NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 1 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE TIME: 11:16:00 EIS REPORT 27 lifetime/draft/mice FACILITY: TSI Mason Research NTP C#: C62419 CONTRACT NUMBER: NO1ES55111 CAS NUMBER: MOUSEAGE ANIMAL SUPPLIER: NOT SPECIFIED CAGE RANGE: ALL DATE RANGE: ALL REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE ALL NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 2 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 301 301 966 05/17/88 966 05/17/88 1/46 Tachypnea REMOVED ** CID 3011 ** REASON - Moribund 969 05/20/88 Abnormal Posture 969 05/20/88 Tachypnea 969 05/20/88 Hypoactivity 302 302 140 02/11/86 644 06/30/87 19/41 Alopecia Entire Animal REMOVED ** CID 3021 ** REASON - Moribund 841 01/13/88 Emaciated 841 01/13/88 Abnormal Posture 841 01/13/88 Tachypnea 841 01/13/88 Hypoactivity 303 303 1022 07/12/88 1022 07/12/88 1/50 Tachypnea 1022 07/12/88 1022 07/12/88 1/50 Ruffled Fur 1008 06/28/88 1022 07/12/88 2/50 Tissue Mass Right Rear Leg 16-20 Mm 994 06/14/88 994 06/14/88 1/50 Tissue Mass Right Rear Leg 3- 5 Mm 897 03/09/88 980 05/31/88 5/50 Tissue Mass Right Rear Leg 6-10 Mm 868 02/09/88 1022 07/12/88 9/50 Alopecia Body Ventral 700 08/25/87 835 01/07/88 6/50 Alopecia Neck REMOVED ** CID 3031 ** REASON - Moribund 1023 07/13/88 Tissue Mass Right Rear Leg 26 or Gr 1023 07/13/88 Ruffled Fur 1023 07/13/88 Tachypnea 1023 07/13/88 Hypoactivity 305 305 897 03/09/88 897 03/09/88 1/43 Tissue Mass Body Dorsal 11-15 Mm 897 03/09/88 897 03/09/88 1/43 Ruffled Fur 897 03/09/88 897 03/09/88 1/43 Emaciated REMOVED ** CID 3051 ** REASON - Moribund 904 03/16/88 Tremors 904 03/16/88 Tissue Mass Body Ventral 26 or Gr 904 03/16/88 Abnormal Posture 904 03/16/88 Tachypnea 904 03/16/88 Hypoactivity 306 306 567 04/14/87 595 05/12/87 2/32 Tissue Mass Body (Trunk) 3- 5 Mm REMOVED ** CID 3061 ** REASON - Dead 601 05/18/87 Tissue Mass Body Ventral 26 or Gr NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 3 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 307 307 672 07/28/87 728 09/22/87 3/38 Sore Nose 0- 2 Mm 756 10/20/87 756 10/20/87 1/38 Tissue Mass Nose 0- 2 Mm REMOVED ** CID 3071 ** REASON - Moribund 779 11/12/87 Dyspnea 779 11/12/87 Emaciated 779 11/12/87 Abnormal Posture 308 308 534 03/12/87 868 02/09/88 12/42 Alopecia Body Ventral 868 02/09/88 868 02/09/88 1/42 Tachypnea 785 11/18/87 868 02/09/88 4/42 Tissue Mass Hip 3- 5 Mm REMOVED ** CID 3081 ** REASON - Moribund 876 02/17/88 Tissue Mass Hip 26 or Gr 876 02/17/88 Abnormal Posture 876 02/17/88 Tachypnea 876 02/17/88 Hypoactivity 309 309 450 12/18/86 672 07/28/87 4/35 Alopecia Body Ventral 506 02/12/87 616 06/02/87 5/35 Alopecia Entire Animal REMOVED ** CID 3091 ** REASON - Moribund 698 08/23/87 Emaciated 698 08/23/87 Abnormal Posture 698 08/23/87 Ruffled Fur 311 311 805 12/08/87 805 12/08/87 1/40 Tissue Mass Hip 6-10 Mm 196 04/08/86 805 12/08/87 20/40 Alopecia Body Ventral 567 04/14/87 616 06/02/87 3/40 Alopecia Entire Animal REMOVED ** CID 3111 ** REASON - Moribund 816 12/19/87 Tissue Mass Body Ventral 21-25 Mm 816 12/19/87 Limb Paralysis Right Rear Leg 816 12/19/87 Limb Paralysis Left Rear Leg 312 312 616 06/02/87 616 06/02/87 1/40 Alopecia Head REMOVED ** CID 3121 ** REASON - Moribund 819 12/22/87 Ataxia 819 12/22/87 Ruffled Fur 819 12/22/87 Hypoactivity NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 4 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 313 313 506 02/12/87 506 02/12/87 1/29 Tissue Mass Body Dorsal 11-15 Mm 478 01/15/87 478 01/15/87 1/29 Alopecia Body Ventral REMOVED ** CID 3131 ** REASON - Moribund 527 03/05/87 Tissue Mass Body Dorsal 26 or Gr 527 03/05/87 Emaciated 314 314 672 07/28/87 700 08/25/87 2/36 Tissue Mass Body Ventral 6-10 Mm REMOVED ** CID 3141 ** REASON - Moribund 717 09/11/87 Dyspnea 717 09/11/87 Emaciated 717 09/11/87 Abnormal Posture 318 318 595 05/12/87 700 08/25/87 5/41 Tissue Mass Body (Trunk) 0- 2 Mm 728 09/22/87 756 10/20/87 2/41 Tissue Mass Body Ventral 0- 2 Mm REMOVED ** CID 3181 ** REASON - Dead 849 01/21/88 Normal 320 320 534 03/12/87 567 04/14/87 2/31 Alopecia Body Ventral REMOVED ** CID 3201 ** REASON - Dead 590 05/07/87 Normal 321 321 478 01/15/87 478 01/15/87 1/33 Alopecia Body Ventral 616 06/02/87 616 06/02/87 1/33 Tissue Mass Body (Trunk) 0- 2 Mm REMOVED ** CID 3211 ** REASON - Dead 618 06/04/87 Normal 322 322 506 02/12/87 506 02/12/87 1/42 Alopecia Body Ventral REMOVED ** CID 3221 ** REASON - Dead 893 03/05/88 Normal 323 323 897 03/09/88 897 03/09/88 1/43 Swelling Body Ventral REMOVED ** CID 3231 ** REASON - Dead 920 04/01/88 Normal NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 5 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 325 325 196 04/08/86 534 03/12/87 3/30 Alopecia Entire Animal 140 02/11/86 478 01/15/87 11/30 Alopecia Body Ventral REMOVED ** CID 3251 ** REASON - Dead 561 04/08/87 Normal 326 326 450 12/18/86 700 08/25/87 4/46 Tissue Mass Tail 3- 5 Mm 364 09/23/86 644 06/30/87 9/46 Tissue Mass Tail 0- 2 Mm 966 05/17/88 966 05/17/88 1/46 Tachypnea 966 05/17/88 966 05/17/88 1/46 Ruffled Fur 924 04/05/88 966 05/17/88 3/46 Tissue Mass Right Rear Leg 3- 5 Mm 728 09/22/87 966 05/17/88 10/46 Tissue Mass Tail 6-10 Mm REMOVED ** CID 3261 ** REASON - Moribund 969 05/20/88 Tissue Mass Tail 11-15 Mm 327 327 534 03/12/87 616 06/02/87 4/34 Alopecia Body Ventral REMOVED ** CID 3271 ** REASON - Dead 666 07/22/87 Normal 328 328 924 04/05/88 924 04/05/88 1/44 Tissue Mass Left Rear Leg 6-10 Mm REMOVED ** CID 3281 ** REASON - Moribund 926 04/07/88 Tissue Mass Left Rear Leg 21-25 Mm 926 04/07/88 Emaciated 926 04/07/88 Abnormal Posture 926 04/07/88 Tachypnea 329 329 616 06/02/87 616 06/02/87 1/33 Dyspnea 616 06/02/87 616 06/02/87 1/33 Emaciated 616 06/02/87 616 06/02/87 1/33 Tissue Mass Neck 0- 2 Mm REMOVED ** CID 3291 ** REASON - Moribund 621 06/07/87 Dyspnea 621 06/07/87 Tissue Mass Neck 11-15 Mm 621 06/07/87 Emaciated 332 332 534 03/12/87 616 06/02/87 4/44 Alopecia Body Ventral 835 01/07/88 897 03/09/88 3/44 Alopecia Hip REMOVED ** CID 3321 ** REASON - Dead 939 04/20/88 Normal NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 6 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 333 333 835 01/07/88 980 05/31/88 7/47 Swelling Body Ventral REMOVED ** CID 3331 ** REASON - Dead 981 06/01/88 Swelling Body Ventral 334 334 196 04/08/86 897 03/09/88 26/43 Alopecia Body Ventral REMOVED ** CID 3341 ** REASON - Dead 912 03/24/88 Normal 335 335 924 04/05/88 924 04/05/88 1/44 Emaciated 616 06/02/87 616 06/02/87 1/44 Alopecia Body Dorsal REMOVED ** CID 3351 ** REASON - Dead 931 04/12/88 Normal 336 336 868 02/09/88 868 02/09/88 1/42 Swelling Body Ventral REMOVED ** CID 3361 ** REASON - Dead 881 02/22/88 Normal 337 337 897 03/09/88 897 03/09/88 1/43 Swelling Body Ventral 897 03/09/88 897 03/09/88 1/43 Ruffled Fur REMOVED ** CID 3371 ** REASON - Dead 902 03/14/88 Normal 339 339 534 03/12/87 567 04/14/87 2/35 Alopecia Body Ventral 595 05/12/87 644 06/30/87 3/35 Tissue Mass Neck 0- 2 Mm 672 07/28/87 672 07/28/87 1/35 Tissue Mass Neck 3- 5 Mm REMOVED ** CID 3391 ** REASON - Moribund 698 08/23/87 Tissue Mass Neck 6-10 Mm 698 08/23/87 Swelling Body Ventral 698 08/23/87 Ruffled Fur 340 340 966 05/17/88 966 05/17/88 1/46 Tachypnea 966 05/17/88 966 05/17/88 1/46 Emaciated 966 05/17/88 966 05/17/88 1/46 Ruffled Fur REMOVED ** CID 3401 ** REASON - Dead NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 7 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 340 340 969 05/20/88 Normal 344 344 805 12/08/87 805 12/08/87 1/40 Swelling Body Ventral 805 12/08/87 805 12/08/87 1/40 Tachypnea REMOVED ** CID 3441 ** REASON - Moribund 818 12/21/87 Ruffled Fur 818 12/21/87 Tachypnea 346 346 567 04/14/87 805 12/08/87 2/40 Emaciated REMOVED ** CID 3461 ** REASON - Dead 808 12/11/87 Normal 347 347 756 10/20/87 756 10/20/87 1/38 Emaciated 616 06/02/87 616 06/02/87 1/38 Tissue Mass Body (Trunk) 3- 5 Mm REMOVED ** CID 3471 ** REASON - Dead 778 11/11/87 Normal 348 348 567 04/14/87 616 06/02/87 3/45 Alopecia Body Ventral REMOVED ** CID 3481 ** REASON - Dead 962 05/13/88 Normal 349 349 140 02/11/86 1022 07/12/88 24/50 Alopecia Body Ventral 897 03/09/88 994 06/14/88 6/50 Swelling Body Ventral 339 08/29/86 616 06/02/87 11/50 Alopecia Entire Animal REMOVED ** CID 3491 ** REASON - Term-Sac 1030 07/20/88 Alopecia Body Ventral 350 350 785 11/18/87 805 12/08/87 2/40 Tachypnea 534 03/12/87 616 06/02/87 4/40 Emaciated REMOVED ** CID 3501 ** REASON - Moribund 820 12/23/87 Dyspnea 820 12/23/87 Emaciated 820 12/23/87 Abnormal Posture NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 8 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 352 352 567 04/14/87 616 06/02/87 3/41 Emaciated REMOVED ** CID 3521 ** REASON - Dead 861 02/02/88 Normal 353 353 966 05/17/88 966 05/17/88 1/46 Tissue Mass Right Front Leg 6-10 Mm 952 05/03/88 966 05/17/88 2/46 Sore Body (Trunk) 3- 5 Mm 952 05/03/88 966 05/17/88 2/46 Emaciated REMOVED ** CID 3531 ** REASON - Dead 973 05/24/88 Tissue Mass Right Front Leg 16-20 Mm 973 05/24/88 Emaciated 973 05/24/88 Sore Body Ventral 16-20 Mm 354 354 728 09/22/87 728 09/22/87 1/37 Tachypnea REMOVED ** CID 3541 ** REASON - Dead 743 10/07/87 Normal 355 355 113 01/15/86 113 01/15/86 1/36 Alopecia Neck 71 12/04/85 85 12/18/85 2/36 Alopecia Face 85 12/18/85 113 01/15/86 2/36 Alopecia Body Dorsal 700 08/25/87 700 08/25/87 1/36 Hyperactive 140 02/11/86 616 06/02/87 18/36 Alopecia Entire Animal 71 12/04/85 113 01/15/86 2/36 Alopecia Body Ventral REMOVED ** CID 3551 ** REASON - Moribund 705 08/30/87 Abnormal Posture 705 08/30/87 Ruffled Fur 358 358 534 03/12/87 567 04/14/87 2/41 Emaciated REMOVED ** CID 3581 ** REASON - Moribund 855 01/27/88 Ataxia 855 01/27/88 Tachypnea 855 01/27/88 Hypoactivity 359 359 924 04/05/88 924 04/05/88 1/44 Tissue Mass Right Rear Leg 11-15 Mm 924 04/05/88 924 04/05/88 1/44 Emaciated REMOVED ** CID 3591 ** REASON - Dead 930 04/11/88 Tissue Mass Right Rear Leg 26 or Gr NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 9 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 360 360 805 12/08/87 805 12/08/87 1/40 Emaciated 672 07/28/87 805 12/08/87 6/40 Swelling Right Eye 805 12/08/87 805 12/08/87 1/40 Tissue Mass Left Front Leg 6-10 Mm 805 12/08/87 805 12/08/87 1/40 Tachypnea 567 04/14/87 616 06/02/87 3/40 Alopecia Body Ventral 756 10/20/87 785 11/18/87 2/40 Tissue Mass Left Front Leg 3- 5 Mm REMOVED ** CID 3601 ** REASON - Moribund 810 12/13/87 Tissue Mass Left Front Leg 16-20 Mm 810 12/13/87 Swelling Right Eye 362 362 196 04/08/86 966 05/17/88 21/46 Alopecia Body Ventral 952 05/03/88 966 05/17/88 2/46 Swelling Body Ventral 952 05/03/88 966 05/17/88 2/46 Tachypnea REMOVED ** CID 3621 ** REASON - Moribund 967 05/18/88 Dyspnea 967 05/18/88 Emaciated 967 05/18/88 Abnormal Posture 967 05/18/88 Hypoactivity 364 364 756 10/20/87 756 10/20/87 1/38 Tissue Mass Body (Trunk) 11-15 Mm 728 09/22/87 756 10/20/87 2/38 Tachypnea REMOVED ** CID 3641 ** REASON - Dead 757 10/21/87 Swelling Body Ventral 365 365 805 12/08/87 805 12/08/87 1/40 Tissue Mass Body Dorsal 6-10 Mm REMOVED ** CID 3651 ** REASON - Moribund 820 12/23/87 Tissue Mass Body Dorsal 26 or Gr 820 12/23/87 Emaciated 366 366 966 05/17/88 994 06/14/88 3/48 Tissue Mass Left Rear Leg 6-10 Mm 85 12/18/85 85 12/18/85 1/48 Alopecia Face 78 12/11/85 835 01/07/88 6/48 Alopecia Body Ventral 140 02/11/86 994 06/14/88 24/48 Alopecia Entire Animal 952 05/03/88 994 06/14/88 4/48 Tachypnea REMOVED ** CID 3661 ** REASON - Dead 998 06/18/88 Tissue Mass Left Rear Leg 21-25 Mm 367 367 728 09/22/87 728 09/22/87 1/37 Tachypnea NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 10 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS ANIMAL DATA - 367 367 616 06/02/87 700 08/25/87 2/37 Emaciated REMOVED ** CID 3671 ** REASON - Moribund 745 10/09/87 Tissue Mass Body Ventral 21-25 Mm 745 10/09/87 Emaciated 369 369 616 06/02/87 616 06/02/87 1/33 Ruffled Fur 616 06/02/87 616 06/02/87 1/33 Emaciated REMOVED ** CID 3691 ** REASON - Dead 642 06/28/87 Normal 371 371 835 01/07/88 835 01/07/88 1/41 Emaciated 534 03/12/87 616 06/02/87 4/41 Alopecia Body