[Code of Federal Regulations]
[Title 21, Volume 7]
[Revised as of April 1, 2001]
From the U.S. Government Printing Office via GPO Access
[CITE: 21CFR610.53]

[Page 76-81]
 
                        TITLE 21--FOOD AND DRUGS
 
          DEPARTMENT OF HEALTH AND HUMAN SERVICES--(Continued)
 
PART 610--GENERAL BIOLOGICAL PRODUCTS STANDARDS--Table of Contents
 
                  Subpart F--Dating Period Limitations
 
Sec. 610.53  Dating periods for licensed biological products.

    (a) General. The minimum dating periods in paragraph (c) of this 
section are based on data relating to usage, clinical experience, or 
laboratory tests that establish the reasonable period beyond which the 
product cannot be expected to yield its specific results and retain its 
safety, purity, and potency, provided the product is maintained at the 
recommended temperatures. The standards prescribed by the regulations in 
this subchapter are designed to ensure the continued safety, purity, and 
potency of the products and are based on the dating periods set forth in 
paragraph (c) of this section. Package labels for each product shall 
recommend storage at the stated temperatures.
    (b) When the dating period begins. The dating period for a product 
shall begin on the date of manufacture, as prescribed in Sec. 610.50. 
The dating period for a combination of two or more products shall be no 
longer than the dating period of the component with the shortest dating 
period.
    (c) Table of dating periods. In using the table in this paragraph, a 
product in column A may be stored by the manufacturer at the prescribed 
temperature and length of time in either column B or C, plus the length 
of time in column D. The dating period in column D shall be applied from 
the day the product leaves the manufacturer's storage, provided the 
product has not exceeded its maximum storage period, as prescribed in 
column B or C. If a product is held in the manufacturer's storage beyond 
the period prescribed, the dating period for the product being 
distributed shall be reduced by a corresponding period.

----------------------------------------------------------------------------------------------------------------
                 A                              B                        C                         D
----------------------------------------------------------------------------------------------------------------
                                                                                          Dating period after
                                      Manufacturer's storage  Manufacturer's storage    leaving manufacturer's
              Product                period 1 to 5 C (unless   period 0 C or colder    storage when stored at 2
                                        otherwise stated)        (unless otherwise     to 8 C (unless otherwise
                                                                      stated)                   stated)
----------------------------------------------------------------------------------------------------------------
Adenovirus Vaccine Live Oral.......  6 months...............  Not applicable........  6 months.
Albumin (Human)....................  3 years................  ......do..............  (a) 5 years.
                                     ......do...............  ......do..............  (b) 3 years, provided
                                                                                       labeling recommends
                                                                                       storage at room
                                                                                       temperature, no warmer
                                                                                       than 37 C.

[[Page 77]]


