US 7,393,831 B2 | ||
Peptide compositions and their use against HCV | ||
Anne Fournillier, Villeurbanne (France); Nourredine Himoudi, Lyons (France); and Geneviève Inchauspe, Lyons (France) | ||
Assigned to Transgene SA, Strasbourg Cedex (France) | ||
Appl. No. 10/514,762 PCT Filed May 15, 2003, PCT No. PCT/FR03/01478 § 371(c)(1), (2), (4) Date Nov. 16, 2004, PCT Pub. No. WO03/097677, PCT Pub. Date Nov. 27, 2003. |
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Claims priority of application No. 02 06111 (FR), filed on May 17, 2002. | ||
Prior Publication US 2007/0020285 A1, Jan. 25, 2007 | ||
Int. Cl. A61K 39/02 (2006.01); A61K 39/29 (2006.01); A61K 39/42 (2006.01); A61P 31/00 (2006.01); C07K 14/18 (2006.01); C07K 14/195 (2006.01); C07K 16/10 (2006.01) |
U.S. Cl. 514—12 [514/2; 424/161.1; 424/185.1; 424/189.1; 424/193.1; 530/300; 530/324; 536/23.5; 536/23.72] | 12 Claims |
1. A peptide composition, characterized in that it comprises at least two separate compounds chosen from:
a B peptide having at least the following amino acid sequence SEQ ID NO: 45:
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in which X18 is L or V, X19 is L or F, X20 is G or S, X21 is C or T, X22 is I or V, X23 is I or V, X24 is K, R or T, X25 is Q or E, X26 is V or N, X27 is D, E or C, X28 is V or A, X29 is V, I, E or M, X30 is L or V, X31 is T, K or A, X32 is Q or H, X33 is S or T, X34 is A or G, X35 is T or S, X36 is C or A, X37 is V, I or T, X38 is V or A, X39 is C or M and X40 is Y or F,
and having at most the 63 amino acids as described in the following sequence SEQ ID NO:46:
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in which X18 to X40 are as defined and X41 is P, S or H, X42 is A or T, X43 is S, A, T or C, X44 is Q or R, X45 is S, T or A, X46 is K or R and X47 is T or I, and
a C peptide having at least the following amino acid sequence SEQ ID NO: 127:
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in which X47 ′is L or P, X48 is A or S, X49 is A or S, X50 is A or S, X51 is I or V, X52 is T, S or A, X53 is T or I, X54 is Q, S or G, X55 is N, Q, H, S, Y or T, X56 is L or M, X57 is L or W, X58 is A or S and X59 is L, P or I,
and having at most the 57 amino acids as described in the following sequence SEQ ID NO:128:
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in which X47 ′ to X59 are as defined above and X60 is T or S, X61 is I, T or V, X62 is G or A, X63 is P or L, X64 is I or M, X65 is A, V or R, X66 is A or R, X67 is P, A or D and X68 is P, A or S.
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