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Title Conjunctival lymphoma: Results and treatment with a single anterior electron field. A lens sparing approach
Creator/Author Dunbar, S.F. ; Linggood, R.M. ; Doppke, K.P. ; Duby, A. ; Wang, C.C. (Massachusetts General Hospital Cancer Center, Boston (USA))
Publication Date1990 Aug 01
OSTI IdentifierOSTI ID: 6367616
Other Number(s)ISSN0360-3016; CODEN: IOBPD
Resource TypeJournal Article
Resource RelationInternational Journal of Radiation Oncology, Biology and Physics ; Vol/Issue: 19:2
Subject550603 -- Medicine-- External Radiation in Therapy-- (1980-); EYES-- LYMPHOMAS;LYMPHOMAS-- RADIOTHERAPY; CRYSTALLINE LENS;ELECTRON BEAMS;ELECTRONS;PATIENTS;RADIATION DOSES;RADIATION PROTECTION
Related SubjectBEAMS;BODY;BODY AREAS;DISEASES;DOSES;ELEMENTARY PARTICLES;EYES;FACE;FERMIONS;HEAD;IMMUNE SYSTEM DISEASES;LEPTON BEAMS;LEPTONS;MEDICINE;NEOPLASMS;NUCLEAR MEDICINE;ORGANS;PARTICLE BEAMS;RADIOLOGY;SENSE ORGANS;THERAPY
Description/Abstract Lymphoma of the conjunctiva is rare.^It presents in older patients as a mass lesion and usually remains localized.^Surgery is limited to biopsy, and radiation therapy is the definitive treatment of choice.^The entire conjunctiva is treated.^Relatively high doses (approximately 30 Gy) are required for local control, which may lead to cataract formation.^Twelve patients with conjunctival lymphoma were treated at the Massachusetts General Hospital between 1979 and 1988.^Ten of 12 patients presented with a unilateral lesion; 2 of 12 with bilateral lesions.^Two of 12 patients were found to have systemic disease at the time of presentation.^One patient developed conjunctival lymphoma 5 years after the diagnosis of generalized disease.^Using electron beam, all patients were treated with a single anterior circular field to total doses ranging from 24 Gy to 30 Gy delivered in 8 to 16 fractions over 9 to 20 days.^In all cases, the lens was shielded by a specially designed plastic contact lens bearing a 12 mm diameter lead shield.^The lens dose was determined at varying depths beneath the shield for 6 MeV and 9 MeV electron beams and ranged from a minimum of 5% to an absolute maximum of 18% of the total dose delivered to the tumor.^Local control was maintained in all patients with follow-up to 9 1/2 years.^One patient relapsed distantly 3 years after treatment.^One of 12 patients died of systemic disease 4 years after treatment of the ocular lesion.^Two patients developed cataracts 4 and 5 years after treatment; one had bilateral cataract, although only one eye had been treated.^Both patients were over 75 years old.^In both cases, the cataracts were felt to be senile cataracts which are ophthalmologically and radiographically distinguishable from radiation induced lesions.
Country of PublicationUnited States
LanguageEnglish
FormatPages: 249-257
System Entry Date2001 May 13

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