Ventral 835 01/07/88 835 01/07/88 1/41 Tachypnea REMOVED ** CID 3711 ** REASON - Moribund 835 01/07/88 Emaciated 835 01/07/88 Tachypnea 835 01/07/88 Hypoactivity 372 372 700 08/25/87 700 08/25/87 1/36 Sore Body Dorsal Yellow 700 08/25/87 700 08/25/87 1/36 Emaciated REMOVED ** CID 3721 ** REASON - Moribund 705 08/30/87 Abnormal Posture 705 08/30/87 Sore Body (Trunk) Red 705 08/30/87 Ruffled Fur 373 373 224 05/06/86 616 06/02/87 15/48 Alopecia Entire Animal 897 03/09/88 897 03/09/88 1/48 Ruffled Fur 196 04/08/86 994 06/14/88 16/48 Alopecia Body Ventral REMOVED ** CID 3731 ** REASON - Moribund 1007 06/27/88 Dyspnea 1007 06/27/88 Comatose 374 374 1008 06/28/88 1022 07/12/88 2/50 Swelling Left Eye 1008 06/28/88 1022 07/12/88 2/50 Emaciated REMOVED ** CID 3741 ** REASON - Term-Sac 1030 07/20/88 Swelling Left Eye NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 11 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 374 374 1030 07/20/88 Emaciated 376 376 196 04/08/86 339 08/29/86 6/30 Alopecia Body Ventral 364 09/23/86 534 03/12/87 7/30 Alopecia Entire Animal REMOVED ** CID 3761 ** REASON - Moribund 555 04/02/87 Emaciated 555 04/02/87 Abnormal Posture 555 04/02/87 Limb Paralysis Right Rear Leg 555 04/02/87 Limb Paralysis Left Rear Leg 378 378 952 05/03/88 994 06/14/88 4/50 Tachypnea 897 03/09/88 1022 07/12/88 8/50 Swelling Body Ventral 952 05/03/88 994 06/14/88 3/50 Ruffled Fur REMOVED ** CID 3781 ** REASON - Term-Sac 1030 07/20/88 Swelling Body Ventral 379 379 980 05/31/88 980 05/31/88 1/47 Tachypnea 980 05/31/88 980 05/31/88 1/47 Ruffled Fur REMOVED ** CID 3791 ** REASON - Dead 993 06/13/88 Tissue Mass Body Ventral 16-20 Mm 380 380 15 10/09/85 15 10/09/85 1/50 Override 835 01/07/88 835 01/07/88 1/50 Exophthalmos 952 05/03/88 1022 07/12/88 6/50 Swelling Left Eye 1022 07/12/88 1022 07/12/88 1/50 Swelling Body Ventral 1008 06/28/88 1022 07/12/88 2/50 Discharge Left Eye REMOVED ** CID 3801 ** REASON - Term-Sac 1030 07/20/88 Swelling Left Eye 1030 07/20/88 Discharge Left Eye 382 382 924 04/05/88 924 04/05/88 1/44 Emaciated 924 04/05/88 924 04/05/88 1/44 Sore Body (Trunk) 6-10 Mm REMOVED ** CID 3821 ** REASON - Moribund 945 04/26/88 Emaciated 945 04/26/88 Hyperactive 945 04/26/88 Abnormal Posture 945 04/26/88 Wound Body Ventral 16-20 Mm NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 12 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 382 382 945 04/26/88 Tachypnea 384 384 364 09/23/86 616 06/02/87 10/41 Alopecia Entire Animal 140 02/11/86 835 01/07/88 15/41 Alopecia Body Ventral 756 10/20/87 756 10/20/87 1/41 Tissue Mass Body Dorsal 6-10 Mm 835 01/07/88 835 01/07/88 1/41 Emaciated REMOVED ** CID 3841 ** REASON - Moribund 859 01/31/88 Swelling Body Ventral 859 01/31/88 Abnormal Posture 859 01/31/88 Hypoactivity 385 385 785 11/18/87 785 11/18/87 1/39 Tachypnea 785 11/18/87 785 11/18/87 1/39 Emaciated 785 11/18/87 785 11/18/87 1/39 Swelling Body Ventral REMOVED ** CID 3851 ** REASON - Moribund 802 12/05/87 Tissue Mass Body Ventral 26 or Gr 802 12/05/87 Abnormal Posture 386 386 534 03/12/87 700 08/25/87 4/36 Emaciated REMOVED ** CID 3861 ** REASON - Moribund 705 08/30/87 Dyspnea 705 08/30/87 Emaciated 705 08/30/87 Abnormal Posture 705 08/30/87 Ruffled Fur 705 08/30/87 Hypoactivity 387 387 224 05/06/86 756 10/20/87 19/39 Alopecia Body Ventral 785 11/18/87 785 11/18/87 1/39 Alopecia Entire Animal REMOVED ** CID 3871 ** REASON - Moribund 793 11/26/87 Tissue Mass Body Dorsal 6-10 Mm 793 11/26/87 Swelling Body Ventral 389 389 567 04/14/87 616 06/02/87 3/40 Alopecia Body Ventral REMOVED ** CID 3891 ** REASON - Moribund 827 12/30/87 Ataxia 827 12/30/87 Tachypnea 827 12/30/87 Hypoactivity NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 13 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 390 390 924 04/05/88 952 05/03/88 2/45 Swelling Body Ventral REMOVED ** CID 3901 ** REASON - Moribund 956 05/07/88 Tachypnea 956 05/07/88 Comatose 392 392 309 07/30/86 616 06/02/87 9/44 Alopecia Body Ventral 924 04/05/88 924 04/05/88 1/44 Ruffled Fur 506 02/12/87 567 04/14/87 3/44 Alopecia Entire Animal 897 03/09/88 924 04/05/88 2/44 Swelling Body Ventral 924 04/05/88 924 04/05/88 1/44 Emaciated REMOVED ** CID 3921 ** REASON - Dead 944 04/25/88 Normal 393 393 835 01/07/88 835 01/07/88 1/41 Emaciated 534 03/12/87 616 06/02/87 4/41 Alopecia Entire Animal 835 01/07/88 835 01/07/88 1/41 Tachypnea REMOVED ** CID 3931 ** REASON - Moribund 842 01/14/88 Emaciated 842 01/14/88 Abnormal Posture 842 01/14/88 Tachypnea 394 394 994 06/14/88 994 06/14/88 1/50 Tissue Mass Body (Trunk) 3- 5 Mm 1022 07/12/88 1022 07/12/88 1/50 Tissue Mass Right Front Leg 26 or Gr 1008 06/28/88 1008 06/28/88 1/50 Tissue Mass Left Front Leg 11-15 Mm 966 05/17/88 980 05/31/88 2/50 Tissue Mass Right Front Leg 6-10 Mm REMOVED ** CID 3941 ** REASON - Term-Sac 1030 07/20/88 Tissue Mass Left Front Leg 11-15 Mm 395 395 952 05/03/88 966 05/17/88 2/46 Ruffled Fur 952 05/03/88 966 05/17/88 2/46 Tachypnea 966 05/17/88 966 05/17/88 1/46 Emaciated REMOVED ** CID 3951 ** REASON - Dead 980 05/31/88 Normal 396 396 567 04/14/87 595 05/12/87 2/32 Alopecia Body Ventral REMOVED ** CID 3961 ** REASON - Dead NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 14 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 396 396 600 05/17/87 Normal 397 397 868 02/09/88 868 02/09/88 1/42 Emaciated 868 02/09/88 868 02/09/88 1/42 Tachypnea 364 09/23/86 364 09/23/86 1/42 Alopecia Right Rear Leg 616 06/02/87 616 06/02/87 1/42 Alopecia Body (Trunk) REMOVED ** CID 3971 ** REASON - Moribund 872 02/13/88 Dyspnea 872 02/13/88 Tissue Mass Skin 6-10 Mm 872 02/13/88 Emaciated 872 02/13/88 Abnormal Posture 400 400 309 07/30/86 616 06/02/87 8/37 Alopecia Body Ventral 616 06/02/87 616 06/02/87 1/37 Ruffled Fur 364 09/23/86 450 12/18/86 4/37 Alopecia Entire Animal REMOVED ** CID 4001 ** REASON - Moribund 749 10/13/87 Head Tilted 749 10/13/87 Tachypnea 402 402 567 04/14/87 616 06/02/87 3/40 Alopecia Body Ventral REMOVED ** CID 4021 ** REASON - Moribund 814 12/17/87 Comatose 403 403 1022 07/12/88 1022 07/12/88 1/50 Emaciated 1022 07/12/88 1022 07/12/88 1/50 Ruffled Fur 1022 07/12/88 1022 07/12/88 1/50 Tachypnea REMOVED ** CID 4031 ** REASON - Moribund 1024 07/14/88 Emaciated 1024 07/14/88 Comatose 408 408 756 10/20/87 756 10/20/87 1/38 Emaciated REMOVED ** CID 4081 ** REASON - Moribund 763 10/27/87 Tissue Mass Face 11-15 Mm 763 10/27/87 Emaciated 763 10/27/87 Abnormal Posture NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 15 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 409 409 835 01/07/88 835 01/07/88 1/41 Tissue Mass Shoulder 6-10 Mm REMOVED ** CID 4091 ** REASON - Moribund 851 01/23/88 Tissue Mass Shoulder 6-10 Mm 851 01/23/88 Swelling Body Ventral 851 01/23/88 Ruffled Fur 410 410 168 03/11/86 1022 07/12/88 34/50 Alopecia Body Ventral 534 03/12/87 616 06/02/87 4/50 Sore Right Ear 0- 2 Mm REMOVED ** CID 4101 ** REASON - Term-Sac 1030 07/20/88 Alopecia Body Ventral 411 411 1008 06/28/88 1008 06/28/88 1/49 Swelling Body Ventral REMOVED ** CID 4111 ** REASON - Moribund 1018 07/08/88 Dyspnea 1018 07/08/88 Swelling Body Ventral 1018 07/08/88 Abnormal Posture 413 413 728 09/22/87 728 09/22/87 1/37 Tissue Mass Body (Trunk) 11-15 Mm REMOVED ** CID 4131 ** REASON - Moribund 747 10/11/87 Tissue Mass Body (Trunk) 26 or Gr 414 414 924 04/05/88 924 04/05/88 1/44 Tissue Mass Body Dorsal 6-10 Mm REMOVED ** CID 4141 ** REASON - Dead 927 04/08/88 Tissue Mass Body Dorsal 11-15 Mm 416 416 196 04/08/86 644 06/30/87 16/34 Malocclusion 644 06/30/87 644 06/30/87 1/34 Emaciated 196 04/08/86 644 06/30/87 17/34 Swelling Nose REMOVED ** CID 4161 ** REASON - Moribund 667 07/23/87 Swelling Face 667 07/23/87 Ataxia 667 07/23/87 Ruffled Fur 667 07/23/87 Hypoactivity 417 417 672 07/28/87 672 07/28/87 1/35 Tissue Mass Body (Trunk) 26 or Gr REMOVED ** CID 4171 ** REASON - Moribund NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 16 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 417 417 672 07/28/87 Dyspnea 672 07/28/87 Swelling Body Ventral 672 07/28/87 Emaciated 420 420 420 11/18/86 420 11/18/86 1/26 Swelling Body Ventral REMOVED ** CID 4201 ** REASON - Moribund 422 11/20/86 Swelling Body Ventral 421 421 567 04/14/87 567 04/14/87 1/31 Emaciated REMOVED ** CID 4211 ** REASON - Dead 572 04/19/87 Normal 422 422 835 01/07/88 835 01/07/88 1/46 Emaciated 835 01/07/88 835 01/07/88 1/46 Tachypnea 952 05/03/88 966 05/17/88 2/46 Tissue Mass Neck 6-10 Mm REMOVED ** CID 4221 ** REASON - Moribund 967 05/18/88 Tissue Mass Neck 21-25 Mm 967 05/18/88 Abnormal Posture 967 05/18/88 Ruffled Fur 967 05/18/88 Hypoactivity 423 423 595 05/12/87 616 06/02/87 2/50 Emaciated 1022 07/12/88 1022 07/12/88 1/50 Ruffled Fur 1022 07/12/88 1022 07/12/88 1/50 Tachypnea REMOVED ** CID 4231 ** REASON - Term-Sac 1030 07/20/88 Normal 424 424 924 04/05/88 924 04/05/88 1/44 Tissue Mass Right Front Leg 6-10 Mm REMOVED ** CID 4241 ** REASON - Moribund 932 04/13/88 Tissue Mass Body Dorsal 16-20 Mm 932 04/13/88 Tachypnea 932 04/13/88 Comatose 425 425 282 07/03/86 534 03/12/87 10/30 Alopecia Body Ventral 478 01/15/87 478 01/15/87 1/30 Dyspnea 450 12/18/86 450 12/18/86 1/30 Tachypnea NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 17 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS ANIMAL DATA - 425 425 140 02/11/86 140 02/11/86 1/30 Alopecia Left Front Leg REMOVED ** CID 4251 ** REASON - Dead 550 03/28/87 Jaundice 426 426 420 11/18/86 616 06/02/87 8/41 Alopecia Body Ventral REMOVED ** CID 4261 ** REASON - Moribund 847 01/19/88 Head Tilted 847 01/19/88 Abnormal Posture 847 01/19/88 Ruffled Fur 847 01/19/88 Tachypnea 427 427 756 10/20/87 756 10/20/87 1/38 Emaciated 253 06/04/86 756 10/20/87 18/38 Alopecia Body Ventral 140 02/11/86 224 05/06/86 4/38 Alopecia Entire Animal REMOVED ** CID 4271 ** REASON - Moribund 758 10/22/87 Hypoactivity 430 430 966 05/17/88 966 05/17/88 1/46 Emaciated 966 05/17/88 966 05/17/88 1/46 Ruffled Fur REMOVED ** CID 4301 ** REASON - Moribund 967 05/18/88 Emaciated 967 05/18/88 Abnormal Posture 967 05/18/88 Tachypnea 967 05/18/88 Hypoactivity 434 434 952 05/03/88 952 05/03/88 1/45 Emaciated REMOVED ** CID 4341 ** REASON - Moribund 954 05/05/88 Tremors 954 05/05/88 Emaciated 954 05/05/88 Ataxia 954 05/05/88 Hypoactivity 435 435 168 03/11/86 1022 07/12/88 32/50 Alopecia Body Ventral REMOVED ** CID 4351 ** REASON - Term-Sac 1030 07/20/88 Alopecia Body Ventral NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 18 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 436 436 534 03/12/87 616 06/02/87 4/49 Alopecia Body Ventral REMOVED ** CID 4361 ** REASON - Dead 1016 07/06/88 Normal 437 437 616 06/02/87 616 06/02/87 1/36 Alopecia Body Ventral REMOVED ** CID 4371 ** REASON - Dead 722 09/16/87 Tissue Mass Neck 16-20 Mm 438 438 506 02/12/87 616 06/02/87 5/33 Alopecia Body Ventral REMOVED ** CID 4381 ** REASON - Dead 638 06/24/87 Normal 439 439 897 03/09/88 897 03/09/88 1/43 Emaciated 897 03/09/88 897 03/09/88 1/43 Tachypnea REMOVED ** CID 4391 ** REASON - Dead 908 03/20/88 Normal 441 441 672 07/28/87 672 07/28/87 1/39 Emaciated 450 12/18/86 728 09/22/87 11/39 Discharge Right Eye 450 12/18/86 728 09/22/87 11/39 Swelling Right Eye 756 10/20/87 785 11/18/87 2/39 Tissue Mass Right Eye 6-10 Mm 450 12/18/86 644 06/30/87 8/39 Ulcer Right Eye 0- 2 Mm 785 11/18/87 785 11/18/87 1/39 Tachypnea REMOVED ** CID 4411 ** REASON - Moribund 788 11/21/87 Tissue Mass Right Eye 6-10 Mm 442 442 616 06/02/87 616 06/02/87 1/36 Tissue Mass Body (Trunk) 0- 2 Mm 506 02/12/87 616 06/02/87 5/36 Emaciated 644 06/30/87 644 06/30/87 1/36 Reddened Right Front Leg 700 08/25/87 700 08/25/87 1/36 Sore Neck Yellow 672 07/28/87 672 07/28/87 1/36 Sore Right Front Leg Red REMOVED ** CID 4421 ** REASON - Moribund 705 08/30/87 Abnormal Posture 705 08/30/87 Wound Neck Red 705 08/30/87 Ruffled Fur NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 19 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 444 444 952 05/03/88 952 05/03/88 1/45 Swelling Body Ventral REMOVED ** CID 4441 ** REASON - Dead 954 05/05/88 Normal 446 446 1008 06/28/88 1008 06/28/88 1/49 Swelling Body Ventral 1008 