•Appendicitis is associated with a neutrophilic infiltration of the muscularis and, usually, the appendix mucosa.
•
•The technetium Tc 99m
labeled Rb5 IgM antibody
binds the CD15 epitopes on the polymorphonuclear
neutrophils found at sites of
infection/ inflammation, allowing imaging
of the site.
•
Rationale for
using this antibody to diagnose equivocal appendicitis is that….
There are
approximately 500,000 binding sites for the anti-DC15 antibody per cell