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EC-NUMBER
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2.1.1.74
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ENZYME-NAME
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methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing)
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ENZYME-SYSNAME
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Up to 25% of the bases in mature tRNA are post-translationally modified or hypermodified. One almost universal post-translational modification is the conversion of U54 (in the TPsiC loop) into ribothymidine (5-methyluridine), and this modification is found in most species studied to date [2]. Unlike this enzyme, which uses 5,10-methylenetetrahydrofolate and FADH2 to supply the atoms for methylation of U54, EC 2.1.1.35, RNA (uracil-5-)-methyltransferase, uses S-adenosyl-L-methionine.
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ENZYME-CLASS
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Transferases Transferring one-carbon groups Methyltransferases
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SYNONYMS
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(FADH2-oxidizing);;
(uracil-5-)-methyl-transferase;
5,10-methylenetetrahydrofolate:tRNA-UPsiC;
5-methyltransferase;;
>>more synonyms
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REACTION
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5,10-methylenetetrahydrofolate + tRNA containing uridine at position 54 + FADH2 = tetrahydrofolate + tRNA containing ribothymidine at position 54 + FAD [RN:R03704]
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PATHWAY
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EMP-PATHWAYS:
NO EMP PATHWAY FOUND
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KEGG-PATHWAYS:
NO KEGG PATHWAY FOUND
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GO_TERM
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GO:0047151:methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity
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ENZYME-COMMENT
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5,10-methylenetetrahydrofolate:tRNA (uracil-5-)-methyl-transferase
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