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EC-NUMBER
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1.4.3.13
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ENZYME-NAME
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protein-lysine 6-oxidase
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ENZYME-SYSNAME
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Also acts on protein 5-hydroxylysine. This enzyme catalyses the final known enzymic step required for collagen and elastin cross-linking in the biosynthesis of normal mature extracellular matrices [4]. These reactions play an important role for the development, elasticity and extensibility of connective tissue. The enzyme is also active on free amines, such as cadaverine or benzylamine [4,5].
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ENZYME-CLASS
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Oxidoreductases Acting on the CH-NH2 group of donors With oxygen as acceptor
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SYNONYMS
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lysyl oxidase;
protein-lysine 6-oxidase;;
>>more synonyms
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REACTION
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peptidyl-L-lysyl-peptide + O2 + H2O = peptidyl-allysyl-peptide + NH3 + H2O2 [RN:R04239]
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PATHWAY
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EMP-PATHWAYS:
NO EMP PATHWAY FOUND
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KEGG-PATHWAYS:
NO KEGG PATHWAY FOUND
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GO_TERM
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GO:0004720:protein-lysine 6-oxidase activity
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ENZYME-COMMENT
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protein-L-lysine:oxygen 6-oxidoreductase (deaminating)
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