Proportional Ventilation and Ventilatory Synchronism - Full Text View

Sponsored by:	Hospices Civils de Lyon
Information provided by:	Hospices Civils de Lyon
ClinicalTrials.gov Identifier:	NCT00133939

Purpose

Synchronism of gas flow delivered by the ventilator and muscular effort of the patient will be studied during two kinds of ventilation. The first one is the proportional assisted ventilation during which the gas flow is theoretically adapted to the patient's muscular effort within the breath. The second is the pressure support ventilation during which the gas flow is delivered to maintain the inspiratory pressure stable. The hypothesis is that the first mode allows a better synchronism.

Condition	Intervention
Mechanical Ventilation	Procedure: Mechanical ventilation

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Non-Randomized, Open Label, Uncontrolled, Crossover Assignment, Efficacy Study
Official Title:	Proportional Ventilation and Ventilatory Synchronism

Further study details as provided by Hospices Civils de Lyon:

Primary Outcome Measures:

Time lag between the onset of diaphragmatic electromyogram (EMG) signal and the zero crossing of the inspiratory flow, over five minutes

Secondary Outcome Measures:

Number per minute of failing breaths: breath with muscular effort without any inspiratory flow

Estimated Enrollment:

10

Eligibility

Ages Eligible for Study:	18 Years to 80 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Patients undergoing partial ventilatory support

Exclusion Criteria:

Patients failing the weaning process

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00133939

Contacts

Contact: Jean-Paul VIALE, MD, PhD

33 472 072 ext 426

jean-paul.viale@chu-lyon.fr

Locations

France
Hôpital de la Croix-Rousse	Recruiting
LYON, France, 69317
Contact: Jean-Paul VIALE, MD, PhD 33 472 072 ext 426 jean-paul.viale@chu-lyon.fr
Principal Investigator: Jean-Paul VIALE, MD, PhD

Sponsors and Collaborators

Hospices Civils de Lyon

Investigators

Principal Investigator:

Jean-Paul VIALE, MD, PhD

Hospices Civils de Lyon

More Information

Publications:

Ganne O, Abisseror M, Menault P, Malhiere S, Chambost V, Charpiat B, Ganne C, Viale JP. Low-dose ketamine failed to spare morphine after a remifentanil-based anaesthesia for ear, nose and throat surgery. Eur J Anaesthesiol. 2005 Jun;22(6):426-30.

Mechet I, Lhuillier F, Blanchet MC, Pouyet M, Viale JP, Goudable J, Annat G, Scoazec JY, Boillot O, Liotard D, Merle E, Delafosse B. Liver function during extracorporeal whole liver perfusion in a pig model of acute ischemic liver failure. ASAIO J. 2004 Sep-Oct;50(5):503-11.

Study ID Numbers:	2004.359
Study First Received:	August 23, 2005
Last Updated:	April 26, 2007
ClinicalTrials.gov Identifier:	NCT00133939
Health Authority:	France: Afssaps - French Health Products Safety Agency

Keywords provided by Hospices Civils de Lyon:

Proportional assisted ventilation
Pressure support ventilation
Synchronism during mechanical ventilation
Patients undergoing partial mechanical ventilation

ClinicalTrials.gov processed this record on February 09, 2009