06/28/88 1008 06/28/88 1/49 Ruffled Fur REMOVED ** CID 4461 ** REASON - Moribund 1009 06/29/88 Tremors 1009 06/29/88 Abnormal Posture 1009 06/29/88 Tachypnea 1009 06/29/88 Hypoactivity 447 447 805 12/08/87 805 12/08/87 1/40 Hyperactive 805 12/08/87 805 12/08/87 1/40 Head Tilted 805 12/08/87 805 12/08/87 1/40 Emaciated REMOVED ** CID 4471 ** REASON - Dead 813 12/16/87 Normal 450 450 567 04/14/87 616 06/02/87 3/50 Alopecia Body Ventral 1022 07/12/88 1022 07/12/88 1/50 Tissue Mass Neck 11-15 Mm REMOVED ** CID 4501 ** REASON - Term-Sac 1030 07/20/88 Tissue Mass Neck 11-15 Mm 451 451 805 12/08/87 805 12/08/87 1/40 Tissue Mass Shoulder 6-10 Mm REMOVED ** CID 4511 ** REASON - Moribund 820 12/23/87 Tissue Mass Body Ventral 26 or Gr 820 12/23/87 Emaciated 820 12/23/87 Abnormal Posture 452 452 309 07/30/86 339 08/29/86 2/39 Alopecia Body Ventral 140 02/11/86 616 06/02/87 15/39 Alopecia Entire Animal REMOVED ** CID 4521 ** REASON - Dead 798 12/01/87 Normal 454 454 966 05/17/88 980 05/31/88 2/48 Swelling Body Ventral REMOVED ** CID 4541 ** REASON - Dead NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 20 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 454 454 1008 06/28/88 Swelling Body Ventral 455 455 506 02/12/87 616 06/02/87 5/50 Alopecia Entire Animal 282 07/03/86 478 01/15/87 8/50 Alopecia Right Rear Leg 1022 07/12/88 1022 07/12/88 1/50 Emaciated 1022 07/12/88 1022 07/12/88 1/50 Tissue Mass Right Rear Leg 16-20 Mm 420 11/18/86 478 01/15/87 3/50 Alopecia Body Ventral 1022 07/12/88 1022 07/12/88 1/50 Ruffled Fur 1022 07/12/88 1022 07/12/88 1/50 Tachypnea REMOVED ** CID 4551 ** REASON - Term-Sac 1030 07/20/88 Tissue Mass Right Rear Leg 16-20 Mm 456 456 534 03/12/87 567 04/14/87 2/31 Alopecia Body Ventral 567 04/14/87 567 04/14/87 1/31 Limb Paralysis Left Rear Foot REMOVED ** CID 4561 ** REASON - Dead 569 04/16/87 Limb Paralysis Right Rear Leg 458 458 952 05/03/88 952 05/03/88 1/45 Ruffled Fur 952 05/03/88 952 05/03/88 1/45 Tachypnea REMOVED ** CID 4581 ** REASON - Moribund 955 05/06/88 Abnormal Posture 955 05/06/88 Ruffled Fur 955 05/06/88 Tachypnea 955 05/06/88 Hypoactivity 459 459 924 04/05/88 980 05/31/88 4/48 Swelling Body Ventral 980 05/31/88 994 06/14/88 2/48 Sore Body Dorsal 6-10 Mm 980 05/31/88 994 06/14/88 2/48 Tachypnea 966 05/17/88 966 05/17/88 1/48 Sore Body Dorsal 3- 5 Mm 980 05/31/88 994 06/14/88 2/48 Emaciated REMOVED ** CID 4591 ** REASON - Dead 1001 06/21/88 Tissue Mass Body Dorsal 16-20 Mm 461 461 868 02/09/88 868 02/09/88 1/42 Tissue Mass Shoulder 3- 5 Mm REMOVED ** CID 4611 ** REASON - Moribund 896 03/08/88 Tissue Mass Body (Trunk) 26 or Gr 896 03/08/88 Abnormal Posture NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 21 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 461 461 896 03/08/88 Tachypnea 462 462 835 01/07/88 868 02/09/88 2/42 Sore Body Dorsal 6-10 Mm 868 02/09/88 868 02/09/88 1/42 Emaciated REMOVED ** CID 4621 ** REASON - Moribund 891 03/03/88 Emaciated 891 03/03/88 Abnormal Posture 891 03/03/88 Sore Body (Trunk) 21-25 Mm 891 03/03/88 Tachypnea 463 463 567 04/14/87 616 06/02/87 3/42 Alopecia Body Ventral 868 02/09/88 868 02/09/88 1/42 Emaciated REMOVED ** CID 4631 ** REASON - Accident 880 02/21/88 Emaciated 464 464 616 06/02/87 616 06/02/87 1/33 Emaciated REMOVED ** CID 4641 ** REASON - Moribund 618 06/04/87 Emaciated 465 465 450 12/18/86 616 06/02/87 7/45 Alopecia Body Ventral 897 03/09/88 952 05/03/88 3/45 Swelling Body Ventral REMOVED ** CID 4651 ** REASON - Moribund 953 05/04/88 Ataxia 953 05/04/88 Tachypnea 953 05/04/88 Hypoactivity 468 468 364 09/23/86 835 01/07/88 16/50 Alopecia Entire Animal 339 08/29/86 1022 07/12/88 12/50 Alopecia Body Ventral 1022 07/12/88 1022 07/12/88 1/50 Tachypnea REMOVED ** CID 4681 ** REASON - Term-Sac 1030 07/20/88 Alopecia Body Ventral 469 469 506 02/12/87 616 06/02/87 5/40 Alopecia Body Ventral REMOVED ** CID 4691 ** REASON - Dead 828 12/31/87 Normal NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 22 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 470 470 868 02/09/88 868 02/09/88 1/42 Swelling Body Ventral REMOVED ** CID 4701 ** REASON - Moribund 890 03/02/88 Diarrhea 890 03/02/88 Abnormal Posture 890 03/02/88 Tachypnea 473 473 567 04/14/87 616 06/02/87 3/45 Alopecia Entire Animal 420 11/18/86 534 03/12/87 5/45 Alopecia Body Ventral 924 04/05/88 952 05/03/88 2/45 Ruffled Fur 952 05/03/88 952 05/03/88 1/45 Emaciated REMOVED ** CID 4731 ** REASON - Dead 966 05/17/88 Normal 476 476 805 12/08/87 805 12/08/87 1/40 Tissue Mass Shoulder 6-10 Mm 616 06/02/87 616 06/02/87 1/40 Emaciated 756 10/20/87 785 11/18/87 2/40 Tissue Mass Body (Trunk) 6-10 Mm REMOVED ** CID 4761 ** REASON - Moribund 809 12/12/87 Tissue Mass Body Ventral 16-20 Mm 809 12/12/87 Ataxia 809 12/12/87 Abnormal Posture 478 478 835 01/07/88 868 02/09/88 2/42 Swelling Left Eye 835 01/07/88 868 02/09/88 2/42 Discharge Left Eye REMOVED ** CID 4781 ** REASON - Moribund 884 02/25/88 Emaciated 884 02/25/88 Abnormal Posture 884 02/25/88 Tachypnea 884 02/25/88 Hypoactivity 479 479 1022 07/12/88 1022 07/12/88 1/50 Swelling Body Ventral 339 08/29/86 339 08/29/86 1/50 Emaciated REMOVED ** CID 4791 ** REASON - Dead 1026 07/16/88 Normal 480 480 567 04/14/87 567 04/14/87 1/31 Emaciated REMOVED ** CID 4801 ** REASON - Moribund NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 23 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 480 480 585 05/02/87 Dyspnea 585 05/02/87 Emaciated 585 05/02/87 Abnormal Posture 585 05/02/87 Hypoactivity 481 481 868 02/09/88 868 02/09/88 1/42 Tissue Mass Shoulder 3- 5 Mm 309 07/30/86 672 07/28/87 3/42 Alopecia Body Ventral 140 02/11/86 140 02/11/86 1/42 Alopecia Body (Trunk) 168 03/11/86 868 02/09/88 23/42 Alopecia Entire Animal REMOVED ** CID 4811 ** REASON - Moribund 877 02/18/88 Abnormal Posture 877 02/18/88 Tachypnea 877 02/18/88 Hypoactivity 483 483 952 05/03/88 952 05/03/88 1/45 Tissue Mass Right Front Leg 6-10 Mm REMOVED ** CID 4831 ** REASON - Dead 965 05/16/88 Tissue Mass Right Front Leg 16-20 Mm 484 484 567 04/14/87 616 06/02/87 3/35 Alopecia Entire Animal 450 12/18/86 534 03/12/87 4/35 Alopecia Body Ventral REMOVED ** CID 4841 ** REASON - Moribund 695 08/20/87 Emaciated 695 08/20/87 Ataxia 695 08/20/87 Abnormal Posture 695 08/20/87 Ruffled Fur 695 08/20/87 Hypoactivity 485 485 534 03/12/87 595 05/12/87 3/32 Emaciated REMOVED ** CID 4851 ** REASON - Moribund 605 05/22/87 Swelling Body Ventral 486 486 897 03/09/88 924 04/05/88 2/44 Ruffled Fur 868 02/09/88 868 02/09/88 1/44 Emaciated 897 03/09/88 924 04/05/88 2/44 Swelling Body Ventral REMOVED ** CID 4861 ** REASON - Moribund 932 04/13/88 Swelling Body Ventral 932 04/13/88 Abnormal Posture NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 24 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 486 486 932 04/13/88 Ruffled Fur 932 04/13/88 Tachypnea 932 04/13/88 Hypoactivity 488 488 868 02/09/88 868 02/09/88 1/42 Tachypnea 868 02/09/88 868 02/09/88 1/42 Head Tilted REMOVED ** CID 4881 ** REASON - Moribund 883 02/24/88 Emaciated 883 02/24/88 Abnormal Posture 883 02/24/88 Tachypnea 883 02/24/88 Hypoactivity 489 489 450 12/18/86 616 06/02/87 7/43 Alopecia Right Rear Leg 616 06/02/87 616 06/02/87 1/43 Alopecia Left Rear Leg REMOVED ** CID 4891 ** REASON - Dead 913 03/25/88 Normal 490 490 253 06/04/86 616 06/02/87 13/44 Alopecia Entire Animal 196 04/08/86 224 05/06/86 2/44 Alopecia Body Ventral REMOVED ** CID 4901 ** REASON - Dead 951 05/02/88 Normal 491 491 785 11/18/87 868 02/09/88 4/42 Swelling Body Ventral 868 02/09/88 868 02/09/88 1/42 Emaciated 785 11/18/87 868 02/09/88 4/42 Tachypnea REMOVED ** CID 4911 ** REASON - Moribund 873 02/14/88 Abnormal Posture 873 02/14/88 Tachypnea 492 492 756 10/20/87 756 10/20/87 1/38 Tissue Mass Body (Trunk) 6-10 Mm REMOVED ** CID 4921 ** REASON - Moribund 765 10/29/87 Tissue Mass Body (Trunk) 21-25 Mm 765 10/29/87 Ruffled Fur 765 10/29/87 Tachypnea 765 10/29/87 Hypoactivity NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 25 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 493 493 835 01/07/88 835 01/07/88 1/41 Emaciated REMOVED ** CID 4931 ** REASON - Dead 852 01/24/88 Normal 494 494 450 12/18/86 478 01/15/87 2/40 Swelling Tail 534 03/12/87 700 08/25/87 7/40 Tissue Mass Tail 0- 2 Mm 785 11/18/87 785 11/18/87 1/40 Tissue Mass Tail 6-10 Mm 728 09/22/87 805 12/08/87 3/40 Tissue Mass Tail 3- 5 Mm 785 11/18/87 785 11/18/87 1/40 Emaciated 805 12/08/87 805 12/08/87 1/40 Tissue Mass Neck 3- 5 Mm 805 12/08/87 805 12/08/87 1/40 Swelling Left Eye REMOVED ** CID 4941 ** REASON - Moribund 817 12/20/87 Tissue Mass Right Eye 6-10 Mm 817 12/20/87 Tissue Mass Neck 6-10 Mm 817 12/20/87 Emaciated 817 12/20/87 Abnormal Posture 817 12/20/87 Ruffled Fur 817 12/20/87 Hypoactivity 497 497 364 09/23/86 364 09/23/86 1/40 Alopecia Right Rear Leg REMOVED ** CID 4971 ** REASON - Dead 814 12/17/87 Normal 498 498 952 05/03/88 980 05/31/88 3/47 Head Tilted 952 05/03/88 980 05/31/88 3/47 Emaciated 952 05/03/88 980 05/31/88 3/47 Tachypnea REMOVED ** CID 4981 ** REASON - Moribund 991 06/11/88 Dyspnea 991 06/11/88 Emaciated 991 06/11/88 Abnormal Posture 500 500 868 02/09/88 868 02/09/88 1/42 Swelling Body Ventral REMOVED ** CID 5001 ** REASON - Moribund 878 02/19/88 Abnormal Posture 878 02/19/88 Tachypnea 878 02/19/88 Hypoactivity 504 504 700 08/25/87 700 08/25/87 1/36 Emaciated NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 26 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ REMOVED ** CID 5041 ** REASON - Dead 504 504 705 08/30/87 Normal 505 505 395 10/24/86 534 03/12/87 6/35 Alopecia Right Rear Leg 567 04/14/87 616 06/02/87 3/35 Alopecia Entire Animal 364 09/23/86 506 02/12/87 6/35 Alopecia Left Rear Leg 534 03/12/87 534 03/12/87 1/35 Alopecia Left Rear Foot 309 07/30/86 339 08/29/86 2/35 Alopecia Body Dorsal REMOVED ** CID 5051 ** REASON - Moribund 688 08/13/87 Dyspnea 688 08/13/87 Ruffled Fur 688 08/13/87 Hypoactivity 506 506 253 06/04/86 616 06/02/87 14/42 Alopecia Entire Animal 196 04/08/86 700 08/25/87 5/42 Alopecia Body Ventral 868 02/09/88 868 02/09/88 1/42 Tissue Mass Body (Trunk) 26 or Gr REMOVED ** CID 5061 ** REASON - Moribund 868 02/09/88 Tissue Mass Left Rear Leg 26 or Gr 868 02/09/88 Ruffled Fur 868 02/09/88 Tachypnea 868 02/09/88 Hypoactivity 507 507 450 12/18/86 506 02/12/87 3/50 Alopecia Left Rear Leg 534 03/12/87 616 06/02/87 4/50 Alopecia Entire Animal 339 08/29/86 1022 07/12/88 24/50 Alopecia Body Ventral REMOVED ** CID 5071 ** REASON - Term-Sac 1030 07/20/88 Alopecia Body Ventral 508 508 196 04/08/86 339 08/29/86 6/34 Alopecia Entire Animal 140 02/11/86 140 02/11/86 1/34 Alopecia Body Dorsal 140 02/11/86 616 06/02/87 6/34 Alopecia Body Ventral REMOVED ** CID 5081 ** REASON - Dead 661 07/17/87 Salivating 509 509 140 02/11/86 168 03/11/86 2/29 Alopecia Body Dorsal 196 04/08/86 478 01/15/87 11/29 Alopecia Entire Animal REMOVED ** CID 5091 ** REASON - Dead NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 27 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 509 509 510 02/16/87 Normal 510 510 897 03/09/88 924 04/05/88 2/44 Tissue Mass Body (Trunk) 6-10 Mm REMOVED ** CID 5101 ** REASON - Dead 939 04/20/88 Swelling Body (Trunk) 511 511 567 04/14/87 616 06/02/87 3/50 Emaciated 1022 07/12/88 1022 07/12/88 1/50 Ruffled Fur 1022 07/12/88 1022 07/12/88 1/50 Tachypnea REMOVED ** CID 5111 ** REASON - Term-Sac 1030 07/20/88 Normal 515 515 57 11/20/85 78 12/11/85 5/25 Alopecia Body Dorsal 78 12/11/85 78 12/11/85 1/25 Alopecia Body (Trunk) 86 12/19/85 395 10/24/86 13/25 Alopecia Entire Animal 64 11/27/85 78 12/11/85 3/25 Alopecia Body Ventral 71 12/04/85 78 12/11/85 2/25 Alopecia Face REMOVED ** CID 5151 ** REASON - Dead 408 11/06/86 Swelling Body Ventral 517 517 868 02/09/88 868 02/09/88 1/42 Tachypnea 868 02/09/88 868 02/09/88 1/42 Swelling Body Ventral 868 02/09/88 868 02/09/88 1/42 Ruffled Fur REMOVED ** CID 5171 ** REASON - Moribund 872 02/13/88 Dyspnea 872 02/13/88 Swelling Body Ventral 520 520 980 05/31/88 980 05/31/88 1/47 Tachypnea 897 03/09/88 897 03/09/88 1/47 Swelling Body Ventral 980 05/31/88 980 05/31/88 1/47 Head Tilted 980 05/31/88 980 05/31/88 1/47 Emaciated