# cumulative hits at level: 4 from root 
# for molecular.clean
hematopoietin/interferon-class (D200-domain) cytokine receptor activity	3
ATP-dependent peptidase activity	65
glucoside transporter activity	6
peptide disulfide oxidoreductase activity	7
purine nucleotide transporter activity	8
RNA ligase activity	51
kinase activity	1072
telomeric DNA binding	1
transition metal ion transporter activity	32
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	102
formate-tetrahydrofolate ligase activity	2
N-acetyldiaminopimelate deacetylase activity	2
transmembrane receptor protein tyrosine kinase docking protein activity	9
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	17
cystathionine gamma-synthase activity	10
biotin carboxylase activity	2
glutamate synthase activity	7
racemase and epimerase activity, acting on carbohydrates and derivatives	48
anion:cation symporter activity	27
aldehyde-lyase activity	97
sodium ion transporter activity	34
ATP-dependent RNA helicase activity	24
eukaryotic elongation factor-2 kinase regulator activity	18
CoA desaturase activity	9
levanase activity	8
ErbB-3 class receptor binding	1
beta-amyrin synthase activity	5
oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor	2
glycerol transporter activity	1
ether hydrolase activity	10
oxidoreductase activity, oxidizing metal ions, oxygen as acceptor	6
transferase activity, transferring alkylthio groups	1
MHC class I protein binding	11
BRE binding	1
thiamin pyridinylase activity	3
porter activity	198
basic amino acid transporter activity	7
steroid hormone receptor activity	1
dihydroorotate dehydrogenase activity	2
SH3 domain binding	9
receptor inhibitor activity	2
G-protein coupled photoreceptor activity	49
amino acid-polyamine transporter activity	45
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	144
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles	2
nuclear localization sequence binding	8
3' to 5' DNA helicase activity	1
MAP kinase kinase kinase activity	25
kinesin binding	2
protein kinase inhibitor activity	17
Rab GTPase activator activity	2
sulfurtransferase activity	9
protein disulfide oxidoreductase activity	5
MAP kinase kinase kinase kinase activity	1
3-oxo-5-beta-steroid 4-dehydrogenase activity	2
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	11
ligase activity, forming aminoacyl-tRNA and related compounds	51
transmembrane receptor protein kinase activity	26
1-aminocyclopropane-1-carboxylate synthase activity	29
CoA carboxylase activity	4
nuclease activity	258
solute:cation symporter activity	32
dimethylallyltranstransferase activity	3
chitin binding	24
oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor	133
oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	28
DNA topoisomerase type I activity	4
potassium ion transporter activity	8
acyl-CoA binding	6
NAD binding	20
pseudouridine synthase activity	17
water channel activity	61
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	680
NF-kappaB-inducing kinase activity	11
methyltransferase activity	148
actin binding	106
transferase activity, transferring amino-acyl groups	2
syntaxin binding	10
spectrin binding	2
3-phosphoshikimate 1-carboxyvinyltransferase activity	6
acyl-CoA dehydrogenase activity	21
lactoylglutathione lyase activity	24
solute:cation antiporter activity	45
malate dehydrogenase activity	44
trialkylsulfonium hydrolase activity	5
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	3
tetracycline transporter activity	42
arsenate reductase (glutaredoxin) activity	7
mRNA binding	64
rubredoxin-NAD+ reductase activity	7
magnesium ion transporter activity	5
cytochrome-c oxidase activity	14
phosphotransferase activity, for other substituted phosphate groups	2
methionine adenosyltransferase activity	23
oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor	15
methionine gamma-lyase activity	2
adenyl nucleotide binding	1651
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	17
cAMP-dependent protein kinase regulator activity	23
ubiquinol-cytochrome-c reductase activity	18
RNA splicing factor activity, transesterification mechanism	34
oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor	5
tRNA binding	36
double-stranded RNA binding	4
