| US 7,358,337 B2 | ||
| Assay for low molecular weight heparin | ||
| Ted C. K. Lee, Matawan, N.J. (US); Amanda B. McBride, Turnersville, N.J. (US); and Frank M. LaDuca, East Brunswick, N.J. (US) | ||
| Assigned to International Technidyne Corporation, Edison, N.J. (US) | ||
| Filed on Aug. 16, 2002, as Appl. No. 10/222,345. | ||
| Prior Publication US 2004/0033551 A1, Feb. 19, 2004 | ||
| Int. Cl. A61K 35/14 (2006.01) | ||
| U.S. Cl. 530—380 | 13 Claims |
| 1. A prothrombin time reagent for determining the concentration of low molecular weight heparin in fresh whole blood and anti-coagulant-treated
blood comprising:
a recombinant animal tissue factor;
a mixture of synthetic phospholipids including a selected phosphatidylalcohol, which mixture lipidates said recombinant animal
tissue factor to form a lipidated tissue factor; and
a buffer solution comprising Hepes, sodium chloride; gamma-cyclodextrin; beta-alanine; serine; sorbitol; bovine serum albumin;
phenol; and butylated hydroxytoluene, and wherein the reagent is exposed in an atmosphere of about 5% to about 10% relative
humidity at about 20° C. to about 37° C. to thereby form an air-dried reagent.
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