7| 9| 6| 5| 2| 6| 5| 6| 7| 8| 7| 5| 8| 7| 6| 7| 6| 5| 9| 5| 2| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + M A + + + + + + + + + +| 48 | Inflammation, Suppurative | 1 | 3 1.3| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | | 1 1.0| __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epithelium, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 | 1 1.0| Eosinophilic Focus | X X | 4 | Hematopoietic Cell Proliferation | 2 | 4 2.3| Inflammation | | 1 2.0| Necrosis | 1 1 1 | 9 1.6| Tension Lipidosis | | 2 | Vacuolization Cytoplasmic | 2 | 1 2.0| __________________________________________________________________________|____________| Mesentery | + + | 8 | Artery, Inflammation | 1 | 2 1.5| Fat, Necrosis | 3 | 6 2.8| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | 3 | 1 3.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erosion | 1 1 | 2 1.0| Epithelium, Hyperplasia | 3 1 | 4 2.3| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 2 | 1 2.0| Epithelium, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Tooth | + | 2 | Inflammation | 3 | 2 2.5| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 46 1.2| Mineralization | 2 | 2 1.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| | DAY ON TEST | 3| 3| 1| 9| 3| 3| 7| 3| 3| 3| 3| 2| 8| 3| 5| 3| 3| 3| 3| 3| 9| 8| 7| 3| 3| | | 5| 5| 7| 9| 6| 5| 2| 6| 5| 6| 7| 8| 7| 5| 8| 7| 6| 7| 6| 5| 9| 5| 2| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Artery, Inflammation | 1 1 2 3 1 | 11 1.8| Atrium, Thrombosis | | 1 2.0| Valve, Inflammation | | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Cystic | | 1 3.0| Hematopoietic Cell Proliferation | | 1 1.0| Hypertrophy | 1 2| 3 1.3| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 2 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 | 2 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + + M + M M + M + M + M M + + + M + I + M M + + M| 29 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 | Pars Distalis, Hyperplasia | 1 2 3 1 2 1 1 1 | 21 1.5| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 2 2 | 4 1.8| Follicular Cell, Hyperplasia | 1 | 2 1.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + M + + + + + + + M M + + + + + + I + M| 41 | __________________________________________________________________________|____________| Ovary | M + + + + + + + + + + M + + + + + + + + M + + + +| 44 | Cyst | 3 2 2 4 2 | 11 2.4| Thrombosis | | 1 4.0| Interstitial Cell, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Oviduct | + | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 4 2 | 3 2.7| Hydrometra | 3 4 3 3 | 8 2.9| Hyperplasia, Cystic | 2 2 3 3 3 1 3 2 1 2 1 2 1 2 3 2 2 3| 36 1.9| Inflammation, Suppurative | | 1 4.0| Thrombosis | | 1 4.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| | DAY ON TEST | 3| 3| 1| 9| 3| 3| 7| 3| 3| 3| 3| 2| 8| 3| 5| 3| 3| 3| 3| 3| 9| 8| 7| 3| 3| | | 5| 5| 7| 9| 6| 5| 2| 6| 5| 6| 7| 8| 7| 5| 8| 7| 6| 7| 6| 5| 9| 5| 2| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Fibrosis | 3 | 1 3.0| Hyperplasia | 3 | 5 2.6| __________________________________________________________________________|____________| Lymph Node | + + | 6 | Lumbar, Angiectasis | 4 | 1 4.0| Lumbar, Hemorrhage | 4 | 1 4.0| Lumbar, Inflammation, Chronic | 3 | 1 3.0| Renal, Angiectasis | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 | Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 33 1.0| Hyperplasia | 2 2 3 2 2 2 2 2 2 2 2 3 2 2 3 | 31 2.2| Artery, Inflammation | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | M + + + + + + + + + M + + M + + + + + + + + + + M| 43 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 2 | 7 2.1| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + M + + + + M + + + + + M + + M + + + + +| 46 | Foreign Body | 1 1 1 1| 7 1.0| Hyperplasia | 3 3 3| 11 2.2| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 1 2 2 2 1 3 2 2 2 2 2 2 | 26 1.9| Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 | 11 2.1| Metaplasia, Osseous | 1 | 1 1.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + M M + + + + + + M + M M| 42 | Hyperplasia, Lymphoid | 2 | 3 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 | 4 2.3| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Inflammation, | | | Chronic | | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 1 2 1 1 2 1 4 | 14 1.6| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Meninges, Infiltration Cellular, | | | Mononuclear Cell | 1 | 2 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| | DAY ON TEST | 3| 3| 1| 9| 3| 3| 7| 3| 3| 3| 3| 2| 8| 3| 5| 3| 3| 3| 3| 3| 9| 8| 7| 3| 3| | | 5| 5| 7| 9| 6| 5| 2| 6| 5| 6| 7| 8| 7| 5| 8| 7| 6| 7| 6| 5| 9| 5| 2| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Spinal Cord | + | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | | 1 1.0| Squamous Epithelium, Hyperplasia | 1 1 1 2 2 1 1 | 10 1.2| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | X X X X X X X X X X X X X X X| 35 | Hemorrhage | 1 1 | 4 1.0| Inflammation, Chronic Active | 2 1 1 2 2 2 1 1 1 2 2 2 1 2 1 1 2 1 2 2 2 1 2| 45 1.7| Thrombosis | | 1 1.0| Alveolar Epithelium, Hyperplasia | 3 | 1 3.0| Alveolus, Infiltration Cellular, | | | Histiocyte | | 2 2.5| Artery, Inflammation | | 1 1.0| Artery, Mediastinum, Inflammation | | 1 2.0| Serosa, Fibrosis | 2 1 3 2 2 2 2 2 2 2 1 1 2 2 1 2 2 2 2 2 2 2 1 2| 47 1.8| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 1 1 2 1 | 7 1.3| Olfactory Epithelium, Atrophy | 1 1 1 | 3 1.0| Olfactory Epithelium, Degeneration, | | | Hyaline | 1 1 1 1 2 2 1 | 10 1.2| Respiratory Epithelium, Degeneration,| | | Hyaline | 1 2 1 1 2 1 1 2 2 1 1 1 1 | 27 1.3| Respiratory Epithelium, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Pleura | | 3 | Mesothelium, Hyperplasia | | 3 1.7| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | Degeneration | | 1 4.0| __________________________________________________________________________|____________| Harderian Gland | | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 3.0| Metaplasia, Osseous | 1 | 4 1.0| Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 43 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| | DAY ON TEST | 3| 3| 1| 9| 3| 3| 7| 3| 3| 3| 3| 2| 8| 3| 5| 3| 3| 3| 3| 3| 9| 8| 7| 3| 3| | | 5| 5| 7| 9| 6| 5| 2| 6| 5| 6| 7| 8| 7| 5| 8| 7| 6| 7| 6| 5| 9| 5| 2| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Artery, Inflammation | | 1 1.0| Renal Tubule, Karyomegaly | | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | 1 | 3 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 6| 7| 4| 7| 6| 7| 5| 6| 7| 7| 5| 6| 4| DAY ON TEST | 3| 3| 3| 3| 8| 0| 2| 3| 3| 1| 4| 3| 5| 3| 9| 3| 4| 3| 7| 5| 3| 3| 1| 9| 8| | 7| 7| 6| 5| 7| 0| 9| 7| 5| 0| 5| 5| 8| 7| 3| 6| 2| 7| 8| 0| 7| 6| 2| 5| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + A + + + + + + M + A + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + A + + + + + + A + A + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + A + + + + + + A + A + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +| Peyer's Patch, Hyperplasia | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 | Basophilic Focus | | Clear Cell Focus | | Eosinophilic Focus | X X X X X X X | Eosinophilic Focus, Multiple | | Hematopoietic Cell Proliferation | 3 | Necrosis | 2 1 | Tension Lipidosis | X | Bile Duct, Degeneration, Hyaline | | __________________________________________________________________________| Mesentery | + + + | Artery, Inflammation | 1 | Fat, Necrosis | 1 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | X | Inflammation, Chronic | 2 | Epithelium, Hyperplasia | 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +| Inflammation, Suppurative | 2 | Necrosis, Focal | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1| Necrosis | | Artery, Inflammation | 1 2 1 2 1 3 | Atrium, Thrombosis | | Epicardium, Inflammation | 2 1 1 | Pericardium, Inflammation | 3 2 2 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 6| 7| 4| 7| 6| 7| 5| 6| 7| 7| 5| 6| 4| DAY ON TEST | 3| 3| 3| 3| 8| 0| 2| 3| 3| 1| 4| 3| 5| 3| 9| 3| 4| 3| 7| 5| 3| 3| 1| 9| 8| | 7| 7| 6| 5| 7| 0| 9| 7| 5| 0| 5| 5| 8| 7| 3| 6| 2| 7| 8| 0| 7| 6| 2| 5| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Amyloid Deposition | | Degeneration, Focal | 2 | Hyperplasia | 2 | Hypertrophy | 1 1 1 1 1 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + M| Hyperplasia | 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | M + + + + M + M + + + + + + M M M + M M + + M + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| Pars Distalis, Hyperplasia | 2 1 4 1 2 4 1 1| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + M + + + + + M + I + + + + M + + M M +| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + I + + + + + + + + + +| Angiectasis | 2 | Cyst | 2 1 2 1 | Thrombosis | | Interstitial Cell, Hyperplasia | 2 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 3 2 | Hydrometra | 4 2 2 2| Hyperplasia, Cystic | 1 2 2 2 1 2 2 2 3 2 2 2 3 1 2 2 | Inflammation, Suppurative | 1 | Thrombosis | 3 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 2 | __________________________________________________________________________| Lymph Node | + + + + | Iliac, Hematopoietic Cell | | Proliferation | | Iliac, Hyperplasia | 3 | Lumbar, Hyperplasia | 2 | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Hematopoietic Cell Proliferation | | Hyperplasia | 2 2 2 2 3 2 2 2 3 2 2 2 2 4 2| Artery, Inflammation | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 6| 7| 4| 7| 6| 7| 5| 6| 7| 7| 5| 6| 4| DAY ON TEST | 3| 3| 3| 3| 8| 0| 2| 3| 3| 1| 4| 3| 5| 3| 9| 3| 4| 3| 7| 5| 3| 3| 1| 9| 8| | 7| 7| 6| 5| 7| 0| 9| 7| 5| 0| 5| 5| 8| 7| 3| 6| 2| 7| 8| 0| 7| 6| 2| 5| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + M + + M M + + + + + + + M + + + + + + +| Hematopoietic Cell Proliferation | | Hyperplasia | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + M + + + + + I + + + + + + + + + + + +| Hematopoietic Cell Proliferation | | Hyperplasia | 2 2 4 2 | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | 1 1 1 1 1 1 1 1 1| Hematopoietic Cell Proliferation | | Hyperplasia | 2 3 2 4 2 2 4 3 2 4 2 2 3 2 2| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + A + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 1 3 2 2 1 2 2 4 2 2 1 | Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 3 2 | __________________________________________________________________________| Thymus | + + + + M + M + + + + + + + + + M + M + M + + + +| Hyperplasia, Lymphoid | 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 | Inflammation, Suppurative | 3 | Hair Follicle, Atrophy | 3 | Subcutaneous Tissue, Hemorrhage | | Subcutaneous Tissue, Inflammation, | | Chronic | 4 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 1 2 1 1 2 2 2 | Maxilla, Fracture | | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Meninges, Infiltration Cellular, | | Mononuclear Cell | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | Squamous Epithelium, Hyperplasia | 2 1 1 2 1 2 1| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | X X X X X X X X X X X X X X X X X X X X X X X X X| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 6| 7| 4| 7| 6| 7| 5| 6| 7| 7| 5| 6| 4| DAY ON TEST | 3| 3| 3| 3| 8| 0| 2| 3| 3| 1| 4| 3| 5| 3| 9| 3| 4| 3| 7| 5| 3| 3| 1| 9| 8| | 7| 7| 6| 5| 7| 0| 9| 7| 5| 0| 5| 5| 8| 7| 3| 6| 2| 7| 8| 0| 7| 6| 2| 5| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Hematopoietic Cell Proliferation | | Hemorrhage | 1 4 | Inflammation, Chronic Active | 3 2 2 2 2 2 2 2 2 3 1 2 2 2 3 2 2 2 2 2 3 2 2 2 3| Thrombosis | 2 | Alveolar Epithelium, Hyperplasia | 2 | Alveolus, Infiltration Cellular, | | Histiocyte | 2 | Alveolus, Proteinosis | 1 1 2 1 | Bronchiole, Bronchus, Degeneration, | | Hyaline | | Interstitium, Fibrosis | 2 | Serosa, Fibrosis | 2 2 4 1 3 3 2 3 4 1 4 2 2 3 4 3 2 2 3 2 4 3 3 4 3| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 1 | Olfactory Epithelium, Atrophy | | Olfactory Epithelium, Degeneration, | | Hyaline | 1 | Respiratory Epithelium, Degeneration,| | Hyaline | 1 1 1 1 1 | __________________________________________________________________________| Pleura | + + + + + + + + + | Mesothelium, Hyperplasia | 2 2 4 1 1 1 2 1 4 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Hyaline | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Metaplasia, Osseous | 1 | Nephropathy | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 | Artery, Inflammation | 2 | Glomerulus, Inflammation, Chronic | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + M + +| Angiectasis | 1 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 1| 7| 7| 6| 7| 5| 6| 6| 5| 6| 6| 7| 7| 4| 7| | DAY ON TEST | 2| 3| 2| 3| 0| 3| 3| 0| 9| 3| 9| 3| 3| 1| 3| 3| 9| 3| 9| 6| 1| 2| 3| 2| 0| | | 1| 6| 7| 5| 8| 6| 5| 5| 6| 6| 7| 6| 6| 5| 5| 3| 5| 3| 4| 9| 9| 6| 7| 1| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | M + + + + + + + + + A + + + + + + + + + + A + + A| 43 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + M + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + A + A + + + + + + + + + + A + + +| 44 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + A + A + + + + + + + A + + + + + +| 44 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 | Peyer's Patch, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 4 | 2 2.5| Basophilic Focus | X X | 2 | Clear Cell Focus | X X | 2 | Eosinophilic Focus | X X X | 10 | Eosinophilic Focus, Multiple | X X | 2 | Hematopoietic Cell Proliferation | 2 3 | 3 2.7| Necrosis | 3 | 3 2.0| Tension Lipidosis | | 1 | Bile Duct, Degeneration, Hyaline | 2 | 1 2.0| __________________________________________________________________________|____________| Mesentery | + | 4 | Artery, Inflammation | | 1 1.0| Fat, Necrosis | 2 | 3 1.7| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 2 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | | 1 | Inflammation, Chronic | | 1 2.0| Epithelium, Hyperplasia | 2 2 | 3 1.7| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Suppurative | | 1 2.0| Necrosis, Focal | | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 2 1| 38 1.1| Necrosis | 1 | 1 1.0| Artery, Inflammation | 1 2 2 2 2 2 2 | 13 1.8| Atrium, Thrombosis | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 1| 7| 7| 6| 7| 5| 6| 6| 5| 6| 6| 7| 7| 4| 7| | DAY ON TEST | 2| 3| 2| 3| 0| 3| 3| 0| 9| 3| 9| 3| 3| 1| 3| 3| 9| 3| 9| 6| 1| 2| 3| 2| 0| | | 1| 6| 7| 5| 8| 6| 5| 5| 6| 6| 7| 6| 6| 5| 5| 3| 5| 3| 4| 9| 9| 6| 7| 1| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Epicardium, Inflammation | 2 2 2 1 | 7 1.6| Pericardium, Inflammation | | 4 2.5| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Amyloid Deposition | 2 1 | 2 1.5| Degeneration, Focal | | 1 2.0| Hyperplasia | | 1 2.0| Hypertrophy | 1 1 1 1 | 10 1.1| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 1 2 | 3 1.3| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Parathyroid Gland | M + M + M + M + M M M + + + + + + + + M + M M M +| 30 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Hyperplasia | 2 1 1 2 1 1 2 | 15 1.7| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 | Inflammation, Suppurative | | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | M + + + M + + + + + + + + + + + + + + M + + + M +| 40 | __________________________________________________________________________|____________| Ovary | + M + + + + + + + + + + + I + + + + + + + + + + +| 47 | Angiectasis | | 1 2.0| Cyst | 2 4 3 3 4 | 9 2.4| Thrombosis | 3 4 | 2 3.5| Interstitial Cell, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 | 5 2.2| Hydrometra | 2 | 5 2.4| Hyperplasia, Cystic | 2 2 3 2 2 3 1 3 2 1 2 2 2 2 3 2 | 32 2.0| Inflammation, Suppurative | | 1 1.0| Thrombosis | | 2 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 2 | 7 2.1| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 1| 7| 7| 6| 7| 5| 6| 6| 5| 6| 6| 7| 7| 4| 7| | DAY ON TEST | 2| 3| 2| 3| 0| 3| 3| 0| 9| 3| 9| 3| 3| 1| 3| 3| 9| 3| 9| 6| 1| 2| 3| 2| 0| | | 1| 6| 7| 5| 8| 6| 5| 5| 6| 6| 7| 6| 6| 5| 5| 3| 5| 3| 4| 9| 9| 6| 7| 1| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + + | 8 | Iliac, Hematopoietic Cell | | | Proliferation | 2 | 1 2.0| Iliac, Hyperplasia | | 1 3.0| Lumbar, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 40 1.0| Hematopoietic Cell Proliferation | 2 | 1 2.0| Hyperplasia | 2 4 2 2 2 2 2 2 1 2 2 2 2 | 28 2.2| Artery, Inflammation | 1 | 1 1.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + M M + + + M + + + + M + +| 42 | Hematopoietic Cell Proliferation | 2 | 1 2.0| Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hematopoietic Cell Proliferation | 4 | 1 4.0| Hyperplasia | 2 2 2 | 7 2.3| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | Foreign Body | 1 1 1 1 1 1 1 | 16 1.0| Hematopoietic Cell Proliferation | 2 | 1 2.0| Hyperplasia | 3 2 3 2 3 2 4 2 2 2 2 2 3 3| 29 2.6| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hematopoietic Cell Proliferation | 2 3 2 2 3 2 2 3 2 | 21 2.1| Hyperplasia, Lymphoid | 2 2 4 4 | 14 2.4| __________________________________________________________________________|____________| Thymus | + + + + M + + M + + + + + + + + M + + + + + + + +| 42 | Hyperplasia, Lymphoid | 2 | 2 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 1| 3 1.7| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 4.0| Inflammation, Suppurative | | 1 3.0| Hair Follicle, Atrophy | | 1 3.0| Subcutaneous Tissue, Hemorrhage | 4 | 1 4.0| Subcutaneous Tissue, Inflammation, | | | Chronic | | 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 1| 7| 7| 6| 7| 5| 6| 6| 5| 6| 6| 7| 7| 4| 7| | DAY ON TEST | 2| 3| 2| 3| 0| 3| 3| 0| 9| 3| 9| 3| 3| 1| 3| 3| 9| 3| 9| 6| 1| 2| 3| 2| 0| | | 1| 6| 7| 5| 8| 6| 5| 5| 6| 6| 7| 6| 6| 5| 5| 3| 5| 3| 4| 9| 9| 6| 7| 1| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | Fibrous Osteodystrophy | 1 1 2 1 1 1 1 1 1| 16 1.3| Maxilla, Fracture | X | 1 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Meninges, Infiltration Cellular, | | | Mononuclear Cell | 2 | 2 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 1 1| 2 1.0| Squamous Epithelium, Hyperplasia | 2 1 2 1 2 1 1 1 | 15 1.4| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | X X X X X X X X X X X X X X X X X X X X X X X X| 49 | Hematopoietic Cell Proliferation | 3 | 1 3.0| Hemorrhage | 2 1 | 4 2.0| Inflammation, Chronic Active | 2 2 2 2 2 2 1 2 3 1 3 1 3 2 2 2 2 2 2 2 2 2 2 3 2| 50 2.1| Thrombosis | | 1 2.0| Alveolar Epithelium, Hyperplasia | 2 | 2 2.0| Alveolus, Infiltration Cellular, | | | Histiocyte | 3 2 | 3 2.3| Alveolus, Proteinosis | 1 2 1 2 | 8 1.4| Bronchiole, Bronchus, Degeneration, | | | Hyaline | 3 2 | 2 2.5| Interstitium, Fibrosis | 1 | 2 1.5| Serosa, Fibrosis | 2 3 2 2 3 1 1 4 4 1 2 1 4 2 1 2 3 2 2 2 3 3 2 3| 49 2.5| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | | 2 1.0| Olfactory Epithelium, Atrophy | 1 1 | 2 1.0| Olfactory Epithelium, Degeneration, | | | Hyaline | 1 | 2 1.0| Respiratory Epithelium, Degeneration,| | | Hyaline | 1 1 2 1 1 3 1 1 1 | 14 1.2| __________________________________________________________________________|____________| Pleura | + + + +| 13 | Mesothelium, Hyperplasia | 1 3 1 2| 13 1.9| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Hyaline | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 1| 7| 7| 6| 7| 5| 6| 6| 5| 6| 6| 7| 7| 4| 7| | DAY ON TEST | 2| 3| 2| 3| 0| 3| 3| 0| 9| 3| 9| 3| 3| 1| 3| 3| 9| 3| 9| 6| 1| 2| 3| 2| 0| | | 1| 6| 7| 5| 8| 6| 5| 5| 6| 6| 7| 6| 6| 5| 5| 3| 5| 3| 4| 9| 9| 6| 7| 1| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Harderian Gland | | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Metaplasia, Osseous | 1 | 2 1.0| Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1 1 1 1| 36 1.1| Artery, Inflammation | 2 2 | 3 2.0| Glomerulus, Inflammation, Chronic | 2 | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Angiectasis | 2 | 2 1.