Gomez FA, Romero SP, Bernal JA, Rosety M, Ruiz P, Garcia-Gil D, Escobar MA, Briceno F; International Conference on AIDS (15th : 2004 : Bangkok, Thailand).

Int Conf AIDS. 2004 Jul 11-16; 15: abstract no. WePeB5848.

Hospital Universitario Puerto Real, Department of Medicine, University of Cadiz, Cadiz, Spain

Background: HAART-induced metabolic alterations (insulin resistance and dyslipemia), are similar to those frequently found in patients with essential arterial hypertension (AHT). Objectives: We have prospectively followed a cohort of HIV patients on HAART to assess the prevalence of AHT and its potential relationship to HAART-induced fat maldistribution and metabolic alterations. Methods: One hundred and twenty two HIV patients (84 men and 38 women), with a mean age of 39 +/- 14 years (x +/- SD), 66% IVDA (n=81), 15% homosexuals/bisexuals (n=18) and, 19% heterosexuals (n=23), with blood pressure<135/85 mmHg at inclusion, have been followed a mean of 52.8+/-7 months, while on HAART. Blood pressure (BP), anthropometic data, hematologic and biochemical parameters were determined quarterly. Results: pVL before HAART was 30,178+/-3,762 copies/mL and, 209+/-63 at month 44th on HAART. CD4 count before HAART was 226+/-79 (/muL) and, 463+/-61 at month 44th. Nine patients were dyslipemic before HAART: Two hypercholesterolemic (283+/-27 mg/dL), three hypertriglyceridemic (269+/-39 mg/dL) and four with mixed hyperlipemia (Chol: 279+/-27, Trigl: 281+/-79). Seventeen patients (14%) developed AHT while on HAART (systolic BP=148+/-41, diastolic BP=97+/-28 and, mean BP=130+/-24 mm Hg). This prevalence of AHT is higher than observed in our area for persons in this age group. Insulin resistance, hypercholesterolemia and obesity (BMI: 29.7+/-3.4 kg/m[2]), were present in the 17 HIV patients who became hypertensive while on HAART. BP (mean, systolic or diastolic), did not correlate with plasma cholesterol, fasting blood glucose or insulin levels. Diastolic BP correlated with the body mass index. Conclusions: Our results suggest that HIV patients have an increased prevalence of arterial hypertension after four years on HAART. Studies with a large number of patients and longer follow up would be needed to assess whether arterial hypertension is assoc iated with HAART.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Antiretroviral Therapy, Highly Active
• Blood Glucose
• Blood Pressure
• Blood Pressure Determination
• Body Mass Index
• CD4 Lymphocyte Count
• Female
• HIV Infections
• HIV Seropositivity
• Humans
• Hypertension
• Insulin Resistance
• Male
• Obesity
• Prevalence
• Systole
• epidemiology

Other ID:

• GWAIDS0039559

UI: 102283775

From Meeting Abstracts