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	116
oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor	1
DNA bending activity	2
dicarboxylic acid transporter activity	26
di-, tri-valent inorganic cation transporter activity	41
transaldolase activity	14
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	227
succinate dehydrogenase activity	25
protein phosphatase type 2A regulator activity	13
oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor	6
ligase activity, forming nitrogen-metal bonds, forming coordination complexes	2
acetylspermidine deacetylase activity	1
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	40
cation:cation antiporter activity	2
histone deacetylase activity	3
3',5'-cGMP binding	6
bent DNA binding	1
3-deoxy-7-phosphoheptulonate synthase activity	4
intramolecular transferase activity, transferring acyl groups	2
endopeptidase activity	454
guanyl-nucleotide exchange factor activity	18
potassium ion binding	16
maleylacetoacetate isomerase activity	4
NEDD8 activating enzyme activity	8
inositol oxygenase activity	6
purine transporter activity	8
phosphatidylinositol transporter activity	1
long-chain fatty acid transporter activity	2
cation-transporting ATPase activity	62
MAP kinase activity	104
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	4
myo-inositol transporter activity	11
phosphotransferase activity, carboxyl group as acceptor	33
thiolester hydrolase activity	33
superoxide dismutase activity	19
steroid hormone receptor binding	5
transketolase activity	3
glycosaminoglycan binding	11
prenyltransferase activity	8
cytoskeletal adaptor activity	2
carbon-nitrogen ligase activity, with glutamine as amido-N-donor	20
oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	6
translation release factor activity	6
oxo-acid-lyase activity	11
GDP-dissociation inhibitor activity	5
farnesol 2-isomerase activity	2
biotin-protein ligase activity	1
thiamin-phosphate diphosphorylase activity	10
oxidoreductase activity, acting on CH2 groups, NAD or NADP as acceptor	4
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity	2
tubulin binding	44
single-stranded DNA binding	87
peptidyl-prolyl cis-trans isomerase activity	50
phosphatidylserine binding	1
phosphotransferase activity, phosphate group as acceptor	16
acid-ammonia (or amide) ligase activity	41
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	15
lipoate-protein ligase activity	4
transition metal ion binding	1135
oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor	27
glutathione transferase activity	36
racemase and epimerase activity, acting on amino acids and derivatives	2
intramolecular oxidoreductase activity, transposing C=C bonds	13
D-cysteine desulfhydrase activity	1
DNA photolyase activity	29
TPR domain binding	29
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	53
pyruvate dehydrogenase activity	13
1-deoxy-D-xylulose-5-phosphate synthase activity	1
sodium channel regulator activity	6
ammonia-lyase activity	17
protein phosphatase inhibitor activity	5
hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances	6
thromboxane-A synthase activity	2
hydroxylamine reductase activity	1
cation channel activity	30
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	47
cycloeucalenol cycloisomerase activity	1
acid-amino acid ligase activity	294
oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	16
alkylglycerone-phosphate synthase activity	1
oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor	6
protein kinase C activity	4
5S rRNA binding	5
oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor	28
oxidoreductase activity, acting on sulfur group of donors, iron-sulfur protein as acceptor	2
phosphotransferase activity, alcohol group as acceptor	909
oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor	2
arachidonic acid monooxygenase activity	3
diphosphoric monoester hydrolase activity	5
cyclin-dependent protein kinase regulator activity	1
inorganic anion transporter activity	10
spermidine synthase activity	7
nicotianamine synthase activity	13
ribosomal DNA (rDNA) binding	5
thiol-disulfide exchange intermediate activity	24
NADP binding	29
oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	35
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	10