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| DAY ON TEST | 8| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 1| 3| 3| 3| 5| 3| 3| 6| 3| 3| 3| | 6| 3| 3| 5| 3| 3| 4| 3| 1| 4| 4| 6| 4| 4| 6| 5| 4| 4| 9| 4| 4| 4| 4| 4| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | A + + + + + + + + + + + + + A + + + + + + A + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | A + + + + + + + A + + + + + A + + + + + + A + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + A + + A + + + + + + + + + A + + +| Peyer's Patch, Hyperplasia | 2 4 2 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 | Basophilic Focus | X X | Clear Cell Focus | | Clear Cell Focus, Multiple | X | Eosinophilic Focus | X X X X| Eosinophilic Focus, Multiple | X | Hematopoietic Cell Proliferation | | Inflammation, Focal, Granulomatous | | Necrosis | | Tension Lipidosis | X X | Vacuolization Cytoplasmic | | __________________________________________________________________________| Mesentery | + + + | Fat, Necrosis | 3 2 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 1 | Duct, Cyst | 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 | Ulcer | 1 | Epithelium, Hyperplasia | 3 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | Necrosis, Focal | | Epithelium, Hyperplasia | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | Mineralization | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1| Artery, Inflammation | 1 1 1 | Artery, Mineralization | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| DAY ON TEST | 8| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 1| 3| 3| 3| 5| 3| 3| 6| 3| 3| 3| | 6| 3| 3| 5| 3| 3| 4| 3| 1| 4| 4| 6| 4| 4| 6| 5| 4| 4| 9| 4| 4| 4| 4| 4| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | | Hyperplasia | 2 | Hypertrophy | 1 2 1 1 2 1 2 2 1 1 1 1 1 1 1 1| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 3 1 1 1| __________________________________________________________________________| Parathyroid Gland | M + + M + M + + + + + M M + M + M + M + + M + + +| __________________________________________________________________________| Pituitary Gland | + + + M + + + + + M + + + + + + + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + M + + + + + + + M + + M + + + + + + + + + +| Follicle, Degeneration, Cystic | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | 2 | Inflammation | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 2 2 2 3 2 2 3 3 1 3 | Hyperplasia, Squamous | 2 | Inflammation | 2 4 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2| Atrophy | 1 2 1 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 | __________________________________________________________________________| Lymph Node | | __________________________________________________________________________| Lymph Node, Bronchial | M + + M + M + + M + + M + M + + M + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Lymph Node, Mandibular | + M M + + + + + M + + + M + + + M + M M + M + M +| Hyperplasia | | __________________________________________________________________________| Lymph Node, Mesenteric | + + M + + + + + + + + M + + + + + + + + + + + + +| Angiectasis | 2 | Hyperplasia | 2 2 2 3 2| Inflammation, Granulomatous | | Artery, Inflammation | 2 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| DAY ON TEST | 8| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 1| 3| 3| 3| 5| 3| 3| 6| 3| 3| 3| | 6| 3| 3| 5| 3| 3| 4| 3| 1| 4| 4| 6| 4| 4| 6| 5| 4| 4| 9| 4| 4| 4| 4| 4| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node, Mediastinal | M + + + + + + + M M + + M + M + + M + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 | Hematopoietic Cell Proliferation | 2 1 2 1 2 2 | __________________________________________________________________________| Thymus | M M + M + + + M I + + M + M M + + + + M + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | Prepuce, Inflammation, Chronic Active| | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 1 | Hyperplasia | 2 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 1 | Epiglottis, Metaplasia, Squamous | | Squamous Epithelium, Hyperplasia | 1 2 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 1 1 3 | Inflammation, Chronic Active | 1 1| Inflammation, Suppurative | 1 | Thrombosis | 1 | Alveolar Epithelium, Hyperplasia | | Bronchiole, Hyperplasia | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 1 | Olfactory Epithelium, Atrophy | 1 | Olfactory Epithelium, Degeneration, | | Hyaline | | Respiratory Epithelium, Degeneration,| | Hyaline | 1 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + A + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| DAY ON TEST | 8| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 1| 3| 3| 3| 5| 3| 3| 6| 3| 3| 3| | 6| 3| 3| 5| 3| 3| 4| 3| 1| 4| 4| 6| 4| 4| 6| 5| 4| 4| 9| 4| 4| 4| 4| 4| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Metaplasia, Osseous | 1 1 1 | Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 3 4 1 1 1 1 1 1 2 1| Glomerulus, Inflammation, Chronic | | Renal Tubule, Hyperplasia | 2 1| __________________________________________________________________________| Ureter | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| | DAY ON TEST | 3| 3| 3| 9| 6| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 6| 3| 3| 3| 0| 3| 3| 6| | | 5| 3| 5| 0| 2| 4| 3| 3| 5| 3| 3| 6| 3| 4| 3| 3| 4| 9| 3| 5| 5| 7| 3| 4| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + M + + + + + + A + + + + + M + + + + + + A| 43 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + + A| 47 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + M + + + + + + A + + + + + A + + + + + + +| 43 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A| 47 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + A| 45 | Peyer's Patch, Hyperplasia | 1 2 | 5 2.2| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 1 1.0| Basophilic Focus | | 2 | Clear Cell Focus | X | 1 | Clear Cell Focus, Multiple | | 1 | Eosinophilic Focus | X X X X X | 9 | Eosinophilic Focus, Multiple | | 1 | Hematopoietic Cell Proliferation | 3 | 1 3.0| Inflammation, Focal, Granulomatous | 1 | 1 1.0| Necrosis | 4 2 2 2 | 4 2.5| Tension Lipidosis | | 2 | Vacuolization Cytoplasmic | 2 2 | 2 2.0| __________________________________________________________________________|____________| Mesentery | + | 4 | Fat, Necrosis | 2 | 4 2.5| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 | 3 1.0| Duct, Cyst | | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Suppurative | | 1 1.0| Ulcer | | 1 1.0| Epithelium, Hyperplasia | | 2 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Suppurative | 2 | 1 2.0| Necrosis, Focal | 1 | 1 1.0| Epithelium, Hyperplasia | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 1 | Mineralization | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| | DAY ON TEST | 3| 3| 3| 9| 6| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 6| 3| 3| 3| 0| 3| 3| 6| | | 5| 3| 5| 0| 2| 4| 3| 3| 5| 3| 3| 6| 3| 4| 3| 3| 4| 9| 3| 5| 5| 7| 3| 4| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 4 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 39 1.1| Artery, Inflammation | | 3 1.0| Artery, Mineralization | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 1 | 1 1.0| Hyperplasia | | 1 2.0| Hypertrophy | 2 2 2 1 1 1 1 1 2 2 2 1 1 1 | 30 1.3| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 | 3 1.3| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 4 1 1 | 8 1.6| __________________________________________________________________________|____________| Parathyroid Gland | M + + M + + + M + + M M + + + M + + + + M M + + +| 33 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Follicle, Degeneration, Cystic | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granuloma Sperm | 4 | 2 3.0| Inflammation | 2 | 1 2.