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ABSTRACT:
Hoi-Ying
Holman has developed the only existing intravascular diagnostic
method that is robust enough for the early and accurate identification
of vulnerable atherosclerotic plaques. While other techniques
focus on plaque structure and activity, this invention is
the first based on the pathology and chemistry of inflammatory
cells in plaques - crucial factors that determine heart attack
risk. This photonic method, which does not use labeling compounds,
will also minimize risks to patients while improving scientists'
and physicians' ability to monitor the effects of medical
treatment on plaques.
The invention detects cholesterol accumulation, thin fibrous
caps, foam cells, infiltrated inflammatory cells, excessive
NO production, and excessive apoptotic/necrotic cells. |