FAD binding	41
scavenger receptor activity	18
delta12-fatty acid dehydrogenase activity	3
cysteine-type peptidase activity	137
calcium sensitive guanylate cyclase activator activity	3
tricarboxylic acid transporter activity	4
cycloartenol synthase activity	5
2-hydroxyglutarate dehydrogenase activity	1
acetolactate synthase activity	10
trans-hexaprenyltranstransferase activity	1
channel inhibitor activity	6
3',5'-cAMP binding	6
glycerol-3-phosphate dehydrogenase activity	6
NAD(P)+ transhydrogenase (B-specific) activity	1
transferase activity, transferring hexosyl groups	223
sugar porter activity	64
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	23
carbon-oxygen lyase activity, acting on phosphates	31
riboflavin synthase activity	3
proline dehydrogenase activity	4
exopeptidase activity	80
acid-thiol ligase activity	22
SH2 domain binding	5
spermine synthase activity	7
anion channel activity	12
formaldehyde transketolase activity	2
lipoprotein receptor activity	5
proton-dependent oligopeptide transporter activity	2
chromatin binding	33
laminin receptor activity	5
transaminase activity	81
SUMO conjugating enzyme activity	5
DNA topoisomerase (ATP-hydrolyzing) activity	1
ferredoxin-NADP+ reductase activity	17
ankyrin binding	1
taurine-transporting ATPase activity	1
phosphotransferase activity, paired acceptors	4
calcium-dependent phospholipid binding	6
transferase activity, transferring pentosyl groups	38
squalene monooxygenase activity	1
hydrolase activity, acting on acid halide bonds, in C-halide compounds	5
oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	15
sodium:dicarboxylate symporter activity	26
non-G-protein coupled 7TM receptor activity	1
anion-transporting ATPase activity	3
monosaccharide binding	48
phosphoinositide binding	6
amidine-lyase activity	2
G-protein coupled receptor activity	65
NADH dehydrogenase (ubiquinone) activity	32
nitrate reductase activity	11
prostaglandin-D synthase activity	1
testosterone 16-alpha-hydroxylase activity	1
potassium channel regulator activity	8
intramolecular oxidoreductase activity, interconverting aldoses and ketoses	122
chorismate mutase activity	1
ferredoxin-NAD+ reductase activity	5
guanyl nucleotide binding	239
oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor	22
disaccharide transporter activity	11
aspartyl esterase activity	1
sulfuric ester hydrolase activity	1
DNA-(apurinic or apyrimidinic site) lyase activity	4
monovalent inorganic cation transporter activity	179
fatty acid (omega-1)-hydroxylase activity	7
acidic amino acid transporter activity	1
oxidoreductase activity, acting on CH2 groups, disulfide as acceptor	3
MAP-kinase scaffold activity	2
organic cation transporter activity	5
glutamate receptor activity	2
carbamoyl-phosphate synthase activity	5
hydro-lyase activity	164
UDP-glycosyltransferase activity	120
intramolecular oxidoreductase activity, transposing S-S bonds	8
damaged DNA binding	23
hydroxymethylbilane synthase activity	3
interleukin-8 receptor binding	1
intramolecular transferase activity, phosphotransferases	17
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	278
transferase activity, transferring groups other than amino-acyl groups	207
carboxylic ester hydrolase activity	181
ion channel activity	52
calcium ion binding	385
oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor	3
protein heterodimerization activity	37
L-mimosine synthase activity	8
oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulfide as acceptor	7
carboxyl- and carbamoyltransferase activity	5
diphosphotransferase activity	13
oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	11
kinase binding	35
oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor	8
nucleotidyltransferase activity	136
histone deacetylase binding	6
protein phosphorylated amino acid binding	32
phosphoric ester hydrolase activity	260
cysteine-S-conjugate beta-lyase activity	2
transmembrane receptor protein phosphatase activity	3
ER retention sequence binding	3
ATP-dependent DNA helicase activity	6
calcium channel regulator activity	2
RNA modification guide activity	2
oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor	1
Rho GTPase activator activity	2
IgE binding	24
