Simian-Human HAV Chimeras Encoding a Hepatitis A Virus Having a Chimeric 2C Protein
Description of Invention:
The claimed invention provides nucleic acid sequences which encode hepatitis A viruses having a chimeric 2C protein. The chimeric 2C gene consists of sequences from both the human strain and the simian AGM-27 strain. The chimeric virus is a promising candidate for an attenuated hepatitis A virus vaccine which may be more economical than an inactivated vaccine, especially in underdeveloped countries where hepatitis A in endemic. Additional information on the chimeras may be found in Rayachaudhuri et al., "Utilization of chimeras between human(HM175) and simian(AGM27) strains of hepatitis A virus to study the molecular basis of virulence," J. Virol. 72:7467-7474(1998).
Inventors:
G Raychaudhuri (NIAID) SU Emerson (NIAID) RH Purcell (NIAID)
Patent Status:
DHHS Reference No. E-082-1996/0 --
U.S. Patent 6,280,734 issued 28 Aug 2001
For Additional Information Please Contact: Susan Ano Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-5515
Email: anos@mail.nih.gov
Fax: (301) 402-0220