REMOVED ** CID 5201 ** REASON - Moribund 983 06/03/88 Dyspnea 983 06/03/88 Emaciated 983 06/03/88 Abnormal Posture NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 28 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 521 521 534 03/12/87 616 06/02/87 4/36 Alopecia Body Ventral REMOVED ** CID 5211 ** REASON - Dead 701 08/26/87 Normal 522 522 196 04/08/86 478 01/15/87 6/50 Alopecia Body Ventral 309 07/30/86 616 06/02/87 9/50 Alopecia Entire Animal REMOVED ** CID 5221 ** REASON - Term-Sac 1030 07/20/88 Normal 523 523 224 05/06/86 282 07/03/86 3/35 Alopecia Body Ventral 309 07/30/86 616 06/02/87 12/35 Alopecia Entire Animal REMOVED ** CID 5231 ** REASON - Dead 680 08/05/87 Alopecia Body Ventral 524 524 897 03/09/88 924 04/05/88 2/44 Emaciated 534 03/12/87 616 06/02/87 4/44 Alopecia Body Ventral 924 04/05/88 924 04/05/88 1/44 Head Tilted REMOVED ** CID 5241 ** REASON - Moribund 933 04/14/88 Tremors 933 04/14/88 Emaciated 933 04/14/88 Abnormal Posture 933 04/14/88 Tachypnea 933 04/14/88 Hypoactivity 525 525 897 03/09/88 966 05/17/88 4/46 Swelling Body Ventral REMOVED ** CID 5251 ** REASON - Dead 980 05/31/88 Swelling Body Ventral 526 526 113 01/15/86 616 06/02/87 19/35 Alopecia Entire Animal 644 06/30/87 672 07/28/87 2/35 Alopecia Body Ventral REMOVED ** CID 5261 ** REASON - Moribund 694 08/19/87 Emaciated 694 08/19/87 Abnormal Posture 694 08/19/87 Hypoactivity 527 527 364 09/23/86 805 12/08/87 13/40 Alopecia Body Ventral NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 29 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS ANIMAL DATA - 527 527 168 03/11/86 616 06/02/87 11/40 Alopecia Entire Animal REMOVED ** CID 5271 ** REASON - Dead 825 12/28/87 Normal 528 528 644 06/30/87 644 06/30/87 1/34 Tissue Mass Mammary 6-10 Mm REMOVED ** CID 5281 ** REASON - Moribund 650 07/06/87 Tissue Mass Body Ventral 26 or Gr 650 07/06/87 Emaciated 529 529 952 05/03/88 952 05/03/88 1/45 Swelling Body Ventral 952 05/03/88 952 05/03/88 1/45 Tachypnea 952 05/03/88 952 05/03/88 1/45 Emaciated REMOVED ** CID 5291 ** REASON - Moribund 953 05/04/88 Tremors 953 05/04/88 Abnormal Posture 953 05/04/88 Ruffled Fur 953 05/04/88 Tachypnea 953 05/04/88 Hypoactivity 531 531 1022 07/12/88 1022 07/12/88 1/50 Tachypnea 1022 07/12/88 1022 07/12/88 1/50 Swelling Body Ventral 1022 07/12/88 1022 07/12/88 1/50 Ruffled Fur 506 02/12/87 1022 07/12/88 2/50 Abnormal Posture REMOVED ** CID 5311 ** REASON - Term-Sac 1030 07/20/88 Normal 533 533 339 08/29/86 339 08/29/86 1/45 Alopecia Body Ventral 897 03/09/88 952 05/03/88 3/45 Swelling Body Ventral 897 03/09/88 897 03/09/88 1/45 Tachypnea 897 03/09/88 897 03/09/88 1/45 Ruffled Fur 897 03/09/88 897 03/09/88 1/45 Emaciated REMOVED ** CID 5331 ** REASON - Moribund 962 05/13/88 Tachypnea 962 05/13/88 Hypoactivity 534 534 756 10/20/87 756 10/20/87 1/39 Tissue Mass Body Dorsal 6-10 Mm 785 11/18/87 785 11/18/87 1/39 Tissue Mass Neck 6-10 Mm NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 30 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ REMOVED ** CID 5341 ** REASON - Dead 534 534 804 12/07/87 Tissue Mass Neck 11-15 Mm 535 535 868 02/09/88 868 02/09/88 1/42 Tissue Mass Neck 6-10 Mm REMOVED ** CID 5351 ** REASON - Moribund 897 03/09/88 Tissue Mass Body (Trunk) 21-25 Mm 537 537 805 12/08/87 835 01/07/88 2/41 Ruffled Fur 805 12/08/87 835 01/07/88 2/41 Tachypnea 805 12/08/87 835 01/07/88 2/41 Swelling Body Ventral 835 01/07/88 835 01/07/88 1/41 Emaciated REMOVED ** CID 5371 ** REASON - Moribund 840 01/12/88 Abnormal Posture 840 01/12/88 Tachypnea 840 01/12/88 Hypoactivity 539 539 450 12/18/86 478 01/15/87 2/28 Emaciated REMOVED ** CID 5391 ** REASON - Dead 483 01/20/87 Normal 540 540 140 02/11/86 616 06/02/87 6/42 Alopecia Body Ventral REMOVED ** CID 5401 ** REASON - Moribund 884 02/25/88 Tachypnea 884 02/25/88 Comatose 541 541 534 03/12/87 616 06/02/87 4/39 Alopecia Body Ventral REMOVED ** CID 5411 ** REASON - Dead 792 11/25/87 Normal 542 542 616 06/02/87 644 06/30/87 2/34 Tissue Mass Body (Trunk) 0- 2 Mm REMOVED ** CID 5421 ** REASON - Dead 666 07/22/87 Normal 543 543 364 09/23/86 364 09/23/86 1/25 Tissue Mass Right Rear Leg 11-15 Mm NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 31 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS ANIMAL DATA - 543 543 282 07/03/86 339 08/29/86 3/25 Tissue Mass Body (Trunk) 6-10 Mm 395 10/24/86 395 10/24/86 1/25 Tissue Mass Right Rear Leg 16-20 Mm 339 08/29/86 339 08/29/86 1/25 Override REMOVED ** CID 5431 ** REASON - Moribund 398 10/27/86 Tissue Mass Right Rear Leg 11-15 Mm 545 545 672 07/28/87 672 07/28/87 1/35 Swelling Right Eye 672 07/28/87 672 07/28/87 1/35 Sore Right Ear Blue-Blk 616 06/02/87 672 07/28/87 3/35 Emaciated REMOVED ** CID 5451 ** REASON - Dead 680 08/05/87 Swelling Right Ear 680 08/05/87 Emaciated 680 08/05/87 Discharge Right Ear 546 546 924 04/05/88 924 04/05/88 1/44 Head Tilted 924 04/05/88 924 04/05/88 1/44 Emaciated REMOVED ** CID 5461 ** REASON - Dead 925 04/06/88 Normal 548 548 567 04/14/87 616 06/02/87 3/33 Emaciated REMOVED ** CID 5481 ** REASON - Moribund 621 06/07/87 Emaciated 550 550 309 07/30/86 364 09/23/86 3/26 Alopecia Body Ventral 395 10/24/86 420 11/18/86 2/26 Alopecia Entire Animal REMOVED ** CID 5501 ** REASON - Moribund 430 11/28/86 Alopecia Body Ventral 430 11/28/86 Swelling Body Ventral 430 11/28/86 Ruffled Fur 552 552 1008 06/28/88 1008 06/28/88 1/49 Tachypnea 1008 06/28/88 1008 06/28/88 1/49 Emaciated 1008 06/28/88 1008 06/28/88 1/49 Ruffled Fur REMOVED ** CID 5521 ** REASON - Moribund 1010 06/30/88 Emaciated 1010 06/30/88 Abnormal Posture NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 32 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 552 552 1010 06/30/88 Hypoactivity 553 553 567 04/14/87 616 06/02/87 3/40 Alopecia Entire Animal 140 02/11/86 805 12/08/87 21/40 Alopecia Body Ventral REMOVED ** CID 5531 ** REASON - Moribund 832 01/04/88 Dyspnea 832 01/04/88 Alopecia Body Ventral 832 01/04/88 Emaciated 832 01/04/88 Abnormal Posture 554 554 168 03/11/86 168 03/11/86 1/37 Alopecia Body Dorsal 196 04/08/86 616 06/02/87 16/37 Alopecia Entire Animal 140 02/11/86 140 02/11/86 1/37 Alopecia Body Ventral REMOVED ** CID 5541 ** REASON - Moribund 733 09/27/87 Swelling Body Ventral 733 09/27/87 Ruffled Fur 733 09/27/87 Hypoactivity 555 555 897 03/09/88 897 03/09/88 1/44 Tissue Mass Right Front Leg 6-10 Mm 924 04/05/88 924 04/05/88 1/44 Tissue Mass Right Front Leg 11-15 Mm REMOVED ** CID 5551 ** REASON - Dead 931 04/12/88 Tissue Mass Right Front Leg 26 or Gr 558 558 140 02/11/86 616 06/02/87 4/34 Alopecia Entire Animal 644 06/30/87 644 06/30/87 1/34 Swelling Left Eye 196 04/08/86 534 03/12/87 13/34 Alopecia Body Ventral 644 06/30/87 644 06/30/87 1/34 Head Tilted REMOVED ** CID 5581 ** REASON - Dead 657 07/13/87 Head Tilted 657 07/13/87 Swelling Left Eye 560 560 339 08/29/86 616 06/02/87 5/50 Alopecia Body Ventral REMOVED ** CID 5601 ** REASON - Dead 1023 07/13/88 Normal 562 562 868 02/09/88 868 02/09/88 1/42 Tissue Mass Neck 11-15 Mm NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 33 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS ANIMAL DATA - 562 562 805 12/08/87 835 01/07/88 2/42 Tissue Mass Neck 6-10 Mm REMOVED ** CID 5621 ** REASON - Moribund 869 02/10/88 Tissue Mass Neck 21-25 Mm 567 567 805 12/08/87 805 12/08/87 1/40 Head Tilted 805 12/08/87 805 12/08/87 1/40 Emaciated REMOVED ** CID 5671 ** REASON - Dead 806 12/09/87 Normal 568 568 567 04/14/87 616 06/02/87 3/44 Alopecia Body Ventral REMOVED ** CID 5681 ** REASON - Dead 946 04/27/88 Normal 571 571 1008 06/28/88 1008 06/28/88 1/49 Tachypnea 1008 06/28/88 1008 06/28/88 1/49 Ruffled Fur 1008 06/28/88 1008 06/28/88 1/49 Emaciated REMOVED ** CID 5711 ** REASON - Dead 1010 06/30/88 Normal 573 573 897 03/09/88 924 04/05/88 2/44 Tissue Mass Right Rear Leg 6-10 Mm 835 01/07/88 868 02/09/88 2/44 Tissue Mass Head 6-10 Mm 897 03/09/88 924 04/05/88 2/44 Tissue Mass Head 11-15 Mm 756 10/20/87 805 12/08/87 3/44 Tissue Mass Head 3- 5 Mm 140 02/11/86 616 06/02/87 18/44 Alopecia Entire Animal REMOVED ** CID 5731 ** REASON - Moribund 939 04/20/88 Tissue Mass Neck 16-20 Mm 939 04/20/88 Comatose 574 574 567 04/14/87 616 06/02/87 3/43 Alopecia Body Ventral 868 02/09/88 897 03/09/88 2/43 Tissue Mass Shoulder 6-10 Mm REMOVED ** CID 5741 ** REASON - Moribund 904 03/16/88 Tremors 904 03/16/88 Tissue Mass Body (Trunk) 21-25 Mm 904 03/16/88 Abnormal Posture 904 03/16/88 Tachypnea 904 03/16/88 Hypoactivity NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 34 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 576 576 980 05/31/88 980 05/31/88 1/47 Swelling Body Ventral REMOVED ** CID 5761 ** REASON - Moribund 984 06/04/88 Tachypnea 984 06/04/88 Comatose 577 577 756 10/20/87 868 02/09/88 5/42 Alopecia Entire Animal 567 04/14/87 728 09/22/87 7/42 Alopecia Body Ventral REMOVED ** CID 5771 ** REASON - Dead 882 02/23/88 Normal 584 584 700 08/25/87 785 11/18/87 4/39 Sore Left Ear Red REMOVED ** CID 5841 ** REASON - Moribund 788 11/21/87 Tissue Mass Neck 6-10 Mm 788 11/21/87 Swelling Body Ventral 585 585 168 03/11/86 728 09/22/87 18/37 Alopecia Body Ventral 567 04/14/87 616 06/02/87 3/37 Alopecia Entire Animal REMOVED ** CID 5851 ** REASON - Dead 729 09/23/87 Normal 586 586 478 01/15/87 805 12/08/87 11/40 Alopecia Entire Animal 805 12/08/87 805 12/08/87 1/40 Emaciated 506 02/12/87 644 06/30/87 2/40 Alopecia Body Ventral REMOVED ** CID 5861 ** REASON - Dead 807 12/10/87 Normal 587 587 644 06/30/87 644 06/30/87 1/34 Emaciated 478 01/15/87 478 01/15/87 1/34 Alopecia Body Ventral REMOVED ** CID 5871 ** REASON - Moribund 661 07/17/87 Hypoactivity 661 07/17/87 Prostration 589 589 805 12/08/87 805 12/08/87 1/40 Sore Body Dorsal 6-10 Mm 785 11/18/87 785 11/18/87 1/40 Sore Body Dorsal 3- 5 Mm NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 35 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ REMOVED ** CID 5891 ** REASON - Moribund 589 589 815 12/18/87 Tissue Mass Body (Trunk) 21-25 Mm 815 12/18/87 Emaciated 815 12/18/87 Abnormal Posture 815 12/18/87 Tachypnea 815 12/18/87 Hypoactivity 591 591 1022 07/12/88 1022 07/12/88 1/50 Tissue Mass Neck 6-10 Mm REMOVED ** CID 5911 ** REASON - Term-Sac 1030 07/20/88 Tissue Mass Neck 11-15 Mm 592 592 616 06/02/87 616 06/02/87 1/43 Alopecia Entire Animal 567 04/14/87 595 05/12/87 2/43 Alopecia Left Rear Foot 567 04/14/87 595 05/12/87 2/43 Alopecia Right Rear Leg 450 12/18/86 450 12/18/86 1/43 Alopecia Left Front Leg 478 01/15/87 534 03/12/87 3/43 Alopecia Left Rear Leg REMOVED ** CID 5921 ** REASON - Dead 899 03/11/88 Normal 593 593 339 08/29/86 616 06/02/87 11/37 Alopecia Body Ventral REMOVED ** CID 5931 ** REASON - Moribund 745 10/09/87 Dyspnea 745 10/09/87 Swelling Body Ventral 745 10/09/87 Hypoactivity 594 594 168 03/11/86 616 06/02/87 17/50 Alopecia Entire Animal 1022 07/12/88 1022 07/12/88 1/50 Emaciated REMOVED ** CID 5941 ** REASON - Dead 1027 07/17/88 Emaciated 596 596 595 05/12/87 616 06/02/87 2/45 Alopecia Body Ventral REMOVED ** CID 5961 ** REASON - Dead 957 05/08/88 Normal 598 598 478 01/15/87 595 05/12/87 5/44 Alopecia Body Ventral REMOVED ** CID 5981 ** REASON - Dead NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 36 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 2 ROOM/AREA: 5502 FIRST DOSE: 09/25/85 SEX: FEMALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 598 598 943 04/24/88 Alopecia Body Ventral 599 599 339 08/29/86 616 06/02/87 5/41 Alopecia Entire Animal 168 03/11/86 835 01/07/88 18/41 Alopecia Body Ventral 140 02/11/86 140 02/11/86 1/41 Alopecia Anal Area 835 01/07/88 835 01/07/88 1/41 Tissue Mass Right Front Foot 6-10 Mm REMOVED ** CID 5991 ** REASON - Moribund 853 01/25/88 Tissue Mass Body Ventral 16-20 Mm 853 01/25/88 Tissue Mass Groin 11-15 Mm 853 01/25/88 Ataxia 853 01/25/88 Abnormal Posture 853 01/25/88 Tachypnea NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 37 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 3 3 168 03/10/86 868 02/08/88 25/42 Alopecia Body Ventral REMOVED ** CID 31 ** REASON - Moribund 877 02/17/88 Abnormal Posture 877 02/17/88 Tachypnea 877 02/17/88 Hypoactivity 5 5 