phospholipase A2 activator activity	1
snoRNA binding	2
deoxynucleotide transporter activity	1
CoA-ligase activity	22
serine-type peptidase activity	237
RNA cap binding	4
adenylosuccinate synthase activity	2
oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	7
acetylornithine deacetylase activity	1
calmodulin inhibitor activity	2
trans-octaprenyltranstransferase activity	1
oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor	17
single-stranded RNA binding	34
O-acetylhomoserine aminocarboxypropyltransferase activity	2
steroid hydroxylase activity	4
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)	36
double-stranded DNA binding	23
oxidoreductase activity, acting on hydrogen as donor, with other known acceptors	1
7S RNA binding	2
luciferin monooxygenase activity	3
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	45
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	45
oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	18
oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor	7
tetracycline:hydrogen antiporter activity	42
alpha-amyrin synthase activity	5
oxidoreductase activity, acting on NADH or NADPH, NAD or NADP as acceptor	22
thyroid hormone receptor binding	2
nuclear export signal receptor activity	1
SUMO activating enzyme activity	3
sulfotransferase activity	1
NADH dehydrogenase (quinone) activity	32
ARF GTPase activator activity	5
calcium ion transporter activity	9
endopeptidase inhibitor activity	69
DNA ligase activity	2
cystathionine gamma-lyase activity	4
putrescine transporter activity	1
monosaccharide transporter activity	36
Rab escort protein activity	1
CTP synthase activity	1
t-SNARE activity	1
lactate dehydrogenase activity	61
plastoquinol-plastocyanin reductase activity	6
fatty-acid ligase activity	12
neuropeptide hormone activity	4
oxidoreductase activity, acting on heme group of donors, oxygen as acceptor	14
metallopeptidase activity	91
magnesium ion binding	430
L-amino acid transporter activity	9
hydrolase activity, hydrolyzing O-glycosyl compounds	282
signal peptidase activity	2
pyruvate carboxylase activity	1
protein homodimerization activity	65
carboxy-lyase activity	326
poly-pyrimidine tract binding	3
selenocysteine lyase activity	5
snRNA binding	4
N-acetylglucosaminylphosphatidylinositol deacetylase activity	1
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	62
lanosterol synthase activity	5
P-P-bond-hydrolysis-driven transporter activity	109
oxidoreductase activity, acting on sulfur group of donors, quinone or similar compound as acceptor	1
Hsp70 protein binding	11
intramolecular oxidoreductase activity, interconverting keto- and enol-groups	8
protein kinase activator activity	20
histone acetyltransferase binding	5
v-SNARE activity	2
cystathionine beta-lyase activity	1
Janus kinase activity	2
rRNA binding	126
GABA receptor activity	1
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD or NADH as one donor, and incorporation of one atom of oxygen	52
pyrimidine transporter activity	1
cysteine synthase activity	9
DNA clamp loader activity	1
heme oxygenase (decyclizing) activity	2
aromatic amino acid transporter activity	1
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	3
dihydropteroate synthase activity	1
alliin lyase activity	2
FK506 binding	36
phosphotransferase activity, nitrogenous group as acceptor	40
racemase and epimerase activity, acting on hydroxy acids and derivatives	5
cationic amino acid transporter activity	7
hydrolase activity, hydrolyzing N-glycosyl compounds	7
monocarboxylic acid transporter activity	6
# cumulative hits at level: 4 from root 
# for molecular.clean
hematopoietin/interferon-class (D200-domain) cytokine receptor activity	2
ATP-dependent peptidase activity	52
glucoside transporter activity	7
DNA replication origin binding	1
peptide disulfide oxidoreductase activity	9
homospermidine synthase (spermidine-specific) activity	1
purine nucleotide transporter activity	26
RNA ligase activity	66
kinase activity	1151
telomeric DNA binding	1
transition metal ion transporter activity	38
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	107
N-acetyldiaminopimelate deacetylase activity	1
formate-tetrahydrofolate ligase activity	1
transmembrane receptor protein tyrosine kinase docking protein activity	9