                                     Not applicable.........  ......do..............  (c) 10 years, if in a
                                                                                       hermetically sealed metal
                                                                                       container and provided
                                                                                       labeling recommends
                                                                                       storage between 2 and 8
                                                                                       C.
Allergenic Extracts labeled ``No
 U.S. Standard of Potency'':
    1. With 50 percent or more       3 years................  ......do..............  3 years.
     glycerin.
    2. With less than 50 percent     18 months..............  ......do..............  18 months.
     glycerin.
    3. Products for which cold       Not applicable.........  ......do..............  18 months (from date of
     storage conditions are                                                            manufacture), provided
     inappropriate.                                                                    labeling recommends
                                                                                       storage at 30 C or
                                                                                       colder.
    4. Powders and tablets.........  ......do...............  ......do..............  5 years (from date of
                                                                                       manufacture), provided
                                                                                       labeling recommends
                                                                                       storage at 30 C or
                                                                                       colder.
    5. Freeze-dried products:
      a. Unreconstituted...........  ......do...............  ......do..............  4 years (from date of
                                                                                       manufacture).
      b. Reconstituted.............  ......do...............  ......do..............  18 months (cannot exceed 4-
                                                                                       year unreconstituted
                                                                                       dating period plus an
                                                                                       additional 12 months).
Allergenic Extracts, Alum            18 months..............  ......do..............  18 months.
 Precipitated labeled ``No U.S.
 Standard of Potency''.
Anthrax Vaccine Adsorbed...........  2 years................  ......do..............  1 year.
Antibody to Hepatitis B Surface
 Antigen:
    1. Antibody to Hepatitis B       6 months...............  ......do..............  6 months.
     Surface Antigen.
    2. Lyophilized coated red blood  ......do...............  ......do..............      Do.
     cells.
    3. Enzyme conjugated products..  ......do...............  ......do..............      Do.
Iodinated (\125\l) products........  Not applicable.........  ......do..............  45 days (from date of
                                                                                       manufacture).
Antihemophilic Factor (Human)......  ......do...............  ......do..............  1 year (from date of
                                                                                       manufacture).
Anti-Human Globulin Liquid.........  ......do...............  ......do..............  2 years.
Anti-Inhibitor Coagulant Complex...  ......do...............  ......do..............      Do.
Antirabies Serum...................  1 year.................  ......do..............      Do.
Antivenin (Crotalidae) Polyvalent..  ......do...............  ......do..............  5 years with an initial 10
                                                                                       percent excess of
                                                                                       potency, provided
                                                                                       labeling recommends
                                                                                       storage at 37  C or
                                                                                       colder.
Antivenin (Latrodectus Mactans)....  ......do...............  ......do..............  5 years with an initial 10
                                                                                       percent excess of
                                                                                       potency.
Antivenin (Micurus fulvius)........  ......do...............  ......do..............      Do.
Asparaginase.......................  Not applicable.........  ......do..............  18 months from the date of
                                                                                       the last valid potency
                                                                                       test.
BCG Vaccine........................  1 year.................  Not applicable........  6 months.
Blood Grouping Reagents
    1. Liquid......................  Not applicable.........  Not applicable........  2 years.
    2. Dried.......................  1 year.................  2 years...............  5 years.
Blood Group Substance AB...........  ......do...............  ......do..............  2 years.
Blood Group Substance A............  ......do...............  ......do..............      Do.
Blood Group Substance B............  ......do...............  ......do..............      Do.
Botulism Antitoxin.................  ......do...............  Not applicable........  5 years with an initial 20
                                                                                       percent excess of
                                                                                       potency.
Cholera Vaccine....................  ......do...............  ......do..............  18 months.
Coccidioidin.......................  ......do...............  ......do..............  3 years.
Collagenase........................  Not applicable.........  ......do..............  4 years (from date of
                                                                                       manufacture), provided
                                                                                       labeling recommends
                                                                                       storage at 37 C or
                                                                                       colder.
Cryoprecipitated AFH...............  ......do...............  ......do..............  12 months from the date of
                                                                                       collection of source
                                                                                       blood, provided labeling
                                                                                       recommends storage at -18
                                                                                       C or colder.
Diphtheria Antitoxin:
    1. Liquid......................  1 year.................  ......do..............  5 years with an initial 20
                                                                                       percent excess of
                                                                                       potency.
    2. Dried.......................  ......do...............  2 years...............  5 years with an initial 10
                                                                                       percent excess of
                                                                                       potency.
Diphtheria and Tetanus Toxoids and   ......do...............  Not applicable........  18 months.
 Pertussis Vaccine Adsorbed.
Diphtheria and Tetanus Toxoids,      ......do...............  ......do..............  2 years.
 Adsorbed.
Diphtheria Toxin for Schick Test...  ......do...............  ......do..............  1 year.
Diphtheria Toxoid..................  ......do...............  ......do..............  2 years.
Diphtheria Toxoid Adsorbed.........  ......do...............  2 years...............      Do.

