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DOI http://dx.doi.org/10.1002/(SICI)1096-8628(19970331)69:3<293::AID-AJMG15>3.0.CO;2-M
Title Omphalocele in Miller-Dieker syndrome: Expanding the phenotype
Creator/Author Chitayat, D. [Toronto Hospital-General Division, Ontario (Canada)]|[Univ. of Toronto, Ontario (Canada)] ; Moola, S. ; Yarkoni, D. [Toronto Hospital-General Division, Ontario (Canada)][and others]
Publication Date1997 Mar 31
OSTI IdentifierOSTI ID: 526003
Other Number(s)AJMGDA; ISSN 0148-7299
Resource TypeJournal Article
Resource RelationAmerican Journal of Medical Genetics ; VOL. 69 ; ISSUE: 3 ; PBD: 31 Mar 1997
Subject55 BIOLOGY AND MEDICINE, BASIC STUDIES ; PATIENTS; HEREDITARY DISEASES; PHENOTYPE; KARYOTYPE; DIAGNOSIS; HUMAN CHROMOSOME 17; CHROMOSOMAL ABERRATIONS; GENETIC MAPPING; DETECTION; GENES; RESOLUTION; BANDING TECHNIQUES; FLUORESCENCE; IN-SITU HYBRIDIZATION; PROBES; BIOLOGICAL MARKERS
Description/Abstract We report on a patient prenatally diagnosed with omphalocele, mild cerebral ventriculomegaly, nuchal fold thickening, and cystic changes in the umbilical cord who was found postnatally to have lissencephaly type I. Prenatal chromosome analysis showed a normal male karyotype; however, postnatal high resolution banding and FISH analysis, using a probe for locus D17S379 in chromosome region 17p13.3, demonstrated a deletion at 17p13.3 consistent with Miller-Dieker syndrome (MDS). A review documented four more cases with MDS/isolated lissencephaly/17p-, with omphalocele. Because MDS is a contiguous gene disorder, we speculate that a gene or genes in this region have a major role in the closure of the lateral folds or the return of the midgut from the body stalk to the abdomen at 5-11 weeks of gestation. Prenatal diagnosis of omphalocele with mild ventriculomegaly should prompt FISH analysis for a deletion in 17p13.3. 44 refs., 7 figs., 1 tab.
Country of PublicationUnited States
LanguageEnglish
Formatpp. 293-298 ; PL:
System Entry Date2001 May 05

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