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National Institute of Child Health and Human Development (NICHD)

Fetal Diagnosis and Therapy in the Third Millennium
September 22 – 23, 2000 • Leuven, Belgium

Agenda

Friday, September 22
Welcome
S Groft, Bethesda (USA) & F A Van Assche, KU Leuven
H. Hyatt-Knorr, ORD, NIH
Prenatal Diagnosis and Screening, Invasive Procedures
Chairs: F de la Cruz, Bethesda, MD (USA) & JP Fryns & E Gratacos, Leuven (BE)
Biochemical screening for Down syndrome
H Cuckle, London (UK)
Early ultrasound as a screening for fetal malformations
K Nicolaides, London (UK)
The 1990s: Chorion villus sampling and amniocentesis: Early, late or … in between?
L Jackson, Philadelphia (USA)
Societal aspects of genetic screening and diagnosis
U Nicolini, Milano (IT)
Wider issues in genetic testing and screening
P Harper, Cardiff (UK)
What does society expect from and is willing to accept: The case of early anomaly screening of fetuses?
P Koch, Swiss Federal Office of Social Security, Bern (CH)
Chairs: Y Ville, Paris (F), M Evans, Detroit (USA) & M Johnson, Philadelphia (USA)
Embryo-reduction and selective feticide
M Evans, Detroit (USA)
Invasive testing in multiplets
L De Catte, Brussels (BE)
Embryoscopy
Y Ville, Paris (F)
The invasiveness of ultrasound based procedures: Instrumentation, complications related to techniques used and the fetal condition, learning curve, and training.
C Weiner, Baltimore (USA)
The Eurofoetus-Registry of fetoscopic procedures
E Gratacos, Leuven (B)
Latrogenic ruptured membranes: Healing dynamics and potential therapy
J Deprest, Leuven (B)
Amniocentesis in preterm labour and PPROM
Y Ville, Paris (F)
Intra-Uterine Transfusion
Chairs: U Nicolini, Milano (I) C Weiner, Baltimore (USA)
Severe fetal anemia after 32 weeks: Intra-uterine transfusion or neonatal intensive care unit ?
F Vandenbussche, Leiden (NL) & Leuven (B)
Accuracy of invasive versus non-invasive testing for severe fetal anemia
D Oepkes, Toronto (CAN)
Non Rh-immunisation
K Moise, Chapel Hill (USA)
New Pathways and Insights in Fetal Diagnosis and Therapy
Chairs: T-H Bui, Stockholm (S), F de la Cruz, Bethesda, MD (USA) & J J Cassiman, Leuven (B)
Non-invasive diagnosis: Fetal cells in maternal blood
D Bianchi, Boston (USA)
In utero gene therapy
C Coutelle, London (UK)
In utero stem cell transplantation
T-H Bui, Stockholm (S)
The potential of embryonic stem cells in fetal therapy
M Westgren, Stockholm (S)
Operative Fetoscopy and Fetal Surgery
Chairs: F Chervenak, New York (USA), K Hecher, Hamburg (D) & H Devlieger, Leuven (B)
Ethical Aspects

Fetal nociception and stress responsiveness
N Fisk, London (UK)

Ethics of in utero surgery
M Whittle, Birmingham (UK)
Obstetrical Endoscopy

Twin-to-Twin Transfusion Syndrome
K Hecher, Hamburg (D)

Amniodrainage and septostomy in TTTS
C Hubinont, Brussels (B)
Selective feticide in monochorionic twins with one non-viable foetus
J Deprest, Leuven (B)
Congenital diaphragmatic hernia
Chairs: M Harrison, San Francisco (USA), T Lerut, Leuven (B) & M Johnson, Philadelphia (USA)
Congenital diaphragmatic hernia as part of malformation syndromes
J P Fryns, Leuven (BE)
Results from post-natal treatment for congenital diaphragmatic hernia and strategy to identify candidates for in utero surgery
T Tracy, Providence (USA)
In utero imaging for diaphragmatic hernia: Prenatal prognostic indicators
M Dommergues, Paris (F)
Requirements for in utero surgery: Diaphragmatic hernia as a model
F Luks, Providence (USA)
Perinatal hormonal ‘surgery’, can we identify the proper patient on an individual base ?
D Tibboel, Rotterdam (NL)
In utero surgery for CDH – criteria and clinical results
M Harrison, San Francisco (USA)
Lung lesions and lower urinary tract obstruction

Lung lesions: Natural history, selection criteria, and in utero surgery
M Harrison, San Francisco (USA)
Lower urinary tract obstruction: Pathophysiology & new pathways in diagnosis and therapy
M P Johnson, Philadelphia (USA)
In utero shunting: Selection criteria, results, and outcome
C Rodeck, London (UK)
Central nervous system
Chairs: P Casaer, Leuven (B) & M Johnson, Philadelphia (USA)
Myelomeningocele and hydrocephalus: Rationale, criteria and results for in utero surgery
J Bruner, Nashville (USA)
The case for or against in utero surgery for neural tube defects and hydrocephalus
C Bannister, Manchester (UK)
Ethics of in utero surgery for non-lethal conditions
F Chervenak, New York (USA)
Organisation of fetal medicine in a European perspective
W Holzgreve, Basel (CH)

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Last Reviewed: October 7, 2003
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