Galera C, Redondo C, Cuesta F, Herrera S, Zapata A, Pagan E; International Conference on AIDS.

Int Conf AIDS. 1993 Jun 6-11; 9: 335 (abstract no. PO-B07-1197).

Hospital Arrixaca, Murcia, Spain.

OBJECTIVE: To study the clinical and epidemiological patterns of Extrapulmonary Tuberculosis (ETB) in 20 HIV infected patients (pts) from a Southeast Spanish hospital. METHODS: Of 250 HIV infected pts seen in the AIDS-Unit of our hospital, we analysed 20 bacteriologically proven cases of ETB. HIV infection was classified according to CDC criteria. RESULTS: 19 were males and 1 female. The mean age was 35 years (range 20-68). Nine were IVDUs (45%), 9 homo-bisexuals, and 2 heterosexuals (10%). Eight pts were not known to be HIV infected at the moment of ETB diagnosis, 8 were symptomatic (group IV CDC) and 20% asymptomatic. The clinical patterns were: FUO in 45%, generalized lymphadenopathy in 35%, miliary form in 10%, and meningeal in 10%. All patients had prolonged fever, 55% had weight loss and 55% had hepatomegaly. All subjects had ESR > 60, 65% had anemia and 35% had abnormalities of hepatic biochemical tests. The average CD4 cell count was 165 x 10(6)/L (range 30-406). The chest Rx were normal in 15 pts, showed mediastinal-hilar adenopathy in 3 pts and miliary pattern in 2. In the patients with FUO, the average time of delayed diagnosis was 55 days (range 29-75). The antituberculous therapy was with standard 3- or 4-drug regimens. 40% of our patients had adverse effects, and in 20% a drug-change was necessary. CONCLUSIONS: In areas with high prevalence of tuberculosis, as in Southern Spain, a diagnosis of tuberculosis must be suspected in HIV patients with prolonged fever. Treatment has an elevated frequency of adverse effects in these patients.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• CD4 Lymphocyte Count
• Centers for Disease Control and Prevention (U.S.)
• Female
• HIV
• HIV Infections
• HIV Seropositivity
• HIV Seroprevalence
• Humans
• Male
• Spain
• Tuberculosis
• United States

Other ID:

• 93334728

UI: 102204102

From Meeting Abstracts