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Our Science – Lifson Website

Jeffrey D. Lifson, M.D.

Selected Publications
1)  Frank I, Stössel H, Gettie A, Turville SG, Bess JW, Lifson JD, Sivin I, Romani N, Robbiani M.
A fusion inhibitor prevents spread of immunodeficiency viruses, but not activation of virus-specific T cells, by dendritic cells.
J. Virol. 82: 5329-39, 2008. [Journal]
2)  Kader M, Hassan WM, Eberly M, Piatak M, Lifson JD, Roederer M, Mattapallil JJ.
Anti-retroviral Therapy Prior to Acute Viral Replication Preserves CD4 T cells in the Periphery but not in Rectal Mucosa During Acute Simian Immunodeficiency Virus infection.
J. Virol. 2008. [Journal]
3)  Vachot L, Williams VG, Bess JW, Lifson JD, Robbiani M.
Candida albicans-Induced DC Activation Partially Restricts HIV Amplification in DCs and Increases DC to T-Cell Spread of HIV.
J. Acquir. Immune Defic. Syndr. 48: 398-407, 2008. [Journal]
4)  DeGottardi MQ, Lew SK, Piatak M, Jia B, Feng Y, Lee SJ, Brenchley JM, Douek DC, Kodama T, Lifson JD, Evans DT.
Comparison of plasma viremia and antibody responses in macaques inoculated with envelope variants of single-cycle simian immunodeficiency virus differing in infectivity and cellular tropism.
J. Virol. 82: 321-34, 2008. [Journal]
5)  Kim EY, Veazey RS, Zahn R, McEvers KJ, Baumeister SH, Foster GJ, Rett MD, Newberg MH, Kuroda MJ, Rieber EP, Piatak M, Lifson JD, Letvin NL, Wolinsky SM, Schmitz JE.
Contribution of CD8+ T cells to containment of viral replication and emergence of mutations in Mamu-A*01-restricted epitopes in Simian immunodeficiency virus-infected rhesus monkeys.
J. Virol. 82: 5631-5, 2008. [Journal]
6)  Turville SG, Aravantinou M, Miller T, Kenney J, Teitelbaum A, Hu L, Chudolij A, Zydowsky TM, Piatak M, Bess JW, Lifson JD, Blanchard J, Gettie A, Robbiani M.
Efficacy of Carraguard-based microbicides in vivo despite variable in vitro activity.
PLoS ONE. 3: e3162, 2008. [Journal]
7)  Minang JT, Barsov EV, Yuan F, Trivett MT, Piatak M, Lifson JD, Ott DE, Ohlen C.
Efficient inhibition of SIV replication in rhesus CD4+ T-cell clones by autologous immortalized SIV-specific CD8+ T-cell clones.
Virology. 372: 430-41, 2008. [Journal]
8)  Manches O, Munn D, Fallahi A, Lifson J, Chaperot L, Plumas J, Bhardwaj N.
HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase-dependent mechanism.
J. Clin. Invest. 2008. [Journal]
9)  Tilton JC, Manion MM, Luskin MR, Johnson AJ, Patamawenu AA, Hallahan CW, Cogliano-Shutta NA, Mican JM, Davey RT, Kottilil S, Lifson JD, Metcalf JA, Lempicki RA, Connors M.
Human immunodeficiency virus viremia induces plasmacytoid dendritic cell activation in vivo and diminished alpha interferon production in vitro.
J. Virol. 82: 3997-4006, 2008. [Journal]
10)  Ambrose Z, Compton L, Piatak M, Lu D, Alvord WG, Lubomirski MS, Hildreth JE, Lifson JD, Miller CJ, KewalRamani VN.
Incomplete protection against simian immunodeficiency virus vaginal transmission in rhesus macaques by a topical antiviral agent revealed by repeat challenges.
J. Virol. 82: 6591-9, 2008. [Journal]
11)  Veazey RS, Acierno PM, McEvers KJ, Baumeister SH, Foster GJ, Rett MD, Newberg MH, Kuroda MJ, Williams K, Kim EY, Wolinsky SM, Rieber EP, Piatak M, Lifson JD, Montefiori DC, Brown CR, Hirsch VM, Schmitz JE.
Increased loss of CCR5+ CD45RA- CD4+ T cells in CD8+ lymphocyte-depleted Simian immunodeficiency virus-infected rhesus monkeys.
J. Virol. 82: 5618-30, 2008. [Journal]
12)  Venneti S, Bonneh-Barkay D, Lopresti BJ, Bissel SJ, Wang G, Mathis CA, Piatak M, Lifson JD, Nyaundi JO, Murphey-Corb M, Wiley CA.
Longitudinal in vivo positron emission tomography imaging of infected and activated brain macrophages in a macaque model of human immunodeficiency virus encephalitis correlates with central and peripheral markers of encephalitis and areas of synaptic degeneration.
Am. J. Pathol. 172: 1603-16, 2008. [Journal]
13)  Das AT, Klaver B, Centlivre M, Harwig A, Ooms M, Page M, Almond N, Yuan F, Piatak M, Lifson JD, Berkhout B.
Optimization of the doxycycline-dependent simian immunodeficiency virus through in vitro evolution.
Retrovirology. 5: 44, 2008. [Journal]
14)  Sato S, Yuste E, Lauer WA, Chang EH, Morgan JS, Bixby JG, Lifson JD, Desrosiers RC, Johnson WE.
Potent antibody-mediated neutralization and evolution of antigenic escape variants of simian immunodeficiency virus strain SIVmac239 in vivo.
J. Virol. 82: 9739-52, 2008. [Journal]
15)  Giraldo-Vela JP, Rudersdorf R, Chung C, Qi Y, Wallace LT, Bimber B, Borchardt GJ, Fisk DL, Glidden CE, Loffredo JT, Piaskowski SM, Furlott JR, Morales-Martinez JP, Wilson NA, Rehrauer WM, Lifson JD, Carrington M, Watkins DI.