[[Page 78]]


Diphtheria Toxoid-Schick Test        Not applicable.........  Not applicable........  1 year.
 Control.
Factor IX Complex..................  ......do...............  ......do..............  1 year (from date of
                                                                                       manufacture).
Fibrinolysin (Human)...............  1 year.................  2 years...............  2 years.
Fibrinolysin and Desoxyribonuclease  ......do...............  ......do..............  3 years, provided labeling
 Combined (Bovine).                                                                    recommends storage at 30
                                                                                       C or colder.
Fibrinolysin and Desoxyribonuclease  ......do...............  ......do..............      Do.
 Combined (Bovine) with
 Chloramphenicol.
Hepatitis B Surface Antigen:
    1. Unlyophilized coated red      Not applicable.........  ......do..............  14 days (from date of
     blood cells.                                                                      manufacture).
    2. Iodinated (\125\ l) product.  ......do...............  ......do..............  45 days (from date of
                                                                                       manufacture).
    3. Enzyme conjugated product...  6 months...............  ......do..............  6 months.
Histoplasmin.......................  1 year.................  Not applicable........  2 years.
Immunoglobulins:
    1. Hepatitis B Immune Globulin   Not applicable.........  ......do..............  1 year.
     (Human).
    2. Immune Globulin (Human).....  3 years................  ......do..............  3 years.
    3. Immune Globulin Intravenous   Not applicable.........  ......do..............  1 year.
     (Human).
    4. Lymphocyte Immune Globulin,   ......do...............  Not applicable........  2 years.
     Anti-Thymocyte Globulin
     (Equine).
    5. Pertussis Immune Globulin     3 years................  ......do..............  3 years from date the
     (Human).                                                                          dried or frozen bulk
                                                                                       product is placed in
                                                                                       final solution.
    6. Rabies Immune Globulin        1 year.................  ......do..............  1 year.
     (Human).
    7. Rho(D) Immune Globulin        6 months...............  ......do..............  6 months.
     (Human).
    8. Tetanus Immune Globulin       1 year.................  ......do..............  3 years with an initial 10
     (Human).                                                                          percent excess of
                                                                                       potency.
    9. Vaccinia Immune Globulin      3 years................  ......do..............  3 years.
     (Human).
    10. Varicella-Zoster Immune      Not applicable.........  ......do..............  1 year.
     Globulin (Human).
Hepatitis B Vaccine................  2 years at 2 to 8 C....  Not applicable........  3 years.
Influenza Virus Vaccine............  1 year.................  ......do..............  18 months.
Limulus Amebocyte Lysate...........  Not applicable.........  Not applicable........  18 months (from date of
                                                                                       manufacture).
Measles, Mumps, and Rubella Virus    ......do...............  1 year (-20 C or        1 year.
 Vaccine Live.                                                 colder).
Measles and Mumps Virus Vaccine      ......do...............  ......do..............  1 year.
 Live.
Measles and Rubella Virus Vaccine    ......do...............  ......do..............      Do.
 Live.
Measles Live and Smallpox Vaccine..  Not applicable.........  ......do..............  1 year (from date of
                                                                                       manufacture).
Measles Virus Vaccine Live.........  ......do...............  ......do..............  1 year.
Meningococcal Polysaccharide
 Vaccine Group A:
    1. Final bulk powder...........  ......do...............  2 years (-20 C or       Not applicable.
                                                               colder).
    2. Final container.............  Not applicable.........  3 years (-20 C or       2 years.
                                                               colder).
Meningococcal Polysaccharide
 Vaccine Group C:
    1. Final bulk powder...........  ......do...............  2 years (-20 C or       Not applicable.
                                                               colder).
    2. Final container.............  ......do...............  3 years (-20 C or       2 years.
                                                               colder).
Meningococcal Polysaccharide
 Vaccine Groups A and C combined:
    1. Final bulk powder...........  ......do...............  2 years (-20 C or       Not applicable.
                                                               colder).
    2. Final container.............  ......do...............  3 years (-20 C or       2 years.
                                                               colder).
Meningococcal Polysaccharide
 Vaccine Groups A, C, Y, and W135
 combined:
    1. Final bulk power............  ......do...............  2 years (-20 C or       Not applicable.
                                                               colder).
    2. Final container.............  ......do...............  3 years (-20 C or       2 years.
                                                               colder).
Mumps Skin Test Antigen............  6 months...............  Not applicable........  18 months.
Mumps Virus Vaccine Live...........  Not applicable.........  1 year (-20 C or        1 year.
                                                               colder).
Normal Horse Serum.................  1 year.................  2 years...............  5 years.
Pertussis Vaccine..................  ......do...............  Not applicable........  18 months.

