National Toxicology Program

Selected toxicity information from HSDB, one of the National Library of Medicine's databases. ¹

Names (NTP)

• PENTAMETHYLENE
• Cyclopentane

Human Toxicity Excerpts

• MODERATELY TOXIC BY INGESTION AND INHALATION. [Sax, N.I. and R.J. Lewis, Sr. (eds.). Hawley's Condensed Chemical Dictionary. 11th ed. New York: Van Nostrand Reinhold Co., 1987., p. 339]**PEER REVIEWED**
  
• Cyclopentane is a CNS depressant and lipid solvent. [Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994., p. 1272]**PEER REVIEWED**
  

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Non-Human Toxicity Excerpts

• Experiments with mice have demonstrated that no safety margin exists between minimal /SRP: CNS depressant/ ... concentration, loss of reflexes, and lethal dose, all occurring at 110 mg/l. When ingested, cyclopentane presented a low to moderate aspiration hazard in mice. Cyclopentane applied to guinea pig skin produced slight erythema and dry appearance. [Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994., p. 1272]**PEER REVIEWED**
  
• The acute toxicities of aqueous soln of 33 hydrocarbons, including cyclopentane, and chlorinated hydrocarbons to Daphnia magnia were measured in a closed bioassay system. For these substances, toxicity was primarily determined by solubility, although cmpd-specific effects were also present. [Bobra AM et al; Chemosphere 12 (9-10): 1121-30 (1983)]**PEER REVIEWED**
  
• Inhalation effects of cyclopentane (8110 ppm 6 hr/day x 12 weeks) resulted in decreased body weight gains in female rats. /From table/ [Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994., p. 1270]**PEER REVIEWED**
  
• WHEN APPLIED TO GUINEA PIG SKIN, UNDILUTED ALICYCLIC HYDROCARBONS CAUSE MORPHOLOGICAL CHANGES (EPIDERMAL THICKENING) AND ALTER EPIDERMAL SOLUBLE ARGINASE ACTIVITY. FOR BOTH CHANGES, THE CHANGES WERE IN THE SEQUENCE: CYCLOOCTANE > CYCLOHEPTANE > CYCLOHEXANE AND CYCLOPENTANE. FOR THE THREE UNDILUTED ALICYCLIC ALKANES AFTER 3 APPLICATIONS ON ALTERNATE DAYS, SKIN IRRITANCY ASSESSED BY GROSS OBSERVATION OF THE SKIN OF GUINEA PIGS WAS SLIGHT, WITH ERYTHEMA AND DRY APPEARANCE. [BROWN VK H, BOX VL; BRIT J DERMATOL; 85(5) 432 (1971)]**PEER REVIEWED**
  

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Human Toxicity Values

• None found

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Non-Human Toxicity Values

• None found

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Absorption, Distribution and Excretion

• None found

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Metabolism/Metabolites

• None found

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TSCA Test Submissions

• None found

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Footnotes

¹ Source: the National Library of Medicine's Hazardous Substance Database, 10/28/2007.