309 07/29/86 364 09/22/86 3/42 Alopecia Body Ventral 395 10/23/86 868 02/08/88 18/42 Alopecia Entire Animal REMOVED ** CID 51 ** REASON - Moribund 878 02/18/88 Abnormal Posture 878 02/18/88 Tachypnea 878 02/18/88 Hypoactivity 6 6 728 09/21/87 728 09/21/87 1/42 Tissue Mass Groin 0- 2 Mm 868 02/08/88 868 02/08/88 1/42 Tachypnea REMOVED ** CID 61 ** REASON - Moribund 871 02/11/88 Tachypnea 871 02/11/88 Comatose 7 7 966 05/16/88 966 05/16/88 1/49 Swelling Body Ventral 1009 06/28/88 1009 06/28/88 1/49 Tachypnea 1009 06/28/88 1009 06/28/88 1/49 Ruffled Fur 1009 06/28/88 1009 06/28/88 1/49 Emaciated REMOVED ** CID 71 ** REASON - Dead 1013 07/02/88 Emaciated 8 8 1094 09/21/88 1094 09/21/88 1/55 Tachypnea 1094 09/21/88 1094 09/21/88 1/55 Ruffled Fur 1065 08/23/88 1094 09/21/88 3/55 Swelling Body Ventral REMOVED ** CID 81 ** REASON - Dead 1099 09/26/88 Swelling Body Ventral 9 9 1122 10/19/88 1122 10/19/88 1/57 Prolapse Penis 1065 08/23/88 1122 10/19/88 5/57 Tachypnea 1065 08/23/88 1122 10/19/88 5/57 Ruffled Fur 728 09/21/87 728 09/21/87 1/57 Tissue Mass Groin 0- 2 Mm REMOVED ** CID 91 ** REASON - Term-Sac NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 38 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 9 9 1134 10/31/88 Prolapse Penis 1134 10/31/88 Ruffled Fur 1134 10/31/88 Tachypnea 10 10 616 06/01/87 616 06/01/87 1/44 Emaciated REMOVED ** CID 101 ** REASON - Dead 929 04/09/88 Normal 13 13 1023 07/12/88 1050 08/08/88 3/52 Swelling Body Ventral REMOVED ** CID 131 ** REASON - Dead 1053 08/11/88 Normal 14 14 1108 10/05/88 1122 10/19/88 2/57 Ruffled Fur 1108 10/05/88 1122 10/19/88 2/57 Tachypnea 1023 07/12/88 1122 10/19/88 8/57 Swelling Body Ventral REMOVED ** CID 141 ** REASON - Term-Sac 1134 10/31/88 Normal 15 15 700 08/24/87 700 08/24/87 1/36 Sore Penis Yellow 700 08/24/87 700 08/24/87 1/36 Prostration REMOVED ** CID 151 ** REASON - Dead 712 09/05/87 Tissue Mass Penis 6-10 Mm 17 17 1065 08/23/88 1108 10/05/88 4/56 Ruffled Fur 981 05/31/88 981 05/31/88 1/56 Emaciated 1009 06/28/88 1108 10/05/88 8/56 Tissue Mass Left Eye 11-15 Mm 1094 09/21/88 1094 09/21/88 1/56 Abnormal Posture 506 02/11/87 995 06/14/88 14/56 Swelling Left Eye 616 06/01/87 995 06/14/88 8/56 Discharge Left Eye 1079 09/06/88 1108 10/05/88 2/56 Tachypnea 756 10/19/87 897 03/08/88 6/56 Tissue Mass Left Eye 6-10 Mm REMOVED ** CID 171 ** REASON - Dead 1117 10/14/88 Tissue Mass Left Eye 11-15 Mm 18 18 785 11/17/87 805 12/07/87 2/44 Tissue Mass Neck 6-10 Mm 835 01/06/88 924 04/04/88 4/44 Tissue Mass Neck 11-15 Mm NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 39 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ REMOVED ** CID 181 ** REASON - Dead 18 18 945 04/25/88 Tissue Mass Neck 21-25 Mm 19 19 785 11/17/87 785 11/17/87 1/39 Tissue Mass Body Ventral 16-20 Mm REMOVED ** CID 191 ** REASON - Dead 785 11/17/87 Normal 21 21 672 07/27/87 672 07/27/87 1/40 Alopecia Neck 450 12/17/86 805 12/07/87 8/40 Alopecia Body Ventral REMOVED ** CID 211 ** REASON - Moribund 817 12/19/87 Dyspnea 817 12/19/87 Abnormal Posture 817 12/19/87 Hypoactivity 24 24 897 03/08/88 924 04/04/88 2/44 Swelling Right Eye 569 04/15/87 924 04/04/88 14/44 Alopecia Body Ventral REMOVED ** CID 241 ** REASON - Moribund 932 04/12/88 Swelling Toes 932 04/12/88 Tachypnea 932 04/12/88 Comatose 25 25 1065 08/23/88 1094 09/21/88 3/55 Ruffled Fur 981 05/31/88 995 06/14/88 2/55 Tachypnea REMOVED ** CID 251 ** REASON - Dead 1100 09/27/88 Normal 26 26 728 09/21/87 728 09/21/87 1/37 Tissue Mass Groin 3- 5 Mm 700 08/24/87 728 09/21/87 2/37 Emaciated REMOVED ** CID 261 ** REASON - Moribund 732 09/25/87 Emaciated 732 09/25/87 Tachypnea 732 09/25/87 Limb Paralysis Right Rear Leg 732 09/25/87 Limb Paralysis Left Rear Leg 27 27 1108 10/05/88 1122 10/19/88 2/57 Ruffled Fur 1108 10/05/88 1122 10/19/88 2/57 Sore Body Dorsal 6-10 Mm NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 40 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS ANIMAL DATA - 27 27 1122 10/19/88 1122 10/19/88 1/57 Prolapse Penis 1122 10/19/88 1122 10/19/88 1/57 Polyuria 1108 10/05/88 1122 10/19/88 2/57 Tachypnea REMOVED ** CID 271 ** REASON - Term-Sac 1134 10/31/88 Alopecia Body Dorsal 1134 10/31/88 Prolapse Penis 1134 10/31/88 Ruffled Fur 1134 10/31/88 Tachypnea 1134 10/31/88 Polyuria 28 28 616 06/01/87 644 06/29/87 2/40 Alopecia Body Ventral REMOVED ** CID 281 ** REASON - Dead 826 12/28/87 Normal 30 30 478 01/14/87 506 02/11/87 2/29 Emaciated REMOVED ** CID 301 ** REASON - Moribund 528 03/05/87 Tremors 528 03/05/87 Hypoactivity 32 32 478 01/14/87 478 01/14/87 1/38 Emaciated REMOVED ** CID 321 ** REASON - Dead 772 11/04/87 Normal 33 33 835 01/06/88 835 01/06/88 1/43 Circling 168 03/10/86 168 03/10/86 1/43 Alopecia Body Ventral REMOVED ** CID 331 ** REASON - Dead 911 03/22/88 Normal 35 35 569 04/15/87 569 04/15/87 1/31 Emaciated 569 04/15/87 569 04/15/87 1/31 Ruffled Fur REMOVED ** CID 351 ** REASON - Moribund 586 05/02/87 Abnormal Posture 586 05/02/87 Ruffled Fur 586 05/02/87 Hypoactivity NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 41 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 38 38 616 06/01/87 616 06/01/87 1/36 Tissue Mass Body (Trunk) 0- 2 Mm 569 04/15/87 700 08/24/87 3/36 Emaciated REMOVED ** CID 381 ** REASON - Moribund 727 09/20/87 Emaciated 727 09/20/87 Abnormal Posture 727 09/20/87 Ruffled Fur 39 39 835 01/06/88 835 01/06/88 1/41 Emaciated 756 10/19/87 785 11/17/87 2/41 Tissue Mass Body Ventral 11-15 Mm 805 12/07/87 835 01/06/88 2/41 Swelling Body Ventral REMOVED ** CID 391 ** REASON - Moribund 861 02/01/88 Swelling Body Ventral 861 02/01/88 Hypoactivity 40 40 309 07/29/86 616 06/01/87 9/39 Alopecia Body Ventral 672 07/27/87 785 11/17/87 5/39 Alopecia Neck REMOVED ** CID 401 ** REASON - Dead 793 11/25/87 Normal 42 42 1065 08/23/88 1108 10/05/88 4/56 Ruffled Fur 1065 08/23/88 1108 10/05/88 4/56 Tachypnea 1038 07/27/88 1108 10/05/88 6/56 Emaciated 1065 08/23/88 1108 10/05/88 4/56 Abnormal Posture REMOVED ** CID 421 ** REASON - Moribund 1117 10/14/88 Dyspnea 1117 10/14/88 Emaciated 1117 10/14/88 Abnormal Posture 1117 10/14/88 Ruffled Fur 1117 10/14/88 Hypoactivity 43 43 1023 07/12/88 1065 08/23/88 4/53 Tachypnea 1009 06/28/88 1065 08/23/88 5/53 Swelling Right Eye REMOVED ** CID 431 ** REASON - Moribund 1076 09/03/88 Tissue Mass Right Eye 3- 5 Mm 1076 09/03/88 Emaciated 1076 09/03/88 Abnormal Posture 1076 09/03/88 Hypoactivity NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 42 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 44 44 450 12/17/86 506 02/11/87 3/57 Malocclusion 805 12/07/87 1122 10/19/88 18/57 Tachypnea 805 12/07/87 1122 10/19/88 16/57 Ruffled Fur 140 02/10/86 140 02/10/86 1/57 Alopecia Left Front Leg 196 04/07/86 1122 10/19/88 39/57 Alopecia Body Ventral 224 05/05/86 224 05/05/86 1/57 Alopecia Mammary 339 08/28/86 616 06/01/87 4/57 Emaciated REMOVED ** CID 441 ** REASON - Dead 1134 10/31/88 Alopecia Body Ventral 1134 10/31/88 Ruffled Fur 48 48 616 06/01/87 700 08/24/87 4/36 Tissue Mass Body Ventral 0- 2 Mm 595 05/11/87 595 05/11/87 1/36 Tissue Mass Body (Trunk) 0- 2 Mm REMOVED ** CID 481 ** REASON - Dead 717 09/10/87 Normal 49 49 981 05/31/88 995 06/14/88 2/49 Emaciated 966 05/16/88 995 06/14/88 3/49 Tachypnea 728 09/21/87 728 09/21/87 1/49 Tissue Mass Groin 3- 5 Mm 966 05/16/88 995 06/14/88 3/49 Ruffled Fur 1009 06/28/88 1009 06/28/88 1/49 Prolapse Penis REMOVED ** CID 491 ** REASON - Moribund 1018 07/07/88 Tremors 1018 07/07/88 Emaciated 1018 07/07/88 Abnormal Posture 1018 07/07/88 Prolapse Penis 1018 07/07/88 Tachypnea 50 50 1050 08/08/88 1050 08/08/88 1/52 Swelling Body Ventral REMOVED ** CID 501 ** REASON - Moribund 1052 08/10/88 Comatose 52 52 506 02/11/87 616 06/01/87 3/38 Emaciated REMOVED ** CID 521 ** REASON - Dead 771 11/03/87 Normal 53 53 981 05/31/88 981 05/31/88 1/47 Swelling Body Ventral 966 05/16/88 981 05/31/88 2/47 Ruffled Fur NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 43 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS ANIMAL DATA - 53 53 756 10/19/87 981 05/31/88 10/47 Tissue Mass Groin 3- 5 Mm 966 05/16/88 981 05/31/88 2/47 Tachypnea REMOVED ** CID 531 ** REASON - Moribund 994 06/13/88 Dyspnea 994 06/13/88 Abnormal Posture 994 06/13/88 Jaundice 994 06/13/88 Ruffled Fur 54 54 1038 07/27/88 1038 07/27/88 1/50 Convulsion/Seizure REMOVED ** CID 541 ** REASON - Moribund 1038 07/27/88 Emaciated 1038 07/27/88 Abnormal Posture 1038 07/27/88 Ruffled Fur 55 55 616 06/01/87 616 06/01/87 1/33 Emaciated REMOVED ** CID 551 ** REASON - Dead 637 06/22/87 Normal 56 56 835 01/06/88 1079 09/06/88 14/54 Alopecia Neck REMOVED ** CID 561 ** REASON - Moribund 1087 09/14/88 Comatose 57 57 450 12/17/86 981 05/31/88 21/47 Alopecia Body Ventral REMOVED ** CID 571 ** REASON - Dead 994 06/13/88 Alopecia Body Ventral 58 58 595 05/11/87 595 05/11/87 1/43 Emaciated 595 05/11/87 700 08/24/87 5/43 Tissue Mass Body (Trunk) 0- 2 Mm REMOVED ** CID 581 ** REASON - Moribund 911 03/22/88 Tissue Mass Tail 6-10 Mm 911 03/22/88 Comatose 59 59 897 03/08/88 897 03/08/88 1/47 Tissue Mass Right Eye 3- 5 Mm 981 05/31/88 981 05/31/88 1/47 Tachypnea 835 01/06/88 868 02/08/88 2/47 Swelling Right Eye NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 44 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS ANIMAL DATA - 59 59 835 01/06/88 981 05/31/88 6/47 Discharge Right Eye 924 04/04/88 981 05/31/88 4/47 Tissue Mass Right Eye 11-15 Mm REMOVED ** CID 591 ** REASON - Moribund 985 06/04/88 Tissue Mass Right Eye 11-15 Mm 985 06/04/88 Emaciated 985 06/04/88 Abnormal Posture 985 06/04/88 Hypoactivity 60 60 533 03/10/87 700 08/24/87 7/40 Alopecia Body Ventral REMOVED ** CID 601 ** REASON - Dead 823 12/25/87 Normal 61 61 981 05/31/88 1023 07/12/88 3/50 Tachypnea 966 05/16/88 1023 07/12/88 4/50 Swelling Body Ventral 1023 07/12/88 1023 07/12/88 1/50 Polyuria 1023 07/12/88 1023 07/12/88 1/50 Abnormal Posture 981 05/31/88 1023 07/12/88 3/50 Ruffled Fur REMOVED ** CID 611 ** REASON - Dead 1024 07/13/88 Normal 62 62 1009 06/28/88 1122 10/19/88 9/57 Ruffled Fur 450 12/17/86 1122 10/19/88 30/57 Alopecia Body Ventral 981 05/31/88 1122 10/19/88 11/57 Tachypnea REMOVED ** CID 621 ** REASON - Term-Sac 1134 10/31/88 Alopecia Body Ventral 1134 10/31/88 Ruffled Fur 1134 10/31/88 Tachypnea 63 63 868 02/08/88 868 02/08/88 1/42 Sore Body Dorsal 3- 5 Mm REMOVED ** CID 631 ** REASON - Moribund 886 02/26/88 Abnormal Posture 886 02/26/88 Tachypnea 886 02/26/88 Hypoactivity 66 66 785 11/17/87 897 03/08/88 5/43 Alopecia Neck 168 03/10/86 168 03/10/86 1/43 Alopecia Body Ventral REMOVED ** CID 661 ** REASON - Dead NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 45 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 66 66 906 03/17/88 Normal 67 67 140 02/10/86 140 02/10/86 1/46 Alopecia Right Front Foot 168 03/10/86 966 05/16/88 21/46 Alopecia Body Ventral 309 07/29/86 478 01/14/87 6/46 Alopecia Neck REMOVED ** CID 671 ** REASON - Dead 981 05/31/88 Alopecia Body Ventral 68 68 168 03/10/86 756 10/19/87 21/38 Alopecia Body Ventral REMOVED ** CID 681 ** REASON - Moribund 770 11/02/87 Dyspnea 770 11/02/87 Alopecia Body Ventral 770 11/02/87 Emaciated 770 11/02/87 Hypothermia 770 11/02/87 Ruffled Fur 770 11/02/87 Prostration 70 70 785 11/17/87 785 11/17/87 1/39 Tissue Mass Tail 0- 2 Mm 756 10/19/87 785 11/17/87 2/39 Sore Body Dorsal 3- 5 Mm REMOVED ** CID 701 ** REASON - Dead 796 11/28/87 Normal 71 71 1009 06/28/88 1122 10/19/88 9/57 Swelling Body Ventral 1108 10/05/88 1122 10/19/88 2/57 Tachypnea REMOVED ** CID 711 ** REASON - Term-Sac 1134 10/31/88 Swelling Body Ventral 1134 10/31/88 Tachypnea 73 73 728 09/21/87 728 09/21/87 1/57 Rales 756 10/19/87 785 11/17/87 2/57 Tissue Mass Body Ventral 3- 5 Mm REMOVED ** CID 731 ** REASON - Term-Sac 1134 10/31/88 Normal 74 74 966 05/16/88 966 05/16/88 1/57 Swelling Right Eye 1023 07/12/88 1122 10/19/88 8/57 Ruffled Fur 1122 10/19/88 1122 10/19/88 1/57 Polyuria NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 46 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS ANIMAL DATA - 74 74 1023 07/12/88 1122 10/19/88 8/57 Tachypnea REMOVED ** CID 741 ** REASON - Term-Sac 1134 10/31/88 Ruffled Fur 