# cumulative hits at level: 4 from root 
# for molecular.clean
hematopoietin/interferon-class (D200-domain) cytokine receptor activity	1
ATP-dependent peptidase activity	20
DNA replication origin binding	1
peptide disulfide oxidoreductase activity	7
purine nucleotide transporter activity	11
RNA ligase activity	32
kinase activity	874
transition metal ion transporter activity	40
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	12
N-acetyldiaminopimelate deacetylase activity	1
formate-tetrahydrofolate ligase activity	3
transmembrane receptor protein tyrosine kinase docking protein activity	1
neutral amino acid transporter activity	1
cystathionine gamma-synthase activity	12
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	19
biotin carboxylase activity	1
glutamate synthase activity	2
myosin binding	3
racemase and epimerase activity, acting on carbohydrates and derivatives	34
anion:cation symporter activity	29
aldehyde-lyase activity	60
sodium ion transporter activity	25
CoA desaturase activity	5
ATP-dependent RNA helicase activity	13
eukaryotic elongation factor-2 kinase regulator activity	7
beta-amyrin synthase activity	2
oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor	2
oxidoreductase activity, oxidizing metal ions, oxygen as acceptor	10
ether hydrolase activity	7
transferase activity, transferring alkylthio groups	1
MHC class I protein binding	9
thiamin pyridinylase activity	1
porter activity	176
steroid hormone receptor activity	6
basic amino acid transporter activity	2
nitric oxide reductase activity	1
receptor inhibitor activity	3
SH3 domain binding	1
3-deoxy-8-phosphooctulonate synthase activity	1
amino acid-polyamine transporter activity	29
G-protein coupled photoreceptor activity	37
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	164
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles	2
amine-lyase activity	3
nuclear localization sequence binding	1
MAP kinase kinase kinase activity	5
NADPH dehydrogenase (quinone) activity	1
kinesin binding	3
protein kinase inhibitor activity	15
Rab GTPase activator activity	1
protein disulfide oxidoreductase activity	2
sulfurtransferase activity	9
MAP kinase kinase kinase kinase activity	1
3-oxo-5-beta-steroid 4-dehydrogenase activity	10
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	3
transmembrane receptor protein kinase activity	24
ligase activity, forming aminoacyl-tRNA and related compounds	32
CoA carboxylase activity	1
1-aminocyclopropane-1-carboxylate synthase activity	9
cytokinin dehydrogenase activity	1
nuclease activity	199
solute:cation symporter activity	53
GMP synthase activity	1
dimethylallyltranstransferase activity	7
oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor	15
chitin binding	58
oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	21
DNA topoisomerase type I activity	1
potassium ion transporter activity	5
acyl-CoA binding	7
NAD binding	19
pseudouridine synthase activity	8
water channel activity	38
argininosuccinate synthase activity	3
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	581
NF-kappaB-inducing kinase activity	2
methyltransferase activity	165
actin binding	96
syntaxin binding	19
transferase activity, transferring amino-acyl groups	4
spectrin binding	2
3-phosphoshikimate 1-carboxyvinyltransferase activity	3
lactoylglutathione lyase activity	20
acyl-CoA dehydrogenase activity	17
malate dehydrogenase activity	30
solute:cation antiporter activity	12
trialkylsulfonium hydrolase activity	8
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	6
arsenate reductase (glutaredoxin) activity	3
tetracycline transporter activity	10
mRNA binding	42
rubredoxin-NAD+ reductase activity	3
magnesium ion transporter activity	1
cytochrome-c oxidase activity	11
phosphotransferase activity, for other substituted phosphate groups	2
methionine adenosyltransferase activity	33
methionine gamma-lyase activity	3
oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor	18
adenyl nucleotide binding	1171
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	7
protein kinase CK2 regulator activity	1
RNA splicing factor activity, transesterification mechanism	21
ubiquinol-cytochrome-c reductase activity	15
cAMP-dependent protein kinase regulator activity	10
tRNA binding	45
oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor	4
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	126
double-stranded RNA binding	3
oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor	1
DNA bending activity	1
di-, tri-valent inorganic cation transporter activity	44
dicarboxylic acid transporter activity	35
transaldolase activity	8
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	66
succinate dehydrogenase activity	14
protein phosphatase type 2A regulator activity	9
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	40
cation:cation antiporter activity	2
histone deacetylase activity	3
bent DNA binding	2
3',5'-cGMP binding	3
3-deoxy-7-phosphoheptulonate synthase activity	10
intramolecular transferase activity, transferring acyl groups	1
endopeptidase activity	338
guanyl-nucleotide exchange factor activity	10
aminophospholipid transporter activity	1
potassium ion binding	30
maleylacetoacetate isomerase activity	5
NEDD8 activating enzyme activity	5
purine transporter activity	11
inositol oxygenase activity	1
phosphatidylinositol transporter activity	6
muconate cycloisomerase activity	3
