P O S T P O N E D


Seminar:  "Maximum likelihood and other new approaches to cryo-EM
           structures of membrane proteins"
Speaker:   Fred Sigworth
           Department of Cellular and Molecular Physiology
           Yale University School of Medicine
Date:        NOT: 9/27/00
Time:        9:00 am
Place:       Building 6, Room 407

Abstract:

Fred will discuss his ideas on using maximum-likelihood (ML)
techniques to enhance the three-dimensional reconstruction of objects
from cryo-electron micrographs.  A 3D reconstruction can be calculated
after the view orientation and translational position of each imaged
particle is determined.  Cryo-EM images of biological macromolecules
are noisy, and hence it is difficult to determine accurate
orientations and translational parameters of the imaged particles.
The ML technique that Fred has developed is less sensitive to noise
than, for example, cross-correlation techniques.