The major histocompatibility complex class II alleles Mamu-DRB1*1003 and -DRB1*0306 are enriched in a cohort of simian immunodeficiency virus-infected rhesus macaque elite controllers.
J. Virol. 82: 859-70, 2008. [Journal]
16)  Morgan C, Marthas M, Miller C, Duerr A, Cheng-Mayer C, Desrosiers R, Flores J, Haigwood N, Hu SL, Johnson RP, Lifson J, Montefiori D, Moore J, Robert-Guroff M, Robinson H, Self S, Corey L.
The use of nonhuman primate models in HIV vaccine development.
PLoS Med. 5: e173, 2008. [Journal]
17)  Mansfield K, Lang SM, Gauduin MC, Sanford HB, Lifson JD, Johnson RP, Desrosiers RC.
Vaccine protection by live, attenuated simian immunodeficiency virus in the absence of high-titer antibody responses and high-frequency cellular immune responses measurable in the periphery.
J. Virol. 82: 4135-48, 2008. [Journal]
18)  Stahl-Hennig C, Eisenblatter M, Franz M, Stoiber H, Tenner-Racz K, Suh YS, Jasny E, Falkensammer B, Ugucchioni M, Georgsson G, Baroni C, Dierich MP, Lifson JD, Steinman RM, Uberla K, Racz P, Ignatius R.
A single vaccination with attenuated SIVmac 239 via the tonsillar route confers partial protection against challenge with SIVmac 251 at a distant mucosal site, the rectum.
Front. Biosci. 12: 2107-23, 2007. [Journal]
19)  Alter G, Martin MP, Teigen N, Carr WH, Suscovich TJ, Schneidewind A, Streeck H, Waring M, Meier A, Brander C, Lifson JD, Allen TM, Carrington M, Altfeld M.
Differential natural killer cell-mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes.
J. Exp. Med. 204: 3027-36, 2007. [Journal]
20)  Sougrat R, Bartesaghi A, Lifson JD, Bennett AE, Bess JW, Zabransky DJ, Subramaniam S.
Electron tomography of the contact between T cells and SIV/HIV-1: implications for viral entry.
PLoS Pathog. 3: e63, 2007. [Journal]
21)  Rutebemberwa A, Bess JW, Brown B, Arroyo M, Eller M, Slike B, Polonis V, McCutchan F, Currier JR, Birx D, Robb M, Marovich M, Lifson JD, Cox JH.
Evaluation of aldrithiol-2-inactivated preparations of HIV type 1 subtypes A, B, and D as reagents to monitor T cell responses.
AIDS Res. Hum. Retroviruses. 23: 532-42, 2007. [Journal]
22)  Sacha JB, Chung C, Rakasz EG, Spencer SP, Jonas AK, Bean AT, Lee W, Burwitz BJ, Stephany JJ, Loffredo JT, Allison DB, Adnan S, Hoji A, Wilson NA, Friedrich TC, Lifson JD, Yang OO, Watkins DI.
Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and viral protein expression.
J. Immunol. 178: 2746-54, 2007. [Journal]
23)  Loffredo JT, Maxwell J, Qi Y, Glidden CE, Borchardt GJ, Soma T, Bean AT, Beal DR, Wilson NA, Rehrauer WM, Lifson JD, Carrington M, Watkins DI.
Mamu-B*08-positive macaques control simian immunodeficiency virus replication.
J. Virol. 81: 8827-32, 2007. [Journal]
24)  Sabado RL, Babcock E, Kavanagh DG, Tjomsland V, Walker BD, Lifson JD, Bhardwaj N, Larsson M.
Pathways utilized by dendritic cells for binding, uptake, processing and presentation of antigens derived from HIV-1.
Eur. J. Immunol. 37: 1752-63, 2007. [Journal]
25)  Sacha JB, Chung C, Reed J, Jonas AK, Bean AT, Spencer SP, Lee W, Vojnov L, Rudersdorf R, Friedrich TC, Wilson NA, Lifson JD, Watkins DI.
Pol-specific CD8+ T cells recognize simian immunodeficiency virus-infected cells prior to Nef-mediated major histocompatibility complex class I downregulation.
J. Virol. 81: 11703-12, 2007. [Journal]
26)  Okoye A, Meier-Schellersheim M, Brenchley JM, Hagen SI, Walker JM, Rohankhedkar M, Lum R, Edgar JB, Planer SL, Legasse A, Sylwester AW, Piatak M, Lifson JD, Maino VC, Sodora DL, Douek DC, Axthelm MK, Grossman Z, Picker LJ.
Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection.
J. Exp. Med. 204: 2171-85, 2007. [Journal]
27)  Earl PL, Americo JL, Wyatt LS, Eller LA, Montefiori DC, Byrum R, Piatak M, Lifson JD, Amara RR, Robinson HL, Huggins JW, Moss B.
Recombinant modified vaccinia virus Ankara provides durable protection against disease caused by an immunodeficiency virus as well as long-term immunity to an orthopoxvirus in a non-human primate.
Virology. 366: 84-97, 2007. [Journal]
28)  Estes JD, Wietgrefe S, Schacker T, Southern P, Beilman G, Reilly C, Milush JM, Lifson JD, Sodora DL, Carlis JV, Haase AT.
Simian immunodeficiency virus-induced lymphatic tissue fibrosis is mediated by transforming growth factor beta 1-positive regulatory T cells and begins in early infection.
J. Infect. Dis. 195: 551-61, 2007. [Journal]
29)  Ambrose Z, Palmer S, Boltz VF, Kearney M, Larsen K, Polacino P, Flanary L, Oswald K, Piatak M, Smedley J, Shao W, Bischofberger N, Maldarelli F, Kimata JT, Mellors JW, Hu SL, Coffin JM, Lifson JD, KewalRamani VN.