cystathionine gamma-synthase activity	6
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	17
myosin binding	2
biotin carboxylase activity	1
glutamate synthase activity	5
racemase and epimerase activity, acting on carbohydrates and derivatives	54
anion:cation symporter activity	25
aldehyde-lyase activity	81
sodium ion transporter activity	48
CoA desaturase activity	8
ATP-dependent RNA helicase activity	29
eukaryotic elongation factor-2 kinase regulator activity	26
levanase activity	6
beta-amyrin synthase activity	2
oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor	2
glycerol transporter activity	1
ether hydrolase activity	10
oxidoreductase activity, oxidizing metal ions, oxygen as acceptor	14
transferase activity, transferring alkylthio groups	2
MHC class I protein binding	10
BRE binding	2
thiamin pyridinylase activity	2
porter activity	293
steroid hormone receptor activity	2
basic amino acid transporter activity	10
dihydroorotate dehydrogenase activity	2
receptor inhibitor activity	3
SH3 domain binding	11
amino acid-polyamine transporter activity	43
G-protein coupled photoreceptor activity	42
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	201
carotene 7,8-desaturase activity	1
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles	4
amine-lyase activity	1
nuclear localization sequence binding	5
3' to 5' DNA helicase activity	1
MAP kinase kinase kinase activity	26
protein kinase inhibitor activity	30
Rab GTPase activator activity	4
protein disulfide oxidoreductase activity	5
sulfurtransferase activity	17
MAP kinase kinase kinase kinase activity	1
3-oxo-5-beta-steroid 4-dehydrogenase activity	9
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	8
transmembrane receptor protein kinase activity	27
ligase activity, forming aminoacyl-tRNA and related compounds	66
CoA carboxylase activity	1
1-aminocyclopropane-1-carboxylate synthase activity	46
cytokinin dehydrogenase activity	1
nuclease activity	311
solute:cation symporter activity	40
dimethylallyltranstransferase activity	2
oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor	122
chitin binding	36
oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	29
DNA topoisomerase type I activity	3
potassium ion transporter activity	10
acyl-CoA binding	7
NAD binding	23
pseudouridine synthase activity	23
water channel activity	106
argininosuccinate synthase activity	1
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	942
NF-kappaB-inducing kinase activity	15
methyltransferase activity	180
actin binding	146
syntaxin binding	15
transferase activity, transferring amino-acyl groups	2
spectrin binding	2
coenzyme A transporter activity	3
3-phosphoshikimate 1-carboxyvinyltransferase activity	4
acyl-CoA dehydrogenase activity	21
lactoylglutathione lyase activity	54
solute:cation antiporter activity	118
malate dehydrogenase activity	44
trialkylsulfonium hydrolase activity	5
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	3
tetracycline transporter activity	114
arsenate reductase (glutaredoxin) activity	7
mRNA binding	83
rubredoxin-NAD+ reductase activity	11
magnesium ion transporter activity	5
cytochrome-c oxidase activity	15
phosphotransferase activity, for other substituted phosphate groups	8
methionine adenosyltransferase activity	44
oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor	26
methionine gamma-lyase activity	1
adenyl nucleotide binding	1787
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	11
protein kinase CK2 regulator activity	2
RNA splicing factor activity, transesterification mechanism	54
cAMP-dependent protein kinase regulator activity	23
ubiquinol-cytochrome-c reductase activity	18
oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor	5
tRNA binding	49
double-stranded RNA binding	10
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	180
oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor	1
DNA bending activity	2
dicarboxylic acid transporter activity	27
di-, tri-valent inorganic cation transporter activity	46
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	197
transaldolase activity	21
succinate dehydrogenase activity	37
protein phosphatase type 2A regulator activity	22
oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor	4
ligase activity, forming nitrogen-metal bonds, forming coordination complexes	2
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	63
histone deacetylase activity	5
cation:cation antiporter activity	3
3',5'-cGMP binding	7
bent DNA binding	1
3-deoxy-7-phosphoheptulonate synthase activity	7
intramolecular transferase activity, transferring acyl groups	1
endopeptidase activity	565
guanyl-nucleotide exchange factor activity	25
aminophospholipid transporter activity	2
potassium ion binding	39
maleylacetoacetate isomerase activity	7
NEDD8 activating enzyme activity	7
purine transporter activity	24
inositol oxygenase activity	6
phosphatidylinositol transporter activity	1
long-chain fatty acid transporter activity	2
cation-transporting ATPase activity	108
MAP kinase activity	92
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	8
myo-inositol transporter activity	9
phosphotransferase activity, carboxyl group as acceptor	52
thiolester hydrolase activity	52
superoxide dismutase activity	35
steroid hormone receptor binding	5
transketolase activity	7
prenyltransferase activity	10
glycosaminoglycan binding	9
cytoskeletal adaptor activity	2
carbon-nitrogen ligase activity, with glutamine as amido-N-donor	17
oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	3
translation release factor activity	5
sulfonylurea receptor activity	2
oxo-acid-lyase activity	8
GDP-dissociation inhibitor activity	11
farnesol 2-isomerase activity	3
biotin-protein ligase activity	1
thiamin-phosphate diphosphorylase activity	11
oxidoreductase activity, acting on CH2 groups, NAD or NADP as acceptor	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity	4
tubulin binding	53
single-stranded DNA binding	93
peptidyl-prolyl cis-trans isomerase activity	69
phosphatidylserine binding	1
acyl carnitine transporter activity	1
phosphotransferase activity, phosphate group as acceptor	25
acid-ammonia (or amide) ligase activity	75
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	15
phosphoribosylamine-glycine ligase activity	1
lipoate-protein ligase activity	3
transition metal ion binding	1293
glutathione transferase activity	98
oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor	22
racemase and epimerase activity, acting on amino acids and derivatives	15
intramolecular oxidoreductase activity, transposing C=C bonds	22
D-cysteine desulfhydrase activity	2
DNA photolyase activity	31
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	79
TPR domain binding	42
pyruvate dehydrogenase activity	9
carbon-oxygen lyase activity, acting on polysaccharides	1
1-deoxy-D-xylulose-5-phosphate synthase activity	2
cAMP response element binding protein binding	1
hematopoietin/interferon-class (D200-domain) cytokine receptor binding	1
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	1
ammonia-lyase activity	34
protein phosphatase inhibitor activity	6
sodium channel regulator activity	3
hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances	2
thromboxane-A synthase activity	8
hydroxylamine reductase activity	1
cation channel activity	49
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	73
AT DNA binding	1
intramolecular transferase activity, transferring amino groups	2
acid-amino acid ligase activity	387
oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	18
alkylglycerone-phosphate synthase activity	1
oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor	5
protein kinase C activity	3
5S rRNA binding	8
insulin-like growth factor binding	4
oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor	22
oxidoreductase activity, acting on sulfur group of donors, iron-sulfur protein as acceptor	5
phosphotransferase activity, alcohol group as acceptor	922
oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor	5
arachidonic acid monooxygenase activity	5
cyclin-dependent protein kinase regulator activity	3
diphosphoric monoester hydrolase activity	3
inorganic anion transporter activity	14
interleukin-6 receptor binding	1
spermidine synthase activity	4
nicotianamine synthase activity	56
bile acid:sodium symporter activity	4
thiol-disulfide exchange intermediate activity	27
ribosomal DNA (rDNA) binding	6
oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	28