long-chain fatty acid transporter activity	2
cation-transporting ATPase activity	74
MAP kinase activity	56
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD or NADH as one donor, and incorporation of two atoms of oxygen into one donor	3
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	2
myo-inositol transporter activity	14
phosphotransferase activity, carboxyl group as acceptor	31
superoxide dismutase activity	32
thiolester hydrolase activity	39
steroid hormone receptor binding	4
transketolase activity	13
glycosaminoglycan binding	8
prenyltransferase activity	12
cytoskeletal adaptor activity	2
carbon-nitrogen ligase activity, with glutamine as amido-N-donor	11
oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	3
translation release factor activity	2
sulfonylurea receptor activity	3
oxo-acid-lyase activity	13
GDP-dissociation inhibitor activity	5
transferrin receptor activity	1
biotin-protein ligase activity	1
farnesol 2-isomerase activity	3
thiamin-phosphate diphosphorylase activity	12
chloromuconate cycloisomerase activity	3
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity	1
tubulin binding	19
single-stranded DNA binding	24
peptidyl-prolyl cis-trans isomerase activity	56
acyl carnitine transporter activity	2
phosphotransferase activity, phosphate group as acceptor	39
chalcone isomerase activity	1
acid-ammonia (or amide) ligase activity	49
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	10
phosphoribosylamine-glycine ligase activity	1
lipoate-protein ligase activity	2
transition metal ion binding	820
glutathione transferase activity	54
oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor	12
racemase and epimerase activity, acting on amino acids and derivatives	12
intramolecular oxidoreductase activity, transposing C=C bonds	11
DNA photolyase activity	37
TPR domain binding	11
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	44
pyruvate dehydrogenase activity	8
carbon-oxygen lyase activity, acting on polysaccharides	2
1-deoxy-D-xylulose-5-phosphate synthase activity	3
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	1
peroxisome targeting signal receptor activity	1
ammonia-lyase activity	33
protein phosphatase inhibitor activity	4
sodium channel regulator activity	1
hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances	3
thromboxane-A synthase activity	1
cation channel activity	15
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	40
intramolecular transferase activity, transferring amino groups	1
acid-amino acid ligase activity	292
oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	13
oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor	4
5S rRNA binding	7
oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor	9
oxidoreductase activity, acting on sulfur group of donors, iron-sulfur protein as acceptor	7
phosphotransferase activity, alcohol group as acceptor	694
oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor	16
cyclin-dependent protein kinase regulator activity	2
arachidonic acid monooxygenase activity	3
inorganic anion transporter activity	19
spermidine synthase activity	2
bile acid:sodium symporter activity	17
nicotianamine synthase activity	4
ribosomal DNA (rDNA) binding	3
thiol-disulfide exchange intermediate activity	16
NADP binding	12
oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	21
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	14
FAD binding	23
scavenger receptor activity	18
delta12-fatty acid dehydrogenase activity	3
cysteine-type peptidase activity	77
centromeric DNA binding	1
calcium sensitive guanylate cyclase activator activity	1
tricarboxylic acid transporter activity	4
cycloartenol synthase activity	2
acetolactate synthase activity	6
3',5'-cAMP binding	3
channel inhibitor activity	5
glycerol-3-phosphate dehydrogenase activity	4
tumor necrosis factor receptor binding	1
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated	10
NAD(P)+ transhydrogenase (B-specific) activity	1
transferase activity, transferring hexosyl groups	190
sugar porter activity	62
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	9
carbon-oxygen lyase activity, acting on phosphates	19
exopeptidase activity	55
acid-thiol ligase activity	24
spermine synthase activity	2
SH2 domain binding	1
anion channel activity	8
lipoprotein receptor activity	6
organic anion transporter activity	3
formaldehyde transketolase activity	6
proton-dependent oligopeptide transporter activity	3
chromatin binding	46
laminin receptor activity	10
transaminase activity	51
SUMO conjugating enzyme activity	13
C-5 sterol desaturase activity	1
ferredoxin-NADP+ reductase activity	6
phosphotransferase activity, paired acceptors	10
calcium-dependent phospholipid binding	9
squalene monooxygenase activity	2
transferase activity, transferring pentosyl groups	33
hydrolase activity, acting on acid halide bonds, in C-halide compounds	1
oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	13
sodium:dicarboxylate symporter activity	28
anion-transporting ATPase activity	4
monosaccharide binding	38
GTPase binding	2
phosphoinositide binding	6
G-protein coupled receptor activity	51
nitrate reductase activity	1
NADH dehydrogenase (ubiquinone) activity	21
anion:anion antiporter activity	2
testosterone 16-alpha-hydroxylase activity	2
potassium channel regulator activity	2
oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor	2
