(1) Plans and conducts the Institute's basic laboratory and clinical research, which encompasses the environmental areas of medicine, biology, pharmacology, neurosciences and pulmonary pathobiology, chemistry, toxicology, genetics, and biophysics; (2) plans and conducts a program of toxicology and carcinogenesis studies to establish and characterize the toxicity of chemicals and other environmental agents, and to develop, validate, and evaluate such methods; (3) plans and conducts basic and applied research related to environmental health in the areas of risk assessment, statistics, biomathematics, and epidemiology; (4) ensures optimal utilization of available resources in the attainment of Institute objectives; (5) evaluates research efforts and establishes intramural priorities; (6) integrates ongoing and new research activities into the division structure; (7) collaborates with other NIH Institutes, divisions and programs; (8) maintains an active association with peer groups in other Federal agencies, academic and private institutions, and international organizations with similar environmental health research interests, and disseminates research results; and (9) provides advice to the Institute Director and staff on matters of scientific interest.