NADP binding	27
delta12-fatty acid dehydrogenase activity	4
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	13
FAD binding	39
scavenger receptor activity	29
cysteine-type peptidase activity	160
calcium sensitive guanylate cyclase activator activity	2
tricarboxylic acid transporter activity	5
cycloartenol synthase activity	2
2-hydroxyglutarate dehydrogenase activity	2
acetolactate synthase activity	17
trans-hexaprenyltranstransferase activity	1
channel inhibitor activity	4
3',5'-cAMP binding	6
glycerol-3-phosphate dehydrogenase activity	9
tumor necrosis factor receptor binding	2
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated	5
NAD(P)+ transhydrogenase (B-specific) activity	1
transferase activity, transferring hexosyl groups	288
sugar porter activity	60
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	16
platelet-derived growth factor binding	1
carbon-oxygen lyase activity, acting on phosphates	29
riboflavin synthase activity	2
exopeptidase activity	92
acid-thiol ligase activity	31
proline dehydrogenase activity	6
SH2 domain binding	7
spermine synthase activity	4
anion channel activity	19
lipoprotein receptor activity	10
organic anion transporter activity	2
formaldehyde transketolase activity	3
proton-dependent oligopeptide transporter activity	6
chromatin binding	42
laminin receptor activity	6
5,10-methylenetetrahydrofolate reductase (FADH2) activity	1
transaminase activity	99
SUMO conjugating enzyme activity	5
DNA topoisomerase (ATP-hydrolyzing) activity	3
C-5 sterol desaturase activity	1
ferredoxin-NADP+ reductase activity	7
phosphotransferase activity, paired acceptors	3
calcium-dependent phospholipid binding	5
squalene monooxygenase activity	2
transferase activity, transferring pentosyl groups	40
hydrolase activity, acting on acid halide bonds, in C-halide compounds	10
sodium:dicarboxylate symporter activity	25
oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	19
non-G-protein coupled 7TM receptor activity	1
anion-transporting ATPase activity	1
monosaccharide binding	34
GTPase binding	1
phosphoinositide binding	6
G-protein coupled receptor activity	66
amidine-lyase activity	1
nitrate reductase activity	11
NADH dehydrogenase (ubiquinone) activity	42
prostaglandin-D synthase activity	1
anion:anion antiporter activity	3
potassium channel regulator activity	6
oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor	2
testosterone 16-alpha-hydroxylase activity	2
inositol-3-phosphate synthase activity	4
intramolecular oxidoreductase activity, interconverting aldoses and ketoses	198
ferredoxin-NAD+ reductase activity	7
chorismate mutase activity	3
guanyl nucleotide binding	368
oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor	17
disaccharide transporter activity	13
aspartyl esterase activity	4
sulfuric ester hydrolase activity	1
monovalent inorganic cation transporter activity	251
DNA-(apurinic or apyrimidinic site) lyase activity	7
fatty acid (omega-1)-hydroxylase activity	14
oxidoreductase activity, acting on CH2 groups, disulfide as acceptor	2
DNA secondary structure binding	1
MAP-kinase scaffold activity	1
glutamate receptor activity	3
organic cation transporter activity	4
carbamoyl-phosphate synthase activity	3
dichloromethane dehalogenase activity	1
hydro-lyase activity	215
UDP-glycosyltransferase activity	157
intramolecular oxidoreductase activity, transposing S-S bonds	11
damaged DNA binding	41
hydroxymethylbilane synthase activity	3
intramolecular transferase activity, phosphotransferases	22
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	365
transferase activity, transferring groups other than amino-acyl groups	264
interleukin-8 receptor binding	2
carboxylic ester hydrolase activity	220
ion channel activity	83
calcium ion binding	483
oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor	4
protein heterodimerization activity	43
IgA binding	1
L-mimosine synthase activity	5
oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulfide as acceptor	7
carboxyl- and carbamoyltransferase activity	3
diphosphotransferase activity	18
oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	20
kinase binding	53
oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor	10
