	US 7,393,831 B2
	Peptide compositions and their use against HCV
Anne Fournillier, Villeurbanne (France); Nourredine Himoudi, Lyons (France); and Geneviève Inchauspe, Lyons (France)
Assigned to Transgene SA, Strasbourg Cedex (France)
Appl. No. 10/514,762 PCT Filed May 15, 2003, PCT No. PCT/FR03/01478 § 371(c)(1), (2), (4) Date Nov. 16, 2004, PCT Pub. No. WO03/097677, PCT Pub. Date Nov. 27, 2003.
Claims priority of application No. 02 06111 (FR), filed on May 17, 2002.
Prior Publication US 2007/0020285 A1, Jan. 25, 2007
Int. Cl. A61K 39/02 (2006.01); A61K 39/29 (2006.01); A61K 39/42 (2006.01); A61P 31/00 (2006.01); C07K 14/18 (2006.01); C07K 14/195 (2006.01); C07K 16/10 (2006.01)

U.S. Cl. 514—12 [514/2; 424/161.1; 424/185.1; 424/189.1; 424/193.1; 530/300; 530/324; 536/23.5; 536/23.72]

12 Claims

1. A peptide composition, characterized in that it comprises at least two separate compounds chosen from:

a B peptide having at least the following amino acid sequence SEQ ID NO: 45:

GX₁₈X₁₉X₂₀X₂₁X₂₂X₂₃TSLTGRDX₂₄NX₂₅X₂₆X₂₇GEX₂₈QX₂₉

X₃₀STAX₃₁X₃₂X₃₃FLX₃₄X₃₅X₃₆X₃₇NGX₃₈X₃₉WTVX₄₀

in which X₁₈is L or V, X₁₉is L or F, X₂₀is G or S, X₂₁is C or T, X₂₂is I or V, X₂₃is I or V, X₂₄is K, R or T, X₂₅is Q or E, X₂₆is V or N, X₂₇is D, E or C, X₂₈is V or A, X₂₉is V, I, E or M, X₃₀is L or V, X₃₁is T, K or A, X₃₂is Q or H, X₃₃is S or T, X₃₄is A or G, X₃₅is T or S, X₃₆is C or A, X₃₇is V, I or T, X₃₈is V or A, X₃₉is C or M and X₄₀is Y or F,

and having at most the 63 amino acids as described in the following sequence SEQ ID NO:46:

AX₄₁ITX₄₂YX₄₃X₄₄QTRGX₁₈X₁₉X₂₀X₂₁X₂₂X₂₃TSLTGRDX₂₄

NX₂₅X₂₆X₂₇GEX₂₈QX₂₉X₃₀STAX₃₁X₃₂X₃₃FLX₃₄X₃₅X₃₆X₃₇

NGX₃₈X₃₉WTVX₄₀HGAGX₄₅X₄₆X₄₇

in which X₁₈to X₄₀are as defined and X₄₁is P, S or H, X₄₂is A or T, X₄₃is S, A, T or C, X₄₄is Q or R, X₄₅is S, T or A, X₄₆is K or R and X₄₇is T or I, and

a C peptide having at least the following amino acid sequence SEQ ID NO: 127:

SX_47'MX₄₈FTX₄₉X₅₀X₅₁TSPLX₅₂X₅₃X₅₄X₅₅TLX₅₆FNIX₅₇

GGWVAX₅₈QX₅₉

in which X_{47 ′}is L or P, X₄₈is A or S, X₄₉is A or S, X₅₀is A or S, X₅₁is I or V, X₅₂is T, S or A, X₅₃is T or I, X₅₄is Q, S or G, X₅₅is N, Q, H, S, Y or T, X₅₆is L or M, X₅₇is L or W, X₅₈is A or S and X₅₉is L, P or I,

and having at most the 57 amino acids as described in the following sequence SEQ ID NO:128:

NFIX₆₀GX₆₁QYLAX₆₂LSTLPGNX₆₃AX₆₄X₆₅SX_47'MX₄₈FTX₄₉

X₅₀X₅₁TSPLX₅₂X₅₃X₅₄X₅₅TLX₅₆FNIX₅₇GGWVAX₅₈QX₅₉X₆₆

X₆₇X₆₈

in which X_{47 ′}to X₅₉are as defined above and X₆₀is T or S, X₆₁is I, T or V, X₆₂is G or A, X₆₃is P or L, X₆₄is I or M, X₆₅is A, V or R, X₆₆is A or R, X₆₇is P, A or D and X₆₈is P, A or S.