Zheng X, Kolbert C, Stockman L, Sandhu GS, Roberts GD; American Society for Microbiology. General Meeting.
Abstr Gen Meet Am Soc Microbiol. 1997 May 4-8; 97: 260 (abstract no. F2).
Division of Clinical Microbiology, Mayo Clinic, Rochester, MN.
Fungal infections have become more significant due to increasing incidence of AIDS as well as the rising number of organ transplantations. Recognition of the phylogenetic relationships among these organisms may facilitate a better understanding of their biological niche and pathological properties. Recently, we analyzed and reported the nucleic acid sequences of a portion of the 28S rRNA genes from 50 species of medically important fungi. In the present study, phylogenetic analysis of these sequences was performed to determine the evolutionary relatedness between species. Our data suggested three primary phylogenetic clusters distinguishing Trichosporon species and Cryptococcus species from each other as well as from other fungal agents. A larger phylogenetic cluster suggested that Candida albicans, Candida parapsilosis, Candida tropicalis, Candida guilliermondii, and Candida kefyr were closely related, but excluded the clinically significant Candida krusei which has a unique antibiotic susceptibility pattern. C. krusei clustered more closely with pathogens such as Coccidioides immitis, Blastomyces dermatitidis, and histoplasma capsulatum. Although the classification of an important pathogen Candida glabrata (Torulopsis glabrata) has been debated, our analysis suggested a unique relatedness with Candida kefyr and Saccharomyces cerevisiae.
Publication Types:
Keywords:
- Base Sequence
- Blastomyces
- Candida
- Candida albicans
- Candida glabrata
- Coccidioides
- Cryptococcosis
- Fungi
- Mycoses
- genetics
- microbiology
Other ID:
UI: 102235323
From Meeting Abstracts