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pfam01454: MAGE 
MAGE family
The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.
Links
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Statistics
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PSSM-Id: 110455
View PSSM: pfam01454
Aligned: 47 rows
Created: 30-Sep-2008
Updated: 30-Oct-2008
Structure
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Aligned Rows:
pfam01454 is a member of the superfamily cl03220.
Sequence Alignment?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74695927   18 VVRFVLSQCESQVrsTVLTKTRFTNAARDIaaaenitTTKY--AKIFDEANAVLEEVYGFRLVGIPNKksasnkasrtgd 95
gi 75150660   25 VIRFILFKFHQSSgtPIKREDLTQIVTKNY-------RQRNlaTHVINEAKKKLSNVFGYDLKELQRArssstgqsr--- 94
gi 74626334   97 VVRYAICSQTSHN--TITRKDIVQKAFPEGt-----sRNLF--QSVFEEADRQLQLSFGFRLVAVTQSnrkkdmavsqlr 167
gi 74627210   31 MVRYILSRGESQN--SIITRNKLQSVIHEAareeniaKPSF--SKMFMDINAILYNVYGFELQGLPSKnnmnaggngsns 106
gi 74600479   43 VIRYVMSRELKSQ--IIRREHITQLYSNR--------RINY--DALITRVKLTLKEVYGLTLVVVPPKrgdkknk----- 105
gi 74587000   60 VVRLFLSRELNGR--TTRPDVIRKHIKHNL-------GRKIttEKLIQQANIILTEVYGLKIEEVPTIkredkkss---- 126
gi 74669638   68 LVRLALASELSRQ--PIRRTDISTKVLGEQg------SRQF--KIVFEMAQKTLRETFGMQLAELPVKekvtiqqrra-- 135
gi 121804701  71 MVRLALASEYARQ--PIRRTEISAKVLGDQg------VRQF--KVVFESAQKVLREKFGMQMVELPGRervtihdrrgaf 140
gi 74618477   53 LVRYALACEYSRT--PIRRDGIKERVLGIH-------GREF--KKVFAGAQKQLRATFGMEMVELPTKdrslltveqkrk 121
gi 74679027   49 LVRLALFQEYKRI--PIRRTEVAKQILPDN-------TRAF--PLVFARAQTILRDTFGCELYEIRARgkgdstedpsqt 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74695927   96 aeaa------------------------------dgdpgstpitdlgfkGDRFILCSTIKAPPaymqmvldqsrqlyvkr 145
gi 75150660   95 ----------------------------------------lpqsqssvdSKSYVLVSELPLE------------------ 116
gi 74626334  168 -------------------------------------rpatsnanssnlHRYWVLRSTLPME------------------ 192
gi 74627210  107 n------------------------------------tnksmpeplghrAQKFILLNNVPHSKnfddfkilqsahtyeel 150
gi 74600479  106 -------------------------------------------sshsngKQQLMLTNCLSPEGrivlqeiwltdseagip 142
gi 74587000  127 -----------------------------------------ksrkvtsdKNPYIVTSSLSSKSrailgelw-nknlaknv 164
gi 74669638  136 ---------------------------------------aqkvdrpsstNKSWILTSTLPLA------------------ 158
gi 121804701 141 fll--------------------------------ylkaaqkvekssstNKSWIVGSTLPAA------------------ 170
gi 74618477  122 --------------------------------------atksqsqkeptSNSYMLVSVLPEH------------------ 145
gi 74679027  118 qamtqtqkkgkgkgrqpnrgldaideeeeeedeeeedatitqkvkretgTKVYILQNILPGKI----------------- 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74695927  146 LGSgqYEPG---TETDhtltsqf----------------dtdqilaLQGIMAVVICIILFSKNNALEQELLTHLAKFGIP 206
gi 75150660  117 VFKkhVVDE---TTSP------------------------------VTGFTFVVLAIVQLAGGKIPEETLWHHLKRMGLH 163
gi 74626334  193 -----LQKD---SRLIvdsv----------------------ldtaYYGFLMTVIAFIAVSHCSVGHSELQSFLQEL-LT 241
gi 74627210  151 IVTgeYIGDdiaSGTSntleskl----------------stdrdlvYKGVLSVILCIVFFSKNNILHQELIKFLETFGIP 214
gi 74600479  143 NNRnsGDNQ---YFLPkynktssl---------------gsntdmvKTGVTLLIMSLLIISENHMSEYELVNGLKRFGLS 204
gi 74587000  165 KKIdiGGNK---FFLPkysitsvp---------------gshyelvKTGIMLVIISHIILNENHVSESALLKTLHKFGIS 226
gi 74669638  159 YRKpeILPP---TRAPle--------------------------gtYTGLYSFIIAVILLNGGSLPEQKLERYLKRTN-- 207
gi 121804701 171 YRRpeILPP---TKAPwe--------------------------stYTGLYSFIIAVIMLNGGSLPEQKLDRYLARTN-- 219
gi 74618477  146 LRVsdIIAP---SKVQsadg-----------------------eaaYIGLYTMLIAIITLSGGELSDPRLRRYLTRLNAA 199
gi 74679027  181 IEA--MAEP---APLPhgievegddddsgallqwdkgdggiighvgLLGIRTLILSLVLCHNRIINDDHLHALLRRLNLH 255
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74695927  207 TDgY----AVPIINmRIQDVL----------SYMVRLEYIqRTApAASETGALDSIF--YsvDRRTQVEFPQESL 265
gi 75150660  164 ENdE----HNPVFG-NNKQTL----------ETLVQQRFLqKEK----VSGPEGSTLf-YdlAERALDPQVSEKV 218
gi 74626334  242 EE------ETTPLHlDITRSL----------SLLVRQGYLdRVK------DDTHNQFv-YyiGSRAVTEISIEGL 293
gi 74627210  215 SDgS----KIAILNiTIEDLI----------KSLEKREYIvRLE----EKSDTDGEVisYriGRRTQAELGLESL 271
gi 74600479  205 DHpNf---KNSSFNaSLPDLI----------NELVKKEYLdK---EVQKDSNNVENVd-YklGRRSLVEFTPLSV 262
gi 74587000  227 SNlNv---KNSNFNlNSQELL----------KELVNKDYIlK---NVIKGRTESENIfdYsiGQRSLVEFSPQGV 285
gi 74669638  208 --------ADTYTPvDRTDRFl---------QRLCKEGYLiRNR----EMEGGEEIIe-YmvGPRGKVEVGVRGV 260
gi 121804701 220 --------ADTYTPiDRTDRLl---------QRLCKEGYLvRTR----EMDGGEELVe-YmvGPRGKMEVGTAGV 272
gi 74618477  200 ENmPssnpNNENAPsEKTELVl---------QRMTKQGYLvRVAdNKNAGDDDAIT---WhvGPRGKVEVDNEAI 262
gi 74679027  256 --------RETVLPyASKDTTdphltldkylELLAKYQYLeKIKnPGPMGQAEGGTVe-WkwGSREA-EFSSKAA 320
Citing CDD
Marchler-Bauer A, Anderson JB, Derbyshire MK, DeWeese-Scott C, Gonzales NR, Gwadz M, Hao L, He S, Hurwitz DI, Jackson JD, Ke Z, Krylov D, Lanczycki CJ, Liebert CA, Liu C, Lu F, Lu S, Marchler GH, Mullokandov M, Song JS, Thanki N, Yamashita RA, Yin JJ, Zhang D, Bryant SH. (2007) CDD: a conserved domain database for interactive domain family analysis. Nucleic Acids Res. 35: D237-40
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