Potential subjects for the study will be identified MSKCC's clinic.

Non-cancer control group participants will be recruited through advertisements and flyers and by asking survivors if they have a friend who might want to volunteer for the study.

Inclusion Criteria:

• Patient is 18 years of age but not older than 70yrs of age
• Stage I, II and III A breast cancer
• Patient is female
• Patient is able to understand English, through verbal and written communication
• Patient is able to provide informed consent
• Patient has a diagnosis of breast cancer, limited to localized disease
• Patient is chemotherapy naïve and is receiving AC-T therapy or is scheduled to receive no chemotherapy as part of adjuvant treatment

Exclusion Criteria:

• Patient has documented evidence of cognitive compromise (Mini-Mental State Exam score > 20 administered prior to enrollment) or a history neurological disorder with cognitive symptoms (e.g., Alzheimer's disease, Parkinson's disease, multiple sclerosis)
• Metal implants that preclude fMRI evaluation
• Pregnant or lactating
• Participant is currently on medication for migraine, diabetes or uncontrollable hypertension
• Participant has a reported fear of enclosed spaces (Claustrophobic)
• Participant has any of the following items that preclude fMRI evaluation
• Cardiac pacemaker, Joint replacements, Aneurysm clips, Transdermal patched, Aortic clips Prosthesis, Intracranial bypass clips, Harrington rod , Coronary Artery bypass clips, Biostimulator, Renal Transplant Clips, Bone or joint pins, Other vascular clips or filters, Tissue expander ,Implanted neurostimulators, Metal mesh, Artificial heart valve, Stents, Insulin pump, Wire structures, Electrodes, Shrapnel/bullets, Hearing Aids implant, Implanted electrical devices, IUD, Metal in eyes, Shunts, Ocular Implants, Hair extensions, Hair implants, Tattoos above the waist, Any possible metal in body
• Participant has dentures, body jewelry or wig that they are unable to remove

History of head injury with evidence of brain injury or loss of consciousness for > 60 minutes or cognitive sequelae

• Untreated or current episode of depression (answering positively to either of the two screening questions from the PHQ-9 (Kroenke, et al., 2001)
• Self-reported sleep disorders that could influence cognitive functioning including sleep apnea and chronic fatigue syndrome
• History of Axis I psychiatric disorder (DSM-IV), major affective disorder (untreated), bipolar disorder, schizophrenia disorder (DSM-IV) or substance use disorders (self reported and/or stated in medical record)
• History of schizophrenia, bipolar disorder or substance use disorders
• Patient is unwilling to undergo fMRI component if selected
• Patient has undergone previous chemotherapy treatment

Healthy Control Inclusion Criteria:

• 18 years of age or older
• Female
• Able to understand English, through verbal and written communication
• Able to provide informed consent
• Participant is able to undergo MRI scanning (verified with pre MRI Safety Screening form.)

Healthy Control Exclusion Criteria:

• Documented evidence of severe cognitive compromise or a neurological disorder with cognitive symptoms (e.g., Alzheimer's disease, Parkinson's disease, multiple sclerosis).
• Metal implants that preclude fMRI evaluation
• Pregnant or lactating
• Participant is currently on medication for migraine, diabetes or uncontrollable hypertension
• Participant has a reported fear of enclosed spaces (Claustrophobic)
• Participant has any of the following items that preclude fMRI evaluation Cardiac pacemaker, Joint replacements, Aneurysm clips, Transdermal patched, Aortic clips Prosthesis, Intracranial bypass clips, Harrington rod , Coronary Artery bypass clips, Biostimulator, Renal Transplant Clips, Bone or joint pins, Other vascular clips or filters, Tissue expander ,Implanted neurostimulators, Metal mesh, Artificial heart valve, Stents, Insulin pump, Wire structures, Electrodes, Shrapnel/bullets, Hearing Aids implant, Implanted electrical devices, IUD, Metal in eyes, Shunts, Ocular Implants, Hair extensions, Hair implants, Tattoos above the waist, Any possible metal in body
• Participant has dentures, body jewelry or wig that they are unable to remove
• History of head injury with evidence of brain injury or loss of consciousness for > 60 minutes or cognitive sequelae
• Untreated or current episode of depression (answering positively to either of the two screening questions from the PHQ-9 (Kroenke, et al., 2001)
• Self-reported sleep disorders that could influence cognitive functioning including sleep apnea and chronic fatigue syndrome
• History of Axis I psychiatric disorder (DSM-IV), major affective disorder (untreated), bipolar disorder, schizophrenia disorder (DSM-IV) or substance use disorders (self reported and/or stated in medical record)
• History of schizophrenia, bipolar disorder or substance use disorders
• Unwilling to undergo fMRI component if selected
• Exposure to chemotherapy for non-cancer medical disorder
• Previous diagnosis of other cancer, except non-melanoma skin cancer