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Title Genotoxic effects of sunlight-activated waste water in cultured mammalian cells
Creator/Author Strniste, G.F. ; Chen, D.J. ; Okinaka, R.T.
Publication Date1982 Jul 01
OSTI IdentifierOSTI ID: 6707380
Other Number(s)CODEN: JJIND
Resource TypeJournal Article
Resource RelationJNCI, J. Natl. Cancer Inst. ; Vol/Issue: 69:1
Research OrgLos Alamos National Laboratory, NM
Subject560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987) ;040700 -- Oil Shales & Tar Sands-- Health & Safety; ;CELL CULTURES-- SENSITIVITY;OIL SHALES-- TOXICITY; FIBROBLASTS;MUTAGENESIS;MUTATION FREQUENCY;NEAR ULTRAVIOLET RADIATION;OVARIES;PHOSPHOTRANSFERASES;PHOTOSENSITIVITY;SKIN;VISIBLE RADIATION;WASTE WATER
Related SubjectANIMAL CELLS;BITUMINOUS MATERIALS;BODY;CARBONACEOUS MATERIALS;CONNECTIVE TISSUE CELLS;ELECTROMAGNETIC RADIATION;ENERGY SOURCES;ENZYMES;FEMALE GENITALS;FOSSIL FUELS;FUELS;GONADS;HYDROGEN COMPOUNDS;LIQUID WASTES;MATERIALS;ORGANS;OXYGEN COMPOUNDS;PHOSPHORUS-GROUP TRANSFERASES;RADIATIONS;SENSITIVITY;SOMATIC CELLS;TRANSFERASES;ULTRAVIOLET RADIATION;WASTES;WATER
Description/Abstract Cultured Chinese hamster ovary cells were incubated with dilutions of an oil shale retort process water and exposed to nautral sunlight.^An enhancement of sevenfold to ninefold was seen in photoinduced cytotoxicity (by a colony-forming assay) and mutagenicity (at the hypoxanthine phosphoribosyltransferase (HPRT) locus) for cells pretreated with the process water compared to effects seen in cells exposed to sunlight only.^Significant photoinduced cytotoxicity was also observed in cultured human skin fibroblasts when exposed to the process water before being exposed to near UV (NUV) radiation.^The mutation frequencies (determined for the HPRT locus) induced by the process water and NUV radiation were as great as those frequencies seen for far UV light alone.^Increases in genotoxicity were observed in excision repair-deficient xeroderma pigmentosum skin fibroblasts when compared to the responses seen in normal cells.^Risks to health resulting from the phototransformation of these oil shale retort process waste waters are unassessed at this time.
Country of PublicationUnited States
LanguageEnglish
FormatPages: 199-203
System Entry Date2001 May 13

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