1134 10/31/88 Tachypnea 1134 10/31/88 Polyuria 75 75 805 12/07/87 805 12/07/87 1/40 Ruffled Fur 533 03/10/87 700 08/24/87 7/40 Alopecia Body Ventral 805 12/07/87 805 12/07/87 1/40 Prolapse Penis 805 12/07/87 805 12/07/87 1/40 Emaciated 595 05/11/87 595 05/11/87 1/40 Swelling Groin REMOVED ** CID 751 ** REASON - Moribund 809 12/11/87 Ruffled Fur 809 12/11/87 Tachypnea 809 12/11/87 Hypoactivity 76 76 981 05/31/88 981 05/31/88 1/48 Swelling Body Ventral REMOVED ** CID 761 ** REASON - Moribund 1001 06/20/88 Dyspnea 1001 06/20/88 Abnormal Posture 1001 06/20/88 Ruffled Fur 77 77 897 03/08/88 897 03/08/88 1/43 Swelling Body Ventral 728 09/21/87 728 09/21/87 1/43 Tissue Mass Groin 3- 5 Mm REMOVED ** CID 771 ** REASON - Dead 911 03/22/88 Normal 79 79 835 01/06/88 868 02/08/88 2/42 Tachypnea REMOVED ** CID 791 ** REASON - Moribund 890 03/01/88 Tremors 890 03/01/88 Abnormal Posture 890 03/01/88 Tachypnea 80 80 1108 10/05/88 1122 10/19/88 2/57 Emaciated 1122 10/19/88 1122 10/19/88 1/57 Urine Stain 1094 09/21/88 1122 10/19/88 3/57 Abnormal Posture 1023 07/12/88 1122 10/19/88 8/57 Ruffled Fur NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 47 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS ANIMAL DATA - 80 80 1023 07/12/88 1122 10/19/88 8/57 Tachypnea REMOVED ** CID 801 ** REASON - Moribund 1125 10/22/88 Emaciated 1125 10/22/88 Abnormal Posture 1125 10/22/88 Prolapse Penis 1125 10/22/88 Tachypnea 1125 10/22/88 Comatose 81 81 1009 06/28/88 1122 10/19/88 9/57 Tachypnea 868 02/08/88 868 02/08/88 1/57 Sore Right Ear 0- 2 Mm 756 10/19/87 995 06/14/88 11/57 Tissue Mass Groin 0- 2 Mm 1108 10/05/88 1122 10/19/88 2/57 Tissue Mass Right Ear 6-10 Mm 924 04/04/88 1094 09/21/88 12/57 Tissue Mass Right Ear 3- 5 Mm REMOVED ** CID 811 ** REASON - Term-Sac 1134 10/31/88 Tissue Mass Right Ear 3- 5 Mm 1134 10/31/88 Tachypnea 82 82 1038 07/27/88 1122 10/19/88 7/57 Ruffled Fur 1108 10/05/88 1122 10/19/88 2/57 Tachypnea REMOVED ** CID 821 ** REASON - Term-Sac 1134 10/31/88 Ruffled Fur 1134 10/31/88 Tachypnea 83 83 1038 07/27/88 1050 08/08/88 2/52 Tachypnea 1050 08/08/88 1050 08/08/88 1/52 Emaciated 1038 07/27/88 1050 08/08/88 2/52 Ruffled Fur REMOVED ** CID 831 ** REASON - Dead 1058 08/16/88 Emaciated 84 84 966 05/16/88 966 05/16/88 1/46 Ruffled Fur 966 05/16/88 966 05/16/88 1/46 Tachypnea REMOVED ** CID 841 ** REASON - Dead 967 05/17/88 Normal 85 85 168 03/10/86 168 03/10/86 1/37 Alopecia Body Ventral REMOVED ** CID 851 ** REASON - Moribund NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 48 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 85 85 754 10/17/87 Abnormal Posture 754 10/17/87 Hypoactivity 86 86 168 03/10/86 168 03/10/86 1/41 Alopecia Body Ventral REMOVED ** CID 861 ** REASON - Moribund 863 02/03/88 Abnormal Posture 863 02/03/88 Tachypnea 863 02/03/88 Hypoactivity 87 87 450 12/17/86 1108 10/05/88 10/56 Alopecia Body Ventral 644 06/29/87 981 05/31/88 14/56 Alopecia Neck 1038 07/27/88 1108 10/05/88 6/56 Ruffled Fur 756 10/19/87 835 01/06/88 4/56 Tissue Mass Groin 3- 5 Mm REMOVED ** CID 871 ** REASON - Dead 1111 10/08/88 Normal 88 88 756 10/19/87 756 10/19/87 1/38 Emaciated REMOVED ** CID 881 ** REASON - Moribund 757 10/20/87 Abnormal Posture 757 10/20/87 Tachypnea 89 89 168 03/10/86 168 03/10/86 1/41 Alopecia Body Ventral REMOVED ** CID 891 ** REASON - Dead 862 02/02/88 Normal 90 90 700 08/24/87 700 08/24/87 1/36 Tissue Mass Right Rear Leg 16-20 Mm REMOVED ** CID 901 ** REASON - Moribund 706 08/30/87 Tissue Mass Groin 16-20 Mm 706 08/30/87 Abnormal Posture 706 08/30/87 Ruffled Fur 92 92 450 12/17/86 450 12/17/86 1/27 Limb Paralysis Left Rear Leg 450 12/17/86 450 12/17/86 1/27 Limb Paralysis Right Rear Leg REMOVED ** CID 921 ** REASON - Accident 451 12/18/86 Hypoactivity NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 49 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 92 92 451 12/18/86 Limb Paralysis Right Rear Leg 451 12/18/86 Limb Paralysis Left Rear Leg 94 94 952 05/02/88 1009 06/28/88 5/49 Swelling Body Ventral 966 05/16/88 966 05/16/88 1/49 Diarrhea 966 05/16/88 1009 06/28/88 2/49 Ruffled Fur 1009 06/28/88 1009 06/28/88 1/49 Polyuria 966 05/16/88 1009 06/28/88 2/49 Tachypnea REMOVED ** CID 941 ** REASON - Dead 1012 07/01/88 Normal 95 95 835 01/06/88 835 01/06/88 1/41 Swelling Left Eye 835 01/06/88 835 01/06/88 1/41 Discharge Left Eye REMOVED ** CID 951 ** REASON - Moribund 862 02/02/88 Head Tilted 862 02/02/88 Swelling Left Eye 862 02/02/88 Ruffled Fur 862 02/02/88 Tachypnea 862 02/02/88 Hypoactivity 96 96 868 02/08/88 897 03/08/88 2/43 Sore Body Dorsal 3- 5 Mm 785 11/17/87 897 03/08/88 5/43 Discharge Right Eye 700 08/24/87 897 03/08/88 8/43 Swelling Right Eye REMOVED ** CID 961 ** REASON - Moribund 918 03/29/88 Tissue Mass Body (Trunk) 21-25 Mm 918 03/29/88 Tissue Mass Right Eye 3- 5 Mm 918 03/29/88 Hyperactive 918 03/29/88 Abnormal Posture 918 03/29/88 Ruffled Fur 918 03/29/88 Tachypnea 97 97 981 05/31/88 995 06/14/88 2/48 Emaciated REMOVED ** CID 971 ** REASON - Dead 1003 06/22/88 Normal 98 98 952 05/02/88 1023 07/12/88 6/50 Tissue Mass Neck 6-10 Mm REMOVED ** CID 981 ** REASON - Dead NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 50 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 98 98 1029 07/18/88 Normal 99 99 868 02/08/88 868 02/08/88 1/42 Emaciated 868 02/08/88 868 02/08/88 1/42 Prostration REMOVED ** CID 991 ** REASON - Moribund 868 02/08/88 Ataxia 868 02/08/88 Abnormal Posture 868 02/08/88 Hypoactivity 101 101 616 06/01/87 700 08/24/87 4/38 Tissue Mass Body (Trunk) 3- 5 Mm 728 09/21/87 756 10/19/87 2/38 Tissue Mass Tail 3- 5 Mm REMOVED ** CID 1011 ** REASON - Dead 762 10/25/87 Tissue Mass Tail 6-10 Mm 103 103 924 04/04/88 995 06/14/88 5/48 Tachypnea 924 04/04/88 995 06/14/88 5/48 Ruffled Fur 924 04/04/88 924 04/04/88 1/48 Emaciated REMOVED ** CID 1031 ** REASON - Dead 998 06/17/88 Normal 104 104 140 02/10/86 140 02/10/86 1/26 Alopecia Left Rear Leg REMOVED ** CID 1041 ** REASON - Dead 427 11/24/86 Normal 105 105 1108 10/05/88 1122 10/19/88 2/57 Tachypnea 1079 09/06/88 1122 10/19/88 3/57 Ruffled Fur REMOVED ** CID 1051 ** REASON - Term-Sac 1134 10/31/88 Ruffled Fur 1134 10/31/88 Tachypnea 106 106 616 06/01/87 616 06/01/87 1/44 Tissue Mass Body (Trunk) 0- 2 Mm 450 12/17/86 478 01/14/87 2/44 Alopecia Face 421 11/18/86 616 06/01/87 7/44 Alopecia Body Ventral REMOVED ** CID 1061 ** REASON - Moribund 938 04/18/88 Tremors NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 51 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 106 106 938 04/18/88 Emaciated 938 04/18/88 Tachypnea 107 107 700 08/24/87 756 10/19/87 3/38 Emaciated REMOVED ** CID 1071 ** REASON - Moribund 759 10/22/87 Emaciated 759 10/22/87 Hypothermia 759 10/22/87 Ruffled Fur 109 109 835 01/06/88 835 01/06/88 1/41 Tachypnea 835 01/06/88 835 01/06/88 1/41 Ruffled Fur 364 09/22/86 616 06/01/87 10/41 Alopecia Body Ventral 835 01/06/88 835 01/06/88 1/41 Emaciated REMOVED ** CID 1091 ** REASON - Moribund 841 01/12/88 Abnormal Posture 841 01/12/88 Tachypnea 841 01/12/88 Hypoactivity 110 110 756 10/19/87 805 12/07/87 3/55 Tissue Mass Groin 3- 5 Mm REMOVED ** CID 1101 ** REASON - Moribund 1106 10/03/88 Prolapse Penis 1106 10/03/88 Urine Stain 1106 10/03/88 Tachypnea 1106 10/03/88 Comatose 111 111 168 03/10/86 168 03/10/86 1/43 Alopecia Body Ventral 644 06/29/87 672 07/27/87 2/43 Tissue Mass Body (Trunk) 6-10 Mm 805 12/07/87 805 12/07/87 1/43 Tissue Mass Groin 3- 5 Mm REMOVED ** CID 1111 ** REASON - Moribund 922 04/02/88 Abnormal Posture 922 04/02/88 Tachypnea 922 04/02/88 Comatose 112 112 533 03/10/87 533 03/10/87 1/30 Tissue Mass Body (Trunk) 0- 2 Mm REMOVED ** CID 1121 ** REASON - Dead 534 03/11/87 Normal NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 52 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 113 113 1050 08/08/88 1050 08/08/88 1/52 Micro-ophthalmia REMOVED ** CID 1131 ** REASON - Moribund 1064 08/22/88 Comatose 114 114 1050 08/08/88 1122 10/19/88 3/57 Tachypnea 1108 10/05/88 1122 10/19/88 2/57 Ruffled Fur 1122 10/19/88 1122 10/19/88 1/57 Prolapse Penis 1079 09/06/88 1122 10/19/88 3/57 Swelling Body Ventral 785 11/17/87 785 11/17/87 1/57 Tissue Mass Groin 3- 5 Mm REMOVED ** CID 1141 ** REASON - Term-Sac 1134 10/31/88 Swelling Body Ventral 1134 10/31/88 Prolapse Penis 1134 10/31/88 Ruffled Fur 1134 10/31/88 Tachypnea 115 115 897 03/08/88 897 03/08/88 1/43 Swelling Body Ventral REMOVED ** CID 1151 ** REASON - Dead 919 03/30/88 Normal 118 118 924 04/04/88 924 04/04/88 1/44 Sore Skin 6-10 Mm 785 11/17/87 924 04/04/88 6/44 Swelling Left Eye REMOVED ** CID 1181 ** REASON - Moribund 928 04/08/88 Emaciated 928 04/08/88 Hyperactive 928 04/08/88 Abnormal Posture 928 04/08/88 Wound Body (Trunk) 16-20 Mm 928 04/08/88 Tachypnea 119 119 981 05/31/88 981 05/31/88 1/47 Tachypnea 966 05/16/88 966 05/16/88 1/47 Tissue Mass Right Rear Leg 11-15 Mm 952 05/02/88 952 05/02/88 1/47 Tissue Mass Left Rear Leg 6-10 Mm 981 05/31/88 981 05/31/88 1/47 Tissue Mass Left Rear Leg 11-15 Mm 981 05/31/88 981 05/31/88 1/47 Ruffled Fur REMOVED ** CID 1191 ** REASON - Dead 982 06/01/88 Tissue Mass Left Rear Leg 6-10 Mm 121 121 1108 10/05/88 1122 10/19/88 2/57 Ruffled Fur 595 05/11/87 616 06/01/87 2/57 Alopecia Body Ventral NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 53 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ REMOVED ** CID 1211 ** REASON - Term-Sac 121 121 1134 10/31/88 Ruffled Fur 122 122 672 07/27/87 700 08/24/87 2/36 Emaciated REMOVED ** CID 1221 ** REASON - Moribund 702 08/26/87 Emaciated 702 08/26/87 Abnormal Posture 702 08/26/87 Ruffled Fur 123 123 897 03/08/88 924 04/04/88 2/44 Sore Body (Trunk) 3- 5 Mm REMOVED ** CID 1231 ** REASON - Moribund 942 04/22/88 Circling 942 04/22/88 Head Tilted 942 04/22/88 Abnormal Posture 942 04/22/88 Prolapse Penis 942 04/22/88 Wound Body (Trunk) 26 or Gr 942 04/22/88 Ruffled Fur 942 04/22/88 Tachypnea 125 125 868 02/08/88 868 02/08/88 1/42 Swelling Body Ventral REMOVED ** CID 1251 ** REASON - Moribund 886 02/26/88 Abnormal Posture 886 02/26/88 Tachypnea 886 02/26/88 Hypoactivity 126 126 868 02/08/88 868 02/08/88 1/42 Emaciated REMOVED ** CID 1261 ** REASON - Moribund 868 02/08/88 Dyspnea 868 02/08/88 Abnormal Posture 868 02/08/88 Ruffled Fur 868 02/08/88 Hypoactivity 129 129 897 03/08/88 897 03/08/88 1/43 Sore Body (Trunk) 3- 5 Mm 868 02/08/88 868 02/08/88 1/43 Sore Neck 0- 2 Mm 897 03/08/88 897 03/08/88 1/43 Tachypnea 897 03/08/88 897 03/08/88 1/43 Ruffled Fur REMOVED ** CID 1291 ** REASON - Moribund NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 54 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 129 129 900 03/11/88 Tissue Mass Body (Trunk) 21-25 Mm 900 03/11/88 Emaciated 900 03/11/88 Hyperactive 900 03/11/88 Tachypnea 130 130 1108 10/05/88 1122 10/19/88 2/57 Tachypnea 1108 10/05/88 1122 10/19/88 2/57 Ruffled Fur 1079 09/06/88 1122 10/19/88 3/57 Tissue Mass Right Ear 0- 2 Mm REMOVED ** CID 1301 ** REASON - Term-Sac 1134 10/31/88 Tissue Mass Right Ear 0- 2 Mm 131 131 616 06/01/87 672 07/27/87 3/37 Tissue Mass Body (Trunk) 0- 2 Mm REMOVED ** CID 1311 ** REASON - Dead 732 09/25/87 Normal 132 132 1108 10/05/88 1122 10/19/88 2/57 Ruffled Fur 1108 10/05/88 1122 10/19/88 2/57 Swelling Body Ventral 1108 10/05/88 1122 10/19/88 2/57 Tachypnea REMOVED ** CID 1321 ** REASON - Dead 1134 10/31/88 Normal 134 134 644 06/29/87 728 09/21/87 4/38 Tissue Mass Body (Trunk) 0- 2 Mm 728 09/21/87 756 10/19/87 2/38 Emaciated REMOVED ** CID 1341 ** REASON - Dead 758 10/21/87 Normal 135 135 756 10/19/87 756 10/19/87 1/38 Alopecia Neck REMOVED ** CID 1351 ** REASON - Dead 759 10/22/87 Normal 137 137 700 08/24/87 868 02/08/88 6/48 Tissue Mass Groin 0- 2 Mm 728 09/21/87 728 09/21/87 1/48 Tissue Mass Groin 3- 5 Mm 952 05/02/88 995 06/14/88 4/48 Sore Body Dorsal 6-10 Mm 966 05/16/88 966 05/16/88 1/48 Ruffled Fur 966 05/16/88 995 06/14/88 3/48 Tachypnea REMOVED ** CID 1371 ** REASON - Moribund NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 55 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 137 137 1001 06/20/88 Hyperactive 1001 06/20/88 Sore Body Dorsal 26 or Gr 138 138 897 03/08/88 1122 10/19/88 10/57 