US 7,365,201 B2
	Process for the preparation of the boron difluoride chelate of quinolone-3-carboxylic acid
Zhi-Xian Wang, Brantford (Canada); Murali Kondamreddy, Brantford (Canada); Joseph DiMartino, Brantford (Canada); and Bhaskar Reddy Guntoori, Brantford (Canada)
Assigned to Apotex Pharmachem Inc., Brantford, ON (US)
Filed on Mar. 02, 2006, as Appl. No. 11/365,598.
Prior Publication US 2007/0208174 A1, Sep. 06, 2007
Int. Cl. C07F 5/02 (2006.01); C07D 491/08 (2006.01)

U.S. Cl. 546—13  [546/90]

2 Claims

1. A process for the preparation of boron difluoride chelate of 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolone carboxylic acid comprising reacting 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolone carboxylic acid ethyl ester with fluoroboric acid in the presence of poly(methylhydrosiloxane).