CLUSTAL W (1.74) multiple sequence alignment BS_nagA ---MAES-LLIKDIAIVTENEVIKNGYVGINDGKISTVSTERP---KEPYSKEIQAPADS BH0421 ---MENGNCVLKGASIVGETQSYDKGFLKVEDGIITEVTEQEI---ENHRHDKSIDLSGC agaA ------------------------------------------------------------ Z4489 ------MTHVLRARRLLTEEGWLDDHQLRIADGVI---AAIEP---IP---VSVTERDAE L173068 ------MTYYIKADQFFYAYETKKGGFLEITDGKFGEWTEEAP---AG---ADILDYSGQ SPy1694 ------MTCYLKADCFYYPTEVRPAGYLSLHDGVFGEWTEIVP---AD---AQIIDYTGY nagA -------MYALTQGRIFTGHEFLDDHAVVIADGLIKSVCPVAE----LPPEIEQRSLNGA ZnagA -------MYALTQGRIFTGHEFLDDHAVVIADGLIKSVCPVAE----LPPEIEQRSLNGA VC0994 -------MYALTNCKIYTGNDVLVKHAVIINGDKIEAVCPIES----LPSEMNVVDLNGA HI0140 ------MKYALINCVIYTKYDVLRDFAVIINGEIIEAVIPQAE----LETGIKTIDLQGN PM0874 -------MYAFVNAVIYTAKDVLYGKALVVDGDKISAILPVED----VPENLQKIDLQGN CC0443 MP------AALINGRVLTESGVVEGKAVLVKDGLILDVIEAAQ----TPSDAKPRDLKGG CC0534 MP------IALVNGRVLTPAGFVSGKAVLVENGVVVALLDARD----VPADAQRHDLGGD XF1465 MMGASSGVAGFINGRVLIDTGFRHDLAVLLRGGCIQALLPHDDP--RVTEGAQWMDLRGG mll4766 MSDR----FALTGARIFDGDDWHDDAALVVRDGLVEAIVPSGA----IARDVRAVDTGGG DRA0066 ----------------MTSPSSLSGRLLLPGGSFVSGTLHFGT----HITALEEGPINGP PA3758 ----------MLEGNILTPQGWVLG-RLHIQDGRIQR-IEGEP--------CDPAGNADP Rv3332 -------MTVLGADAVVIDGRICRPGWVHTADGRILSGGAGAP-----P-MPADAEFPDA TM0814 --------MIVEKVLIVDPIDGEFTGDVEIEEGKIVK-VEKRE------------CIPRG VC1783 -----MALKAISATRLFDGIQYYENAAMVWEGSHIHSIVPIES----LTEDIEHQHFDGA BB0151 ----MPNFCLFNSKSVLTGNDKIDNSAVLIKDNKIFDIVTSDRLKKMDLEEYQMIDTKGN BS_nagA VLLPGMIDIHIHGGYGADTMD---ASFSTLD-IMSSRLPEEGTTSFLATTITQEHGNISQ BH0421 YVVPGFIDVHIHGSHGADTMD---ASQICLE-TIAKSIVREGTTGFLATTITQGQGRIEQ agaA ------------------------------------------------------------ Z4489 LLCPAYIDTHVHGGAGVDVMD---DAPDVLD-KLAMHKAREGVGSWLPTTVTAPLSTIHA L173068 SIAPGLVETHIHGFGGADAQD---AEVEGIMGTMSEGLLSAGVTSFLPSPLTDDHEGLKA SPy1694 QIAPGLVDTHIHGYAGADVMD---NSAQGIH-QMSEGLLATGVTSFLPTTLTSTFEQLEK nagA ILSPGFIDVQLNGCGGVQFNDTAEAVSVETLEIMQKANEKSGCTNYLPTLITTSDELMKQ ZnagA ILSPGFIDVQLNGCGGVQFNDTAEAVSVETLEIMQKANEKSGCTNYLPTLITTSDELMKQ VC0994 NLSPGFIDLQLNGCGGVMFND--E-ITAETIDTMHKANLKSGCTSFLPTLITSSDENMRQ HI0140 NLTAGFIDLQLNGCGGVMFNDQ---TSVETLEIMQETNLKSGCTSFLPTFITAPDENIKS