Suppression of viremia and evolution of human immunodeficiency virus type 1 drug resistance in a macaque model for antiretroviral therapy.
J. Virol. 81: 12145-55, 2007. [Journal]
30)  Andersen H, Barsov EV, Trivett MT, Trubey CM, Giavedoni LD, Lifson JD, Ott DE, Ohlén C.
Transduction with human telomerase reverse transcriptase immortalizes a rhesus macaque CD8+ T cell clone with maintenance of surface marker phenotype and function.
AIDS Res. Hum. Retroviruses. 23: 456-65, 2007. [Journal]
31)  Kaur A, Sanford HB, Garry D, Lang S, Klumpp SA, Watanabe D, Bronson RT, Lifson JD, Rosati M, Pavlakis GN, Felber BK, Knipe DM, Desrosiers RC.
Ability of herpes simplex virus vectors to boost immune responses to DNA vectors and to protect against challenge by simian immunodeficiency virus.
Virology. 2006. [Journal]
32)  Hatziioannou T, Princiotta M, Piatak M, Yuan F, Zhang F, Lifson JD, Bieniasz PD.
Generation of simian-tropic HIV-1 by restriction factor evasion.
Science. 314: 95, 2006. [Journal]
33)  Sambrook JG, Bashirova A, Andersen H, Piatak M, Vernikos GS, Coggill P, Lifson JD, Carrington M, Beck S.
Identification of the ancestral killer immunoglobulin-like receptor gene in primates.
BMC Genomics. 7: 209, 2006. [Journal]
34)  Gauduin MC, Yu Y, Barabasz A, Carville A, Piatak M, Lifson JD, Desrosiers RC, Johnson RP.
Induction of a virus-specific effector-memory CD4+ T cell response by attenuated SIV infection.
J. Exp. Med. 203: 2661-72, 2006. [Journal]
35)  Teleshova N, Kenney J, Van Nest G, Marshall J, Lifson JD, Sivin I, Dufour J, Bohm R, Gettie A, Robbiani M.
Local and systemic effects of intranodally injected CpG-C immunostimulatory-oligodeoxyribonucleotides in macaques.
J. Immunol. 177: 8531-41, 2006. [Journal]
36)  Stone GW, Barzee S, Snarsky V, Spina CA, Lifson JD, Pillai VK, Amara RR, Villinger F, Kornbluth RS.
Macaque multimeric soluble CD40 ligand and GITR ligand constructs are immunostimulatory molecules in vitro.
Clin Vaccine Immunol. 2006. [Journal]
37)  Chertova E, Chertov O, Coren LV, Roser JD, Trubey CM, Bess JW, Sowder RC, Barsov E, Hood BL, Fisher RJ, Nagashima K, Conrads TP, Veenstra TD, Lifson JD, Ott DE.
Proteomic and biochemical analysis of purified human immunodeficiency virus type 1 produced from infected monocyte-derived macrophages.
J. Virol. 80: 9039-52, 2006. [Journal]
38)  Swigut T, Alexander L, Morgan J, Lifson J, Mansfield KG, Lang S, Johnson RP, Skowronski J, Desrosiers R.
Impact of Nef-mediated downregulation of major histocompatibility complex class I on immune response to simian immunodeficiency virus.
J. Virol. 78: 13335-44, 2004. [Journal]
39)  Busch M, Lu D, Fritts L, Lifson JD, Miller CJ.
Comparison of virology and immunology in SHIV 89.6 proviral DNA and virus-inoculated rhesus macaques.
J. Med. Primatol. 32: 240-6, 2003. [Journal]
40)  Alexander L, Illyinskii PO, Lang SM, Means RE, Lifson J, Mansfield K, Desrosiers RC.
Determinants of increased replicative capacity of serially passaged simian immunodeficiency virus with nef deleted in rhesus monkeys.
J. Virol. 77: 6823-35, 2003. [Journal]
41)  Veazey RS, Lifson JD, Schmitz JE, Kuroda MJ, Piatak M, Pandrea I, Purcell J, Bohm R, Blanchard J, Williams KC, Lackner AA.
Dynamics of Simian immunodeficiency virus-specific cytotoxic T-cell responses in tissues.
J. Med. Primatol. 32: 194-200, 2003. [Journal]
42)  Lifson JD, Piatak M, Cline AN, Rossio JL, Purcell J, Pandrea I, Bischofberger N, Blanchard J, Veazey RS.
Transient early post-inoculation anti-retroviral treatment facilitates controlled infection with sparing of CD4+ T cells in gut-associated lymphoid tissues in SIVmac239-infected rhesus macaques, but not resistance to rechallenge.
J. Med. Primatol. 32: 201-10, 2003. [Journal]
43)  Kumar A, Mukherjee S, Shen J, Buch S, Li Z, Adany I, Liu Z, Zhuge W, Piatak M, Lifson J, McClure H, Narayan O.
Immunization of macaques with live simian human immunodeficiency virus (SHIV) vaccines conferred protection against AIDS induced by homologous and heterologous SHIVs and simian immunodeficiency virus.
Virology. 301: 189-205, 2002. [Journal]
44)  Kumar A, Buch S, Foresman L, Bischofberger N, Lifson JD, Narayan O.
Development of virus-specific immune responses in SHIV(KU)-infected macaques treated with PMPA.
Virology. 279: 97-108, 2001. [Journal]
45)  Earl PL, Sugiura W, Montefiori DC, Broder CC, Lee SA, Wild C, Lifson J, Moss B.
Immunogenicity and protective efficacy of oligomeric human immunodeficiency virus type 1 gp140.
J. Virol. 75: 645-53, 2001. [Journal]
46)  Smith MS, Foresman L, Lopez GJ, Tsay J, Wodarz D, Lifson JD, Page A, Wang C, Li Z, Adany I, Buch S, Bischofberger N, Narayan O.