[[Page 79]]


Pertussis Vaccine Adsorbed.........  ......do...............  ......do..............      Do.
Plague Vaccine.....................  ......do...............  ......do..............      Do.
Plasma products:
    1. Fresh Frozen Plasma.........  Not applicable.........  ......do..............  1 year from date of
                                                                                       collection of source
                                                                                       blood (-18 C or colder).
    2. Liquid Plasma...............  ......do...............  ......do..............  (a) 26 days from date of
                                                                                       collection of source
                                                                                       blood (between 1 and 6
                                                                                       C).
                                                                                      (b) 40 days from date of
                                                                                       collection of source
                                                                                       blood only when CPDA-1
                                                                                       solution is used as the
                                                                                       anticoagulant (between 1
                                                                                       and 6 C).
    3. Plasma......................  ......do...............  ......do..............  5 years from date of
                                                                                       collection of source
                                                                                       blood (-18 C or colder).
    4. Platelet Rich Plasma........  ......do...............  ......do..............  72 hours from time of
                                                                                       collection of source
                                                                                       blood, provided labeling
                                                                                       recommends storage (20 to
                                                                                       24 C or between 1 and 6
                                                                                       C). 5 days if certain
                                                                                       approved containers are
                                                                                       used (20 to 24 C).
    5. Source Leukocytes...........  ......do...............  ......do..............  In lieu of expiration
                                                                                       date, the collection date
                                                                                       shall appear on the
                                                                                       label.
    6. Source Plasma...............  ......do...............  ......do..............  10 years (at the
                                                                                       recommended storage
                                                                                       temperature stated on the
                                                                                       label).
    7. Therapeutic Exchange Plasma.  ......do...............  ......do..............  10 years.
Plasma Protein Fraction (Human)....  1 year.................  ......do..............  (a) 5 years.
                                                                                      (b) 3 years provided
                                                                                       labeling recommends
                                                                                       storage at room
                                                                                       temperature, no warmer
                                                                                       than 30 C).
Platelets..........................  Not applicable.........  ......do..............  72 hours from time of
                                                                                       collection of source
                                                                                       blood, provided labeling
                                                                                       recommends storage at 20
                                                                                       to 24 C or between 1 and
                                                                                       6 C. 5 days if certain
                                                                                       approved containers are
                                                                                       used (20 to 24 C).
Pneumococcal Vaccine Polyvalent:
    1. Final bulk powder...........  ......do...............  24 months after         Not applicable.
                                                               potency assay (-20 C
                                                               or colder).
    2. Final container.............  ......do...............  Not applicable........  2 years (from date of
                                                                                       manufacture).
Poliovirus Vaccine Inactivated.....  1 year.................  ......do..............  1 year.
Poliovirus Vaccine Live Oral
 Trivalent:
    1. Frozen......................  Not applicable.........  1 year (-10 C or        1 year, provided labeling
                                                               colder).                recommends storage at a
                                                                                       temperature which will
                                                                                       maintain ice continuously
                                                                                       in a solid state.
    2. Liquid......................  ......do...............  Not applicable........  30 days, provided labeling
                                                                                       recommends storage
                                                                                       between 2 and 8 C and
                                                                                       container has been
                                                                                       unopened.
Poliovirus Vaccine Live Oral Type
 I:
    1. Frozen......................  ......do...............  1 year (-10 C or        1 year, provided labeling
                                                               colder).                recommends storage at a
                                                                                       temperature which will
                                                                                       maintain ice continuously
                                                                                       in a solid state.
    2. Liquid......................  ......do...............  Not applicable........  30 days, provided labeling
                                                                                       recommends storage
                                                                                       between 2 and 8 C and
                                                                                       container has been
                                                                                       unopened.
Poliovirus Vaccine Live Oral Type
 II:
    1. Frozen......................  ......do...............  1 year (-10 C or        1 year, provided labeling
                                                               colder).                recommends storage at a
                                                                                       temperature which will
                                                                                       maintain ice continuously
                                                                                       in a solid state.
    2. Liquid......................  ......do...............  Not applicable........  30 days, provided labeling
                                                                                       recommends storage
                                                                                       between 2 and 8 C and
                                                                                       container has been
                                                                                       unopened.
Poliovirus Vaccine Live Oral Type
 III:
    1. Frozen......................  ......do...............  1 year (-10 C or        1 year, provided labeling
                                                               colder).                recommends storage at a
                                                                                       temperature which will
                                                                                       maintain ice continuously
                                                                                       in a solid state.

