DAVID Bioinformatics
The Database for Annotation, Visualization and Integrated Discovery
DAVID Bioinformatics Resources 2008
National Institute of Allergy and Infectious Diseases (NIAID), NIH
DAVID Gene Report
Gene Report

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3026954 chemokine (c-x-c motif) ligand 3 Related Genes Homo sapiens
SP_COMMENT PTM:N-terminal processed form GRO-gamma(5-73) is produced by proteolytic cleavage after secretion from peripheral blood monocytes., function:Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes., similarity:Belongs to the intercrine alpha (chemokine CxC) family., subcellular location:Secreted.,
REFSEQ_PROTEIN NP_002081,
REFSEQ_MRNA NM_002090,
GENPEPT_ACCESSION AAA03454, AAA63184, AAH16308, AAH65743, AAY41006, ABW03903, CAA37809, EAX05697, EAX05698, Genomic_DNA, Unassigned_DNA, mRNA,
GENE_SYMBOL Cxcl3,
GENE_NAME C-X-C motif chemokine 3, Chemokine (C-X-C motif) ligand 3, isoform CRA_b, GRO-gamma, GRO-gamma(1-73), Growth-regulated protein gamma, MIP2-beta, Macrophage inflammatory protein 2-beta precursor, Melanoma growth stimulatory activity gamma, Melanoma growth stimulatory activity gamma (Fragment), Putative uncharacterized protein CXCL3, Putative uncharacterized protein CXCL3 (Chemokine (C-X-C motif) ligand 3, isoform CRA_b), chemokine (C-X-C motif) ligand 3,
GENERIF_SUMMARY demonstrates, for the first time, that BIRC3 (anti-apoptotic protein), COL3A1 (matrix protein synthesis), and CXCL3 (chemokine) were up-regulated in the thrombin-stimulated human umbilical vein endothelial cells, GRO-gamma is a promising candidate for Th2-associated glomerular permeability factor in minimal change disease., Inhibition of ERK phosphorylation decreased expression of GRO3.,
CHROMOSOME 4,
ENTREZ_GENE_ID 2921,
UNIGENE Hs.89690,
PIR_NREF_ID NF00081326, NF00110403, NF00131481,
UNIREF100_ID UniRef100_P19876,
UNIPROT_ID MIP2B_HUMAN, Q4W5H9_HUMAN, Q6LD32_HUMAN,
CYTOBAND 4q21,


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