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Title Soman- or kainic acid-induced convulsions decrease muscarinic receptors but not benzodiazepine receptors
Creator/Author Churchill, L. ; Pazdernik, T.L. ; Cross, R.S. ; Nelson, S.R. ; Samson, F.E. (Univ. of Kansas Medical Center, Kansas City (USA))
Publication Date1990 Mar 01
OSTI IdentifierOSTI ID: 6522653
Other Number(s)ISSN0161-813X; CODEN: NRTXD
Resource TypeJournal Article
Resource RelationNeurotoxicology (Park Forest South, Illinois) ; Vol/Issue: 11:1
Subject550901 -- Pathology-- Tracer Techniques; CHOLINE-- BIOCHEMICAL REACTION KINETICS;NERVOUS SYSTEM DISEASES-- PATHOGENESIS;PARASYMPATHOMIMETICS-- RECEPTORS; AUTORADIOGRAPHY;CHOLINESTERASE;ENZYME INHIBITORS;INHIBITION;NERVE CELLS;RATS;TRITIUM COMPOUNDS
Related SubjectALCOHOLS;AMINES;AMMONIUM COMPOUNDS;ANIMAL CELLS;ANIMALS;AUTONOMIC NERVOUS SYSTEM AGENTS;CARBOXYLESTERASES;DISEASES;DRUGS;ENZYMES;ESTERASES;HYDROGEN COMPOUNDS;HYDROLASES;HYDROXY COMPOUNDS;KINETICS;LIPOTROPIC FACTORS;MAMMALS;MEMBRANE PROTEINS;ORGANIC COMPOUNDS;PROTEINS;QUATERNARY COMPOUNDS;REACTION KINETICS;RODENTS;SOMATIC CELLS;VERTEBRATES
Description/Abstract (3H)Quinuclidinyl benzilate (QNB) binding to muscarinic receptors decreased in the rat forebrain after convulsions induced by a single dose of either soman, a potent inhibitor of acetylcholinesterase, or kainic acid, an excitotoxin.^A Rosenthal plot revealed that the receptors decreased in number rather than affinity.^When the soman-induced convulsions were blocked, the decrease in muscarinic receptors at 3 days was less extensive than when convulsions occurred and at 10 days they approached control levels in most of the brain areas.^The most prominent decrements in QNB binding were in the piriform cortex where the decline in QNB binding is probably related to the extensive convulsion-associated neuropathology.^The decrements in QNB binding after convulsions suggest that the convulsive state leads to a down-regulation of muscarinic receptors in some brain areas.^In contrast to the decrease in QNB binding after convulsions, (3H)flunitrazepam binding to benzodiazepine receptors did not change even in the piriform cortex where the loss in muscarinic receptors was most prominent.^Thus, it appears that those neuronal processes that bear muscarinic receptors are more vulnerable to convulsion-induced change than those with benzodiazepine receptors.
Country of PublicationUnited States
LanguageEnglish
FormatPages: 57-71
System Entry Date2001 May 13

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