Bibliographic Citation
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Title | Futility of pericardiectomy for postirradiation constrictive pericarditis |
Creator/Author | Ni, Y. ; von Segesser, L.K. ; Turina, M. (University Hospital, Zuerich (Switzerland)) |
Publication Date | 1990 Mar 01 |
OSTI Identifier | OSTI ID: 6968147 |
Other Number(s) | ISSN0003-4975; CODEN: ATHSA |
Resource Type | Journal Article |
Resource Relation | Annals of Thoracic Surgery ; Vol/Issue: 49:3 |
Subject | 560151 -- Radiation Effects on Animals-- Man; HODGKINS DISEASE-- RADIOTHERAPY;PERICARDIUM-- DELAYED RADIATION EFFECTS;RADIOTHERAPY-- SIDE EFFECTS; PATIENTS;RADIATION INJURIES;REVIEWS |
Related Subject | BIOLOGICAL EFFECTS;BIOLOGICAL RADIATION EFFECTS;BODY;CARDIOVASCULAR SYSTEM;DISEASES;DOCUMENT TYPES;HEART;IMMUNE SYSTEM DISEASES;INJURIES;LYMPHOMAS;MEDICINE;MEMBRANES;NEOPLASMS;NUCLEAR MEDICINE;ORGANS;RADIATION EFFECTS;RADIOLOGY;SEROUS MEMBRANES;THERAPY |
Description/Abstract | Two patients underwent pericardiectomy for postirradiation constrictive pericarditis.^Both had received radiotherapy (more than 6,000 rads) for treatment of Hodgkin`s disease 17 (patient 2) and 20 years (patient 1) earlier.^At the time of operation, the patients were in New York Heart Association functional class III-IV or IV.^Preoperative catheterization showed the following pressures for patients 1 and 2, respectively: right atrial, 30 and 14 mm Hg; right ventricular end-diastolic, 28 and 14 mm Hg; wedge, 29 and 13 mm Hg; and left ventricular end-diastolic, 27 and 14 mm Hg.^Complete epicardiectomy and pericardiectomy was attempted in both patients.^However, hospital mortality was 100%; patient 1 died of multiorgan failure after six days, and patient 2 died of biventricular failure after 3 months.^A review of the literature revealed 44 cases of pericardiectomy for postirradiation constrictive pericarditis and a late survival rate of less than 50%.^The poor results in these patients compared with patients having pericardiectomy for other reasons seem to be due mainly to the various kinds of radiation-induced damage to the heart as a whole, including untimely coronary artery disease, myocardial fibrosis, atrioventricular conduction disturbances, and valve dysfunction, with the result that complete relief by epicardiectomy and pericardiectomy may not be technically feasible.^13 references. |
Country of Publication | United States |
Language | English |
Format | Pages: 445-448 |
System Entry Date | 2001 May 13 |
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