inositol-3-phosphate synthase activity	11
intramolecular oxidoreductase activity, interconverting aldoses and ketoses	147
ferredoxin-NAD+ reductase activity	2
chorismate mutase activity	3
guanyl nucleotide binding	260
oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor	6
aspartyl esterase activity	6
monovalent inorganic cation transporter activity	160
DNA-(apurinic or apyrimidinic site) lyase activity	2
oxidoreductase activity, acting on the CH-NH group of donors, with a flavin as acceptor	1
acidic amino acid transporter activity	1
fatty acid (omega-1)-hydroxylase activity	14
oxidoreductase activity, acting on CH2 groups, disulfide as acceptor	5
MAP-kinase scaffold activity	1
organic cation transporter activity	1
glutamate receptor activity	1
D-2-hydroxy-acid dehydrogenase activity	1
hydro-lyase activity	143
UDP-glycosyltransferase activity	120
damaged DNA binding	36
intramolecular oxidoreductase activity, transposing S-S bonds	6
hydroxymethylbilane synthase activity	1
intramolecular transferase activity, phosphotransferases	7
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	327
transferase activity, transferring groups other than amino-acyl groups	202
carboxylic ester hydrolase activity	173
ion channel activity	36
calcium ion binding	328
oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor	2
protein heterodimerization activity	14
L-mimosine synthase activity	12
oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulfide as acceptor	3
carboxyl- and carbamoyltransferase activity	1
peroxisome targeting sequence binding	1
diphosphotransferase activity	2
oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	13
kinase binding	35
oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor	4
nucleotidyltransferase activity	77
3-oxo-5-alpha-steroid 4-dehydrogenase activity	1
histone deacetylase binding	2
protein phosphorylated amino acid binding	18
phosphoric ester hydrolase activity	209
cysteine-S-conjugate beta-lyase activity	2
transmembrane receptor protein phosphatase activity	1
calcium channel regulator activity	3
ATP-dependent DNA helicase activity	5
RNA modification guide activity	2
cyclo-ligase activity	1
IgE binding	19
ErbB-2 class receptor binding	1
deoxynucleotide transporter activity	3
snoRNA binding	3
sulfur amino acid transporter activity	1
CoA-ligase activity	24
serine-type peptidase activity	193
RNA cap binding	2
oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	7
NAD(P)H dehydrogenase (quinone) activity	1
acetylornithine deacetylase activity	1
oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor	40
cyanate hydratase activity	3
steroid hydroxylase activity	8
O-acetylhomoserine aminocarboxypropyltransferase activity	2
single-stranded RNA binding	19
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)	8
phosphatidylethanolamine binding	1
double-stranded DNA binding	8
7S RNA binding	5
luciferin monooxygenase activity	1
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	64
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	43
oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	15
oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor	2
alpha-amyrin synthase activity	2
tetracycline:hydrogen antiporter activity	10
oxidoreductase activity, acting on NADH or NADPH, NAD or NADP as acceptor	8
sulfotransferase activity	3
SUMO activating enzyme activity	1
NADH dehydrogenase (quinone) activity	21
calcium ion transporter activity	3
endopeptidase inhibitor activity	58
cystathionine gamma-lyase activity	4
monosaccharide transporter activity	39
CTP synthase activity	2
lactate dehydrogenase activity	28
plastoquinol-plastocyanin reductase activity	4
fatty-acid ligase activity	7
neuropeptide hormone activity	3
oxidoreductase activity, acting on heme group of donors, oxygen as acceptor	11
magnesium ion binding	327
metallopeptidase activity	68
L-amino acid transporter activity	6
hydrolase activity, hydrolyzing O-glycosyl compounds	198
signal peptidase activity	2
protein homodimerization activity	35
carboxy-lyase activity	129
poly-pyrimidine tract binding	7
selenocysteine lyase activity	3
snRNA binding	1
N-acetylglucosaminylphosphatidylinositol deacetylase activity	2
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	49
metallochaperone activity	1
lanosterol synthase activity	2
P-P-bond-hydrolysis-driven transporter activity	103
oxidoreductase activity, acting on sulfur group of donors, quinone or similar compound as acceptor	3
Hsp70 protein binding	6
intramolecular oxidoreductase activity, interconverting keto- and enol-groups	7
UDPsulfoquinovose synthase activity	1
phospholipase A2 inhibitor activity	5
histone acetyltransferase binding	2
protein kinase activator activity	8
v-SNARE activity	3
cystathionine beta-lyase activity	5
rRNA binding	132
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD or NADH as one donor, and incorporation of one atom of oxygen	53
cysteine synthase activity	13
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	4
CoA-transferase activity	1
alliin lyase activity	1
FK506 binding	32
URM1 activating enzyme activity	1
phosphotransferase activity, nitrogenous group as acceptor	35
racemase and epimerase activity, acting on hydroxy acids and derivatives	4
cationic amino acid transporter activity	1
hydrolase activity, hydrolyzing N-glycosyl compounds	16
monocarboxylic acid transporter activity	36