Heneine W, Switzer WM, Shanmugam V, Bhullar V, Parekh B, Cong M, Boneva R, Chapman LE, Yee J, Lerche N, Folks TM; International Conference on AIDS (15th : 2004 : Bangkok, Thailand).
Int Conf AIDS. 2004 Jul 11-16; 15: abstract no. ThPeA6973.
Centers for Disease Control and Prevention, Atlanta, United States
Background: The recognition that AIDS originated as a zoonosis heightens concerns associated with human infection with simian retroviruses (SRs) endemic in nonhuman primates (NHPs), including simian immunodeficiency virus (SIV), simian type D retrovirus (SRV), simian T-cell lymphotropic virus (STLV), and simian foamy virus (SFV). Although few SR infections in persons occupationally exposed to NHPs have been reported, the characteristics and significance of these zoonoses are not fully defined. We report new results from the surveillance of four SRs in persons working with NHP. Methods: Participants from North American primate research centers and zoos provided a serum sample for serologic testing for SIV, SRV, STLV, and SFV. PCR and phylogenetic analysis was done to determine the NHP species origin of the infections. Spouses of seropositive persons were also tested. Results: Testing of 418 participants from 15 institutions identified no STLV infection. Two persons with known SIV infection were detected. Two persons were seropositive for SRV but negative by PCR and virus isolation. Sera from 14 persons (3.35%; 12 males, 2 females) were SFV-positive. SFV integrase sequences were PCR-amplified from the PBL DNA available from 13 cases. Phylogenetic analysis showed SFV infection originating from African green monkeys (n=1), baboons (n=4), and chimpanzees (n=8). Archived sera from 12 cases documented minimal SFV seropositivity of 0.5-26.0 yrs (median 15.5 yrs). All 13 cases report general good health. Wives of six SFV cases were tested and remain uninfected. Eleven SFV cases reported donating blood more than once; six (54.5%) were seropositive at the time of donation. Conclusions: Our study documents persistent SFV infection originating from three NHP species in occupationally exposed workers and shows that SRs cross into humans more frequently than previously thought. These findings highlight the importance of defining the public health significance of these zoonoses.
Publication Types:
Keywords:
- Animals
- Cercopithecus aethiops
- Communicable Diseases
- Female
- Humans
- Infection
- Male
- Pan troglodytes
- Papio
- Polymerase Chain Reaction
- Primates
- Retroviruses, Simian
- Simian T-lymphotropic virus 1
- Simian immunodeficiency virus
- Spumavirus
- Zoonoses
Other ID:
UI: 102280757
From Meeting Abstracts