PM0874 NLTAGFIDLQLNGCGGVMFNED---ISVKTLEIMQETNLKSGTTSYLPTFITSPDEGMKD CC0443 LLVPGFIDTQVNGGGGVLFNDA---PTVETIATIGAAHRRFGTTGFLPTLISDDLRVVDQ CC0534 RLVPGFIDTQVNGGGGALFNDA---PTARTIATIGEAHRAYGTTGFLPTLISDDLEVVDA XF1465 LLLPGFIDIQVNGGGGVLFNNA---RDVDALATIARAHRRYGTTGLLPTLISDTVEVMAE mll4766 MLVPGFVDIQVNGGGGVMLNDH---PDVASIETICRAHAPFGTTALLPTLITDTPAITAA DRA0066 LILPGFVDTHLHGGGGGDAMDG-----AEGVRTLARLHARHGTTTLLPTTMTNPWDKVLA PA3758 YLLPGFIDLHVHGGGGRDIME-----GGDAFATIARTHRRFGTTSLLATTMTAPREEIAD Rv3332 IVVPGFVDMHVHGGGGASFADG----NAADIARAAEFHLRHGTTTTLASLVTAGPAELLS TM0814 VLMPGFVDPHIHGVVGADTMN-------CDFSEMEEFLYSQGVTTFLATTVSTSLEKMKE VC1783 LIAPGFIDLQVNGGGDVMFNN---DMTLAGIDSICRAHRTHGTAYLLPTLISATPEHINR BB0151 YITPGLYDNHIHGFHGHGTDQ----CSTESILKMSEHLAQYGVVGFLPTLYPRPIDEMIK BS_nagA ALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIR-PSDVELFKKWQQEA BH0421 ALANVAEYAKGPHN--EGAQLLGVHLEGPFISAKRAGAQPVEHIL-EPNLSLFNRWYEVS agaA ------------------------------------------------------------ Z4489 ALKRIAQRCQRGGP---GAQVLGSYLEGPYFTPQNKGAHPPELFR-ELEIAELDQLIAVS L173068 VCTVVGEHYQEAR----GAKVRGIFFEGPFFTEEKKGAQNPKYMR-DAKMWELEDWQEAA SPy1694 VSGTIASVADQVK----GAKIQGIYFEGPYFTEEYKGAQNPSYMK-TPRLEEFDAWQKAA nagA GVRVMREYLAKHP-----NQALGLHLEGPWLNLVKKGTHNPNFVR-KPDAALVDFLCENA ZnagA GVRVMREYLAKHP-----NQALGLHLEGPWLNLVKKGTHNPNFVR-KPDAALVDFLCENA VC0994 AIAAAREYQAKYP-----NQSLGLHLEGPYLNVMKKGIHSVDFIR-PSDDTMIDTICANS HI0140 AVKIMREYLNKHK-----NQALGLHIEGPYLSIEKKGVHRPEYIR-EITPEMKDFLCENG PM0874 AVKVMREYLTQYK-----NQALGLHFEGPYLSVEKKGVHREEYIR-AISPEMKTFLCDNA CC0443 AMRATEEAIARGV-----PGVLGLHIEGPFLNPKRKGIHDAGKFR-VIDDEALALLTSLK CC0534 ALRATEDAIAQGV-----PGVLGVHIEGPFLNPKRKGIHDEAKFR-VIDEDAIALLSSLK XF1465 AIAATRAAIAQGV-----PGILGIHLEGPYLNPLRKGTHDHTQFR-VPQLHEVMRCTALD mll4766 AIAAGEAAALQKV-----PSFLGLHLEGPHLSIARKGAHDPALIRPMTDADQVMLIAARP DRA0066 ALRGVREVMDAGGVPG-GADVPGAHLEGPFISPQRLGAQPPCTLA--PTPERVAEVLALD PA3758 ILSQLGAYCRRSLEG--GSRILGVHLEGPYINSGKLGAQPNFAHA--AVLEEVEDYLRRA Rv3332 AVGALAEATRDGV-------VAGIHLEGPWLSPARCGAHDHTRMR-APDPAEIESVLAAA TM0814 ILRKARDYILENP----STSLLGVHLEGPYISKEKKGAHSEKHIR-PPSERELSEIDSPA VC1783 ALDAIQSAIENQV-----SGVLGIHLEGPWLNPEKKGAHNPDLFY-SPTPEQLSQFHWPT BB0151 