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 2 2 2 2 2 2 2 2 3 3 2 3 3 2 | 25 2.3| Hyperplasia, Squamous | | 1 2.0| Inflammation | 3 3 2 | 5 2.8| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 1 2.0| Atrophy | 2 2 | 6 1.7| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 2 | 5 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| | DAY ON TEST | 3| 3| 3| 9| 6| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 6| 3| 3| 3| 0| 3| 3| 6| | | 5| 3| 5| 0| 2| 4| 3| 3| 5| 3| 3| 6| 3| 4| 3| 3| 4| 9| 3| 5| 5| 7| 3| 4| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node | + | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + M M + + M + + + + + M + M + M + + + M + M +| 35 | Hyperplasia | 3 | 2 2.5| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + M M M M + M M + M + + + M M M + M + + M M| 28 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Angiectasis | | 1 2.0| Hyperplasia | 2 2 2 3 2 3 | 11 2.3| Inflammation, Granulomatous | 3 2 | 2 2.5| Artery, Inflammation | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M + + M + + + M + + + + + + + + + + + + + M + +| 40 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 | 2 2.5| Hematopoietic Cell Proliferation | 1 1 1 2 4 1 1 2 | 14 1.6| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + M + M + + M + M M + + + M +| 35 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 | 2 2.0| Prepuce, Inflammation, Chronic Active| 4 | 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Fibrous Osteodystrophy | 1 | 2 1.0| Hyperplasia | | 1 2.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 1 1 1 | 5 1.0| Epiglottis, Metaplasia, Squamous | 1 | 1 1.0| Squamous Epithelium, Hyperplasia | 1 1 1 2 | 6 1.3| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 1 1 | 5 1.4| Inflammation, Chronic Active | | 2 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| | DAY ON TEST | 3| 3| 3| 9| 6| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 6| 3| 3| 3| 0| 3| 3| 6| | | 5| 3| 5| 0| 2| 4| 3| 3| 5| 3| 3| 6| 3| 4| 3| 3| 4| 9| 3| 5| 5| 7| 3| 4| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Inflammation, Suppurative | | 1 1.0| Thrombosis | | 1 1.0| Alveolar Epithelium, Hyperplasia | 2 1 | 2 1.5| Bronchiole, Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Suppurative | 1 | 3 1.0| Olfactory Epithelium, Atrophy | 1 | 2 1.0| Olfactory Epithelium, Degeneration, | | | Hyaline | 1| 1 1.0| Respiratory Epithelium, Degeneration,| | | Hyaline | 1 1 1| 5 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + I + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + | 1 | __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 | 2 2.0| Metaplasia, Osseous | 1 1 | 5 1.0| Nephropathy | 1 1 1 1 4 2 1 2 2 1 1 1 1 1 1 1 1 1 1 2 2 1 1 1 1| 47 1.3| Glomerulus, Inflammation, Chronic | 2 | 1 2.0| Renal Tubule, Hyperplasia | 1 1 1 | 5 1.2| __________________________________________________________________________|____________| Ureter | + | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 5| 4| 5| 6| 7| 7| 7| 7| 3| 5| 7| 4| 7| 5| 7| DAY ON TEST | 3| 3| 8| 3| 2| 0| 3| 3| 3| 3| 7| 2| 7| 8| 3| 3| 3| 3| 3| 5| 3| 5| 3| 6| 3| | 5| 5| 9| 0| 9| 0| 3| 3| 8| 4| 4| 1| 1| 2| 5| 3| 0| 5| 1| 7| 4| 7| 3| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + A + + + A + + + + + + + + + + + +| Degeneration, Hyaline | | Inflammation, Suppurative | | Epithelium, Hyperplasia | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + M +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + A + + +| Inflammation, Chronic | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + + +| Amyloid Deposition | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | 2 | Basophilic Focus | X | Clear Cell Focus | | Eosinophilic Focus | X X X X X X | Eosinophilic Focus, Multiple | | Necrosis | 4 2 3 | Tension Lipidosis | | __________________________________________________________________________| Mesentery | + + | Artery, Inflammation | 4 4 | Fat, Necrosis | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mast Cell | 2 | Ulcer | | Artery, Inflammation | | Epithelium, Hyperplasia | 1 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | | Inflammation | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | Aorta, Aneurysm | | Aorta, Hemorrhage | | Aorta, Inflammation | | Aorta, Mineralization | 2 | Aorta, Necrosis | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 2| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 5| 4| 5| 6| 7| 7| 7| 7| 3| 5| 7| 4| 7| 5| 7| DAY ON TEST | 3| 3| 8| 3| 2| 0| 3| 3| 3| 3| 7| 2| 7| 8| 3| 3| 3| 3| 3| 5| 3| 5| 3| 6| 3| | 5| 5| 9| 0| 9| 0| 3| 3| 8| 4| 4| 1| 1| 2| 5| 3| 0| 5| 1| 7| 4| 7| 3| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Hemorrhage | 2 | Artery, Inflammation | 2 1 1 2 1 1| Atrium, Inflammation, Chronic | 1 | Atrium, Thrombosis | 2 | Epicardium, Inflammation | 2 | Pericardium, Inflammation | 2 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | 2 | Angiectasis | | Degeneration, Focal | | Hyperplasia | | Hypertrophy | 1 1 1 1 1 1 1| Necrosis | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | + + M + M M + + M I + M + + + M + + + + + + M M M| Amyloid Deposition | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| Pars Distalis, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| Amyloid Deposition | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 2 2 3 2 3 2 3| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1 1 | __________________________________________________________________________| Lymph Node | + | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 5| 4| 5| 6| 7| 7| 7| 7| 3| 5| 7| 4| 7| 5| 7| DAY ON TEST | 3| 3| 8| 3| 2| 0| 3| 3| 3| 3| 7| 2| 7| 8| 3| 3| 3| 3| 3| 5| 3| 5| 3| 6| 3| | 5| 5| 9| 0| 9| 0| 3| 3| 8| 4| 4| 1| 1| 2| 5| 3| 0| 5| 1| 7| 4| 7| 3| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hyperplasia | 2 3 2 2 2 4 4 2 3 2 1 2 2 2 2 2 2 2 | __________________________________________________________________________| Lymph Node, Mandibular | M M M + + + + + M + + M + M + + M + + M + + + M M| Hyperplasia | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + + + + + + M| Hyperplasia | | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | 1 1 1 1 1 1 1 1 | Hematopoietic Cell Proliferation | 2 | Hyperplasia | 3 2 2 2 4 4 2 3 2 2 2 2 2 4 2 1 2 | Artery, Inflammation | 1 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | 3 | Angiectasis | | Hematopoietic Cell Proliferation | 2 3 3 4 2 3 2 1 2 2 2 2 2 1 2 2 3 | Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Thymus | + M + + + M M + M + + M + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M + M M M M M M M M M M + M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Inflammation, Suppurative | | Prepuce, Inflammation, Chronic Active| 4 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + | Maxilla, Fracture | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + A + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 | Squamous Epithelium, Hyperplasia | 1 2 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | X X X X X X X X X X X X X X X X X X X X X X X 1 X| Hemorrhage | | Inflammation, Chronic Active | 2 3 3 2 2 3 3 3 3 2 2 3 3 2 3 2 4 3 4 3 3 2 3 4 2| Alveolar Epithelium, Hyperplasia | 2 2| Alveolus, Infiltration Cellular, | | Histiocyte | | Alveolus, Proteinosis | 1 1 1 1 1 1| Artery, Mediastinum, Inflammation | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 7| 7| 5| 5| 7| 7| 7| 7| 6| 7| 5| 4| 5| 6| 7| 7| 7| 7| 3| 5| 7| 4| 7| 5| 7| DAY ON TEST | 3| 3| 8| 3| 2| 0| 3| 3| 3| 3| 7| 2| 7| 8| 3| 3| 3| 3| 3| 5| 3| 5| 3| 6| 3| | 5| 5| 9| 0| 9| 0| 3| 3| 8| 4| 4| 1| 1| 2| 5| 3| 0| 5| 1| 7| 4| 7| 3| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.03 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Interstitium, Fibrosis | | Serosa, Fibrosis | 3 3 4 4 3 4 4 4 4 4 3 2 4 4 4 3 4 4 3 2 3 4 4 2 4| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | | Hemorrhage | | Inflammation, Suppurative | 1 1 1 | Olfactory Epithelium, Atrophy | 2 1 | Respiratory Epithelium, Degeneration,| | Hyaline | 1 | __________________________________________________________________________| Pleura | + + + + + + + | Mesothelium, Hyperplasia | 4 4 1 2 1 1 1 | __________________________________________________________________________| Trachea | + + + + + + + + A + + + + + + + + + + + + + + I +| Inflammation, Suppurative | 2 | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Degeneration | 4 | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | 3 | Cyst | | Infiltration Cellular, Focal, Mixed | | Cell | | Nephropathy | 1 1 1 1 2 1 1 1 1 3 1 1 3 1 4 2 2 | Artery, Inflammation | 3 1 | Glomerulus, Inflammation, Chronic | 3 | Renal Tubule, Hyperplasia | 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Necrosis | 1 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 5| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 4| | DAY ON TEST | 3| 6| 1| 0| 3| 3| 3| 3| 0| 0| 3| 8| 0| 0| 3| 3| 3| 3| 8| 8| 3| 6| 3| 3| 0| | | 5| 2| 5| 0| 3| 4| 3| 4| 4| 5| 4| 7| 6| 0| 3| 4| 4| 5| 7| 7| 5| 2| 4| 3| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | M + A + + + + + + + + + M + + + + + + + M + + + A| 43 | Degeneration, Hyaline | 1 | 1 1.0| Inflammation, Suppurative | 1 | 1 1.0| Epithelium, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + A| 47 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + A I + + + + A A + + + + M + + + + + + + + + A| 43 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + A + + + + + A A + + + + + + + + + + + + + + A| 44 | Inflammation, Chronic | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + A| 47 | Amyloid Deposition | 2 | 1 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Amyloid Deposition | 4 | 2 3.0| Basophilic Focus | | 1 | Clear Cell Focus | X | 1 | Eosinophilic Focus | X X X X X X X X X | 15 | Eosinophilic Focus, Multiple | X | 1 | Necrosis | 2 | 4 2.8| Tension Lipidosis | X | 1 | __________________________________________________________________________|____________| Mesentery | + + + | 5 | Artery, Inflammation | 4 2 | 4 3.5| Fat, Necrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mast Cell | | 1 2.0| Ulcer | 2 1 | 2 1.5| Artery, Inflammation | 2 | 1 2.0| Epithelium, Hyperplasia | 1 2 3 2 | 6 1.7| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Tooth | + + | 2 | Inflammation | 2 3 | 2 2.5| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 2 | Aorta, Aneurysm | 4 | 1 4.0| Aorta, Hemorrhage | 4 | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 5| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 4| | DAY ON TEST | 3| 6| 1| 0| 3| 3| 3| 3| 0| 0| 3| 8| 0| 0| 3| 3| 3| 3| 8| 8| 3| 6| 3| 3| 0| | | 5| 2| 5| 0| 3| 4| 3| 4| 4| 5| 4| 7| 6| 0| 3| 4| 4| 5| 7| 7| 5| 2| 4| 3| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Aorta, Inflammation | 4 | 1 4.0| Aorta, Mineralization | | 1 2.0| Aorta, Necrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1| 41 1.1| Hemorrhage | | 1 2.0| Artery, Inflammation | 3 1 2 1 3 2 2 4 2 2 1 2| 18 1.8| Atrium, Inflammation, Chronic | | 1 1.0| Atrium, Thrombosis | | 1 2.0| Epicardium, Inflammation | 3 | 2 2.5| Pericardium, Inflammation | 2 2 3 1 | 6 2.2| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Amyloid Deposition | 3 | 2 2.5| Angiectasis | 2 | 1 2.0| Degeneration, Focal | 1 | 1 1.0| Hyperplasia | 2 | 1 2.0| Hypertrophy | 1 1 2 1 2 1 1 1 | 15 1.1| Necrosis | 1 | 1 1.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 | 2 1.5| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Parathyroid Gland | M + + M M + + M M + + M M M + + M + + + + + + + M| 30 | Amyloid Deposition | 1 | 1 1.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + M| 47 | Pars Distalis, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 | Amyloid Deposition | 2 | 2 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 2 2 2 2 4 2 2 4 2 2 2 3 2 | 21 2.4| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + I + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 5| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 4| | DAY ON TEST | 3| 6| 1| 0| 3| 3| 3| 3| 0| 0| 3| 8| 0| 0| 3| 3| 3| 3| 8| 8| 3| 6| 3| 3| 0| | | 5| 2| 5| 0| 3| 4| 3| 4| 4| 5| 4| 7| 6| 0| 3| 4| 4| 5| 7| 7| 5| 2| 4| 3| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + A + + + + + + + + + + + + + + A| 47 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 2 2 1| 9 1.7| __________________________________________________________________________|____________| Lymph Node | | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + + + + + M + + + + + M + + + + + +| 48 | Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 43 1.0| Hyperplasia | 2 1 2 2 2 2 3 2 4 2 2 4 2 2 2 2 2 2| 36 2.3| __________________________________________________________________________|____________| Lymph Node, Mandibular | + M M + + + + + + + + + + + + + M + M M M M + M +| 32 | Hyperplasia | 2 2 | 2 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + M + + + +| 47 | Hyperplasia | 2 2 | 2 2.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 | Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 24 1.0| Hematopoietic Cell Proliferation | | 1 2.0| Hyperplasia | 2 3 2 3 3 2 4 2 2 3 3 2 2 2 3 3 2| 34 2.5| Artery, Inflammation | | 1 1.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Amyloid Deposition | 3 | 2 3.0| Angiectasis | 1 2 | 2 1.5| Hematopoietic Cell Proliferation | 2 2 2 1 2 2 2 1 2 2 1 3 1 2 2 2 2| 34 2.0| Hyperplasia, Lymphoid | 2 2 | 3 2.0| __________________________________________________________________________|____________| Thymus | + + M M + + + + + + + + M + + + + M + M + + + + M| 39 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 | 1 3.0| Inflammation, Suppurative | 2 | 1 2.0| Prepuce, Inflammation, Chronic Active| 4 | 2 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Maxilla, Fracture | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 5| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 4| | DAY ON TEST | 3| 6| 1| 0| 3| 3| 3| 3| 0| 0| 3| 8| 0| 0| 3| 3| 3| 3| 8| 8| 3| 6| 3| 3| 0| | | 5| 2| 5| 0| 3| 4| 3| 4| 4| 5| 4| 7| 6| 0| 3| 4| 4| 5| 7| 7| 5| 2| 4| 3| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Suppurative | 1 1 | 3 1.0| Squamous Epithelium, Hyperplasia | 1 | 3 1.3| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | X X X X X X X X X X X X X X X X X X X X X X X X | 49 1.0| Hemorrhage | 4 | 1 4.0| Inflammation, Chronic Active | 3 4 3 2 3 3 3 4 2 2 3 3 3 3 2 4 2 3 4 3 4 2 2 3 4| 50 2.9| Alveolar Epithelium, Hyperplasia | 4 3 1 | 5 2.4| Alveolus, Infiltration Cellular, | | | Histiocyte | 3 | 1 3.0| Alveolus, Proteinosis | 1 1 1 1 1 1 1 1 | 14 1.0| Artery, Mediastinum, Inflammation | 4 4 | 2 4.0| Interstitium, Fibrosis | 2 2 | 2 2.0| Serosa, Fibrosis | 3 4 4 4 4 3 3 2 3 3 3 4 4 4 4 4 3 3 4 4 3 3 4 4 3| 50 3.5| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | X | 1 | Hemorrhage | 4 | 1 4.0| Inflammation, Suppurative | 2 1 | 5 1.2| Olfactory Epithelium, Atrophy | 1 1 | 4 1.3| Respiratory Epithelium, Degeneration,| | | Hyaline | 1 | 2 1.0| __________________________________________________________________________|____________| Pleura | + + + + + + + + + + + + | 19 | Mesothelium, Hyperplasia | 1 2 2 4 1 2 3 1 3 1 4 1 | 19 2.1| __________________________________________________________________________|____________| Trachea | + + + I + + + + + + + + + + + + + + I + + + + + +| 46 | Inflammation, Suppurative | | 1 2.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | Degeneration | | 1 4.0| __________________________________________________________________________|____________| Harderian Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Amyloid Deposition | 3 | 2 3.0| Cyst | 2 | 1 2.0| Infiltration Cellular, Focal, Mixed | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 5| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 4| | DAY ON TEST | 3| 6| 1| 0| 3| 3| 3| 3| 0| 0| 3| 8| 0| 0| 3| 3| 3| 3| 8| 8| 3| 6| 3| 3| 0| | | 5| 2| 5| 0| 3| 4| 3| 4| 4| 5| 4| 7| 6| 0| 3| 4| 4| 5| 7| 7| 5| 2| 4| 3| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0.03 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Cell | 1 | 1 1.0| Nephropathy | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 4 3 1 1 1| 40 1.4| Artery, Inflammation | 2 2 1 | 5 1.8| Glomerulus, Inflammation, Chronic | | 1 3.0| Renal Tubule, Hyperplasia | 1 | 2 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 1 2.0| Necrosis | | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 6| 6| 5| 7| 7| DAY ON TEST | 3| 2| 7| 3| 4| 9| 3| 3| 3| 5| 7| 3| 3| 5| 3| 8| 3| 3| 3| 7| 8| 8| 6| 3| 3| | 3| 8| 8| 3| 4| 7| 4| 4| 4| 7| 8| 3| 4| 0| 5| 2| 3| 5| 3| 2| 1| 1| 2| 4| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.1MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + M + + + A + + + + + + + + + + + + + M A + + + +| Inflammation, Suppurative | 1 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +| Inflammation, Chronic | | __________________________________________________________________________| Intestine Large, Rectum | + + + + M + + + + + + + + + + + + + + A + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A A + + + +| Inflammation, Suppurative | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + A M + + A + + + + + + + + + A A + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + A A + + + +| Inflammation, Acute | 1 | __________________________________________________________________________| Intestine Small, Ileum | + + + + A + + + + A + + + + + + + + + A A + + + +| Artery, Inflammation | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | | Clear Cell Focus, Multiple | X | Eosinophilic Focus | X X X | Eosinophilic Focus, Multiple | X X X| Inflammation, Chronic Active | 2 | Inflammation, Focal, Granulomatous | 2 | Mixed Cell Focus | | Necrosis | 4 1 | Vacuolization Cytoplasmic | | __________________________________________________________________________| Mesentery | + + + | Artery, Inflammation | | Fat, Necrosis | 3 4 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + A + + + + +| Atrophy | 2 | Artery, Inflammation | 4 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + A + + + + +| Infiltration Cellular | | Inflammation, Chronic | | Ulcer | 1 | Epithelium, Hyperplasia | 2 1 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + + + + +| Infiltration Cellular | | Inflammation, Suppurative | 1 | Necrosis, Focal | 1 | Epithelium, Hyperplasia | 4 | __________________________________________________________________________| Tooth | + | Inflammation | 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 6| 6| 5| 7| 7| DAY ON TEST | 3| 2| 7| 3| 4| 9| 3| 3| 3| 5| 7| 3| 3| 5| 3| 