Testing Information

Testing Status of Agents at NTP

Acrolein

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http://ntp.niehs.nih.gov/go/TS-10515-N

CASRN: 107-02-8

Formula: C3 H4 O

Synonyms/Common Names:

  • ACRALDEHYDE
  • 2-PROPENAL (9CI)

Known Uses:

INTERMEDIATE FOR GLYCERINE, POLYURETHANE, POLYESTER RESINS, METHIONINE AND VARIOUS PHARMACEUTICALS. COLLOIDAL SUSPENSIONS OF METALS. MILITARY POISON GAS MIXTURES. TISSUE FIXATIVE. SLIMICIDE IN PAPER MANUFACTURE. CONTROL OF AQUATIC WEEDS, JET FUELS (CEH)

Short-Term Toxicity

  • 13-WEEK (Gavage)  (C02802C) Report Complete 
    • TOX-48   (Peer Review 05/14/2004)
      Comparative Toxicity Studies of Allyl Acetate (CAS No. 591-87-7), Allyl Alcohol (CAS No. 107-18-6) and Acrolein (CAS No. 107-02-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 0.75, 1.25, 2.5, 5, OR 10 MG/KG M: 0, 1.25, 2.5, 5, 10, OR 20 MG/KG; 10 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (134448) Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Weakly Positive 
  • Drosophila  (395759) Completed 
    • Citation: Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (472710) Completed 
    • Citation: Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Micronucleus  (A59477) Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (326814) Completed 
    •  Negative 
  • Salmonella  (326815) Completed 
    •  Negative 
  • Salmonella  (870479) Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Weakly Positive 

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Web page last updated on January 22, 2009