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 EC-number:  1.13.12.7 ----- Photinus-luciferin 4-monooxygenase (ATP-hydrolysing)
EC-NUMBER 1.13.12.7
ENZYME-NAME Photinus-luciferin 4-monooxygenase (ATP-hydrolysing)
ENZYME-SYSNAME Photinus (firefly) is a bioluminescent insect. The first step in the reaction is the formation of an acid anhydride between the carboxylic group and AMP, with the release of diphosphate. The enzyme may be assayed by measurement of light emission.
ENZYME-CLASS Oxidoreductases Acting on single donors with incorporation of molecular oxygen (oxygenases) With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
SYNONYMS Photinus luciferin 4-monooxygenase (adenosine; Photinus pyralis luciferase; Photinus-luciferin 4-monooxygenase (ATP-hydrolysing);; firefly luciferase;;   >>more synonyms
REACTION Photinus luciferin + O2 + ATP = oxidized Photinus luciferin + CO2 + AMP + diphosphate + hn [RN:R04036]
PATHWAY EMP-PATHWAYS: NO EMP PATHWAY FOUND
KEGG-PATHWAYS: NO KEGG PATHWAY FOUND
GO_TERM GO:0047077:Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity
ENZYME-COMMENT Photinus-luciferin:oxygen 4-oxidoreductase (decarboxylating, ATP-hydrolysing)
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ExternalDB ----- DBLINKS
Diseases
Structure
Gene
Motif
Ortholog
Literature
Other
InterPro Domains found in sequences annotated as EC 1.13.12.7
   IPR000051 SAM (and some other nucleotide) binding motif
   IPR000215 Proteinase inhibitor I4, serpin
   IPR000379 Esterase/lipase/thioesterase
   IPR000873 AMP-dependent synthetase and ligase
   IPR001031 Thioesterase
   IPR001242 Condensation domain
   IPR001601 Generic methyltransferase
   IPR002016 Haem peroxidase, plant/fungal/bacterial
   IPR006162 Phosphopantetheine attachment site
   IPR006163 Phosphopantetheine-binding
   IPR009081 Acyl carrier protein-like
   IPR010071 Amino acid adenylation
   IPR013216 Methyltransferase type 11
   IPR013217 Methyltransferase type 12
       
PIR SuperFamilies containing EC 1.13.12.7
SF001552 4-coumarate-CoA ligase
Taxonomic breakdown of EC 1.13.12.7 sequences
To perform phylogenetic analysis, first select some protein ids by clicking on their checkboxes, then click on one of the buttons below.
  Additional gi numbers:   
Bacteria
Cyanobacteria
Anabaena variabilis
75812663
IPR000051 SAM (and some other nucleotide) binding motif
IPR000379 Esterase/lipase/thioesterase
IPR000873 AMP-dependent synthetase and ligase
IPR001031 Thioesterase
IPR001242 Condensation domain
IPR001601 Generic methyltransferase
IPR002016 Haem peroxidase, plant/fungal/bacterial
IPR006162 Phosphopantetheine attachment site
IPR006163 Phosphopantetheine-binding
IPR009081 Acyl carrier protein-like
IPR010071 Amino acid adenylation
IPR013216 Methyltransferase type 11
IPR013217 Methyltransferase type 12
Eukaryota
Arthropoda
Insecta
Lampyris noctiluca
899315
IPR000215 Proteinase inhibitor I4, serpin
IPR000873 AMP-dependent synthetase and ligase
Lampyris turkestanicus
52631875
IPR000215 Proteinase inhibitor I4, serpin
IPR000873 AMP-dependent synthetase and ligase
Luciola cruciata
126500
IPR000873 AMP-dependent synthetase and ligase
Luciola lateralis
9527
IPR000873 AMP-dependent synthetase and ligase
Luciola mingrelica
409317
IPR000873 AMP-dependent synthetase and ligase
Photinus pyralis
160794
IPR000873 AMP-dependent synthetase and ligase
1469266
IPR000873 AMP-dependent synthetase and ligase
1469268
IPR000873 AMP-dependent synthetase and ligase
Photuris pennsylvanica
41688574
IPR000873 AMP-dependent synthetase and ligase
Pyrophorus plagiophthalamus
33333113
IPR000873 AMP-dependent synthetase and ligase
Chordata
Mammalia
Mus musculus
74196295
IPR000873 AMP-dependent synthetase and ligase
  Additional gi numbers:   

To perform phylogenetic analysis:

  1. Select some ids by clicking on their checkboxes.
  2. Click on one of the buttons above.