[[Page 80]]


    2. Liquid......................  ......do...............  Not applicable........  30 days, provided labeling
                                                                                       recommends storage
                                                                                       between 2 and 8 C and
                                                                                       container has been
                                                                                       unopened.
Polyvalent bacterial antigens with   1 year.................  ......do..............  18 months.
 ``No U.S. Standard of Potency''
 liquid.
Polyvalent bacterial vaccines with   ......do...............  ......do..............      Do.
 ``No U.S. Standard of Potency''
 liquid.
Rabies Vaccine:
    1. Dried.......................  ......do...............  2 years...............      Do.
    2. Liquid......................  3 months...............  Not applicable........  6 months.
Reagent red blood cells............  Not applicable.........  Not applicable........  Thirty-five days from
                                                                                       earliest date of
                                                                                       collection if kept in
                                                                                       liquid form (indefinite
                                                                                       storage of reagent red
                                                                                       blood cell source
                                                                                       material at -65 C or
                                                                                       colder).
ACD Red Blood Cells................  ......do...............  ......do..............  (a) 21 days from date of
                                                                                       collection of source
                                                                                       blood, provided labeling
                                                                                       recommends storage
                                                                                       between 1 and 6 C and the
                                                                                       hermetic seal is not
                                                                                       broken during processing.
                                                                                      (b) 24 hours after plasma
                                                                                       removal, provided
                                                                                       labeling recommends
                                                                                       storage between 1 and 6 C
                                                                                       and the hermetic seal is
                                                                                       broken during processing.
CPD Red Blood Cells................  ......do...............  ......do..............  (a) 21 days from date of
                                                                                       collection of source
                                                                                       blood, provided labeling
                                                                                       recommends storage
                                                                                       between 1 and 6 C and the
                                                                                       hermetic seal is not
                                                                                       broken during processing.
                                                                                      (b) 24 hours after plasma
                                                                                       removal, provided
                                                                                       labeling recommends
                                                                                       storage between 1 and 6 C
                                                                                       and the hermetic seal is
                                                                                       broken during processing.
CPDA-1 Red Blood Cells.............  ......do...............  ......do..............  (a) 35 days from date of
                                                                                       collection of source
                                                                                       blood, provided labeling
                                                                                       recommends storage
                                                                                       between 1 and 6 C and the
                                                                                       hermetic seal is not
                                                                                       broken during processing.
                                                                                      (b) 24 hours after plasma
                                                                                       removal, provided
                                                                                       labeling recommends
                                                                                       storage between 1 and 6 C
                                                                                       and the hermetic seal is
                                                                                       broken during processing.
Red Blood Cells Deglycerolized.....  ......do...............  ......do..............  24 hours after removal
                                                                                       from storage at -65 C or
                                                                                       colder, provided labeling
                                                                                       recommends storage
                                                                                       between 1 and 6 C.
Red Blood Cells Frozen.............  ......do...............  ......do..............  3 years from date of
                                                                                       collection of source
                                                                                       blood, provided labeling
                                                                                       recommends storage at -65
                                                                                       C or colder.
Rubella and Mumps Virus Vaccine      ......do...............  1 year (-20 C or        1 year.
 Live.                                                         colder).
Rubella Virus Vaccine Live.........  ......do...............  ......do..............      Do.
Skin Test Antigens for Cellular      6 months...............  Not applicable........      Do.
 Hypersensitivity.
Smallpox Vaccine:
    1. Liquid......................  Not applicable.........  9 months (-10 C or      3 months, provided
                                                               colder, if product is   labeling recommends
                                                               maintained as           storage at 0 C or colder.
                                                               glycerinated or
                                                               equivalent vaccine in
                                                               bulk or final
                                                               containers).
    2. Dried.......................  6 months...............  Not applicable........  18 months.
Streptokinase......................  Not applicable.........  ......do..............      Do.
Tetanus and Diphtheria Toxoids       1 year.................  ......do..............  2 years.
 Adsorbed for Adult Use.
Tetanus Antitoxin:
    1. Liquid......................  ......do...............  ......do..............  5 years with an initial 20
                                                                                       percent excess or
                                                                                       potency.