Lasting effects of transient postinoculation tenofovir [9-R-(2-Phosphonomethoxypropyl)adenine] treatment on SHIV(KU2) infection of rhesus macaques.
Virology. 277: 306-15, 2000. [Journal]
47)  Barsov EV, Andersen H, Coalter VJ, Carrington M, Lifson JD, Ott DE.
Capture of antigen-specific T lymphocytes from human blood by selective immortalization to establish long-term T-cell lines maintaining primary cell characteristics.
Immunol. Lett. 105: 26-37, 2006. [Journal]
48)  Teleshova N, Kenney J, Williams V, Van Nest G, Marshall J, Lifson JD, Sivin I, Dufour J, Bohm R, Gettie A, Pope M.
CpG-C ISS-ODN activation of blood-derived B cells from healthy and chronic immunodeficiency virus-infected macaques.
J. Leukoc. Biol. 79: 257-67, 2006. [Journal]
49)  Zhu P, Liu J, Bess J, Chertova E, Lifson JD, Grisé H, Ofek GA, Taylor KA, Roux KH.
Distribution and three-dimensional structure of AIDS virus envelope spikes.
Nature. 441: 847-52, 2006. [Journal]
50)  Zhang R, Lifson JD, Chougnet C.
Failure of HIV-exposed CD4+ T cells to activate dendritic cells is reversed by restoration of CD40/CD154 interactions.
Blood. 107: 1989-95, 2006. [Journal]
51)  Koff WC, Johnson PR, Watkins DI, Burton DR, Lifson JD, Hasenkrug KJ, McDermott AB, Schultz A, Zamb TJ, Boyle R, Desrosiers RC.
HIV vaccine design: insights from live attenuated SIV vaccines.
Nat. Immunol. 7: 19-23, 2006. [Journal]
52)  Picker LJ, Reed-Inderbitzin EF, Hagen SI, Edgar JB, Hansen SG, Legasse A, Planer S, Piatak M, Lifson JD, Maino VC, Axthelm MK, Villinger F.
IL-15 induces CD4 effector memory T cell production and tissue emigration in nonhuman primates.
J. Clin. Invest. 116: 1514-24, 2006. [Journal]
53)  Estes JD, Li Q, Reynolds MR, Wietgrefe S, Duan L, Schacker T, Picker LJ, Watkins DI, Lifson JD, Reilly C, Carlis J, Haase AT.
Premature induction of an immunosuppressive regulatory T cell response during acute simian immunodeficiency virus infection.
J. Infect. Dis. 193: 703-12, 2006. [Journal]
54)  Yant LJ, Friedrich TC, Johnson RC, May GE, Maness NJ, Enz AM, Lifson JD, O'Connor DH, Carrington M, Watkins DI.
The high-frequency major histocompatibility complex class I allele Mamu-B*17 is associated with control of simian immunodeficiency virus SIVmac239 replication.
J. Virol. 80: 5074-7, 2006. [Journal]
55)  Herbeuval JP, Grivel JC, Boasso A, Hardy AW, Chougnet C, Dolan MJ, Yagita H, Lifson JD, Shearer GM.
CD4+ T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosis.
Blood. 106: 3524-31, 2005. [Journal]
56)  Schmitz JE, Johnson RP, McClure HM, Manson KH, Wyand MS, Kuroda MJ, Lifton MA, Khunkhun RS, McEvers KJ, Gillis J, Piatak M, Lifson JD, Grosschupff G, Racz P, Tenner-Racz K, Rieber EP, Kuus-Reichel K, Gelman RS, Letvin NL, Montefiori DC, Ruprecht RM, Desrosiers RC, Reimann KA.
Effect of CD8+ lymphocyte depletion on virus containment after simian immunodeficiency virus SIVmac251 challenge of live attenuated SIVmac239delta3-vaccinated rhesus macaques.
J. Virol. 79: 8131-41, 2005. [Journal]
57)  Busch M, Abel K, Li J, Piatak M, Lifson JD, Miller CJ.
Efficacy of a SHIV 89.6 proviral DNA vaccine against mucosal SIVmac239 challenge.
Vaccine. 23: 4036-47, 2005. [Journal]
58)  Morcock DR, Thomas JA, Gagliardi TD, Gorelick RJ, Roser JD, Chertova EN, Bess JW, Ott DE, Sattentau QJ, Frank I, Pope M, Lifson JD, Henderson LE, Crise BJ.
Elimination of retroviral infectivity by N-ethylmaleimide with preservation of functional envelope glycoproteins.
J. Virol. 79: 1533-42, 2005. [Journal]
59)  Beignon AS, McKenna K, Skoberne M, Manches O, DaSilva I, Kavanagh DG, Larsson M, Gorelick RJ, Lifson JD, Bhardwaj N.
Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions.
J. Clin. Invest. 115: 3265-75, 2005. [Journal]
60)  Cline AN, Bess JW, Piatak M, Lifson JD.
Highly sensitive SIV plasma viral load assay: practical considerations, realistic performance expectations, and application to reverse engineering of vaccines for AIDS.
J. Med. Primatol. 34: 303-12, 2005. [Journal]
61)  Louder MK, Sambor A, Chertova E, Hunte T, Barrett S, Ojong F, Sanders-Buell E, Zolla-Pazner S, McCutchan FE, Roser JD, Gabuzda D, Lifson JD, Mascola JR.
HIV-1 envelope pseudotyped viral vectors and infectious molecular clones expressing the same envelope glycoprotein have a similar neutralization phenotype, but culture in peripheral blood mononuclear cells is associated with decreased neutralization sensitivity.
Virology. 339: 226-38, 2005. [Journal]
62)  Evans DT, Bricker JE, Sanford HB, Lang S, Carville A, Richardson BA, Piatak M, Lifson JD, Mansfield KG, Desrosiers RC.
Immunization of macaques with single-cycle simian immunodeficiency virus (SIV) stimulates diverse virus-specific immune responses and reduces viral loads after challenge with SIVmac239.
