Skip CCR Main Navigation National Cancer Institute National Cancer Institute U.S. National Institutes of Health www.cancer.gov
CCR - For Our Staff| Home |

Our Science – Dean Website

Michael Dean, Ph.D.

Selected Publications
1)  Chloupková M, Pickert A, Lee JY, Souza S, Trinh YT, Connelly SM, Dumont ME, Dean M, Urbatsch IL.
Expression of 25 human ABC transporters in the yeast Pichia pastoris and characterization of the purified ABCC3 ATPase activity.
Biochemistry. 46: 7992-8003, 2007. [Journal]
2)  O'Brien TR, Kachapati K, Zhang M, Bergeron J, Edlin BR, Dean M.
HCV infection clearance with functional or non-functional caspase-12.
Scand. J. Gastroenterol. 42: 416-7, 2007. [Journal]
3)  Tan W, Wang Y, Gold B, Chen J, Dean M, Harrison PJ, Weinberger DR, Law AJ.
Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia.
J. Biol. Chem. 282: 24343-51, 2007. [Journal]
4)  Saugstad OD, Hansen TW, Rønnestad A, Nakstad B, Tølløfsrud PA, Reinholt F, Hamvas A, Coles FS, Dean M, Wert SE, Whitsett JA, Nogee LM.
Novel mutations in the gene encoding ATP binding cassette protein member A3 (ABCA3) resulting in fatal neonatal lung disease.
Acta Paediatr. 96: 185-90, 2007. [Journal]
5)  Remsberg JR, Lou H, Tarasov SG, Dean M, Tarasova NI.
Structural analogues of smoothened intracellular loops as potent inhibitors of Hedgehog pathway and cancer cell growth.
J. Med. Chem. 50: 4534-8, 2007. [Journal]
6)  Lou H, Dean M.
Targeted therapy for cancer stem cells: the patched pathway and ABC transporters.
Oncogene. 26: 1357-60, 2007. [Journal]
7)  Li X, Gold B, O'hUigin C, Diaz-Griffero F, Song B, Si Z, Li Y, Yuan W, Stremlau M, Mische C, Javanbakht H, Scally M, Winkler C, Dean M, Sodroski J.
Unique features of TRIM5alpha among closely related human TRIM family members.
Virology. 360: 419-33, 2007. [Journal]
8)  Henrich CJ, Bokesch HR, Dean M, Bates SE, Robey RW, Goncharova EI, Wilson JA, McMahon JB.
A high-throughput cell-based assay for inhibitors of ABCG2 activity.
Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening. 11: 176-83, 2006. [Journal]
9)  Dean M.
Cancer stem cells: redefining the paradigm of cancer treatment strategies.
Mol. Interv. 6: 140-8, 2006. [Journal]
10)  Javanbakht H, An P, Gold B, Petersen DC, O'Huigin C, Nelson GW, O'Brien SJ, Kirk GD, Detels R, Buchbinder S, Donfield S, Shulenin S, Song B, Perron MJ, Stremlau M, Sodroski J, Dean M, Winkler C.
Effects of human TRIM5alpha polymorphisms on antiretroviral function and susceptibility to human immunodeficiency virus infection.
Virology. 354: 15-27, 2006. [Journal]
11)  Si Z, Vandegraaff N, O'huigin C, Song B, Yuan W, Xu C, Perron M, Li X, Marasco WA, Engelman A, Dean M, Sodroski J.
Evolution of a cytoplasmic tripartite motif (TRIM) protein in cows that restricts retroviral infection.
Proc. Natl. Acad. Sci. U.S.A. 103: 7454-9, 2006. [Journal]
12)  Annilo T, Chen ZQ, Shulenin S, Costantino J, Thomas L, Lou H, Stefanov S, Dean M.
Evolution of the vertebrate ABC gene family: analysis of gene birth and death.
Genomics. 88: 1-11, 2006. [Journal]
13)  Hageman GS, Hancox LS, Taiber AJ, Gehrs KM, Anderson DH, Johnson LV, Radeke MJ, Kavanagh D, Richards A, Atkinson J, Meri S, Bergeron J, Zernant J, Merriam J, Gold B, Allikmets R, Dean M.
Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications.
Ann. Med. 38: 592-604, 2006. [Journal]
14)  Guo XC, Scott K, Liu Y, Dean M, David V, Nelson GW, Johnson RC, Dilks HH, Lautenberger J, Kessing B, Martenson J, Guan L, Sun S, Deng H, Zheng Y, de The G, Liao J, Zeng Y, O'Brien SJ, Winkler CA.
Genetic factors leading to chronic Epstein-Barr virus infection and nasopharyngeal carcinoma in South East China: study design, methods and feasibility.
Hum. Genomics. 2: 365-75, 2006. [Journal]
15)  Bacolla A, Collins JR, Gold B, Chuzhanova N, Yi M, Stephens RM, Stefanov S, Olsh A, Jakupciak JP, Dean M, Lempicki RA, Cooper DN, Wells RD.
Long homopurine*homopyrimidine sequences are characteristic of genes expressed in brain and the pseudoautosomal region.
Nucleic Acids Res. 34: 2663-75, 2006. [Journal]
16)  Polgar O, Ozvegy-Laczka C, Robey RW, Morisaki K, Okada M, Tamaki A, Koblos G, Elkind NB, Ward Y, Dean M, Sarkadi B, Bates SE.
Mutational studies of G553 in TM5 of ABCG2: a residue potentially involved in dimerization.
Biochemistry. 45: 5251-60, 2006. [Journal]
17)  Kachapati K, O'Brien TR, Bergeron J, Zhang M, Dean M.
Population distribution of the functional caspase-12 allele.
Hum. Mutat. 27: 975, 2006. [Journal]
18)  Wang Z, Stalcup LD, Harvey BJ, Weber J, Chloupkova M, Dumont ME, Dean M, Urbatsch IL.
Purification and ATP hydrolysis of the putative cholesterol transporters ABCG5 and ABCG8.
Biochemistry. 45: 9929-39, 2006. [Journal]
19)  Garmany TH, Moxley MA, White FV, Dean M, Hull WM, Whitsett JA, Nogee LM, Hamvas A.
Surfactant composition and function in patients with ABCA3 mutations.
Pediatr. Res. 59: 801-5, 2006. [Journal]
20)  Goldstone JV, Hamdoun A, Cole BJ, Howard-Ashby M, Nebert DW, Scally M, Dean M, Epel D, Hahn ME, Stegeman JJ.
The chemical defensome: environmental sensing and response genes in the Strongylocentrotus purpuratus genome.
Dev. Biol. 300: 366-84, 2006. [Journal]
21)  Chen ZQ, Dong J, Ishimura A, Daar I, Hinnebusch AG, Dean M.
The essential vertebrate ABCE1 protein interacts with eukaryotic initiation factors.
J. Biol. Chem. 281: 7452-7, 2006. [Journal]
22)  Robey RW, Fetsch PA, Polgar O, Dean M, Bates SE.
The livestock photosensitizer, phytoporphyrin (phylloerythrin), is a substrate of the ATP-binding cassette transporter ABCG2.
Res. Vet. Sci. 81: 345-9, 2006. [Journal]
23)  Gold B, Merriam JE, Zernant J, Hancox LS, Taiber AJ, Gehrs K, Cramer K, Neel J, Bergeron J, Barile GR, Smith RT, Hageman GS, Dean M, Allikmets R.
Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration.
Nat. Genet. 38: 458-62, 2006. [Journal]

This page was last updated on 11/16/2007.