Ortiz I, Lugo RG, Perez CM, Suarez E, Febo I, Mendez I, Aguayo R, Vazquez J, Delgado R, Bertolli J; International Conference on AIDS.

Int Conf AIDS. 1998; 12: 133 (abstract no. 13237).

UPR School of Medicine, Dept of Pediatrics, San Juan.

BACKGROUND: Wasting Syndrome (WS) accounts for 17% of AIDS Defining Conditions reported among children with AIDS in the USA, and 28% of pediatric cases in Puerto Rico, (P.R.). Active surveillance for pediatric HIV infection is being conducted by the Pediatric Spectrum of Disease Project (PSD) in several geographic areas of the USA including P.R. The cumulative incidence of WS in the AIDS cases monitored in this study, excluding P.R., is 16% while it is 41% in the P.R. data. Differences in diagnostic or treatment practices have been proposed as an explanation of the high incidence of WS in P.R. OBJECTIVE: To describe and compare the trends in the incidence of WS and Failure to Thrive (FTT) not attributed to WS among perinatally HIV-infected children in P.R. METHODS: We analyzed data on 460 perinatally HIV-infected children monitored for a total of 2619 person-semesters, (p/s) in the PSD study in P.R. from 1992 to 1997. This study collects data from medical records at six-month intervals. Incidence density of WS and FTT were calculated by year of diagnosis. A Poisson regression model was used to examine trends over time. RESULTS: Of the 460 perinatally HIV-infected children monitored, 11% had WS with an incidence density of 19 cases per 1000 p/s and 41% or 70 cases per 1000 p/s had FTT not diagnosed as WS. The WS and FTT cases per 1000 p/s by calendar year were: 1992: 60 vs 172; 1993: 22 vs 80; 1994: 8 vs 33; 1995: 2 vs 12; 1996: 2 vs 10; 1997: 0.3 vs 3. The average rate of decline for both conditions is 59% per year (95% CI: 55%, 63%). CONCLUSION: A significant and persistent decreasing trend has been observed in the occurrence of both WS and FTT among our study population. Further investigation is required to determine whether this trend is likely due to changes in diagnostic or treatment practices.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Child
• Failure to Thrive
• HIV Infections
• HIV Seropositivity
• Humans
• Incidence
• Puerto Rico
• Wasting Syndrome

Other ID:

• 98388694

UI: 102227624

From Meeting Abstracts