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    2. Dried.......................  ......do...............  2 years...............  5 years with an initial 10
                                                                                       percent excess or
                                                                                       potency.
Tetanus Toxoid.....................  ......do...............  Not applicable........  2 years.
Tetanus Toxoid Adsorbed............  ......do...............  ......do..............      Do.
Thrombin...........................  ......do...............  2 year................  3 years.
Thrombin Impregnated Pad...........  Not applicable.........  Not applicable........  1 year, or 6 months at 20
                                                                                       to 24 C.
Tuberculin:
    1. Purified Protein Derivative,  6 months...............  ......do..............  1 year.
     diluted.
    2. Old or Purified Protein       1 year (not to exceed    ......do..............  2 years, provided labeling
     Derivative dried on multiple     30 C; do not                                     recommends storage at a
     puncture device.                 refrigerate).                                    temperature not to exceed
                                                                                       30 C. Do not refrigerate.
    3. Old on multiple puncture      ......do...............  ......do..............      Do.
     device.
Typhoid Vaccine....................  1 year.................  ......do..............  18 months.
ACD Whole Blood....................  Not applicable.........  ......do..............  21 days from date of
                                                                                       collection, provided
                                                                                       labeling recommends
                                                                                       storage between 1 and 6
                                                                                       C.
CPD Whole Blood....................  ......do...............  ......do..............      Do.
CPDA-1 Whole Blood.................  ......do...............  ......do..............  35 days from date of
                                                                                       collection, provided
                                                                                       labeling recommends
                                                                                       storage between 1 and 6
                                                                                       C.
Heparin Whole Blood................  ......do...............  ......do..............  48 hours from date of
                                                                                       collection, provided
                                                                                       labeling recommends
                                                                                       storage between 1 and 6
                                                                                       C.
Yellow Fever Vaccine...............  ......do...............  1 year (-20 C or        1 year, provided labeling
                                                               colder).                recommends storage at 5 C
                                                                                       or colder.
----------------------------------------------------------------------------------------------------------------

    (d)  Exemptions. Exemptions or modifications shall be made only upon 
written approval, in the form of a supplement to the biologics license 
application, issued by the Director, Center for Biologics Evaluation and 
Research.

[50 FR 4134, Jan. 29, 1985, as amended at 51 FR 15607, Apr. 25, 1986; 51 
FR 19750, June 2, 1986; 52 FR 37450, Oct. 7, 1987; 53 FR 12764, Apr. 19, 
1988; 62 FR 15110, Mar. 31, 1997; 64 FR 56453, Oct. 20, 1999]