8| 3| 3| 3| 7| 8| 8| 6| 3| 3| | 3| 8| 8| 3| 4| 7| 4| 4| 4| 7| 8| 3| 4| 0| 5| 2| 3| 5| 3| 2| 1| 1| 2| 4| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.1MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | __________________________________________________________________________| Blood Vessel | + | Inflammation | 2 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 2 1 2 1 1 1 1 1 1 2 1 1 4 1 2 1 1| Mineralization | 1 | Artery, Inflammation | 3 1 2 2 1 1 3 | Epicardium, Inflammation | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + A + + + + +| Hyperplasia | 2 2 | Hypertrophy | 1 1 2 1 1 1 2 1 1 3| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + A + + + + +| Hyperplasia | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + A + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Parathyroid Gland | M + + + M + + M + M M M + + + + + + + A + + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + M + + M + + + A + + + + +| Pars Distalis, Hyperplasia | 1 | Pars Intermedia, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + A + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 4 2 2 2 2 2 3 4 3| Inflammation | 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + A + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + A + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 | Interstitial Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 | __________________________________________________________________________| Lymph Node | + | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + M +| Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Hyperplasia | 2 2 2 1 2 1 2 2 2 2 2 2 2 2 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 6| 6| 5| 7| 7| DAY ON TEST | 3| 2| 7| 3| 4| 9| 3| 3| 3| 5| 7| 3| 3| 5| 3| 8| 3| 3| 3| 7| 8| 8| 6| 3| 3| | 3| 8| 8| 3| 4| 7| 4| 4| 4| 7| 8| 3| 4| 0| 5| 2| 3| 5| 3| 2| 1| 1| 2| 4| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.1MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node, Mandibular | + M + M + + + M M + + + + M + + + M + M M + + + +| Hyperplasia | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + A + + + + +| Hemorrhage | | Hyperplasia | 2 2 2 | __________________________________________________________________________| Lymph Node, Mediastinal | M + + + + + + + + + + + + I + + + + + + + + + + +| Foreign Body | 1 1 1 1 1 | Hyperplasia | 2 1 2 3 2 3 2 2 | Artery, Inflammation | 1 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + A + + + + +| Hematopoietic Cell Proliferation | 3 1 2 2 2 2 2 2 1 2 3 2 | Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Thymus | + + + + M M M + + M + + + M + + + M + + + + + + +| Epithelial Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 3 | Inflammation, Suppurative | 3 3 | Mineralization | 1 | Ulcer | 3 | Prepuce, Inflammation, Chronic Active| 4 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 1 | Maxilla, Fracture | X | __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration | 1 | Meninges, Infiltration Cellular, | | Mononuclear Cell | 1 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + A + + + + +| Inflammation, Suppurative | 1 | Squamous Epithelium, Hyperplasia | 2 1 1 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | X X X X X X X X X X X X X X X X X X X X X | Hemorrhage | 1 | Inflammation, Chronic Active | 2 1 1 1 2 1 2 2 1 2 1 1 1 1 1 2 2 2 2 1 1 2| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 6| 6| 5| 7| 7| DAY ON TEST | 3| 2| 7| 3| 4| 9| 3| 3| 3| 5| 7| 3| 3| 5| 3| 8| 3| 3| 3| 7| 8| 8| 6| 3| 3| | 3| 8| 8| 3| 4| 7| 4| 4| 4| 7| 8| 3| 4| 0| 5| 2| 3| 5| 3| 2| 1| 1| 2| 4| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.1MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Alveolar Epithelium, Hyperplasia | 2 | Artery, Mediastinum, Inflammation | 3 | Serosa, Cyst | 2 | Serosa, Fibrosis | 2 2 3 1 2 1 1 2 3 1 2 1 2 1 2 2 2 2 2 3 2 3 1 2| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 3 1 | Olfactory Epithelium, Atrophy | 1 | Respiratory Epithelium, Degeneration,| | Hyaline | 1 | __________________________________________________________________________| Pleura | + | Mesothelium, Hyperplasia | 4 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + A + + + + +| Mineralization | 1 | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Degeneration | 4 | Cornea, Inflammation | | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + A + + + + +| Infiltration Cellular, Mast Cell | 2 | Metaplasia, Osseous | | Nephropathy | 1 1 2 2 1 2 2 1 1 2 1 2 1 1 1 1 1 1 1| Artery, Inflammation | 1 2 2 | Capsule, Hemorrhage | 4 | Renal Tubule, Hyperplasia | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + A + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 4| 7| 6| | DAY ON TEST | 6| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 3| 3| 6| 7| 8| 3| 3| 3| 3| 3| 9| 3| 2| | | 4| 4| 4| 5| 7| 3| 3| 5| 5| 5| 3| 3| 4| 3| 9| 2| 1| 4| 3| 3| 4| 4| 1| 4| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + A + + + + A + + M + + + M + + + + + + + A| 41 | Inflammation, Suppurative | | 1 1.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | Inflammation, Chronic | 2| 1 2.0| __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + A + + + + A + + + + + + + + + + + + + + +| 46 | Inflammation, Suppurative | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + M + A| 42 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +| 46 | Inflammation, Acute | | 1 1.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + A + + + + A + + + + + + + + + + + + A + +| 43 | Artery, Inflammation | 2 | 1 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X | 2 | Clear Cell Focus, Multiple | X | 2 | Eosinophilic Focus | X X X X X X X X X X X| 14 | Eosinophilic Focus, Multiple | X X | 5 | Inflammation, Chronic Active | | 1 2.0| Inflammation, Focal, Granulomatous | | 1 2.0| Mixed Cell Focus | X | 1 | Necrosis | | 2 2.5| Vacuolization Cytoplasmic | 1| 1 1.0| __________________________________________________________________________|____________| Mesentery | + + | 5 | Artery, Inflammation | 3 | 1 3.0| Fat, Necrosis | 2 | 4 2.8| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | 1 | 2 1.5| Artery, Inflammation | | 1 4.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | Infiltration Cellular | 4 | 1 4.0| Inflammation, Chronic | 2 | 1 2.0| Ulcer | 1 1 | 3 1.0| Epithelium, Hyperplasia | 2 2 3 2 1 | 8 1.9| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | Infiltration Cellular | 4 | 1 4.0| Inflammation, Suppurative | 1| 2 1.0| Necrosis, Focal | | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 4| 7| 6| | DAY ON TEST | 6| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 3| 3| 6| 7| 8| 3| 3| 3| 3| 3| 9| 3| 2| | | 4| 4| 4| 5| 7| 3| 3| 5| 5| 5| 3| 3| 4| 3| 9| 2| 1| 4| 3| 3| 4| 4| 1| 4| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Epithelium, Hyperplasia | | 1 4.0| __________________________________________________________________________|____________| Tooth | | 1 | Inflammation | | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | Inflammation | | 1 2.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1 | 42 1.2| Mineralization | 1 | 2 1.0| Artery, Inflammation | 3 2 3 1 1 2 2| 14 1.9| Epicardium, Inflammation | 3| 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | Hyperplasia | | 2 2.0| Hypertrophy | 2 1 1 1 1 2 2 1 1 2 1 1 1 | 23 1.3| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 1 | 3 1.3| __________________________________________________________________________|____________| Parathyroid Gland | M + + + + + + + + M + + + I M M M + M + + + M + +| 34 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + M + M + + + + + + + + + +| 45 | Pars Distalis, Hyperplasia | | 1 1.0| Pars Intermedia, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + A + + + + + M + + + + + + + + +| 47 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | | 1 1.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 2 3 3 2 2 2 2 2 2 3 | 19 2.5| Inflammation | 3 3 | 3 2.7| __________________________________________________________________________|____________| Prostate | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 4| 7| 6| | DAY ON TEST | 6| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 3| 3| 6| 7| 8| 3| 3| 3| 3| 3| 9| 3| 2| | | 4| 4| 4| 5| 7| 3| 3| 5| 5| 5| 3| 3| 4| 3| 9| 2| 1| 4| 3| 3| 4| 4| 1| 4| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Atrophy | 2 | 2 1.5| Interstitial Cell, Hyperplasia | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 1 3 2 | 6 2.0| __________________________________________________________________________|____________| Lymph Node | | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + M + + + + M + + + + M + + + + + + + M + + + + +| 45 | Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 40 1.0| Hyperplasia | 3 2 2 2 3 1 4 2 | 22 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + M + + + M + + M M + + M M M + M I + +| 33 | Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemorrhage | 4 | 1 4.0| Hyperplasia | 3 2 2 2 2 2 3| 10 2.2| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + M M + + + M + + + + + + + + + + +| 45 | Foreign Body | 1 1 1 1 1 1 1 1 1| 14 1.0| Hyperplasia | 2 2 3 2 2 2 2 2 2| 17 2.1| Artery, Inflammation | 1 | 2 1.