McKinsey D, Stanford J, Mason M; International Conference on AIDS.
Int Conf AIDS. 1994 Aug 7-12; 10: 148 (abstract no. PB0604).
Kansas City AIDS Research Consortium, MO.
OBJECTIVES: To determine the annual incidence of histoplasmosis in patients [pts] with HIV infection residing in an endemic area; to identify risk factors for histoplasmosis. METHODS: 305 HIV-seropositive pts in Kansas City were followed for a median period of 20.1 months and were monitored for evidence of histoplasmosis. Upon enrollment, the following potential risk factors were assessed: CD4 lymphocyte count, histoplasmin skin test status, H. capsulatum serology test results, and presence of pulmonary calcifications. RESULTS: Among the 305 pts, 20 [6.6%] developed histoplasmosis. The annual incidence of disease was 2.6% for all pts and 8.8% for those with baseline CD4 counts below 150/microL. Among pts who developed histoplasmosis, none had reactive histoplasmin tests [compared to 16.3% of other cohort members], 50% had positive serology tests [compared to 29.5%], and 73.3% had pulmonary calcifications [compared to 53.7%]. DISCUSSION AND CONCLUSIONS: Baseline CD4 count < 150 is the most useful predictor for pts at highest risk for developing histoplasmosis. Pts who developed histoplasmosis were more likely to be anergic, to have positive serology tests, or to have pulmonary calcifications, but these findings were not sensitive or specific enough to serve as useful markers for high-risk pts.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Antigens, CD4
- CD4 Lymphocyte Count
- HIV Infections
- HIV Seropositivity
- Histoplasmin
- Histoplasmosis
- Humans
- Incidence
- Kansas
- Risk Factors
- Serologic Tests
- Skin Tests
- epidemiology
- immunology
Other ID:
UI: 102210037
From Meeting Abstracts