J. Virol. 79: 7707-20, 2005. [Journal]
63)  Peretti S, Shaw A, Blanchard J, Bohm R, Morrow G, Lifson JD, Gettie A, Pope M.
Immunomodulatory effects of HSV-2 infection on immature macaque dendritic cells modify innate and adaptive responses.
Blood. 106: 1305-13, 2005. [Journal]
64)  Williams K, Westmoreland S, Greco J, Ratai E, Lentz M, Kim WK, Fuller RA, Kim JP, Autissier P, Sehgal PK, Schinazi RF, Bischofberger N, Piatak M, Lifson JD, Masliah E, González RG.
Magnetic resonance spectroscopy reveals that activated monocytes contribute to neuronal injury in SIV neuroAIDS.
J. Clin. Invest. 115: 2534-45, 2005. [Journal]
65)  Li Q, Lifson JD, Duan L, Schacker TW, Reilly C, Carlis J, Estes JD, Haase AT.
Potential roles of follicular dendritic cell-associated osteopontin in lymphoid follicle pathology and repair and in B cell regulation in HIV-1 and SIV infection.
J. Infect. Dis. 192: 1269-76, 2005. [Journal]
66)  Kim EY, Busch M, Abel K, Fritts L, Bustamante P, Stanton J, Lu D, Wu S, Glowczwskie J, Rourke T, Bogdan D, Piatak M, Lifson JD, Desrosiers RC, Wolinsky S, Miller CJ.
Retroviral recombination in vivo: viral replication patterns and genetic structure of simian immunodeficiency virus (SIV) populations in rhesus macaques after simultaneous or sequential intravaginal inoculation with SIVmac239Deltavpx/Deltavpr and SIVmac239Deltanef.
J. Virol. 79: 4886-95, 2005. [Journal]
67)  Herbeuval JP, Boasso A, Grivel JC, Hardy AW, Anderson SA, Dolan MJ, Chougnet C, Lifson JD, Shearer GM.
TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected patients and its in vitro production by antigen-presenting cells.
Blood. 105: 2458-64, 2005. [Journal]
68)  Andersen H, Rossio JL, Coalter V, Poore B, Martin MP, Carrington M, Lifson JD.
Characterization of rhesus macaque natural killer activity against a rhesus-derived target cell line at the single-cell level.
Cell. Immunol. 231: 85-95, 2004. In Press. [Journal]
69)  Gloster SE, Newton P, Cornforth D, Lifson JD, Williams I, Shaw GM, Borrow P.
Association of strong virus-specific CD4 T cell responses with efficient natural control of primary HIV-1 infection.
AIDS. 18: 749-55, 2004. [Journal]
70)  Zhang R, Fichtenbaum CJ, Hildeman DA, Lifson JD, Chougnet C.
CD40 ligand dysregulation in HIV infection: HIV glycoprotein 120 inhibits signaling cascades upstream of CD40 ligand transcription.
J Immunol. 172: 2678-86, 2004. [Journal]
71)  Verthelyi D, Wang VW, Lifson JD, Klinman DM.
CpG oligodeoxynucleotides improve the response to hepatitis B immunization in healthy and SIV-infected rhesus macaques.
AIDS. 18: 1003-8, 2004. [Journal]
72)  Teleshova N, Kenney J, Jones J, Marshall J, Van Nest G, Dufour J, Bohm R, Lifson JD, Gettie A, Pope M.
CpG-C immunostimulatory oligodeoxyribonucleotide activation of plasmacytoid dendritic cells in rhesus macaques to augment the activation of IFN-gamma-secreting simian immunodeficiency virus-specific T cells.
J. Immunol. 173: 1647-57, 2004. [Journal]
73)  Lifson JD, Rossio JL, Piatak M, Bess J, Chertova E, Schneider DK, Coalter VJ, Poore B, Kiser RF, Imming RJ, Scarzello AJ, Henderson LE, Alvord WG, Hirsch VM, Benveniste RE, Arthur LO.
Evaluation of the safety, immunogenicity, and protective efficacy of whole inactivated simian immunodeficiency virus (SIV) vaccines with conformationally and functionally intact envelope glycoproteins.
AIDS Res. Hum. Retroviruses. 20: 772-87, 2004. [Journal]
74)  Fonteneau JF, Larsson M, Beignon AS, McKenna K, Dasilva I, Amara A, Liu YJ, Lifson JD, Littman DR, Bhardwaj N.
Human immunodeficiency virus type 1 activates plasmacytoid dendritic cells and concomitantly induces the bystander maturation of myeloid dendritic cells.
J. Virol. 78: 5223-32, 2004. [Journal]
75)  Turville SG, Santos JJ, Frank I, Cameron PU, Wilkinson J, Miranda-Saksena M, Dable J, Stössel H, Romani N, Piatak M, Lifson JD, Pope M, Cunningham AL.
Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cells.
Blood. 103: 2170-9, 2004. [Journal]
76)  Picker LJ, Hagen SI, Lum R, Reed-Inderbitzin EF, Daly LM, Sylwester AW, Walker JM, Siess DC, Piatak M, Wang C, Allison DB, Maino VC, Lifson JD, Kodama T, Axthelm MK.
Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection.
J. Exp. Med. 200: 1299-314, 2004. [Journal]
77)  Villamide-Herrera L, Ignatius R, Eller MA, Wilkinson K, Griffin C, Mehlhop E, Jones J, Han SY, Lewis MG, Parrish S, Vancott TC, Lifson JD, Schlesinger S, Mascola JR, Pope M.
Macaque dendritic cells infected with SIV-recombinant canarypox ex vivo induce SIV-specific immune responses in vivo.
AIDS Res. Hum. Retroviruses. 20: 871-84, 2004. [Journal]
78)  Fitzgerald W, Sylwester AW, Grivel JC, Lifson JD, Margolis LB.