nucleotidyltransferase activity	129
histone deacetylase binding	8
cysteine-S-conjugate beta-lyase activity	2
protein phosphorylated amino acid binding	42
phosphoric ester hydrolase activity	299
transmembrane receptor protein phosphatase activity	6
ATP-dependent DNA helicase activity	12
calcium channel regulator activity	3
sirohydrochlorin ferrochelatase activity	2
RNA modification guide activity	2
oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor	1
cyclo-ligase activity	1
Rho GTPase activator activity	1
IgE binding	36
phospholipase A2 activator activity	1
ErbB-2 class receptor binding	1
deoxynucleotide transporter activity	1
snoRNA binding	2
DEAD/H-box RNA helicase binding	3
CoA-ligase activity	31
serine-type peptidase activity	286
adenylosuccinate synthase activity	2
RNA cap binding	2
oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	5
NAD(P)H dehydrogenase (quinone) activity	1
pyrimidine nucleotide sugar transporter activity	1
calmodulin inhibitor activity	1
trans-octaprenyltranstransferase activity	1
oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor	12
cyanate hydratase activity	1
steroid hydroxylase activity	7
single-stranded RNA binding	40
O-acetylhomoserine aminocarboxypropyltransferase activity	1
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)	30
phosphatidylethanolamine binding	1
double-stranded DNA binding	27
7S RNA binding	4
luciferin monooxygenase activity	3
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	61
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	64
oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	18
oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor	10
tetracycline:hydrogen antiporter activity	114
alpha-amyrin synthase activity	2
oxidoreductase activity, acting on NADH or NADPH, NAD or NADP as acceptor	30
thyroid hormone receptor binding	1
nuclear export signal receptor activity	1
sulfotransferase activity	3
SUMO activating enzyme activity	1
axon guidance receptor activity	1
NADH dehydrogenase (quinone) activity	42
ARF GTPase activator activity	7
calcium ion transporter activity	9
endopeptidase inhibitor activity	102
cystathionine gamma-lyase activity	6
DNA ligase activity	1
monosaccharide transporter activity	39
Rab escort protein activity	4
CTP synthase activity	3
t-SNARE activity	2
PDZ domain binding	3
lactate dehydrogenase activity	58
hydroxydechloroatrazine ethylaminohydrolase activity	1
plastoquinol-plastocyanin reductase activity	2
fatty-acid ligase activity	13
neuropeptide hormone activity	5
oxidoreductase activity, acting on heme group of donors, oxygen as acceptor	15
metallopeptidase activity	104
magnesium ion binding	538
L-amino acid transporter activity	14
hydrolase activity, hydrolyzing O-glycosyl compounds	422
signal peptidase activity	3
protein homodimerization activity	89
carboxy-lyase activity	293
poly-pyrimidine tract binding	10
pyruvate carboxylase activity	1
snRNA binding	3
selenocysteine lyase activity	2
N-acetylglucosaminylphosphatidylinositol deacetylase activity	1
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	83
lanosterol synthase activity	2
P-P-bond-hydrolysis-driven transporter activity	177
oxidoreductase activity, acting on sulfur group of donors, quinone or similar compound as acceptor	1
Hsp70 protein binding	13
intramolecular oxidoreductase activity, interconverting keto- and enol-groups	11
phospholipase A2 inhibitor activity	1
v-SNARE activity	3
histone acetyltransferase binding	8
protein kinase activator activity	28
cystathionine beta-lyase activity	2
Janus kinase activity	1
rRNA binding	160
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD or NADH as one donor, and incorporation of one atom of oxygen	70
cysteine synthase activity	5
aromatic amino acid transporter activity	3
heme oxygenase (decyclizing) activity	1
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	6
dihydropteroate synthase activity	2
alliin lyase activity	2
FK506 binding	50
phosphotransferase activity, nitrogenous group as acceptor	53
racemase and epimerase activity, acting on hydroxy acids and derivatives	4
cationic amino acid transporter activity	10
hydrolase activity, hydrolyzing N-glycosyl compounds	10
monocarboxylic acid transporter activity	23