de Jose MI, Garcia MJ, Ramos JT, Martin P, Hernandez T, Fortuny C, Beltran JM; International Conference on AIDS.

Int Conf AIDS. 1996 Jul 7-12; 11: 110 (abstract no. Mo.B.1321).

Hospital Infantil La Paz, Madrid, Spain.

Objective: To determine the incidence, clinical, immunological and evolutive features of Cryptosporidium gastroenteritis in HIV-1 infected children. Methods: 505 children infected either by haemoderivates or vertically, with HIV, are restrospectively studied.Clinical features tested were anorexia,abdominal pain, malnutrition, number and characteristics of the stools and time of the diarrhoea onset before the diagnosis was established analitical tests were directed in order to find esteatorrea, and CD4 count. The evolution, treatment, collangitis and mortality ratio were evaluated. Results: We have found 43 cases (8.5%) of gastroenteritis due to Cryptosporidium in children infected by HIV (71% perinatally acquired and 29 % by hemoderivates). Following the CDC classification we found: B2= 4, B3 = 5, C2=2, and C3=26 cases. 65% of the patients had opportunistic infections previous to the diagnosis. Anorexia was present in 95%, abdominal pain in 68% and malnutrition in 81% of the cases. Malabsortion was objetivated in 73%, collangitis in 30% (in 10 cases of them associated to CMV) and CD 4 count level was 200 46. Duration of diarrhoea previous to the diagnostic onset was 83 days (4 -300) with a median of 7-8 stools per day (3-20). Only in 13% had stools with blood. Signs of hepatic celular necrosis (ASAT and ALAT over 120 U/L) in 8 cases, and signs of collestasis (GGT greater than 80 U/L) in 18 cases. Nineteen per cent of cases (6/43) had an acute gastroenteritis, that responded with to treatment. Twenty six per cent (11/43) had a long time favourable evolution of cronic gastroenteritis. Fifty five per cent (24/43) died after a torpid evolution. Conclusion: Cryptosporidiasis is a frequent opportunistic infection in severaly immunoincompetent HIV children and a lot of cases derive in malabsortion with important nutritional impairment and high mortality. Early diagnosis is desirable even though the lack of available therapies up to now.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Animals
• Anorexia
• CD4 Lymphocyte Count
• Child
• Cryptosporidiosis
• Cryptosporidium
• Diarrhea
• Gastroenteritis
• HIV Infections
• HIV Seropositivity
• HIV-1
• Humans
• Incidence

Other ID:

• 96921385

UI: 102217284

From Meeting Abstracts