Noninfectious X4 but not R5 human immunodeficiency virus type 1 virions inhibit humoral immune responses in human lymphoid tissue ex vivo.
J. Virol. 78: 7061-8, 2004. [Journal]
79)  Gauduin MC, Kaur A, Ahmad S, Yilma T, Lifson JD, Johnson RP.
Optimization of intracellular cytokine staining for the quantitation of antigen-specific CD4+ T cell responses in rhesus macaques.
J. Immunol. Methods. 288: 61-79, 2004. [Journal]
80)  Lederman MM, Veazey RS, Offord R, Mosier DE, Dufour J, Mefford M, Piatak M, Lifson JD, Salkowitz JR, Rodriguez B, Blauvelt A, Hartley O.
Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5.
Science. 306: 485-7, 2004. [Journal]
81)  Friedrich TC, Dodds EJ, Yant LJ, Vojnov L, Rudersdorf R, Cullen C, Evans DT, Desrosiers RC, Mothé BR, Sidney J, Sette A, Kunstman K, Wolinsky S, Piatak M, Lifson J, Hughes AL, Wilson N, O'Connor DH, Watkins DI.
Reversion of CTL escape-variant immunodeficiency viruses in vivo.
Nat Med. 10: 275-81, 2004. [Journal]
82)  Zhang ZQ, Wietgrefe SW, Li Q, Shore MD, Duan L, Reilly C, Lifson JD, Haase AT.
Roles of substrate availability and infection of resting and activated CD4+ T cells in transmission and acute simian immunodeficiency virus infection.
Proc. Natl. Acad. Sci. U.S.A. 101: 5640-5, 2004. [Journal]
83)  Willey RL, Byrum R, Piatak M, Kim YB, Cho MW, Rossio Jr JL, Bess Jr J, Igarashi T, Endo Y, Arthur LO, Lifson JD, Martin MA.
Control of viremia and prevention of simian-human immunodeficiency virus-induced disease in rhesus macaques immunized with recombinant vaccinia viruses plus inactivated simian immunodeficiency virus and human immunodeficiency virus type 1 particles.
J Virol. 77: 1163-74, 2003. [Journal]
84)  Verthelyi D, Gursel M, Kenney RT, Lifson JD, Liu S, Mican J, Klinman DM.
CpG oligodeoxynucleotides protect normal and SIV-infected macaques from Leishmania infection.
J Immunol. 170: 4717-23, 2003. [Journal]
85)  Kaur A, Kassis N, Hale CL, Simon M, Elliott M, Gomez-Yafal A, Lifson JD, Desrosiers RC, Wang F, Barry P, Mach M, Johnson RP.
Direct relationship between suppression of virus-specific immunity and emergence of cytomegalovirus disease in simian AIDS.
J Virol. 77: 5749-58, 2003. [Journal]
86)  Schmitz JE, Kuroda MJ, Santra S, Simon MA, Lifton MA, Lin W, Khunkhun R, Piatak M, Lifson JD, Grosschupff G, Gelman RS, Racz P, Tenner-Racz K, Mansfield KA, Letvin NL, Montefiori DC, Reimann KA.
Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virus.
J Virol. 77: 2165-73, 2003. [Journal]
87)  Zhu P, Chertova E, Bess J, Lifson JD, Arthur LO, Liu J, Taylor KA, Roux KH.
Electron tomography analysis of envelope glycoprotein trimers on HIV and simian immunodeficiency virus virions.
Proc Natl Acad Sci U S A. 100: 15812-7, 2003. [Journal]
88)  Johnson WE, Lifson JD, Lang SM, Johnson RP, Desrosiers RC.
Importance of B-cell responses for immunological control of variant strains of simian immunodeficiency virus.
J Virol. 77: 375-81, 2003. [Journal]
89)  Evans DT, Chen LM, Gillis J, Lin KC, Harty B, Mazzara GP, Donis RO, Mansfield KG, Lifson JD, Desrosiers RC, Galán JE, Johnson RP.
Mucosal priming of simian immunodeficiency virus-specific cytotoxic T-lymphocyte responses in rhesus macaques by the Salmonella type III secretion antigen delivery system.
J Virol. 77: 2400-9, 2003. [Journal]
90)  Bashirova AA, Wu L, Cheng J, Martin TD, Martin MP, Benveniste RE, Lifson JD, KewalRamani VN, Hughes A, Carrington M.
Novel member of the CD209 (DC-SIGN) gene family in primates.
J Virol. 77: 217-27, 2003. [Journal]
91)  Frank I, Santos JJ, Mehlhop E, Villamide-Herrera L, Santisteban C, Gettie A, Ignatius R, Lifson JD, Pope M.
Presentation of exogenous whole inactivated simian immunodeficiency virus by mature dendritic cells induces CD4+ and CD8+ T-cell responses.
J Acquir Immune Defic Syndr. 34: 7-19, 2003. [Journal]
92)  Trubey CM, Chertova E, Coren LV, Hilburn JM, Hixson CV, Nagashima K, Lifson JD, Ott DE.
Quantitation of HLA class II protein incorporated into human immunodeficiency type 1 virions purified by anti-CD45 immunoaffinity depletion of microvesicles.
J Virol. 77: 12699-709, 2003. [Journal]
93)  Veazey RS, Lifson JD, Pandrea I, Purcell J, Piatak M, Lackner AA.
Simian immunodeficiency virus infection in neonatal macaques.
J Virol. 77: 8783-92, 2003. [Journal]
94)  Chertova E, Crise BJ, Morcock DR, Bess JW, Henderson LE, Lifson JD.
Sites, mechanism of action and lack of reversibility of primate lentivirus inactivation by preferential covalent modification of virion internal proteins.
Curr Mol Med. 3: 265-72, 2003. [Journal]
95)  Veazey RS, Klasse PJ, Ketas TJ, Reeves JD, Piatak M, Kunstman K, Kuhmann SE, Marx PA, Lifson JD, Dufour J, Mefford M, Pandrea I, Wolinsky SM, Doms RW, DeMartino JA, Siciliano SJ, Lyons K, Springer MS, Moore JP.
