Cassinello A, Garcia S, Guerra P, Duque B, Ladron de Guevara C, Vazquez JJ, Carcas AJ, Gonzalez-Garcia J; IAS Conference on HIV Pathogenesis and Treatment (2nd : 2003 : Paris, France).

Antivir Ther. 2003; 8 (Suppl.1): abstract no. 858.

Departments of Internal Medicine, Clinical Pharmacology, and Microbiology. Hospital Universitario La Paz, Facultad de Medicina, UAM, Madrid, Spain

OBJECTIVES: To explore in a non-selected population the relation between treatment adherence, nelfinavir plasma concentration and antiviral response. To describe the kinetic model of our patient population. METHODS: A cohort of 72 HIV-positive patients (47 male, 25 female) without change in therapy within the last 3 months was studied. An adherence questionnaire was passed, a single nelfinavir plasma concentration measured, and to patients showing 31000 virus copies/ml a genotype resistance test was applied. Patient population characteristics, plasma nelfinavir levels and viral response (including drug resistance) was analysed through bi-variant and logistic regression aiming to find possible relationship. To elaborate a kinetic model describing our patients we used a monocompartmental distribution model with no lag time of absorption. RESULTS: 91% of patients declared to take 390% of doses for the last 7 days of treatment (good compliance). There were no females in the remaining 9%. Viral load was measured in 65 patients and 26% showed good clinical response (virus Publication Types:

• Meeting Abstracts

Keywords:

• Antiretroviral Therapy, Highly Active
• Area Under Curve
• Drug Therapy, Combination
• Female
• Genotype
• HIV
• HIV-1
• Humans
• Male
• Nelfinavir
• Patient Compliance
• Retroviridae
• Social Behavior
• Viral Load
• drug therapy
• genetics
• therapy

Other ID:

• GWAIDS0023513

UI: 102263137

From Meeting Abstracts