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | Hematopoietic Cell Proliferation | 2 2 1 2 2 4 3 2 1 2 1 | 23 2.0| Hyperplasia, Lymphoid | 2 2 2 | 4 2.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + M A + + + + + + + + + + + + M + +| 41 | Epithelial Cell, Hyperplasia | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 2 3.0| Inflammation, Suppurative | 4 | 3 3.3| Mineralization | | 1 1.0| Ulcer | | 1 3.0| Prepuce, Inflammation, Chronic Active| 4 1 | 3 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 1 | 2 1.0| Maxilla, Fracture | | 1 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 4| 7| 6| | DAY ON TEST | 6| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 3| 3| 6| 7| 8| 3| 3| 3| 3| 3| 9| 3| 2| | | 4| 4| 4| 5| 7| 3| 3| 5| 5| 5| 3| 3| 4| 3| 9| 2| 1| 4| 3| 3| 4| 4| 1| 4| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration | | 1 1.0| Meninges, Infiltration Cellular, | | | Mononuclear Cell | 2 | 2 1.5| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Suppurative | | 1 1.0| Squamous Epithelium, Hyperplasia | 1| 4 1.3| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | X X X X X X X X X X X X X X X X X X X X X| 42 | Hemorrhage | 2 | 2 1.5| Inflammation, Chronic Active | 2 2 1 2 1 2 1 2 2 2 2 2 2 1 1 1 2 2 1 2 2 2 2| 45 1.6| Alveolar Epithelium, Hyperplasia | 4 2 | 3 2.7| Artery, Mediastinum, Inflammation | 4 | 2 3.5| Serosa, Cyst | | 1 2.0| Serosa, Fibrosis | 3 2 1 2 4 1 3 1 2 2 2 2 2 2 2 2 2 1 2 2 3 2 3 2 3| 49 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Inflammation, Suppurative | 1 1 | 4 1.5| Olfactory Epithelium, Atrophy | 1 | 2 1.0| Respiratory Epithelium, Degeneration,| | | Hyaline | 1 1 | 3 1.0| __________________________________________________________________________|____________| Pleura | + + + | 4 | Mesothelium, Hyperplasia | 1 2 1 | 4 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | Mineralization | | 1 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 3 | Degeneration | 4 | 2 4.0| Cornea, Inflammation | 1 | 1 1.0| __________________________________________________________________________|____________| Harderian Gland | + + | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Infiltration Cellular, Mast Cell | | 1 2.0| Metaplasia, Osseous | 2 1 | 2 1.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 4| 7| 6| | DAY ON TEST | 6| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 3| 3| 6| 7| 8| 3| 3| 3| 3| 3| 9| 3| 2| | | 4| 4| 4| 5| 7| 3| 3| 5| 5| 5| 3| 3| 4| 3| 9| 2| 1| 4| 3| 3| 4| 4| 1| 4| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 0.1MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 | 41 1.2| Artery, Inflammation | 3 1 3 | 6 2.0| Capsule, Hemorrhage | 4 | 2 4.0| Renal Tubule, Hyperplasia | 1 1 | 3 1.3| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 6| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7| DAY ON TEST | 3| 1| 7| 6| 3| 6| 3| 3| 3| 3| 3| 9| 1| 8| 8| 2| 0| 8| 3| 0| 6| 3| 0| 3| 3| | 4| 9| 1| 8| 3| 2| 4| 4| 3| 2| 3| 5| 5| 9| 7| 7| 6| 9| 3| 8| 2| 3| 1| 3| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + A + + + + + A + + + + A + + + + + + + A + +| Degeneration, Hyaline | 2 | Inflammation, Chronic | 3 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + A + +| Inflammation, Chronic | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + + + + A + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + A + +| __________________________________________________________________________| Intestine Small, Duodenum | + A + + + + + + + A + + + + + + + + + + + + A + +| __________________________________________________________________________| Intestine Small, Jejunum | + A + + + + + + + A + + + + + + + + + + + + + + +| Fibrosis | 3 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + A + +| Epithelium, Hyperplasia | 2 | Peyer's Patch, Hyperplasia | 1 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Eosinophilic Focus | X X X X X X X | Eosinophilic Focus, Multiple | X | Mixed Cell Focus | X | Necrosis | 2 2 2 2 2 | __________________________________________________________________________| Mesentery | + + + +| Artery, Inflammation | 3 | Fat, Inflammation | | Fat, Necrosis | 2| __________________________________________________________________________| Oral Mucosa | | __________________________________________________________________________| Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +| Atrophy | 1 | Hypertrophy | 1 | Duct, Cyst | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 2 2 | Ulcer | 1 | Epithelium, Hyperplasia | 2 2 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 2 | Necrosis, Focal | 2 | __________________________________________________________________________| Tooth | | Malformation | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Mineralization | | Artery, Inflammation | 2 3 2 2 1 2 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 6| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7| DAY ON TEST | 3| 1| 7| 6| 3| 6| 3| 3| 3| 3| 3| 9| 1| 8| 8| 2| 0| 8| 3| 0| 6| 3| 0| 3| 3| | 4| 9| 1| 8| 3| 2| 4| 4| 3| 2| 3| 5| 5| 9| 7| 7| 6| 9| 3| 8| 2| 3| 1| 3| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Atrium, Inflammation, Chronic | 4 | Atrium, Metaplasia, Osseous | 3 | Atrium, Thrombosis | 4 | Pericardium, Inflammation | 2 2 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Hypertrophy | 1 1 1 1 1 1 3 1| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + M + + + + + + + + + + + +| Hyperplasia | 1 1 1 2 2| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + + +| Hyperplasia | 3 1 | __________________________________________________________________________| Parathyroid Gland | + I + + M + + + M + + M + + M M + M + + M M M + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Intermedia, Hyperplasia | 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | 4 | Inflammation | 1 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 4 2 2 3 3 2 3 2 2| __________________________________________________________________________| Prostate | + + + + + + + + + A + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + A + + + + + + + + + + + + A + +| Congestion | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Inflammation, Granulomatous | | Interstitial Cell, Hyperplasia | 2| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Lymph Node | + + | __________________________________________________________________________| Lymph Node, Bronchial | + + + M + + + + + + + + + + + + + + + + + + + + +| Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Hyperplasia | 2 1 1 2 2 2 2 2 2 | Artery, Inflammation | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 6| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7| DAY ON TEST | 3| 1| 7| 6| 3| 6| 3| 3| 3| 3| 3| 9| 1| 8| 8| 2| 0| 8| 3| 0| 6| 3| 0| 3| 3| | 4| 9| 1| 8| 3| 2| 4| 4| 3| 2| 3| 5| 5| 9| 7| 7| 6| 9| 3| 8| 2| 3| 1| 3| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node, Mandibular | + + + M M + + + + M + M M + + M + + + M + + + M +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + M + + A + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 | __________________________________________________________________________| Lymph Node, Mediastinal | + M + + + + + + + + + + M + + + + + + + + + + + +| Foreign Body | 1 1 1 1 1 1 1 1 1| Hematopoietic Cell Proliferation | 2 | Hyperplasia | 2 2 2 2 2 2 2 2 2 4| Infiltration Cellular, Histiocyte | 4 | Artery, Inflammation | | __________________________________________________________________________| Spleen | + + + + + + + + + A + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 1| Hyperplasia, Lymphoid | 2 2| __________________________________________________________________________| Thymus | + + M + + + + + + M + + M M + M + + + M + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Prepuce, Inflammation, Chronic Active| 3 | Subcutaneous Tissue, Edema | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 2 | __________________________________________________________________________| Skeletal Muscle | + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Developmental Malformation | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 | Squamous Epithelium, Hyperplasia | 1 2 2 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | X X X X X X X X X X X X X X X X X X X X X X X X X| Hemorrhage | 1 1 | Infiltration Cellular, Mast Cell | | Inflammation, Chronic Active | 2 2 1 3 3 3 2 2 2 2 3 2 4 2 2 2 1 2 2 2 1 3 2| Alveolar Epithelium, Hyperplasia | 2 1 1 1 | Alveolus, Proteinosis | 1 1 1 | Serosa, Fibrosis | 2 2 1 2 2 2 2 2 2 1 4 2 2 4 3 3 4 3 1 1 3 2 2 4 2| Serosa, Metaplasia, Osseous | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 6| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7| DAY ON TEST | 3| 1| 7| 6| 3| 6| 3| 3| 3| 3| 3| 9| 1| 8| 8| 2| 0| 8| 3| 0| 6| 3| 0| 3| 3| | 4| 9| 1| 8| 3| 2| 4| 4| 3| 2| 3| 5| 5| 9| 7| 7| 6| 9| 3| 8| 2| 3| 1| 3| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0.3MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Olfactory Epithelium, Atrophy | | Respiratory Epithelium, Degeneration,| | Hyaline | 1 1 1 1 | __________________________________________________________________________| Pleura | + + + + | Mesothelium, Hyperplasia | 1 1 4 1 | __________________________________________________________________________| Trachea | + + + + + + + + + A + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Cornea, Inflammation | | __________________________________________________________________________| Harderian Gland | + | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | 2 | Inflammation, Chronic Active | 1 2| Metaplasia, Osseous | | Nephropathy | 2 1 1 1 1 1 1 1 3 1 1 3 1 1 1 1 3 2 1 1| Artery, Inflammation | 1 | Capsule, Inflammation, Chronic | | Renal Tubule, Hyperplasia | 1 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + + + + +| Degeneration | 2 | Inflammation | 3 | Transitional Epithelium, Hyperplasia | 3 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 4| 7| 7| | DAY ON TEST | 3| 4| 7| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 3| 6| 1| 3| 3| 3| 7| 3| 3| | | 4| 5| 0| 4| 3| 4| 3| 5| 4| 3| 5| 5| 4| 8| 3| 4| 3| 4| 5| 3| 3| 3| 1| 4| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + A A M + + + + M + + + + A + + + + A + + + A I +| 38 | Degeneration, Hyaline | 2 | 2 2.0| Inflammation, Chronic | | 1 3.