Use of a small molecule CCR5 inhibitor in macaques to treat simian immunodeficiency virus infection or prevent simian-human immunodeficiency virus infection.
J Exp Med. 198: 1551-62, 2003. [Journal]
96)  Larsson M, Fonteneau JF, Lirvall M, Haslett P, Lifson JD, Bhardwaj N.
Activation of HIV-1 specific CD4 and CD8 T cells by human dendritic cells: roles for cross-presentation and non-infectious HIV-1 virus.
AIDS. 16: 1319-29, 2002. [Journal]
97)  Allen TM, Jing P, Calore B, Horton H, O'Connor DH, Hanke T, Piekarczyk M, Ruddersdorf R, Mothé BR, Emerson C, Wilson N, Lifson JD, Belyakov IM, Berzofsky JA, Wang C, Allison DB, Montefiori DC, Desrosiers RC, Wolinsky S, Kunstman KJ, Altman JD, Sette A, McMichael AJ, Watkins DI.
Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) Gag CTL epitope on the course of SIVmac239 infection.
J Virol. 76: 10507-11, 2002. [Journal]
98)  Mehlhop E, Villamide LA, Frank I, Gettie A, Santisteban C, Messmer D, Ignatius R, Lifson JD, Pope M.
Enhanced in vitro stimulation of rhesus macaque dendritic cells for activation of SIV-specific T cell responses.
J Immunol Methods. 260: 219-34, 2002. [Journal]
99)  Chertova E, Bess Jr JW, Crise BJ, Sowder II RC, Schaden TM, Hilburn JM, Hoxie JA, Benveniste RE, Lifson JD, Henderson LE, Arthur LO.
Envelope glycoprotein incorporation, not shedding of surface envelope glycoprotein (gp120/SU), Is the primary determinant of SU content of purified human immunodeficiency virus type 1 and simian immunodeficiency virus.
J Virol. 76: 5315-25, 2002. [Journal]
100)  Frank I, Piatak M, Stoessel H, Romani N, Bonnyay D, Lifson JD, Pope M.
Infectious and whole inactivated simian immunodeficiency viruses interact similarly with primate dendritic cells (DCs): differential intracellular fate of virions in mature and immature DCs.
J Virol. 76: 2936-51, 2002. [Journal]
101)  Ling B, Veazey RS, Penedo C, Xu K, Lifson JD, Marx PA.
Longitudinal follow up of SIVmac pathogenesis in rhesus macaques of Chinese origin: emergence of B cell lymphoma.
J Med Primatol. 31: 154-63, 2002. [Journal]
102)  Bissel SJ, Wang G, Ghosh M, Reinhart TA, Capuano S, Stefano Cole K, Murphey-Corb M, Piatak Jr M, Lifson JD, Wiley CA.
Macrophages relate presynaptic and postsynaptic damage in simian immunodeficiency virus encephalitis.
Am J Pathol. 160: 927-41, 2002. [Journal]
103)  Lifson JD, Martin MA.
One step forwards, one step back.
Nature. 415: 272-3, 2002. [Journal]
104)  Ling B, Veazey RS, Luckay A, Penedo C, Xu K, Lifson JD, Marx PA.
SIV(mac) pathogenesis in rhesus macaques of Chinese and Indian origin compared with primary HIV infections in humans.
AIDS. 16: 1489-96, 2002. [Journal]
105)  Clements JE, Babas T, Mankowski JL, Suryanarayana K, Piatak M, Tarwater PM, Lifson JD, Zink MC.
The central nervous system as a reservoir for simian immunodeficiency virus (SIV): steady-state levels of SIV DNA in brain from acute through asymptomatic infection.
J Infect Dis. 186: 905-13, 2002. [Journal]
106)  Lifson JD, Piatak M, Rossio JL, Bess J, Chertova E, Schneider D, Kiser R, Coalter V, Poore B, Imming R, Desrosiers RC, Henderson LE, Arthur LO.
Whole inactivated SIV virion vaccines with functional envelope glycoproteins: safety, immunogenicity, and activity against intrarectal challenge.
J Med Primatol. 31: 205-16, 2002. [Journal]
107)  Esser MT, Graham DR, Coren LV, Trubey CM, Bess JW, Arthur LO, Ott DE, Lifson JD.
Differential incorporation of CD45, CD80 (B7-1), CD86 (B7-2), and major histocompatibility complex class I and II molecules into human immunodeficiency virus type 1 virions and microvesicles: implications for viral pathogenesis and immune regulation.
J Virol. 75: 6173-82, 2001. [Journal]
108)  Veazey RS, Gauduin MC, Mansfield KG, Tham IC, Altman JD, Lifson JD, Lackner AA, Johnson RP.
Emergence and kinetics of simian immunodeficiency virus-specific CD8(+) T cells in the intestines of macaques during primary infection.
J Virol. 75: 10515-9, 2001. [Journal]
109)  Fultz PN, Vance PJ, Endres MJ, Tao B, Dvorin JD, Davis IC, Lifson JD, Montefiori DC, Marsh M, Malim MH, Hoxie JA.
In vivo attenuation of simian immunodeficiency virus by disruption of a tyrosine-dependent sorting signal in the envelope glycoprotein cytoplasmic tail.
J Virol. 75: 278-91, 2001. [Journal]
110)  Buseyne F, Le Gall S, Boccaccio C, Abastado JP, Lifson JD, Arthur LO, Rivière Y, Heard JM, Schwartz O.
MHC-I-restricted presentation of HIV-1 virion antigens without viral replication.
Nat Med. 7: 344-9, 2001. [Journal]
111)  Esser MT, Bess JW, Suryanarayana K, Chertova E, Marti D, Carrington M, Arthur LO, Lifson JD.
