After Queen Isabella's death in 1504, Columbus lost his influence at the court. As he lies on his death bed, priests and friends are gathered around him, and one priest holds up a crucifix for him. Columbus died at Valladolid on May 20, 1506. The figures on either side of the panel represent King John II of Portugal and Martín Alonzo Pinzón, the commander of the Pinta.