Tachypnea 1023 07/12/88 1122 10/19/88 8/57 Tissue Mass Left Eye 6-10 Mm 1094 09/21/88 1094 09/21/88 1/57 Abnormal Posture 897 03/08/88 1009 06/28/88 7/57 Tissue Mass Left Eye 3- 5 Mm 728 09/21/87 868 02/08/88 6/57 Swelling Left Eye 897 03/08/88 1122 10/19/88 10/57 Ruffled Fur REMOVED ** CID 1381 ** REASON - Term-Sac 1134 10/31/88 Tissue Mass Left Eye 3- 5 Mm 1134 10/31/88 Ruffled Fur 1134 10/31/88 Tachypnea 139 139 1023 07/12/88 1023 07/12/88 1/50 Prolapse Penis REMOVED ** CID 1391 ** REASON - Dead 1029 07/18/88 Prolapse Penis 144 144 835 01/06/88 1050 08/08/88 12/52 Swelling Body Ventral 835 01/06/88 1050 08/08/88 12/52 Tachypnea 835 01/06/88 835 01/06/88 1/52 Emaciated 756 10/19/87 785 11/17/87 2/52 Tissue Mass Groin 0- 2 Mm 835 01/06/88 1050 08/08/88 6/52 Ruffled Fur REMOVED ** CID 1441 ** REASON - Dead 1060 08/18/88 Normal 146 146 966 05/16/88 966 05/16/88 1/52 Swelling Body Ventral REMOVED ** CID 1461 ** REASON - Dead 1053 08/11/88 Normal 147 147 1009 06/28/88 1009 06/28/88 1/49 Tachypnea 1009 06/28/88 1009 06/28/88 1/49 Ruffled Fur REMOVED ** CID 1471 ** REASON - Dead 1016 07/05/88 Emaciated 149 149 700 08/24/87 700 08/24/87 1/36 Tissue Mass Body Ventral 6-10 Mm NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 56 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ REMOVED ** CID 1491 ** REASON - Dead 149 149 706 08/30/87 Normal 151 151 595 05/11/87 1122 10/19/88 21/57 Alopecia Body Ventral REMOVED ** CID 1511 ** REASON - Term-Sac 1134 10/31/88 Normal 152 152 952 05/02/88 952 05/02/88 1/45 Sore Tail 6-10 Mm 952 05/02/88 952 05/02/88 1/45 Ruffled Fur 868 02/08/88 952 05/02/88 4/45 Swelling Groin 785 11/17/87 835 01/06/88 3/45 Tissue Mass Groin 0- 2 Mm 952 05/02/88 952 05/02/88 1/45 Tachypnea REMOVED ** CID 1521 ** REASON - Dead 962 05/12/88 Normal 154 154 952 05/02/88 1009 06/28/88 5/49 Swelling Body Ventral 981 05/31/88 995 06/14/88 2/49 Tachypnea REMOVED ** CID 1541 ** REASON - Moribund 1019 07/08/88 Dyspnea 1019 07/08/88 Swelling Body Ventral 1019 07/08/88 Abnormal Posture 155 155 924 04/04/88 1050 08/08/88 9/52 Ruffled Fur 924 04/04/88 1050 08/08/88 9/52 Tachypnea 1009 06/28/88 1050 08/08/88 4/52 Tissue Mass Right Eye 3- 5 Mm 506 02/11/87 616 06/01/87 4/52 Discharge Right Eye 595 05/11/87 995 06/14/88 17/52 Swelling Right Eye REMOVED ** CID 1551 ** REASON - Moribund 1053 08/11/88 Tissue Mass Right Eye 11-15 Mm 1053 08/11/88 Ruffled Fur 1053 08/11/88 Tachypnea 156 156 1065 08/23/88 1122 10/19/88 5/57 Swelling Body Ventral 1065 08/23/88 1122 10/19/88 5/57 Tachypnea 1094 09/21/88 1122 10/19/88 3/57 Ruffled Fur 1122 10/19/88 1122 10/19/88 1/57 Abnormal Posture REMOVED ** CID 1561 ** REASON - Moribund NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 57 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 156 156 1124 10/21/88 Dyspnea 1124 10/21/88 Abnormal Posture 1124 10/21/88 Urine Stain 157 157 595 05/11/87 868 02/08/88 11/42 Alopecia Body Ventral 78 12/10/85 78 12/10/85 1/42 Pallor 868 02/08/88 868 02/08/88 1/42 Emaciated 506 02/11/87 506 02/11/87 1/42 Alopecia Neck REMOVED ** CID 1571 ** REASON - Moribund 869 02/09/88 Abnormal Posture 869 02/09/88 Ruffled Fur 869 02/09/88 Tachypnea 869 02/09/88 Hypoactivity 158 158 805 12/07/87 805 12/07/87 1/41 Tissue Mass Tail 3- 5 Mm 835 01/06/88 835 01/06/88 1/41 Tissue Mass Tail 6-10 Mm REMOVED ** CID 1581 ** REASON - Dead 845 01/16/88 Normal 159 159 168 03/10/86 224 05/05/86 3/40 Alopecia Body Ventral REMOVED ** CID 1591 ** REASON - Dead 820 12/22/87 Normal 160 160 868 02/08/88 868 02/08/88 1/43 Sore Body Dorsal 3- 5 Mm 897 03/08/88 897 03/08/88 1/43 Swelling Body Ventral 897 03/08/88 897 03/08/88 1/43 Sore Body (Trunk) 3- 5 Mm 897 03/08/88 897 03/08/88 1/43 Tachypnea REMOVED ** CID 1601 ** REASON - Moribund 900 03/11/88 Tissue Mass Body Dorsal 11-15 Mm 900 03/11/88 Emaciated 900 03/11/88 Ruffled Fur 900 03/11/88 Hypoactivity 161 161 1108 10/05/88 1122 10/19/88 2/57 Tachypnea 1108 10/05/88 1122 10/19/88 2/57 Ruffled Fur REMOVED ** CID 1611 ** REASON - Term-Sac 1134 10/31/88 Ruffled Fur NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 58 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 161 161 1134 10/31/88 Tachypnea 162 162 1079 09/06/88 1122 10/19/88 3/57 Swelling Body Ventral 1122 10/19/88 1122 10/19/88 1/57 Ruffled Fur REMOVED ** CID 1621 ** REASON - Moribund 1130 10/27/88 Swelling Body Ventral 163 163 700 08/24/87 700 08/24/87 1/36 Swelling Left Eye REMOVED ** CID 1631 ** REASON - Dead 728 09/21/87 Normal 164 164 616 06/01/87 616 06/01/87 1/37 Alopecia Body Ventral REMOVED ** CID 1641 ** REASON - Dead 747 10/10/87 Dyspnea 747 10/10/87 Hypoactivity 167 167 1122 10/19/88 1122 10/19/88 1/57 Prolapse Penis 1108 10/05/88 1122 10/19/88 2/57 Ruffled Fur 1079 09/06/88 1079 09/06/88 1/57 Swelling Left Eye REMOVED ** CID 1671 ** REASON - Term-Sac 1134 10/31/88 Normal 168 168 1079 09/06/88 1094 09/21/88 2/55 Tachypnea 1079 09/06/88 1079 09/06/88 1/55 Swelling Body Ventral 1050 08/08/88 1050 08/08/88 1/55 Emaciated 1079 09/06/88 1094 09/21/88 2/55 Ruffled Fur REMOVED ** CID 1681 ** REASON - Dead 1100 09/27/88 Normal 171 171 835 01/06/88 868 02/08/88 2/42 Tissue Mass Groin 0- 2 Mm REMOVED ** CID 1711 ** REASON - Moribund 883 02/23/88 Tissue Mass Groin 6-10 Mm 883 02/23/88 Emaciated 883 02/23/88 Abnormal Posture 883 02/23/88 Hypoactivity NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 59 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 174 174 616 06/01/87 672 07/27/87 3/35 Tissue Mass Body (Trunk) 0- 2 Mm REMOVED ** CID 1741 ** REASON - Moribund 682 08/06/87 Tissue Mass Left Rear Leg 16-20 Mm 175 175 569 04/15/87 569 04/15/87 1/31 Emaciated REMOVED ** CID 1751 ** REASON - Moribund 589 05/05/87 Swelling Body Ventral 176 176 1108 10/05/88 1122 10/19/88 2/57 Ruffled Fur REMOVED ** CID 1761 ** REASON - Term-Sac 1134 10/31/88 Ruffled Fur 177 177 924 04/04/88 924 04/04/88 1/44 Tachypnea 897 03/08/88 924 04/04/88 2/44 Emaciated REMOVED ** CID 1771 ** REASON - Moribund 928 04/08/88 Emaciated 928 04/08/88 Abnormal Posture 928 04/08/88 Ruffled Fur 928 04/08/88 Tachypnea 928 04/08/88 Hypoactivity 178 178 1065 08/23/88 1122 10/19/88 5/57 Ruffled Fur 1009 06/28/88 1009 06/28/88 1/57 Discharge Right Eye 835 01/06/88 1009 06/28/88 9/57 Swelling Right Eye 1023 07/12/88 1122 10/19/88 8/57 Tissue Mass Right Eye 6-10 Mm REMOVED ** CID 1781 ** REASON - Term-Sac 1134 10/31/88 Tissue Mass Right Eye 6-10 Mm 1134 10/31/88 Ruffled Fur 179 179 700 08/24/87 700 08/24/87 1/36 Emaciated REMOVED ** CID 1791 ** REASON - Moribund 714 09/07/87 Emaciated 714 09/07/87 Abnormal Posture 714 09/07/87 Ruffled Fur NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 60 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 180 180 966 05/16/88 966 05/16/88 2/47 Ruffled Fur 966 05/16/88 966 05/16/88 2/47 Tachypnea REMOVED ** CID 1801 ** REASON - Dead 986 06/05/88 Normal 181 181 1108 10/05/88 1108 10/05/88 1/56 Ruffled Fur 168 03/10/86 168 03/10/86 1/56 Alopecia Body Ventral 1065 08/23/88 1108 10/05/88 4/56 Swelling Body Ventral REMOVED ** CID 1811 ** REASON - Dead 1108 10/05/88 Swelling Body Ventral 182 182 1050 08/08/88 1050 08/08/88 1/53 Tachypnea 756 10/19/87 1065 08/23/88 16/53 Swelling Right Eye REMOVED ** CID 1821 ** REASON - Moribund 1072 08/30/88 Swelling Left Eye 1072 08/30/88 Abnormal Posture 1072 08/30/88 Prolapse Penis 1072 08/30/88 Tachypnea 1072 08/30/88 Comatose 183 183 728 09/21/87 728 09/21/87 1/37 Emaciated REMOVED ** CID 1831 ** REASON - Moribund 728 09/21/87 Emaciated 728 09/21/87 Abnormal Posture 728 09/21/87 Tachypnea 184 184 1108 10/05/88 1122 10/19/88 2/57 Ruffled Fur 981 05/31/88 1122 10/19/88 10/57 Swelling Body Ventral REMOVED ** CID 1841 ** REASON - Term-Sac 1134 10/31/88 Normal 185 185 835 01/06/88 952 05/02/88 5/45 Tissue Mass Tail 3- 5 Mm 785 11/17/87 805 12/07/87 2/45 Tissue Mass Tail 0- 2 Mm REMOVED ** CID 1851 ** REASON - Dead 959 05/09/88 Tissue Mass Tail 11-15 Mm NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 61 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 187 187 168 03/10/86 168 03/10/86 1/41 Alopecia Body Ventral 835 01/06/88 835 01/06/88 1/41 Tissue Mass Left Ear 0- 2 Mm REMOVED ** CID 1871 ** REASON - Dead 845 01/16/88 Normal 188 188 196 04/07/86 672 07/27/87 16/36 Alopecia Entire Animal 616 06/01/87 700 08/24/87 3/36 Emaciated 168 03/10/86 533 03/10/87 2/36 Alopecia Body Ventral 168 03/10/86 224 05/05/86 2/36 Alopecia Head 224 05/05/86 224 05/05/86 1/36 Alopecia Body (Trunk) REMOVED ** CID 1881 ** REASON - Moribund 706 08/30/87 Alopecia Entire Animal 706 08/30/87 Emaciated 706 08/30/87 Abnormal Posture 706 08/30/87 Ruffled Fur 189 189 616 06/01/87 616 06/01/87 1/33 Tissue Mass Body (Trunk) 0- 2 Mm REMOVED ** CID 1891 ** REASON - Moribund 622 06/07/87 Swelling Body Ventral 622 06/07/87 Abnormal Posture 622 06/07/87 Hypoactivity 192 192 835 01/06/88 835 01/06/88 1/41 Emaciated 835 01/06/88 835 01/06/88 1/41 Hypothermia REMOVED ** CID 1921 ** REASON - Moribund 835 01/06/88 Ruffled Fur 835 01/06/88 Hypoactivity 193 193 756 10/19/87 897 03/08/88 6/56 Alopecia Neck 1108 10/05/88 1108 10/05/88 1/56 Tachypnea 1108 10/05/88 1108 10/05/88 1/56 Swelling Body Ventral 450 12/17/86 1094 09/21/88 23/56 Alopecia Body Ventral 1108 10/05/88 1108 10/05/88 1/56 Ruffled Fur 1108 10/05/88 1108 10/05/88 1/56 Emaciated REMOVED ** CID 1931 ** REASON - Dead 1111 10/08/88 Normal 194 194 168 03/10/86 224 05/05/86 3/32 Alopecia Body Ventral NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 62 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ REMOVED ** CID 1941 ** REASON - Dead 194 194 602 05/18/87 Normal 195 195 1065 08/23/88 1065 08/23/88 1/53 Tachypnea 1065 08/23/88 1065 08/23/88 1/53 Ruffled Fur 1065 08/23/88 1065 08/23/88 1/53 Hypoactivity REMOVED ** CID 1951 ** REASON - Moribund 1071 08/29/88 Swelling Groin 1071 08/29/88 Comatose 196 196 1108 10/05/88 1108 10/05/88 1/55 Emaciated 1108 10/05/88 1108 10/05/88 1/55 Tachypnea 1108 10/05/88 1108 10/05/88 1/55 Swelling Body Ventral 1108 10/05/88 1108 10/05/88 1/55 Ruffled Fur 1108 10/05/88 1108 10/05/88 1/55 Abnormal Posture REMOVED ** CID 1961 ** REASON - Dead 1111 10/08/88 Emaciated 201 201 1108 10/05/88 1122 10/19/88 2/57 Ruffled Fur 196 04/07/86 196 04/07/86 1/57 Alopecia Body Ventral 805 12/07/87 924 04/04/88 5/57 Swelling Groin REMOVED ** CID 2011 ** REASON - Term-Sac 1134 10/31/88 Ruffled Fur 202 202 700 08/24/87 700 08/24/87 1/37 Tissue Mass Body Ventral 3- 5 Mm 728 09/21/87 728 09/21/87 1/37 Tissue Mass Body Ventral 6-10 Mm REMOVED ** CID 2021 ** REASON - Moribund 733 09/26/87 Dyspnea 733 09/26/87 Tissue Mass Body Ventral 26 or Gr 733 09/26/87 Hypoactivity 203 203 168 03/10/86 196 04/07/86 2/41 Alopecia Body Ventral REMOVED ** CID 2031 ** REASON - Moribund 847 01/18/88 Abnormal Posture 847 01/18/88 Ruffled Fur 847 01/18/88 Tachypnea 847 01/18/88 Hypoactivity NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 63 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 204 204 616 06/01/87 672 07/27/87 3/37 Tissue Mass Body (Trunk) 0- 2 Mm REMOVED ** CID 2041 ** REASON - Dead 739 10/02/87 Normal 205 205 1023 07/12/88 1023 07/12/88 1/50 Ruffled Fur 1023 07/12/88 1023 07/12/88 1/50 Tachypnea REMOVED ** CID 2051 ** REASON - Dead 1036 07/25/88 Normal 206 206 785 11/17/87 805 12/07/87 2/48 Tissue Mass Groin 0- 2 Mm REMOVED ** CID 2061 ** REASON - Dead 998 06/17/88 Normal 207 207 1108 10/05/88 1122 10/19/88 2/57 Ruffled Fur 569 04/15/87 569 04/15/87 1/57 Emaciated REMOVED ** CID 2071 ** REASON - Term-Sac 1134 10/31/88 Normal 208 208 364 09/22/86 981 05/31/88 22/47 Alopecia Body Ventral REMOVED ** CID 2081 ** REASON - Moribund 985 06/04/88 Tachypnea 985 06/04/88 Comatose 210 210 1009 06/28/88 1065 08/23/88 5/53 Swelling Body Ventral 1023 07/12/88 1065 08/23/88 4/53 Tachypnea REMOVED ** CID 2101 ** REASON - Dead 1075 09/02/88 Normal 212 212 569 04/15/87 700 08/24/87 4/38 Emaciated REMOVED ** CID 2121 ** REASON - Moribund 780 11/12/87 Alopecia Body Ventral 780 11/12/87 Emaciated 780 11/12/87 Abnormal Posture NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 64 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 214 214 