Partial activation and induction of apoptosis in CD4(+) and CD8(+) T lymphocytes by conformationally authentic noninfectious human immunodeficiency virus type 1.
J Virol. 75: 1152-64, 2001. [Journal]
112)  Crotty S, Miller CJ, Lohman BL, Neagu MR, Compton L, Lu D, Lü FX, Fritts L, Lifson JD, Andino R.
Protection against simian immunodeficiency virus vaginal challenge by using Sabin poliovirus vectors.
J Virol. 75: 7435-52, 2001. [Journal]
113)  Lifson JD, Rossio JL, Piatak M, Parks T, Li L, Kiser R, Coalter V, Fisher B, Flynn BM, Czajak S, Hirsch VM, Reimann KA, Schmitz JE, Ghrayeb J, Bischofberger N, Nowak MA, Desrosiers RC, Wodarz D.
Role of CD8(+) lymphocytes in control of simian immunodeficiency virus infection and resistance to rechallenge after transient early antiretroviral treatment.
J Virol. 75: 10187-99, 2001. [Journal]
114)  Kumar A, Lifson JD, Li Z, Jia F, Mukherjee S, Adany I, Liu Z, Piatak M, Sheffer D, McClure HM, Narayan O.
Sequential immunization of macaques with two differentially attenuated vaccines induced long-term virus-specific immune responses and conferred protection against AIDS caused by heterologous simian human immunodeficiency Virus (SHIV(89.6)P).
Virology. 279: 241-56, 2001. [Journal]
115)  Wodarz D, Page KM, Arnaout RA, Thomsen AR, Lifson JD, Nowak MA.
A new theory of cytotoxic T-lymphocyte memory: implications for HIV treatment.
Philos Trans R Soc Lond B Biol Sci. 355: 329-43, 2000. [Journal]
116)  Lifson JD, Rossio JL, Arnaout R, Li L, Parks TL, Schneider DK, Kiser RF, Coalter VJ, Walsh G, Imming RJ, Fisher B, Flynn BM, Bischofberger N, Piatak M, Hirsch VM, Nowak MA, Wodarz D.
Containment of simian immunodeficiency virus infection: cellular immune responses and protection from rechallenge following transient postinoculation antiretroviral treatment.
J Virol. 74: 2584-93, 2000. [Journal]
117)  Wang SW, Kozlowski PA, Schmelz G, Manson K, Wyand MS, Glickman R, Montefiori D, Lifson JD, Johnson RP, Neutra MR, Aldovini A.
Effective induction of simian immunodeficiency virus-specific systemic and mucosal immune responses in primates by vaccination with proviral DNA producing intact but noninfectious virions.
J Virol. 74: 10514-22, 2000. [Journal]
118)  Kumar A, Lifson JD, Silverstein PS, Jia F, Sheffer D, Li Z, Narayan O.
Evaluation of immune responses induced by HIV-1 gp120 in rhesus macaques: effect of vaccination on challenge with pathogenic strains of homologous and heterologous simian human immunodeficiency viruses.
Virology. 274: 149-64, 2000. [Journal]
119)  Goldstein S, Brown CR, Dehghani H, Lifson JD, Hirsch VM.
Intrinsic susceptibility of rhesus macaque peripheral CD4(+) T cells to simian immunodeficiency virus in vitro is predictive of in vivo viral replication.
J Virol. 74: 9388-95, 2000. [Journal]
120)  Gorelick RJ, Lifson JD, Yovandich JL, Rossio JL, Piatak M, Scarzello AJ, Knott WB, Bess JW, Fisher BA, Flynn BM, Henderson LE, Arthur LO, Benveniste RE.
Mucosal challenge of Macaca nemestrina with simian immunodeficiency virus (SIV) following SIV nucleocapsid mutant DNA vaccination.
J Med Primatol. 29: 209-19, 2000. [Journal]
121)  Silverstein PS, Mackay GA, Mukherjee S, Li Z, Piatak M, Lifson JD, Narayan O, Kumar A.
Pathogenic simian/human immunodeficiency virus SHIV(KU) inoculated into immunized macaques caused infection, but virus burdens progressively declined with time.
J Virol. 74: 10489-97, 2000. [Journal]
122)  Gorelick RJ, Benveniste RE, Lifson JD, Yovandich JL, Morton WR, Kuller L, Flynn BM, Fisher BA, Rossio JL, Piatak M, Bess JW, Henderson LE, Arthur LO.
Protection of Macaca nemestrina from disease following pathogenic simian immunodeficiency virus (SIV) challenge: utilization of SIV nucleocapsid mutant DNA vaccines with and without an SIV protein boost.
J Virol. 74: 11935-49, 2000. [Journal]
123)  Miley WJ, Suryanarayana K, Manns A, Kubota R, Jacobson S, Lifson JD, Waters D.
Real-time polymerase chain reaction assay for cell-associated HTLV type I DNA viral load.
AIDS Res Hum Retroviruses. 16: 665-75, 2000. [Journal]
124)  Hirsch VM, Lifson JD.
Simian immunodeficiency virus infection of monkeys as a model system for the study of AIDS pathogenesis, treatment, and prevention.
Adv Pharmacol. 49: 437-77, 2000. [Journal]
125)  Wodarz D, Arnaout RA, Nowak MA, Lifson JD.
Transient antiretroviral treatment during acute simian immunodeficiency virus infection facilitates long-term control of the virus.
Philos Trans R Soc Lond B Biol Sci. 355: 1021-9, 2000. [Journal]
126)  Murphy CG, Lucas WT, Means RE, Czajak S, Hale CL, Lifson JD, Kaur A, Johnson RP, Knipe DM, Desrosiers RC.
Vaccine protection against simian immunodeficiency virus by recombinant strains of herpes simplex virus.
J Virol. 74: 7745-54, 2000. [Journal]

This page was last updated on 9/23/2008.