| Proc Natl Acad Sci U S A. 1992 June 1; 89(11): 5006–5010. | PMCID: PMC49217 |
Compartmentation in mammalian cerebellum: Zebrin II and P-path antibodies define three classes of sagittally organized bands of Purkinje cells. N Leclerc, G A Schwarting, K Herrup, R Hawkes, and M Yamamoto E. K. Shriver Center, Waltham, MA 02254. Abstract The respective roles of genetic and epigenetic factors in generation of pattern formation in the vertebrate nervous system are still poorly elucidated. The mammalian cerebellum is subdivided in parasagittal modules defined by anatomical, physiological, and biochemical criteria. Immunostaining of adult mouse cerebellum with two monoclonal antibodies, P-path, which recognizes 9-O-acetylated glycolipids, and Zebrin II, which recognizes a 36-kDa protein, reveals three classes of sagittally organized bands of Purkinje cells: two complementary groups distinctly immunoreactive to one antibody but not the other and a third group that contains double-labeled cells. No Purkinje cells could be detected that were unreactive to either antibody. The specific and reproducible topography of these three classes of Purkinje cells may be related to the compartmentation of the cerebellum into developmental genetic modules. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.8M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. Images in this article Click on the image to see a larger version. These references are in PubMed. This may not be the complete list of references from this article. - Hawkes, R; colonnier, M; Leclerc, N. Monoclonal antibodies reveal sagittal banding in the rodent cerebellar cortex. Brain Res. 1985 May 6;333(2):359–365. [PubMed]
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