897 03/08/88 897 03/08/88 1/43 Swelling Body Ventral REMOVED ** CID 2141 ** REASON - Dead 910 03/21/88 Normal 216 216 897 03/08/88 952 05/02/88 3/45 Swelling Body Ventral REMOVED ** CID 2161 ** REASON - Dead 958 05/08/88 Normal 218 218 1065 08/23/88 1122 10/19/88 5/57 Sore Body Dorsal 6-10 Mm 1065 08/23/88 1122 10/19/88 5/57 Tachypnea 1108 10/05/88 1122 10/19/88 2/57 Emaciated 1108 10/05/88 1122 10/19/88 2/57 Abnormal Posture 981 05/31/88 1122 10/19/88 11/57 Swelling Left Eye 1108 10/05/88 1122 10/19/88 2/57 Ruffled Fur REMOVED ** CID 2181 ** REASON - Dead 1134 10/31/88 Swelling Left Eye 1134 10/31/88 Emaciated 1134 10/31/88 Abnormal Posture 1134 10/31/88 Sore Left Rear Leg 11-15 Mm 1134 10/31/88 Ruffled Fur 221 221 644 06/29/87 728 09/21/87 4/39 Alopecia Neck 785 11/17/87 785 11/17/87 1/39 Tissue Mass Body Ventral 11-15 Mm 616 06/01/87 616 06/01/87 1/39 Alopecia Body Ventral REMOVED ** CID 2211 ** REASON - Dead 791 11/23/87 Normal 222 222 897 03/08/88 897 03/08/88 1/43 Tachypnea 897 03/08/88 897 03/08/88 1/43 Tissue Mass Tail 3- 5 Mm 897 03/08/88 897 03/08/88 1/43 Ruffled Fur 897 03/08/88 897 03/08/88 1/43 Emaciated REMOVED ** CID 2221 ** REASON - Moribund 904 03/15/88 Abnormal Posture 904 03/15/88 Tachypnea 904 03/15/88 Hypoactivity NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 65 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 223 223 897 03/08/88 897 03/08/88 1/43 Tachypnea 897 03/08/88 897 03/08/88 1/43 Emaciated 897 03/08/88 897 03/08/88 1/43 Swelling Body Ventral REMOVED ** CID 2231 ** REASON - Moribund 900 03/11/88 Comatose 225 225 569 04/15/87 595 05/11/87 2/32 Swelling Left Eye REMOVED ** CID 2251 ** REASON - Moribund 602 05/18/87 Swelling Left Eye 602 05/18/87 Emaciated 227 227 1108 10/05/88 1122 10/19/88 2/57 Ruffled Fur REMOVED ** CID 2271 ** REASON - Term-Sac 1134 10/31/88 Ruffled Fur 229 229 1065 08/23/88 1122 10/19/88 5/57 Tachypnea 1108 10/05/88 1122 10/19/88 2/57 Swelling Body Ventral 1065 08/23/88 1122 10/19/88 5/57 Ruffled Fur REMOVED ** CID 2291 ** REASON - Dead 1129 10/26/88 Normal 230 230 1094 09/21/88 1094 09/21/88 1/55 Ruffled Fur 1065 08/23/88 1094 09/21/88 3/55 Tachypnea 644 06/29/87 1094 09/21/88 21/55 Alopecia Body Ventral 756 10/19/87 756 10/19/87 1/55 Alopecia Neck 1023 07/12/88 1094 09/21/88 6/55 Swelling Body Ventral REMOVED ** CID 2301 ** REASON - Moribund 1103 09/30/88 Tremors 1103 09/30/88 Alopecia Body Ventral 1103 09/30/88 Swelling Body Ventral 1103 09/30/88 Abnormal Posture 1103 09/30/88 Ruffled Fur 1103 09/30/88 Hypoactivity 231 231 616 06/01/87 616 06/01/87 1/33 Tissue Mass Body (Trunk) 0- 2 Mm 450 12/17/86 478 01/14/87 2/33 Alopecia Body Ventral REMOVED ** CID 2311 ** REASON - Moribund NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 66 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 231 231 622 06/07/87 Emaciated 235 235 1079 09/06/88 1079 09/06/88 1/54 Swelling Body Ventral 728 09/21/87 728 09/21/87 1/54 Tissue Mass Groin 6-10 Mm 785 11/17/87 805 12/07/87 2/54 Tissue Mass Groin 3- 5 Mm 835 01/06/88 1079 09/06/88 14/54 Swelling Right Eye REMOVED ** CID 2351 ** REASON - Dead 1089 09/16/88 Swelling Right Eye 236 236 897 03/08/88 897 03/08/88 1/43 Swelling Body Ventral REMOVED ** CID 2361 ** REASON - Moribund 918 03/29/88 Tremors 918 03/29/88 Abnormal Posture 918 03/29/88 Tachypnea 918 03/29/88 Hypoactivity 238 238 533 03/10/87 533 03/10/87 1/30 Tissue Mass Body (Trunk) 0- 2 Mm REMOVED ** CID 2381 ** REASON - Moribund 555 04/01/87 Swelling Body (Trunk) 242 242 1065 08/23/88 1079 09/06/88 2/54 Tachypnea 569 04/15/87 616 06/01/87 3/54 Alopecia Body Ventral 1009 06/28/88 1079 09/06/88 6/54 Prolapse Penis 1065 08/23/88 1079 09/06/88 2/54 Ruffled Fur REMOVED ** CID 2421 ** REASON - Moribund 1083 09/10/88 Emaciated 1083 09/10/88 Prolapse Penis 1083 09/10/88 Ruffled Fur 1083 09/10/88 Tachypnea 244 244 756 10/19/87 805 12/07/87 3/41 Tissue Mass Groin 3- 5 Mm 835 01/06/88 835 01/06/88 1/41 Tissue Mass Groin 0- 2 Mm REMOVED ** CID 2441 ** REASON - Moribund 861 02/01/88 Abnormal Posture 861 02/01/88 Ruffled Fur 861 02/01/88 Tachypnea 861 02/01/88 Hypoactivity NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 67 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 245 245 616 06/01/87 835 01/06/88 9/41 Discharge Left Eye 506 02/11/87 506 02/11/87 1/41 Swelling Right Eye 569 04/15/87 835 01/06/88 11/41 Swelling Left Eye 785 11/17/87 835 01/06/88 3/41 Emaciated REMOVED ** CID 2451 ** REASON - Moribund 836 01/07/88 Dyspnea 836 01/07/88 Tissue Mass Left Eye 3- 5 Mm 836 01/07/88 Emaciated 836 01/07/88 Abnormal Posture 248 248 835 01/06/88 835 01/06/88 1/41 Emaciated REMOVED ** CID 2481 ** REASON - Moribund 844 01/15/88 Abnormal Posture 844 01/15/88 Tachypnea 844 01/15/88 Hypoactivity 249 249 196 04/07/86 835 01/06/88 16/41 Alopecia Body Ventral 785 11/17/87 835 01/06/88 3/41 Tissue Mass Neck 0- 2 Mm REMOVED ** CID 2491 ** REASON - Moribund 847 01/18/88 Abnormal Posture 847 01/18/88 Tachypnea 847 01/18/88 Hypoactivity 251 251 569 04/15/87 868 02/08/88 12/44 Swelling Left Eye 897 03/08/88 924 04/04/88 2/44 Tissue Mass Left Eye 6-10 Mm 616 06/01/87 924 04/04/88 12/44 Discharge Left Eye REMOVED ** CID 2511 ** REASON - Dead 941 04/21/88 Tissue Mass Left Eye 6-10 Mm 254 254 506 02/11/87 1009 06/28/88 21/57 Swelling Right Eye 1065 08/23/88 1122 10/19/88 5/57 Ruffled Fur 1050 08/08/88 1050 08/08/88 1/57 Tissue Mass Left Front Leg 6-10 Mm 569 04/15/87 616 06/01/87 3/57 Discharge Right Eye 1023 07/12/88 1122 10/19/88 8/57 Tissue Mass Right Eye 6-10 Mm 1065 08/23/88 1122 10/19/88 5/57 Tachypnea 1108 10/05/88 1122 10/19/88 2/57 Abnormal Posture 1050 08/08/88 1050 08/08/88 1/57 Tissue Mass Groin 6-10 Mm 168 03/10/86 168 03/10/86 1/57 Override NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 68 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ REMOVED ** CID 2541 ** REASON - Term-Sac 254 254 1134 10/31/88 Tissue Mass Right Eye 6-10 Mm 1134 10/31/88 Abnormal Posture 1134 10/31/88 Ruffled Fur 1134 10/31/88 Tachypnea 255 255 805 12/07/87 805 12/07/87 1/42 Emaciated 835 01/06/88 868 02/08/88 2/42 Tachypnea REMOVED ** CID 2551 ** REASON - Moribund 882 02/22/88 Abnormal Posture 882 02/22/88 Tachypnea 882 02/22/88 Hypoactivity 257 257 1108 10/05/88 1122 10/19/88 2/57 Ruffled Fur REMOVED ** CID 2571 ** REASON - Term-Sac 1134 10/31/88 Ruffled Fur 258 258 897 03/08/88 897 03/08/88 1/43 Tachypnea 897 03/08/88 897 03/08/88 1/43 Hyperactive 897 03/08/88 897 03/08/88 1/43 Swelling Body Ventral 897 03/08/88 897 03/08/88 1/43 Emaciated REMOVED ** CID 2581 ** REASON - Moribund 904 03/15/88 Tremors 904 03/15/88 Tachypnea 904 03/15/88 Hypoactivity 259 259 1108 10/05/88 1122 10/19/88 2/57 Ruffled Fur 1108 10/05/88 1122 10/19/88 2/57 Swelling Left Eye 1108 10/05/88 1122 10/19/88 2/57 Tachypnea 1079 09/06/88 1079 09/06/88 1/57 Swelling Body Ventral REMOVED ** CID 2591 ** REASON - Dead 1127 10/24/88 Swelling Left Eye 1127 10/24/88 Abnormal Posture 1127 10/24/88 Ruffled Fur 260 260 533 03/10/87 533 03/10/87 1/38 Alopecia Body Ventral REMOVED ** CID 2601 ** REASON - Dead NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 69 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 260 260 758 10/21/87 Normal 261 261 595 05/11/87 595 05/11/87 1/32 Emaciated REMOVED ** CID 2611 ** REASON - Moribund 602 05/18/87 Swelling Body Ventral 262 262 981 05/31/88 1009 06/28/88 3/49 Swelling Body Ventral REMOVED ** CID 2621 ** REASON - Dead 1020 07/09/88 Normal 263 263 897 03/08/88 924 04/04/88 2/44 Swelling Body Ventral 533 03/10/87 533 03/10/87 1/44 Wound Tail Red REMOVED ** CID 2631 ** REASON - Moribund 942 04/22/88 Swelling Body Ventral 942 04/22/88 Abnormal Posture 942 04/22/88 Tachypnea 942 04/22/88 Hypoactivity 266 266 835 01/06/88 835 01/06/88 1/41 Emaciated REMOVED ** CID 2661 ** REASON - Moribund 844 01/15/88 Abnormal Posture 844 01/15/88 Tachypnea 844 01/15/88 Hypoactivity 268 268 835 01/06/88 835 01/06/88 1/41 Emaciated 506 02/11/87 533 03/10/87 2/41 Swelling Groin 395 10/23/86 478 01/14/87 4/41 Alopecia Entire Animal 595 05/11/87 616 06/01/87 2/41 Alopecia Body Ventral 805 12/07/87 835 01/06/88 2/41 Tissue Mass Groin 3- 5 Mm REMOVED ** CID 2681 ** REASON - Moribund 862 02/02/88 Emaciated 862 02/02/88 Ruffled Fur 862 02/02/88 Tachypnea 862 02/02/88 Hypoactivity 271 271 282 07/02/86 282 07/02/86 1/42 Alopecia Body Dorsal NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 70 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS ANIMAL DATA - 271 271 364 09/22/86 728 09/21/87 14/42 Alopecia Entire Animal 450 12/17/86 478 01/14/87 2/42 Malocclusion 868 02/08/88 868 02/08/88 1/42 Alopecia Body Ventral REMOVED ** CID 2711 ** REASON - Moribund 869 02/09/88 Abnormal Posture 869 02/09/88 Hypoactivity 274 274 756 10/19/87 805 12/07/87 3/45 Alopecia Neck 196 04/07/86 952 05/02/88 9/45 Alopecia Body Ventral REMOVED ** CID 2741 ** REASON - Moribund 961 05/11/88 Emaciated 961 05/11/88 Abnormal Posture 961 05/11/88 Comatose 275 275 506 02/11/87 506 02/11/87 1/32 Wound Right Ear Red REMOVED ** CID 2751 ** REASON - Moribund 597 05/13/87 Dyspnea 597 05/13/87 Abnormal Posture 282 282 952 05/02/88 952 05/02/88 1/45 Sore Body (Trunk) 6-10 Mm 644 06/29/87 952 05/02/88 12/45 Swelling Left Eye REMOVED ** CID 2821 ** REASON - Moribund 965 05/15/88 Tissue Mass Left Eye 6-10 Mm 965 05/15/88 Sore Body Dorsal 21-25 Mm 965 05/15/88 Ruffled Fur 965 05/15/88 Hypoactivity 284 284 805 12/07/87 805 12/07/87 1/40 Swelling Right Eye REMOVED ** CID 2841 ** REASON - Dead 824 12/26/87 Swelling Right Eye 287 287 785 11/17/87 785 11/17/87 1/39 Emaciated REMOVED ** CID 2871 ** REASON - Moribund 798 11/30/87 Circling 798 11/30/87 Dyspnea NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 71 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 289 289 952 05/02/88 952 05/02/88 1/45 Ruffled Fur 952 05/02/88 952 05/02/88 1/45 Head Tilted 952 05/02/88 952 05/02/88 1/45 Tachypnea 952 05/02/88 952 05/02/88 1/45 Emaciated REMOVED ** CID 2891 ** REASON - Moribund 952 05/02/88 Comatose 290 290 897 03/08/88 897 03/08/88 1/43 Swelling Body Ventral REMOVED ** CID 2901 ** REASON - Moribund 899 03/10/88 Comatose 293 293 952 05/02/88 952 05/02/88 1/46 Swelling Right Eye REMOVED ** CID 2931 ** REASON - Dead 981 05/31/88 Swelling Right Eye 294 294 868 02/08/88 868 02/08/88 1/42 Swelling Body Ventral REMOVED ** CID 2941 ** REASON - Moribund 884 02/24/88 Emaciated 884 02/24/88 Hyperactive 884 02/24/88 Tachypnea 295 295 478 01/14/87 478 01/14/87 1/28 Swelling Body Ventral REMOVED ** CID 2951 ** REASON - Moribund 494 01/30/87 Swelling Body Ventral 494 01/30/87 Emaciated 494 01/30/87 Ruffled Fur 296 296 785 11/17/87 785 11/17/87 1/39 Emaciated 196 04/07/86 672 07/27/87 9/39 Alopecia Body Ventral 700 08/24/87 785 11/17/87 4/39 Alopecia Neck 785 11/17/87 785 11/17/87 1/39 Tissue Mass Scrotum 3- 5 Mm REMOVED ** CID 2961 ** REASON - Dead 788 11/20/87 Normal 298 298 981 05/31/88 981 05/31/88 1/46 Alopecia Body Ventral 835 01/06/88 981 05/31/88 6/46 Swelling Right Eye NTP EXP/TEST: 05126-02 MOUSE AGEING STUDY PAGE: 72 TEST TYPE: CHRONIC-LIFETIME CLINICAL OBSERVATIONS BY ANIMAL DATE: 11/06/02 ROUTE: NOT APPLICABLE EISRPT27 TIME: 11:16:00 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-B6C3F1 TRT#: 1 ROOM/AREA: 5501 FIRST DOSE: 09/24/85 SEX: MALE TRT: LIFETIME PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS ANIMAL DATA - 298 298 981 05/31/88 981 05/31/88 1/46 Tachypnea 981 05/31/88 981 05/31/88 1/46 Swelling Body Ventral REMOVED ** CID 2981 ** REASON - Moribund 981 05/31/88 Tremors 981 05/31/88 Swelling Right Eye 981 05/31/88 Swelling Body Ventral 981 05/31/88 Tachypnea 981 05/31/88 Hypoactivity 299 299 981 05/31/88 995 06/14/88 2/47 Sore Right Front Leg 3- 5 Mm 981 05/31/88 995 06/14/88 2/47 Tachypnea REMOVED ** CID 2991 ** REASON - Dead 1006 06/25/88 Normal 300 300 1009 06/28/88 1023 07/12/88 2/49 Tachypnea 1009 06/28/88 1023 07/12/88 2/49 Ruffled Fur 1023 07/12/88 1023 07/12/88 1/49 Abnormal Posture REMOVED ** CID 3001 ** REASON - Dead 1025 07/14/88 Emaciated ----------------------------------- ---------- END-OF-REPORT ---------- -----------------------------------