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + A + +| 46 | Inflammation, Chronic | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + A + +| 46 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + + A + +| 46 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + A + + + + + + + + + + A + + + + + + + + A + +| 44 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + A + + + + A + + + + + A + + + + + + + + A + +| 44 | Fibrosis | | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + A + + + + + + + + + + A + + + + + + + + A + +| 45 | Epithelium, Hyperplasia | | 1 2.0| Peyer's Patch, Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Eosinophilic Focus | X X X | 10 | Eosinophilic Focus, Multiple | X X X X X X X| 8 | Mixed Cell Focus | | 1 | Necrosis | 1 3 | 7 2.0| __________________________________________________________________________|____________| Mesentery | + + + + | 8 | Artery, Inflammation | | 1 3.0| Fat, Inflammation | 2 | 1 2.0| Fat, Necrosis | 2 2 2 | 4 2.0| __________________________________________________________________________|____________| Oral Mucosa | A | | __________________________________________________________________________|____________| Pancreas | + + A + + + + + + + + + + + + + + + + + + + A + +| 47 | Atrophy | 1 | 2 1.0| Hypertrophy | 2 | 2 1.5| Duct, Cyst | 4 | 1 4.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erosion | | 2 2.0| Ulcer | | 1 1.0| Epithelium, Hyperplasia | 4 2 | 5 2.4| __________________________________________________________________________|____________| Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + A + +| 47 | Inflammation, Suppurative | | 2 2.0| Necrosis, Focal | | 1 2.0| __________________________________________________________________________|____________| Tooth | + + | 2 | Malformation | X X | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 4| 7| 7| | DAY ON TEST | 3| 4| 7| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 3| 6| 1| 3| 3| 3| 7| 3| 3| | | 4| 5| 0| 4| 3| 4| 3| 5| 4| 3| 5| 5| 4| 8| 3| 4| 3| 4| 5| 3| 3| 3| 1| 4| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1| 41 1.0| Mineralization | 1 | 1 1.0| Artery, Inflammation | 3 2 2 1 | 10 2.0| Atrium, Inflammation, Chronic | | 1 4.0| Atrium, Metaplasia, Osseous | | 1 3.0| Atrium, Thrombosis | 2 | 2 3.0| Pericardium, Inflammation | 2 2 | 5 2.2| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 | 1 2.0| Hypertrophy | 1 1 1 1 1 1 1 1 2 1 1 | 19 1.2| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 | 6 1.5| __________________________________________________________________________|____________| Islets, Pancreatic | + + A + + + + + + + + + + + + + + + + + + + A + +| 47 | Hyperplasia | 2 1 | 4 1.8| __________________________________________________________________________|____________| Parathyroid Gland | + + M + + M + + + + M + M M + + + + M + + + + + +| 34 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Intermedia, Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granuloma Sperm | 2 | 2 3.0| Inflammation | 1 | 2 1.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 | Ectasia | 4 2 2 2 3 2 2 2 2 2 | 20 2.4| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + I + + + + + + + + + + + +| 48 | Inflammation, Suppurative | | 1 2.0| __________________________________________________________________________|____________| Seminal Vesicle | + + A + + + + + + + + + + + + + + + + + + + + + +| 47 | Congestion | 4 | 1 4.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 1 | 2 1.0| Inflammation, Granulomatous | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 4| 7| 7| | DAY ON TEST | 3| 4| 7| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 3| 6| 1| 3| 3| 3| 7| 3| 3| | | 4| 5| 0| 4| 3| 4| 3| 5| 4| 3| 5| 5| 4| 8| 3| 4| 3| 4| 5| 3| 3| 3| 1| 4| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Interstitial Cell, Hyperplasia | 1 | 2 1.5| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 | 4 2.0| __________________________________________________________________________|____________| Lymph Node | | 2 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 | Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 40 1.0| Hyperplasia | 2 2 3 2 2 2 2 2 2 2 3 2 2| 22 2.0| Artery, Inflammation | 1 | 1 1.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + M M + + + + + M + + M + M + + M + + +| 36 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + M + + + + + M + + + + + + + + A + +| 45 | Hyperplasia | 4 2 2 2 2 2 2| 10 2.2| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 25 1.0| Hematopoietic Cell Proliferation | | 1 2.0| Hyperplasia | 2 2 2 2 2 2 2 3 4 3 2 2 2 2 2 2 2 | 27 2.2| Infiltration Cellular, Histiocyte | | 1 4.0| Artery, Inflammation | 2 | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 | Hematopoietic Cell Proliferation | 2 2 2 1 2 2 2 1 2 1 1 2 | 29 1.9| Hyperplasia, Lymphoid | 2 | 3 2.0| __________________________________________________________________________|____________| Thymus | + + M M + + M + + M + M M + M M + + + M + + + + +| 35 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Prepuce, Inflammation, Chronic Active| 2 4 | 3 3.0| Subcutaneous Tissue, Edema | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 2 | 2 2.0| __________________________________________________________________________|____________| Skeletal Muscle | | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Developmental Malformation | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 4| 7| 7| | DAY ON TEST | 3| 4| 7| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 3| 6| 1| 3| 3| 3| 7| 3| 3| | | 4| 5| 0| 4| 3| 4| 3| 5| 4| 3| 5| 5| 4| 8| 3| 4| 3| 4| 5| 3| 3| 3| 1| 4| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 1 1 1 | 4 1.0| Squamous Epithelium, Hyperplasia | 2 2 2 1 | 7 1.7| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | X X X X X X X X X X X X X X X X X X X X X X X X| 49 | Hemorrhage | | 2 1.0| Infiltration Cellular, Mast Cell | 4 | 1 4.0| Inflammation, Chronic Active | 2 2 2 2 2 2 1 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 46 2.1| Alveolar Epithelium, Hyperplasia | 4 2 4 | 7 2.1| Alveolus, Proteinosis | 1 1 1 1 1 1 1 | 10 1.0| Serosa, Fibrosis | 3 4 3 3 2 2 1 4 3 3 1 1 3 4 2 3 3 2 3 4 2 2 1 3 2| 50 2.4| Serosa, Metaplasia, Osseous | | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 1 1 1 1 | 5 1.0| Olfactory Epithelium, Atrophy | 1 | 1 1.0| Respiratory Epithelium, Degeneration,| | | Hyaline | | 4 1.0| __________________________________________________________________________|____________| Pleura | + + | 6 | Mesothelium, Hyperplasia | 1 1 | 6 1.5| __________________________________________________________________________|____________| Trachea | + + A + + + + + + + + + + + + + + + + + + + A + +| 47 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | Cornea, Inflammation | 3 | 1 3.0| __________________________________________________________________________|____________| Harderian Gland | + | 2 | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Amyloid Deposition | 4 | 2 3.0| Inflammation, Chronic Active | | 2 1.5| Metaplasia, Osseous | 1 | 1 1.0| Nephropathy | 1 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1 1| 41 1.2| Artery, Inflammation | 2 | 2 1.5| Capsule, Inflammation, Chronic | 2 | 1 2.0| Renal Tubule, Hyperplasia | 1 1 1| 5 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + A + + + + + + + + + + + + + + + + + + + A + +| 47 | Degeneration | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88124-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:21 __________________________________________________________________________________________________________________________________ | 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 4| 7| 7| | DAY ON TEST | 3| 4| 7| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 3| 6| 1| 3| 3| 3| 7| 3| 3| | | 4| 5| 0| 4| 3| 4| 3| 5| 4| 3| 5| 5| 4| 8| 3| 4| 3| 4| 5| 3| 3| 3| 1| 4| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 0.3MG/M3 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Inflammation | | 1 3.0| Transitional Epithelium, Hyperplasia | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------