From: ncbi-seminar-bounces@ncbi.nlm.nih.gov on behalf of Aron
Marchler-Bauer [bauer@ncbi.nlm.nih.gov]
Sent: Monday, April 21, 2003 5:57 PM
To: ncbi-seminar@kalafati.ncbi.nlm.nih.gov
Subject: Re: CBB Seminar tomorrow, 4/22

I forgot to add time and place:

 Tuesday April 22 at 11:00 AM
 Bldg. 38A, 5th floor conference room, see

 http://www.ncbi.nlm.nih.gov/CBBresearch/Seminar/

   - Aron

On Apr 21,  5:39pm, Aron Marchler-Bauer wrote:
> Subject: CBB Seminar tomorrow, 4/22
> CDD Seminar Series, Part3:
> 
>  CDD - A conserved domain database.
> 
>  This seminar concludes a three-part series about the background of  
> and software tools developed for the Conserved Domain Database (CDD).  
> Our goal is to build a well-curated resource for the accurate  
> annotation of functional domains and associated conserved sites in  
> proteins. I will summarize the efforts undertaken to increase CDD's  
> coverage, the sensitivity, and the specificity of the annotation  
> system.  We find that diverse domain families can not be represented 
> well with  single alignment and search models. The redundancy created 
> by splitting  such cases into several (more specific) sub-families may 
> be inherent to  all comprehensive domain model collections. By linking 
> related models  into hierarchical trees we attempt to make that 
> redundancy transparent.  I will summarize the curation process and 
> explain the principles we  try to follow. Upcoming versions of CDD 
> will allow the browsing of  curated domain family hierarchies.
> 
>  CDD is available as part of Entrez, or at  
> http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml
> 
> ______________________________________________
> 
>  Aron Marchler-Bauer, PhD
>  NCBI, National Library of Medicine,
>  NIH, Bldg. 38A, Room 8N805
>  8600 Rockville Pike, Bethesda, MD 20894
>  Tel:   +1-301-435-4919
>  Fax:   +1-301-435-7794, +1-301-480-9241
>  Email: bauer@ncbi.nlm.nih.gov  
>______________________________________________
>-- End of excerpt from Aron Marchler-Bauer