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Title Effect of electrical convulsions on uridine labeling and activity pattern in nerve cells in mice
Creator/Author Pakkenberg, H. ; Pakkenberg, B. ; Fog, R.
Publication Date1985 Jul 01
OSTI IdentifierOSTI ID: 5177502
Other Number(s)CODEN: EXNEA
Resource TypeJournal Article
Resource RelationExp. Neurol. ; Vol/Issue: 1
Research OrgHvidovre Univ. Hospital, Denmark
Subject551001 -- Physiological Systems-- Tracer Techniques; ELECTRIC SHOCK-- BIOLOGICAL EFFECTS;NERVE CELLS-- TISSUE DISTRIBUTION;URIDINE-- LABELLING; ANOXIA;AUTORADIOGRAPHY;CEREBRAL CORTEX;HIPPOCAMPUS;INTRAVENOUS INJECTION;MICE;TRACER TECHNIQUES;TRITIUM COMPOUNDS
Related SubjectANIMAL CELLS;ANIMALS;AZINES;BODY;BRAIN;CENTRAL NERVOUS SYSTEM;CEREBRUM;DISTRIBUTION;HETEROCYCLIC COMPOUNDS;HYDROXY COMPOUNDS;INJECTION;INTAKE;ISOTOPE APPLICATIONS;LABELLED COMPOUNDS;MAMMALS;NERVOUS SYSTEM;NUCLEOSIDES;NUCLEOTIDES;ORGANIC COMPOUNDS;ORGANIC NITROGEN COMPOUNDS;ORGANS;PYRIMIDINES;RIBOSIDES;RODENTS;SOMATIC CELLS;URACILS;VERTEBRATES
Description/Abstract Male white mice were exposed to electroshock and then injected intravenously with 5-(3H)uridine immediately after the shock.^After 5, 30, or 60 min or 6, 12, or 24 h, the mice were killed, microautoradiographs were prepared, and grains were counted in the cortex, hippocampus, and basal ganglia.^The results of the grain counts were compared with grain counts in the cortex, hippocampus, and basal ganglia of mice exposed to anoxia for 25 s and then treated in the same manner as the first groups.^After electroshock the grain count decreased to 25% of that in control animals in the hippocampus and to 50% in the cortex but was normal in the basal ganglia.^The counts returned to normal values within 6 h in the hippocampus, and within 1 h in the cortex.^After anoxia, the grain counts were normal in the cortex and hippocampus but increased in the basal ganglia.^The distribution of cells with a high or low grain count in vertical and horizontal columns of the cortex in control and convulsion animals was analyzed.^There were random variations from column to column in both control and convulsion animals.^In some anatomic layers there were significantly different grain counts, indicating differences in functional activity.
Country of PublicationUnited States
LanguageEnglish
FormatPages: 115-122
System Entry Date2001 May 13

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