TIKACIAAIGKEK----GAKILGLHLEGPFFSPEKKGAHPVSYLH-EPSIEVMQKLIDAA BS_nagA GGLIK-----------IVTLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKA- BH0421 GRTIK-----------LVTLAPETEQGLQLVGALRSRQIIASIGHSDAVHEQMMDAISH- agaA ------------------------------------------------------------ Z4489 QHTLR-----------VVALAPEKEGALQAIRHLKQQNVRVMLGHSAATWQQTRAAFDA- L173068 HGMLK-----------KIGLAPERDGSEDFIRKATESGVVIALGHSNATYKQAVAGVQA- SPy1694 KGLIK-----------KIALAPERDGVKEFVSAVTKQGVTVALGHSNGTYQEAKEAVQA- nagA DV-IT-----------KVTLAPEMVP-AEVISKLANAGIVVSAGHSNATLKEAKAGFRA- ZnagA DV-IT-----------KVTLAPEMVP-AEVISKLANAGIVVSAGHSNATLKEAKAGFRA- VC0994 DV-IA-----------KVTLAPENNK-PEHIEKLVKAGIVVSIGHTNATYSEARKSFES- HI0140 DV-IT-----------KMTIAAENPT-INYTPDFVKAGIIVSVGHSNATYEVAKAAFHK- PM0874 DV-IT-----------KITLAAENPT-AQYIPDFVEKGIIVSLGHSNATYDVAQQAIEK- CC0443 RG-KT-----------LVTLAPERTT-PQIIRRLADAGVIVAAGHTNALYATMRQALEH- CC0534 RG-KL-----------LLTLAPERTT-PDIIARLAAAGVIVAAGHTNAHYETMRRALDH- XF1465 NG-VT-----------LVTLAPEQVP-LEMIRVFVERGAIVFAGHTAATYEQVRAGIAA- mll4766 KLPVL-----------LTTIAPESVD-PTRVAALAKAGIIVSLGHSDTGYATAKGFAEA- DRA0066 VV--S-----------AVTLAPEVEGGLAAALTFAQAGVRVGIGHTAADADTVRACLQAV PA3758 PI--R-----------VITIAPEIAGHRPLIRALAERGVRLQIGHTLGSYEDGVAALEA- Rv3332 DGAVR-----------MVTLAPELPGSDAAIRRFRDAEVVVAVGHTDATYTQTRHAIDL- TM0814 KM---------------LTFAPEIES-SELLLRLVKRDIVLSAGHSIATFEEFMKFYKE- VC1783 KG-KV-----------LVTVAAENLS-IDSLKWLKDHHVTLSCGHSNATTAQLTTEKLA- BB0151 GGVFTGSNGKRKTHISTMTVAPELKGMRELAIFCLENNINLQAGHTNATYENMIEGFQV- BS_nagA ----GASHMTHLYNAMSPFH-HREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAK BH0421 ----GANHVTHLYNGMRGFH-HREPGVAGTALARNELTVELIVDGIHVHPEVVKATYDAK agaA ---------MHCYNGMTGLH-HREPGMVGAGLTDKRAWLELIADGHHVHPAAMSLCC-CC Z4489 ----GADGLVHCYNGMTGLH-HREPGMVGAGLTDKRAWLELIADGHHVHPAAMSLCC-CC L173068 ----GASVWVHTFNGMSGMT-HQEPGMVGAILNTPNTYAELICDGHHVRPEAAEIVMKMK SPy1694 ----GASVWVHAYNGMRGLT-HREPGMVGAVYNLPNTYAELICDGHHVSPIACDILMQQK nagA ----GITFATHLYNAMPYIT-GREPGLAGAILDEADIYCGIIADGLHVDYANIRNAKRLK ZnagA ----GITFATHLYNAMPYIT-GREPGLAGAILDEADIYCGIIADGLHVDYANIRNAKRLK VC0994 ----GITFATHLFNAMTPMV-GREPGVVGAIYDTPEVYAGIIADGFHVDYANIRIAHKIK HI0140 ----GATFATHLHNAMSPISSGREMGVVGAVLDS-DVYTGIIVDGVHINYGNVRIDKKIK PM0874 ----GASFATHLHNAMSPISSGRAMGVVGAVLDS-DIYTGIIVDGLHVDYGNIRLDKKVK CC0443 ----GLTGFTHLFNAMSPLT-SREPGAVGAALESPDAWCGIIVDGRHVDPVVLKIALRTR CC0534 ----GLTGVTHLFNAMSPLT-SREPGVVGAVLENQNAWAGIIVDGRHVDPVTLKIALRTR XF1465 ----GVTGFTHLYNAMSQLV-GREPNVVGAALEDPDTWCGIIVDGVHVHPASLRVALAAK mll4766 ----GAAVVTHLFNAMSQIG-NREPGLVGAAIDIGTLSAGLIADGIHVHPAAIRIALDAK DRA0066 HAAGGRTAGTHLFNAMGGIQ-GREPGVPGALLADPHAFAEMILDGFHLHPLSFLLARAAA PA3758 ----GASSFTHLYNAMTGLH-HREPGIVGAALAH-ARYAELIPDLLHVHPGAIRVALRSI Rv3332 ----GATVGTHLFNAMPPLD-HRAPGPVLALLCDPRVTVEIIADGVHVHPAVVHAVIEAV TM0814 ----GVKRITHFPNGLKPLH-HREIGITGAGLLLDDVKLELICDGVHLSREMVKLVYKVK VC1783 ----LIDGFTHLFNAMSPFE-SREPGVVGTALNTDHAWCSVITDGIHVHPQSFLLAKRIK BB0151 ----GILHTTHFFNAMSKLD-HRNPNAIGAVLIHGDVSCEIIADGHHIHPKLILMLRKLK * *.: : : . : :* * * BS_nagA GS-SKLILITDSMRAKGL--KDGVYEFGGQSVTV-RGRTALLS-DGTLAGSILKMNEGAR BH0421 TA-DNIILITDAMRAKWL--ADGTYELGGQTVHV-KNGKALLQ-DGTLAGSVLKMNDAVK agaA AK-ERIVLITDAMQAAGM--PDGRYTLCGEEVQM-HGGVVRTA-SGGLAGSTLSVDAAVR Z4489 AK-ERIVLITDAMQAAGM--PDGRYTLCGEEVQM-HGGVVRTA-SGGLAGSTLSVDAAVR L173068 GA-DHVVLITDSMRAAGL--PDGPYMLGEYEVEV-RDGAAWLP-TGRPAASILTLKTAVK SPy1694 GH-DHVAMITDCMRAGGS--PDGDYLLGEFSVVV-ANGTARLKESGNLAGSILKLKDGLR nagA GD--KLCLVTDATAPAGA--NIEQFIFAGKTIYY-RNGLCVDE-NGTLSGSSLTMIEGVR ZnagA GD--KLCLVTDATAPAGA--NIEQFIFAGKTIYY-RNGLCVDE-NGTLSGSSLTMIEGVR VC0994 GE--KLVLVTDATAPAGA--EMDYFIFVGKKVYY-RDGKCVDE-NGTLGGSALTMIEAVQ HI0140 GD--KLCIVTDSIAAAGAPPELESFTFVGKTIYI-KEGRCYDA-NDTIAGASITMMESIK PM0874 GD--KLCIVTDATAAAGA--DIDSFVFVGKTVYV-RDGKCYDS-NGTLGGAAITMIESVK CC0443 AL-DRFMLVTDAMPTVGL--PDKRFNLQGRDIRV-VDGVCVDD-HGTLAGSDLDMIGAVR CC0534 PL-DRFMLVTDAMPTVGL--TNKRFNLQGREIVV-RDGVCVDE-AGTLAGSDLDMAAAVR XF1465 PR-GKVLLVTDAMPPVGS--DSVHYDLYGETITV-MDGVVRNA-AGALAGAALDMATAVR mll4766 QGPGKIVLVTDAMATIGT--DMTSFTLNGRTIYR-KDGSLRLA-DGTLAGADLDMISAVR DRA0066 SE--RILLITDAMRAAGQ--GDGESELGGQPVTV-TGGRAALA-NGSLAGSVLTMDVALK PA3758 PC---LYCVTDSTAAAGM--PDGQYKLGSHTVTK-CLGGVRLP-DGTLAGSTLTMDQALR Rv3332 GP-DRVAVVTDAIAAAGC--GDGAFRLGTMPIEV-ESSVARVAGASTLAGSTTTMDQLFR TM0814 KA-NGIVLVTDSISAAGL--KDGTTTLGDLVVKV-KDGVPRLE-DGTLAGSTLFFSQAVK VC1783 