US 7,390,491 B2
	Agents comprising midkine or an inhibitor thereof as active ingredient
Tohru Takada, Aichi (Japan); Kazuhiro Toriyama, Aichi (Japan); Hisako Muramatsu, Aichi (Japan); and Takashi Muramatsu, Aichi (Japan)
Assigned to Takashi Muramatsu, (Japan)
Filed on Nov. 18, 2002, as Appl. No. 10/298,889.
Application 10/298889 is a division of application No. 09/462725, abandoned, previously published as PCT/JP98/03161, filed on Jul. 14, 1998.
Claims priority of application No. 9/205320 (JP), filed on Jul. 14, 1997; and application No. 9/205332 (JP), filed on Jul. 14, 1997.
Prior Publication US 2003/0072739 A1, Apr. 17, 2003
Int. Cl. A61K 39/395 (2006.01); C07K 16/22 (2006.01); C07K 16/46 (2006.01)

U.S. Cl. 424—145.1  [424/133.1; 424/141.1; 424/142.1; 424/158.1; 530/387.3; 530/388.1; 530/388.15; 530/388.23; 530/389.1; 530/389.2]

15 Claims

1. A method for inhibiting a neutrophilic function, wherein the inhibition is achieved by administering to a subject in need thereof, an effective amount of an inhibitor of mammalian midkine, wherein said inhibitor of mammalian midkine is an anti-midkine antibody.