PK-DKLLIVTDAMASLGS--VTSQFELDGETIRV-IDNKLINS-RGNLAGAHIGMDESVA BB0151 DI-SKIVLVTDGLTPNCQ--TCGKLIANGDEVYIAEDGLFHSVKSNTIAGSTLTMIQGLK . :** . : . ..: . BS_nagA HMREF-------TNCSWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVIL BH0421 NVMTY-------TGCSLEEAVQMASVNPAKQLNVFDRKGSIRVGKDADLTVLDQDWNVVL agaA NMVEL-------TGVTPAEAIHMASLHPARMLGVDGVLGSLKPGKRARVVALDSGLHVQQ Z4489 NMVEL-------TGVTPAEAIHMASLHPARMLGVDGVLGSLKPGKRASVVALDSGLHVQQ L173068 NVIDW-------GIATPAEAIMMASLTPAKSVNIDDVCGQIKPGLSADFIVLDNDFDLVA SPy1694 NVVAW-------GIATPAEAIHMATYVPAVSVGIDDVCGQIKAGHAADFIVLDKDLTLVA nagA NLVEH-------CGIALDEVLRMATLYPARAIGVEKRLGTLAAGKVANLTAFTPDFKITK ZnagA NLVEH-------CGIALDEVLRMATLYPARAIGVEKRLGTLAAGKVANLTAFTPDFKITK VC0994 NTVEH-------VGIALDEALRMATLYPAKAIGVDEKLGRIKKGMIANLTVFDRDFNVKA HI0140 NAVEY-------VEIPLAEAIRMSNLYPARAIGIDDRLGSVEKGKIANLAVFTPNYQVIG PM0874 NAVQE-------VGIPLDETLRMCNYYPAKAIGVDHKLGSIEVGKIANLTAFTNDFNVLG CC0443 NAIDL-------LDLSLDDAVMMASHAPASFLGLGHGRGLIAPGYAADLCLLNDRLEVAA CC0534 NAVSM-------LGLTLEDAVMMASAAPSALLGLQQRRGAIAPGLAADFCRLDDALNVTS XF1465 NTVHW-------LGVDLAEAVRMASTYPAQCIGLGDRLGRIAPGYQADLVWIDDDVQVQG mll4766 FMHNI-------VGVDLSEALRMASLYPAQAIGQSHRLGRLANGTVADIVALSDGLDIRS DRA0066 NAVS--------VGVPLPEASRMLSLAPARSLGLEDR-GELRVGKRADLVVLNDDLEVQE PA3758 NLVK--------IGLPLAEASQRLSQFPADYLGLAER-GRLAPAAWADVVRLDRSLELDA Rv3332 TVAGLGSKSDSAGDVALAAAVQVTSATPARALGLTGV-GRLAAGYAANLVVLDRDLRVTA TM0814 NFRKF-------TGCSITELAKVSSYNSCVELGLDDR-GRIAEGTRADLVLLDEDLNVVM VC1783 NVIRW-------G-IAEDEALKMASSYPAQAIQCDDL-GQLKPNYRAAATVLNSKYESLA BB0151 NLIEF-------G-FSLSDAVQASSYNPTRILNIDKK-GLICHGYDANLNVLDKDFNLKL . . : * : * . BS_nagA TICRGNIAFIS--KEADQI BH0421 TMCQGRIVYQKGAKSYENH agaA IWIQGQLASF--------- Z4489 IWIQGQLASF--------- L173068 TYLDGEKRYEA-------- SPy1694 TYLNGQKAFDA-------- nagA TIVNGNEVVTQ-------- ZnagA TIVNGNEVVTQ-------- VC0994 TVVNGQYEQN--------- HI0140 TVVNGKWKEN--------- PM0874 TAVNGEWKAK--------- CC0443 TWIDGQEG----------- CC0534 TWIDGKETHARQEALLV-- XF1465 TWIAGVGD----------- mll4766 VWIGGDKVFEAGASR---- DRA0066 VYVGGERLAR--------- PA3758 VMVEGELE----------- Rv3332 VMVNDDWRVG--------- TM0814 TIKEGEVVFRSR------- VC1783 VVSEGVLYN---------- BB0151 TMIESKIIFNNL------- .